Development Level

Tbio 1,638 | 11,445
Tchem 593 | 1,598
Tclin 214 | 613
Tdark 54 | 6,588

Collection

RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 180 | 979
preweaning lethality, incomple... 85 | 499
embryonic lethality prior to t... 59 | 278
embryonic lethality prior to o... 45 | 239
abnormal behavior 44 | 298
abnormal embryo size 44 | 220
enlarged heart 42 | 210
decreased vertical activity 41 | 208
abnormal bone structure 39 | 187
abnormal heart morphology 35 | 162
decreased total body fat amoun... 31 | 207
decreased body weight 28 | 161
increased startle reflex 27 | 112
decreased bone mineral content 25 | 151
decreased bone mineral density 25 | 126
increased total body fat amoun... 25 | 134
increased lean body mass 24 | 172
hyperactivity 22 | 148
increased circulating alkaline... 22 | 122
abnormal seminal vesicle morph... 21 | 114
decreased lean body mass 21 | 135
increased mean corpuscular hem... 20 | 96
cataract 19 | 92
decreased circulating choleste... 19 | 93
decreased mean corpuscular vol... 19 | 79
embryonic growth retardation 19 | 106
hypoactivity 19 | 132
increased circulating HDL chol... 19 | 80
abnormal lens morphology 17 | 81
abnormal retina morphology 17 | 71
decreased body length 17 | 101
decreased circulating glucose ... 17 | 126
decreased lymphocyte cell numb... 17 | 83
impaired glucose tolerance 17 | 75
increased bone mineral content 17 | 108
increased mean corpuscular vol... 17 | 92
decreased grip strength 16 | 116
decreased prepulse inhibition 16 | 82
short tibia 16 | 97
decreased erythrocyte cell num... 15 | 62
decreased hemoglobin content 15 | 68
decreased leukocyte cell numbe... 15 | 73
increased neutrophil cell numb... 15 | 46
male infertility 15 | 123
small superior vagus ganglion 15 | 74
abnormal gait 14 | 69
increased bone mineral density 14 | 72
thrombocytopenia 14 | 56
abnormal kidney morphology 13 | 65
decreased circulating insulin ... 13 | 76
decreased neutrophil cell numb... 13 | 42
improved glucose tolerance 13 | 79
increased circulating choleste... 13 | 66
increased monocyte cell number 13 | 63
tremors 13 | 39
abnormal neural tube closure 12 | 46
abnormal sleep behavior 12 | 70
decreased circulating HDL chol... 12 | 68
decreased circulating triglyce... 12 | 79
decreased hematocrit 12 | 46
decreased fasted circulating g... 11 | 65
decreased mean corpuscular hem... 11 | 50
edema 11 | 59
female infertility 11 | 60
increased fasted circulating g... 11 | 76
prenatal lethality prior to he... 11 | 87
small testis 11 | 58
abnormal eye morphology 10 | 68
abnormal testis morphology 10 | 43
increased heart weight 10 | 62
increased lymphocyte cell numb... 10 | 32
abnormal bone mineralization 9 | 38
abnormal skin morphology 9 | 50
decreased circulating alkaline... 9 | 46
increased circulating sodium l... 9 | 71
increased circulating triglyce... 9 | 42
increased hemoglobin content 9 | 45
increased mean corpuscular hem... 9 | 36
limb grasping 9 | 41
corneal opacity 8 | 32
decreased circulating LDL chol... 8 | 38
decreased circulating alanine ... 8 | 47
decreased circulating creatini... 8 | 39
decreased circulating serum al... 8 | 82
decreased red blood cell distr... 8 | 41
enlarged lymph nodes 8 | 37
increased blood urea nitrogen ... 8 | 48
increased circulating creatini... 8 | 38
increased grip strength 8 | 41
increased or absent threshold ... 8 | 101
pale yolk sac 8 | 25
abnormal epididymis morphology 7 | 42
decreased circulating calcium ... 7 | 36
decreased circulating total pr... 7 | 49
decreased startle reflex 7 | 75
enlarged spleen 7 | 41
increased body length 7 | 32
increased circulating calcium ... 7 | 34
increased circulating total pr... 7 | 28
pallor 7 | 34

Disease

Cancer 2,499 | 2,499
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 2,345 | 18,159
Digestive Tract 2,328 | 17,369
Female tissues 2,321 | 17,400
Skin and soft tissues 2,316 | 17,230
Male tissues 2,310 | 17,142
Blood and immune system 2,294 | 16,909
Liver and Pancreas 2,285 | 16,750
Urinary Tract 2,281 | 16,678
Respiratory system 2,262 | 16,393
Nervous System 2,259 | 16,725
Cardiovascular System 2,118 | 15,192

Target Family

Non-IDG 1,305 | 12,091
Enzyme 526 | 4,145
Transcription Factor 258 | 1,400
Kinase 193 | 634
Epigenetic 78 | 242
GPCR 50 | 408
Transporter 40 | 473
Nuclear Receptor 25 | 48
Ion Channel 15 | 344
TF/Epigenetic 9 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A Tbio Non-IDG -1.79111 52.4 187
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436