Development Level

Tbio 2,559 | 11,651
Tdark 528 | 6,593
Tchem 353 | 1,388
Tclin 138 | 612

Collection

GPCR: IDG Consortium (Targets) 19 | 126
Kinase: IDG Consortium (Target... 18 | 125
Ion Channel: IDG Consortium (T... 11 | 99
Kinase: IDG Consortium (Comple... 8 | 37
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 211 | 979
preweaning lethality, incomple... 134 | 499
embryonic lethality prior to t... 77 | 278
abnormal behavior 65 | 298
abnormal embryo size 55 | 220
embryonic lethality prior to o... 55 | 239
enlarged heart 47 | 210
abnormal bone structure 46 | 187
decreased vertical activity 45 | 208
increased lean body mass 44 | 172
decreased total body fat amoun... 43 | 207
hypoactivity 40 | 132
increased total body fat amoun... 38 | 134
abnormal heart morphology 36 | 162
decreased body weight 36 | 161
decreased bone mineral content 34 | 151
hyperactivity 33 | 148
decreased lean body mass 32 | 135
decreased grip strength 30 | 116
increased mean corpuscular vol... 30 | 92
short tibia 30 | 97
decreased bone mineral density 29 | 126
embryonic growth retardation 29 | 106
abnormal seminal vesicle morph... 28 | 114
cataract 28 | 92
increased circulating alkaline... 28 | 122
decreased circulating choleste... 26 | 93
decreased circulating glucose ... 25 | 126
increased bone mineral content 24 | 108
increased startle reflex 24 | 112
male infertility 24 | 123
abnormal lens morphology 23 | 81
decreased body length 23 | 101
increased fasted circulating g... 23 | 76
decreased circulating triglyce... 22 | 79
increased circulating HDL chol... 22 | 80
abnormal retina morphology 21 | 71
decreased circulating insulin ... 21 | 76
decreased fasted circulating g... 21 | 65
decreased prepulse inhibition 21 | 82
impaired glucose tolerance 20 | 75
increased mean corpuscular hem... 20 | 96
thrombocytopenia 20 | 56
abnormal sleep behavior 19 | 70
decreased mean corpuscular vol... 19 | 79
decreased startle reflex 19 | 75
increased or absent threshold ... 18 | 101
decreased circulating HDL chol... 17 | 68
decreased circulating serum al... 17 | 82
abnormal coat-hair pigmentatio... 16 | 64
abnormal gait 16 | 69
abnormal kidney morphology 16 | 65
abnormal skin morphology 16 | 50
improved glucose tolerance 16 | 79
increased bone mineral density 16 | 72
increased circulating triglyce... 16 | 42
abnormal behavioral response t... 15 | 66
decreased circulating total pr... 15 | 49
decreased leukocyte cell numbe... 15 | 73
decreased lymphocyte cell numb... 15 | 83
increased blood urea nitrogen ... 15 | 48
increased hematocrit 15 | 46
abnormal spleen morphology 14 | 55
edema 14 | 59
increased grip strength 14 | 41
increased hemoglobin content 14 | 45
increased leukocyte cell numbe... 14 | 47
increased circulating choleste... 13 | 66
increased heart weight 13 | 62
prenatal lethality prior to he... 13 | 87
small testis 13 | 58
abnormal bone mineralization 12 | 38
abnormal eye morphology 12 | 68
abnormal neural tube closure 12 | 46
decreased circulating alanine ... 12 | 47
decreased circulating calcium ... 12 | 36
decreased hemoglobin content 12 | 68
decreased red blood cell distr... 12 | 41
limb grasping 12 | 41
tremors 12 | 39
cardiovascular system phenotyp... 11 | 36
decreased blood urea nitrogen ... 11 | 51
decreased erythrocyte cell num... 11 | 62
increased erythrocyte cell num... 11 | 39
increased red blood cell distr... 11 | 34
prolonged QT interval 11 | 38
small superior vagus ganglion 11 | 74
abnormal craniofacial morpholo... 10 | 33
abnormal cranium morphology 10 | 36
abnormal epididymis morphology 10 | 42
abnormal locomotor behavior 10 | 24
abnormal testis morphology 10 | 43
enlarged spleen 10 | 41
increased circulating calcium ... 10 | 34
increased monocyte cell number 10 | 63
decreased caudal vertebrae num... 9 | 53
decreased circulating free fat... 9 | 31
decreased circulating iron lev... 9 | 32
decreased mean corpuscular hem... 9 | 31
microphthalmia 9 | 26

Disease

Breast cancer 3,578 | 3,578
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 3,529 | 18,159
Female tissues 3,509 | 17,400
Digestive Tract 3,501 | 17,369
Skin and soft tissues 3,498 | 17,230
Male tissues 3,492 | 17,142
Blood and immune system 3,465 | 16,909
Urinary Tract 3,453 | 16,678
Liver and Pancreas 3,445 | 16,750
Nervous System 3,442 | 16,725
Respiratory system 3,436 | 16,393
Cardiovascular System 3,279 | 15,192

Target Family

Non-IDG 2,142 | 12,091
Enzyme 736 | 4,145
Transcription Factor 261 | 1,400
Kinase 155 | 634
Transporter 91 | 473
GPCR 57 | 408
Ion Channel 57 | 344
Epigenetic 56 | 242
Nuclear Receptor 14 | 48
TF/Epigenetic 7 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63