Development Level

Tbio 72 | 11,445
Tclin 15 | 613
Tchem 7 | 1,598
Tdark 7 | 6,588

Collection

GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal behavior 6 | 298
increased lean body mass 6 | 172
decreased circulating HDL chol... 5 | 68
decreased total body fat amoun... 5 | 207
abnormal bone structure 4 | 187
decreased grip strength 4 | 116
increased bone mineral content 4 | 108
increased total body fat amoun... 4 | 134
abnormal locomotor behavior 3 | 24
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased lean body mass 3 | 135
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
increased circulating amylase ... 3 | 25
increased circulating chloride... 3 | 41
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
tremors 3 | 39
abnormal behavioral response t... 2 | 66
decreased body length 2 | 101
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased fasted circulating g... 2 | 65
decreased lymphocyte cell numb... 2 | 83
decreased pulmonary respirator... 2 | 5
embryonic lethality prior to t... 2 | 278
enlarged stomach 2 | 2
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased or absent threshold ... 2 | 101
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
increased vertical activity 2 | 24
small thymus 2 | 16
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal response to new envir... 1 | 10
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal stomach morphology 1 | 10
abnormal vitreous body morphol... 1 | 10
abnormal vocalization 1 | 21
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased NK T cell number 1 | 2
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased hemoglobin content 1 | 68
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased erythrocyte cell num... 1 | 39
increased fluid intake 1 | 1
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
thrombocytopenia 1 | 56

Disease

Autism spectrum disorder 101 | 101
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 98 | 18,159
Nervous System 96 | 16,725
Female tissues 95 | 17,400
Digestive Tract 93 | 17,369
Skin and soft tissues 92 | 17,230
Blood and immune system 91 | 16,909
Male tissues 91 | 17,142
Liver and Pancreas 90 | 16,750
Urinary Tract 88 | 16,678
Respiratory system 85 | 16,393
Cardiovascular System 76 | 15,192

Target Family

Non-IDG 41 | 12,091
Enzyme 17 | 4,145
Transcription Factor 16 | 1,400
Epigenetic 7 | 242
Ion Channel 7 | 344
GPCR 6 | 408
Transporter 4 | 473
TF/Epigenetic 2 | 38
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Cadherin-10 CDH10 Tbio Non-IDG -0.86821 9.34 155
Protein capicua homolog CIC Tbio Transcription Factor -1.88267 74.4 156
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Myelin transcription factor 1-like protein MYT1L Tbio Transcription Factor -1.49407 30.1 40
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Methylcytosine dioxygenase TET3 TET3 Tbio Enzyme -1.96016 82.2 167
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Reelin RELN Tbio Non-IDG -2.78255 645.2 121
Patched domain-containing protein 1 PTCHD1 Tbio Non-IDG -0.84569 7.72 81