Development Level

Tbio 609 | 10,625
Tchem 157 | 1,890
Tdark 134 | 7,003
Tclin 44 | 602

Collection

Eligible Ion Channel Proteins 6 | 117
Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 32 | 633
preweaning lethality, incomple... 16 | 260
abnormal behavior 14 | 226
decreased body weight 13 | 174
decreased bone mineral content 13 | 157
decreased lean body mass 13 | 195
decreased total body fat amoun... 13 | 186
decreased grip strength 12 | 123
abnormal retina morphology 11 | 100
increased bone mineral content 10 | 92
decreased bone mineral density 9 | 126
increased circulating alkaline... 9 | 119
increased lean body mass 9 | 107
increased mean corpuscular vol... 9 | 91
decreased prepulse inhibition 8 | 52
enlarged heart 8 | 111
increased or absent threshold ... 8 | 128
thrombocytopenia 8 | 46
abnormal bone structure 7 | 131
abnormal gait 7 | 51
abnormal lens morphology 7 | 73
decreased circulating choleste... 7 | 85
decreased circulating glucose ... 7 | 121
decreased startle reflex 7 | 48
embryonic lethality prior to t... 7 | 187
increased fasted circulating g... 7 | 68
increased mean corpuscular hem... 7 | 93
abnormal coat appearance 6 | 25
abnormal eye morphology 6 | 38
abnormal retinal pigmentation 6 | 61
decreased body length 6 | 108
decreased circulating insulin ... 6 | 75
hyperactivity 6 | 108
improved glucose tolerance 6 | 56
abnormal embryo size 5 | 112
abnormal heart morphology 5 | 51
abnormal testis morphology 5 | 30
decreased circulating triglyce... 5 | 83
decreased heart weight 5 | 44
decreased mean corpuscular vol... 5 | 50
hypoactivity 5 | 89
impaired glucose tolerance 5 | 52
increased blood urea nitrogen ... 5 | 44
increased circulating calcium ... 5 | 32
increased circulating chloride... 5 | 43
increased hematocrit 5 | 36
increased rib number 5 | 41
increased total body fat amoun... 5 | 57
small testis 5 | 37
abnormal behavioral response t... 4 | 52
abnormal coat/ hair morphology 4 | 18
abnormal coat/hair pigmentatio... 4 | 54
abnormal sleep behavior 4 | 63
cardiovascular system phenotyp... 4 | 35
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating serum al... 4 | 79
decreased hemoglobin content 4 | 53
decreased vertical activity 4 | 22
embryonic lethality prior to o... 4 | 148
female infertility 4 | 34
increased circulating choleste... 4 | 53
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 37
male infertility 4 | 62
short tibia 4 | 82
abnormal coping response 3 | 12
abnormal cornea morphology 3 | 24
abnormal cranium morphology 3 | 32
abnormal kidney morphology 3 | 30
abnormal seminal vesicle morph... 3 | 47
abnormal skin appearance 3 | 8
abnormal tail morphology 3 | 17
abnormal tooth morphology 3 | 24
abnormal vibrissa morphology 3 | 17
corneal opacity 3 | 25
decreased basophil cell number 3 | 11
decreased circulating alkaline... 3 | 41
decreased granulocyte number 3 | 8
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular hem... 3 | 34
decreased rib number 3 | 59
decreased spleen weight 3 | 13
embryonic growth retardation 3 | 28
enlarged lymph nodes 3 | 27
increased bone mineral density 3 | 52
increased circulating HDL chol... 3 | 63
increased circulating bilirubi... 3 | 16
increased circulating triglyce... 3 | 24
increased startle reflex 3 | 38
limb grasping 3 | 35
tremors 3 | 34
abnormal heart left ventricle ... 2 | 20
decreased IgG1 level 2 | 4
decreased circulating iron lev... 2 | 25
decreased lumbar vertebrae num... 2 | 62
increased circulating iron lev... 2 | 25
increased circulating serum al... 2 | 25
increased grip strength 2 | 83
straub tail 2 | 26

Disease

Atopic dermatitis 944 | 944
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 936 | 18,473
Female tissues 932 | 18,647
Nervous System 931 | 18,561
Skin and soft tissues 931 | 18,115
Urinary Tract 930 | 18,444
Liver and Pancreas 926 | 18,136
Cardiovascular System 919 | 17,958
Endocrine System 915 | 18,512
Blood and immune system 914 | 17,995
Male tissues 912 | 17,969
Respiratory system 894 | 17,484

Target Family

Non-IDG 579 | 11,971
Enzyme 232 | 4,146
Transcription Factor 43 | 1,400
Kinase 32 | 634
Transporter 20 | 473
GPCR 16 | 406
Ion Channel 10 | 341
Nuclear Receptor 7 | 48
Epigenetic 3 | 242
TF/Epigenetic 1 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523