Development Level

Tbio 162 | 10,625
Tchem 112 | 1,890
Tclin 60 | 602
Tdark 15 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, incomple... 9 | 260
preweaning lethality, complete... 8 | 633
decreased lean body mass 6 | 195
embryonic lethality prior to t... 4 | 187
increased circulating alkaline... 4 | 119
decreased CD8-positive, alpha-... 3 | 26
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating alanine ... 3 | 53
decreased circulating glucose ... 3 | 121
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
improved glucose tolerance 3 | 56
abnormal behavioral response t... 2 | 52
abnormal bone structure 2 | 131
decreased CD4-positive, alpha ... 2 | 19
decreased NK T cell number 2 | 28
decreased T cell number 2 | 31
decreased alpha-beta T cell nu... 2 | 12
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased mean corpuscular vol... 2 | 50
decreased monocyte cell number 2 | 28
embryonic lethality prior to o... 2 | 148
increased body weight 2 | 42
increased effector memory CD8-... 2 | 14
increased fasted circulating g... 2 | 68
increased mean corpuscular vol... 2 | 91
increased monocyte cell number 2 | 27
increased neutrophil cell numb... 2 | 15
increased total body fat amoun... 2 | 57
abnormal QRS complex 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal inner nuclear... 1 | 5
abnormal retinal vasculature m... 1 | 15
abnormal skin appearance 1 | 8
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal vibrissa morphology 1 | 17
convulsive seizures 1 | 11
decreased basophil cell number 1 | 11
decreased circulating creatini... 1 | 31
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
edema 1 | 11
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased effector memory T-he... 1 | 5
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
increased spleen weight 1 | 3
increased startle reflex 1 | 38
short tibia 1 | 82
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

Asthma 349 | 349
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 343 | 18,473
Nervous System 343 | 18,561
Female tissues 342 | 18,647
Endocrine System 341 | 18,512
Urinary Tract 341 | 18,444
Blood and immune system 339 | 17,995
Liver and Pancreas 337 | 18,136
Skin and soft tissues 336 | 18,115
Respiratory system 332 | 17,484
Male tissues 331 | 17,969
Cardiovascular System 330 | 17,958

Target Family

Non-IDG 201 | 11,971
Enzyme 70 | 4,146
GPCR 36 | 406
Transcription Factor 15 | 1,400
Kinase 14 | 634
Transporter 5 | 473
Ion Channel 3 | 341
Nuclear Receptor 3 | 48
Epigenetic 2 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Acidic mammalian chitinase CHIA Tchem Enzyme -2.59382 419.7 126
Interleukin-1 receptor type 1 IL1R1 Tclin Non-IDG -2.63413 362.9 482
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.08442 120.9 537
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Toll-like receptor 7 TLR7 Tclin Non-IDG -2.92878 974.2 670