Development Level

Tbio 139 | 10,625
Tchem 77 | 1,890
Tclin 27 | 602
Tdark 5 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
abnormal femur morphology 2 | 14
decreased body length 2 | 108
decreased circulating free fat... 2 | 39
decreased circulating glucose ... 2 | 121
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
embryonic lethality prior to o... 2 | 148
improved glucose tolerance 2 | 56
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal behavior 1 | 226
abnormal brain morphology 1 | 6
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal neural tube morpholog... 1 | 8
abnormal placement of pupils 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased NK T cell number 1 | 28
decreased alpha-beta T cell nu... 1 | 12
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating calcium ... 1 | 33
decreased circulating thyroxin... 1 | 5
decreased circulating triglyce... 1 | 83
decreased dendritic cell numbe... 1 | 3
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased late germinal center... 1 | 2
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydroencephaly 1 | 6
impaired glucose tolerance 1 | 52
increased KLRG1-positive gamma... 1 | 2
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating total pr... 1 | 20
increased early germinal cente... 1 | 2
increased effector memory CD8-... 1 | 14
increased effector memory T-he... 1 | 5
increased gamma-delta T cell n... 1 | 16
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased myeloid cell number 1 | 2
increased or absent threshold ... 1 | 128
increased spleen weight 1 | 3
increased thoracic vertebrae n... 1 | 8
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
limb grasping 1 | 35
mydriasis 1 | 9
narrow eye opening 1 | 15
oligodactyly 1 | 14
pale yolk sac 1 | 12
polydactyly 1 | 22
thrombocytopenia 1 | 46
vertebral transformation 1 | 12

Disease

Arthritis 248 | 248
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 191 | 18,561
Digestive Tract 190 | 18,473
Endocrine System 190 | 18,512
Female tissues 190 | 18,647
Urinary Tract 190 | 18,444
Blood and immune system 189 | 17,995
Liver and Pancreas 187 | 18,136
Respiratory system 187 | 17,484
Cardiovascular System 186 | 17,958
Male tissues 185 | 17,969
Skin and soft tissues 184 | 18,115

Target Family

Non-IDG 173 | 11,969
Enzyme 40 | 4,146
Kinase 12 | 634
Transcription Factor 9 | 1,400
GPCR 6 | 408
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
Transporter 2 | 473
Ion Channel 1 | 341

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.59865 595.2 0
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.59865 595.2 386
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561
Scavenger receptor cysteine-rich type 1 protein M130 CD163 Tbio Non-IDG -2.86758 701.8 663
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.67984 438.1 349
Resistin RETN Tbio Non-IDG -3.05251 1235.3 583
A disintegrin and metalloproteinase with thrombospondin motifs 1 ADAMTS1 Tchem Enzyme -2.41810 263.7 203
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -2.40709 4042.7 585