Development Level

Tbio 269 | 11,651
Tclin 46 | 612
Tchem 45 | 1,388
Tdark 5 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 24 | 979
embryonic lethality prior to t... 13 | 278
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to o... 8 | 239
abnormal embryo size 6 | 220
decreased bone mineral content 6 | 151
increased mean corpuscular hem... 6 | 96
corneal opacity 5 | 32
decreased mean corpuscular vol... 5 | 79
decreased vertical activity 5 | 208
embryonic growth retardation 5 | 106
small superior vagus ganglion 5 | 74
abnormal bone structure 4 | 187
abnormal eye morphology 4 | 68
decreased body weight 4 | 161
decreased mean corpuscular hem... 4 | 50
decreased total body fat amoun... 4 | 207
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
abnormal behavior 3 | 298
abnormal cornea morphology 3 | 31
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
decreased heart weight 3 | 27
decreased hemoglobin content 3 | 68
decreased leukocyte cell numbe... 3 | 73
enlarged heart 3 | 210
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased circulating iron lev... 3 | 30
increased monocyte cell number 3 | 63
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal lens morphology 2 | 81
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating insulin ... 2 | 76
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
enlarged uterus 2 | 11
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
pale yolk sac 2 | 25
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
decreased IgG1 level 1 | 8
decreased circulating calcium ... 1 | 36
decreased circulating creatine... 1 | 4
decreased circulating iron lev... 1 | 32
decreased hematocrit 1 | 46
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood uric acid leve... 1 | 5
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
long tibia 1 | 25
thrombocytosis 1 | 27
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Anemia 365 | 365
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 334 | 18,159
Digestive Tract 333 | 17,369
Blood and immune system 331 | 16,909
Male tissues 330 | 17,142
Skin and soft tissues 330 | 17,230
Liver and Pancreas 328 | 16,750
Female tissues 327 | 17,400
Urinary Tract 325 | 16,678
Nervous System 312 | 16,725
Respiratory system 311 | 16,393
Cardiovascular System 285 | 15,192

Target Family

Non-IDG 207 | 12,091
Enzyme 101 | 4,145
Kinase 16 | 634
Transcription Factor 16 | 1,400
Transporter 13 | 473
Ion Channel 6 | 344
Epigenetic 3 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.87605 76.4 263
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Solute carrier family 35 member G5 SLC35G5 Tbio Transporter -2.29194 155.0 61
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Gastric intrinsic factor GIF Tbio Non-IDG -3.20615 1559.4 172
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895