Development Level

Tbio 315 | 11,445
Tchem 78 | 1,598
Tdark 39 | 6,588
Tclin 19 | 613

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 6 | 125
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 37 | 979
preweaning lethality, incomple... 20 | 499
abnormal behavior 10 | 298
embryonic lethality prior to t... 9 | 278
abnormal embryo size 8 | 220
decreased total body fat amoun... 8 | 207
abnormal bone structure 7 | 187
embryonic lethality prior to o... 7 | 239
hypoactivity 7 | 132
decreased body weight 6 | 161
decreased vertical activity 6 | 208
enlarged heart 6 | 210
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased circulating glucose ... 5 | 126
decreased body length 4 | 101
decreased bone mineral content 4 | 151
decreased lymphocyte cell numb... 4 | 83
edema 4 | 59
hyperactivity 4 | 148
increased circulating sodium l... 4 | 71
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
abnormal heart morphology 3 | 162
abnormal limb morphology 3 | 13
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
abnormal tail morphology 3 | 25
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating LDL chol... 3 | 38
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 31
decreased neutrophil cell numb... 3 | 42
decreased red blood cell distr... 3 | 41
hemorrhage 3 | 23
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating chloride... 3 | 41
increased erythrocyte cell num... 3 | 39
increased hematocrit 3 | 46
increased lean body mass 3 | 172
increased leukocyte cell numbe... 3 | 47
short tibia 3 | 97
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal facial morphology 2 | 17
abnormal gait 2 | 69
abnormal joint morphology 2 | 23
abnormal lens morphology 2 | 81
abnormal lung morphology 2 | 26
abnormal tooth morphology 2 | 24
absent startle reflex 2 | 24
brachydactyly 2 | 19
cardiovascular system phenotyp... 2 | 36
cyanosis 2 | 7
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased circulating alkaline... 2 | 46
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased startle reflex 2 | 75
decreased threshold for audito... 2 | 26
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
impaired glucose tolerance 2 | 75
increased body length 2 | 32
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating triglyce... 2 | 42
increased heart rate 2 | 23
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
microphthalmia 2 | 26
polycystic kidney 2 | 15
prolonged QT interval 2 | 38
shortened QT interval 2 | 4
syndactyly 2 | 23
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal cornea morphology 1 | 31
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
absent spleen 1 | 3
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
enlarged spleen 1 | 41
increased circulating amylase ... 1 | 25
increased circulating iron lev... 1 | 30
increased startle reflex 1 | 112

Disease

Amyotrophic lateral sclerosis 451 | 451
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 446 | 18,159
Digestive Tract 443 | 17,369
Skin and soft tissues 443 | 17,230
Female tissues 441 | 17,400
Nervous System 440 | 16,725
Liver and Pancreas 439 | 16,750
Male tissues 439 | 17,142
Urinary Tract 437 | 16,678
Blood and immune system 434 | 16,909
Respiratory system 434 | 16,393
Cardiovascular System 422 | 15,192

Target Family

Non-IDG 272 | 12,091
Enzyme 86 | 4,145
Transcription Factor 31 | 1,400
Kinase 26 | 634
Ion Channel 12 | 344
Transporter 10 | 473
Epigenetic 7 | 242
GPCR 3 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
LIM domain only protein 7 LMO7 Tbio Non-IDG -1.24771 19.7 80
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
A-kinase anchor protein 11 AKAP11 Tbio Enzyme -1.02415 11.7 38
Nicotinamide N-methyltransferase NNMT Tchem Enzyme -2.09313 121.9 268
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Testis-specific Y-encoded-like protein 4 TSPYL4 Tdark Non-IDG -0.11115 0.87 119
Acidic leucine-rich nuclear phosphoprotein 32 family member E ANP32E Tbio Non-IDG -0.82034 5.60 97
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94