Development Level

Tbio 294 | 10,625
Tchem 83 | 1,890
Tdark 39 | 7,003
Tclin 16 | 602

Collection

Kinase: IDG Consortium (Targets) 6 | 125
GPCR: IDG Consortium (Targets) 1 | 127
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 21 | 633
decreased total body fat amoun... 9 | 186
abnormal behavior 7 | 226
decreased body weight 7 | 174
decreased lean body mass 7 | 195
preweaning lethality, incomple... 7 | 260
decreased body length 5 | 108
decreased bone mineral content 5 | 157
decreased circulating glucose ... 5 | 121
embryonic lethality prior to t... 5 | 187
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
abnormal embryo size 4 | 112
decreased circulating HDL chol... 4 | 77
decreased grip strength 4 | 123
embryonic lethality prior to o... 4 | 148
increased lean body mass 4 | 107
abnormal bone structure 3 | 131
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
decreased bone mineral density 3 | 126
decreased circulating alkaline... 3 | 41
decreased circulating choleste... 3 | 85
decreased circulating fructosa... 3 | 31
decreased heart weight 3 | 44
hyperactivity 3 | 108
improved glucose tolerance 3 | 56
increased circulating chloride... 3 | 43
increased mean corpuscular hem... 3 | 93
increased or absent threshold ... 3 | 128
short tibia 3 | 82
abnormal cranium morphology 2 | 32
abnormal head morphology 2 | 10
abnormal tooth morphology 2 | 24
cardiovascular system phenotyp... 2 | 35
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating insulin ... 2 | 75
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased startle reflex 2 | 48
enlarged heart 2 | 111
hydrops fetalis 2 | 22
increased circulating glucose ... 2 | 16
increased circulating sodium l... 2 | 71
irregularly shaped pupil 2 | 7
persistence of hyaloid vascula... 2 | 22
polycystic kidney 2 | 9
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal locomotor activation 1 | 26
abnormal lung morphology 1 | 15
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal thoracic vertebrae mo... 1 | 16
absent teeth 1 | 4
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating potassiu... 1 | 17
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating amylase ... 1 | 13
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
thrombocytopenia 1 | 46

Disease

Amyotrophic Lateral Sclerosis 432 | 432
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 430 | 17,994
Cardiovascular System 430 | 17,957
Digestive Tract 430 | 18,472
Endocrine System 430 | 18,511
Female tissues 430 | 18,646
Liver and Pancreas 430 | 18,135
Nervous System 430 | 18,560
Urinary Tract 430 | 18,443
Male tissues 428 | 17,968
Respiratory system 427 | 17,483
Skin and soft tissues 427 | 18,114

Target Family

Non-IDG 257 | 11,969
Enzyme 83 | 4,146
Transcription Factor 32 | 1,400
Kinase 25 | 634
Ion Channel 11 | 341
Transporter 11 | 473
Epigenetic 6 | 242
GPCR 3 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Protein N-lysine methyltransferase METTL21A METTL21A Tchem Enzyme 0.02 1.05 62
ERBB receptor feedback inhibitor 1 ERRFI1 Tbio Non-IDG -1.84249 72.2 131
CD40 ligand CD40LG Tchem Non-IDG -4.56976 36580.5 1095
Alternative prion protein PRNP Tbio Non-IDG -3.44085 5471.9 0
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.58792 56.8 175
E3 ubiquitin-protein ligase Praja-2 PJA2 Tbio Enzyme -0.64427 2.59 159
Tripartite motif-containing protein 55 TRIM55 Tdark Non-IDG -0.67847 4.68 117
LIM and calponin homology domains-containing protein 1 LIMCH1 Tdark Non-IDG -0.53907 2.66 42
EGF-containing fibulin-like extracellular matrix protein 1 EFEMP1 Tbio Non-IDG -2.12889 148.3 205