Development Level

Tbio 388 | 10,625
Tchem 129 | 1,890
Tdark 77 | 7,003
Tclin 50 | 602

Collection

Eligible Ion Channel Proteins 4 | 117
Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 30 | 633
preweaning lethality, incomple... 21 | 260
abnormal behavior 15 | 226
decreased body weight 13 | 174
embryonic lethality prior to t... 12 | 187
increased lean body mass 12 | 107
decreased total body fat amoun... 11 | 186
abnormal bone structure 10 | 131
decreased circulating glucose ... 10 | 121
decreased circulating choleste... 9 | 85
decreased lean body mass 9 | 195
decreased lumbar vertebrae num... 9 | 62
increased or absent threshold ... 9 | 128
increased sacral vertebrae num... 9 | 62
decreased rib number 8 | 59
increased circulating alkaline... 8 | 119
decreased circulating HDL chol... 7 | 77
decreased circulating alanine ... 7 | 53
decreased circulating serum al... 7 | 79
decreased circulating triglyce... 7 | 83
decreased fasted circulating g... 7 | 49
decreased grip strength 7 | 123
enlarged heart 7 | 111
increased circulating HDL chol... 7 | 63
abnormal embryo size 6 | 112
decreased bone mineral content 6 | 157
decreased circulating total pr... 6 | 41
decreased prepulse inhibition 6 | 52
embryonic lethality prior to o... 6 | 148
increased circulating choleste... 6 | 53
abnormal bone mineralization 5 | 55
abnormal retina morphology 5 | 100
cardiovascular system phenotyp... 5 | 35
decreased circulating LDL chol... 5 | 37
decreased mature B cell number 5 | 25
decreased mean corpuscular vol... 5 | 50
increased bone mineral density 5 | 52
increased circulating phosphat... 5 | 24
increased circulating sodium l... 5 | 71
increased mean corpuscular hem... 5 | 93
abnormal cranium morphology 4 | 32
abnormal rib morphology 4 | 28
abnormal seminal vesicle morph... 4 | 47
abnormal sleep behavior 4 | 63
abnormal tooth morphology 4 | 24
decreased body length 4 | 108
decreased bone mineral density 4 | 126
decreased circulating alkaline... 4 | 41
decreased circulating aspartat... 4 | 27
decreased circulating fructosa... 4 | 31
decreased circulating insulin ... 4 | 75
hypoactivity 4 | 89
increased body weight 4 | 42
increased fasted circulating g... 4 | 68
tremors 4 | 34
abnormal QRS complex 3 | 25
abnormal behavioral response t... 3 | 52
abnormal cornea morphology 3 | 24
abnormal gait 3 | 51
abnormal lens morphology 3 | 73
corneal opacity 3 | 25
decreased NK T cell number 3 | 28
decreased erythrocyte cell num... 3 | 43
decreased mean corpuscular hem... 3 | 34
decreased startle reflex 3 | 48
decreased total retina thickne... 3 | 20
hyperactivity 3 | 108
immune system phenotype 3 | 17
improved glucose tolerance 3 | 56
increased body length 3 | 20
increased circulating LDL chol... 3 | 15
increased circulating chloride... 3 | 43
increased grip strength 3 | 83
increased heart weight 3 | 37
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 25
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
limb grasping 3 | 35
narrow eye opening 3 | 15
persistence of hyaloid vascula... 3 | 22
vertebral fusion 3 | 23
abnormal coat/hair pigmentatio... 2 | 54
abnormal epididymis morphology 2 | 31
abnormal locomotor activation 2 | 26
abnormal vertebrae morphology 2 | 14
abnormal vibrissa morphology 2 | 17
decreased T cell number 2 | 31
decreased circulating chloride... 2 | 32
decreased circulating glycerol... 2 | 19
decreased effector memory CD8-... 2 | 24
decreased heart rate variabili... 2 | 11
female infertility 2 | 34
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased circulating bilirubi... 2 | 16
prenatal lethality prior to he... 2 | 64
thrombocytopenia 2 | 46

Disease

Alzheimer's disease 644 | 644
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 635 | 18,647
Nervous System 635 | 18,561
Endocrine System 634 | 18,512
Liver and Pancreas 634 | 18,136
Digestive Tract 633 | 18,473
Urinary Tract 632 | 18,444
Blood and immune system 630 | 17,995
Cardiovascular System 629 | 17,958
Male tissues 627 | 17,969
Skin and soft tissues 626 | 18,115
Respiratory system 624 | 17,484

Target Family

Non-IDG 361 | 11,971
Enzyme 155 | 4,146
Transcription Factor 32 | 1,400
Kinase 29 | 634
Transporter 26 | 473
Ion Channel 14 | 341
GPCR 12 | 406
Epigenetic 10 | 242
Nuclear Receptor 4 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
Neurofilament heavy polypeptide NEFH Tbio Non-IDG -2.73883 563.3 681
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244