Development Level

Tbio 419 | 11,445
Tchem 116 | 1,598
Tdark 72 | 6,588
Tclin 51 | 613

Collection

RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Target... 4 | 125
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 44 | 979
preweaning lethality, incomple... 31 | 499
embryonic lethality prior to t... 16 | 278
abnormal behavior 15 | 298
decreased vertical activity 13 | 208
increased lean body mass 12 | 172
increased total body fat amoun... 12 | 134
abnormal bone structure 10 | 187
abnormal embryo size 10 | 220
decreased body weight 10 | 161
decreased lean body mass 10 | 135
embryonic lethality prior to o... 10 | 239
decreased total body fat amoun... 9 | 207
abnormal seminal vesicle morph... 8 | 114
decreased circulating glucose ... 8 | 126
decreased circulating triglyce... 8 | 79
decreased prepulse inhibition 7 | 82
enlarged heart 7 | 210
increased circulating alkaline... 7 | 122
increased circulating sodium l... 7 | 71
cataract 6 | 92
decreased mean corpuscular vol... 6 | 79
hypoactivity 6 | 132
increased circulating chloride... 6 | 41
increased mean corpuscular vol... 6 | 92
increased startle reflex 6 | 112
abnormal gait 5 | 69
cardiovascular system phenotyp... 5 | 36
decreased bone mineral content 5 | 151
decreased circulating HDL chol... 5 | 68
decreased circulating insulin ... 5 | 76
decreased circulating total pr... 5 | 49
increased circulating phosphat... 5 | 26
increased fasted circulating g... 5 | 76
short tibia 5 | 97
abnormal cranium morphology 4 | 36
abnormal epididymis morphology 4 | 42
abnormal eye morphology 4 | 68
abnormal lens morphology 4 | 81
abnormal retina morphology 4 | 71
decreased blood urea nitrogen ... 4 | 51
decreased circulating LDL chol... 4 | 38
decreased circulating alanine ... 4 | 47
decreased circulating alkaline... 4 | 46
decreased circulating aspartat... 4 | 34
decreased circulating choleste... 4 | 93
decreased circulating serum al... 4 | 82
decreased erythrocyte cell num... 4 | 62
decreased fasted circulating g... 4 | 65
decreased grip strength 4 | 116
decreased startle reflex 4 | 75
embryonic growth retardation 4 | 106
hyperactivity 4 | 148
increased bone mineral density 4 | 72
increased circulating choleste... 4 | 66
increased circulating creatini... 4 | 38
increased heart weight 4 | 62
increased mean corpuscular hem... 4 | 36
increased or absent threshold ... 4 | 101
limb grasping 4 | 41
pallor 4 | 34
persistence of hyaloid vascula... 4 | 33
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
tremors 4 | 39
abnormal rib morphology 3 | 10
abnormal sleep behavior 3 | 70
abnormal tail morphology 3 | 25
abnormal vertebrae morphology 3 | 18
absent startle reflex 3 | 24
decreased basophil cell number 3 | 16
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating free fat... 3 | 31
decreased circulating fructosa... 3 | 30
decreased circulating glycerol... 3 | 16
decreased heart rate variabili... 3 | 13
decreased lactate dehydrogenas... 3 | 16
decreased neutrophil cell numb... 3 | 42
edema 3 | 59
enlarged epididymis 3 | 31
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased circulating iron lev... 3 | 30
increased circulating triglyce... 3 | 42
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 96
increased red blood cell distr... 3 | 34
narrow eye opening 3 | 12
prenatal lethality prior to he... 3 | 87
small superior vagus ganglion 3 | 74
thrombocytopenia 3 | 56
vertebral fusion 3 | 23
abnormal coat-hair pigmentatio... 2 | 64
abnormal locomotor behavior 2 | 24
corneal opacity 2 | 32
increased hematocrit 2 | 46
increased prepulse inhibition 2 | 32

Disease

Alzheimer's disease 658 | 658
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 639 | 18,159
Female tissues 630 | 17,400
Skin and soft tissues 630 | 17,230
Digestive Tract 629 | 17,369
Liver and Pancreas 625 | 16,750
Nervous System 624 | 16,725
Male tissues 619 | 17,142
Urinary Tract 619 | 16,678
Blood and immune system 617 | 16,909
Respiratory system 612 | 16,393
Cardiovascular System 584 | 15,192

Target Family

Non-IDG 367 | 12,091
Enzyme 154 | 4,145
Transcription Factor 36 | 1,400
Kinase 32 | 634
Transporter 29 | 473
GPCR 13 | 408
Ion Channel 12 | 344
Epigenetic 10 | 242
Nuclear Receptor 4 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine deaminase GDA Tbio Enzyme -1.48687 32.3 196
Sodium/myo-inositol cotransporter SLC5A3 Tbio Transporter -1.62043 40.4 145
Alpha-1-antichymotrypsin SERPINA3 Tbio Non-IDG -2.94780 812.7 276
Trophinin TRO Tbio Non-IDG -1.94679 89.7 37
Cystatin-C CST3 Tbio Non-IDG -3.52815 3278.8 866
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 MACF1 Tbio Non-IDG -2.05246 115.8 45
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
ATP-dependent zinc metalloprotease YME1L1 YME1L1 Tbio Enzyme -2.42377 268.0 75
Fibrocystin PKHD1 Tbio Non-IDG -1.71770 56.1 82
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735