Development Level

Tbio 64 | 11,651
Tchem 31 | 1,388
Tclin 27 | 612

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased vertical activity 4 | 208
increased circulating alkaline... 4 | 122
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
impaired glucose tolerance 3 | 75
increased bone mineral content 3 | 108
increased total body fat amoun... 3 | 134
abnormal cornea morphology 2 | 31
abnormal gait 2 | 69
abnormal tooth morphology 2 | 24
cataract 2 | 92
decreased circulating bilirubi... 2 | 19
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating sodium l... 2 | 22
decreased neutrophil cell numb... 2 | 42
decreased spleen weight 2 | 10
decreased total body fat amoun... 2 | 207
increased bone mineral density 2 | 72
increased circulating LDL chol... 2 | 13
increased circulating free fat... 2 | 20
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 36
increased startle reflex 2 | 112
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
cleft palate 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating insulin ... 1 | 3
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Adenocarcinoma 122 | 122
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 120 | 18,159
Female tissues 118 | 17,400
Digestive Tract 117 | 17,369
Male tissues 117 | 17,142
Skin and soft tissues 116 | 17,230
Blood and immune system 115 | 16,909
Liver and Pancreas 114 | 16,750
Respiratory system 114 | 16,393
Urinary Tract 114 | 16,678
Nervous System 113 | 16,725
Cardiovascular System 102 | 15,192

Target Family

Non-IDG 56 | 12,091
Enzyme 27 | 4,145
Kinase 13 | 634
Transcription Factor 11 | 1,400
Nuclear Receptor 6 | 48
Epigenetic 4 | 242
GPCR 2 | 408
Ion Channel 2 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Runt-related transcription factor 3 RUNX3 Tbio Transcription Factor -2.71721 536.2 438