Development Level

Tbio 223 | 11,651
Tdark 56 | 6,593
Tchem 38 | 1,388
Tclin 19 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 26 | 979
preweaning lethality, incomple... 16 | 499
abnormal behavior 11 | 298
hypoactivity 9 | 132
decreased vertical activity 8 | 208
abnormal embryo size 7 | 220
abnormal heart morphology 7 | 162
embryonic lethality prior to t... 7 | 278
abnormal seminal vesicle morph... 6 | 114
decreased bone mineral content 6 | 151
decreased lymphocyte cell numb... 6 | 83
enlarged heart 6 | 210
small testis 6 | 58
decreased bone mineral density 5 | 126
decreased circulating choleste... 5 | 93
decreased total body fat amoun... 5 | 207
embryonic lethality prior to o... 5 | 239
abnormal bone structure 4 | 187
abnormal eye morphology 4 | 68
abnormal gait 4 | 69
decreased body weight 4 | 161
decreased circulating HDL chol... 4 | 68
decreased circulating insulin ... 4 | 76
increased hemoglobin content 4 | 45
increased lean body mass 4 | 172
increased mean corpuscular vol... 4 | 92
abnormal testis morphology 3 | 43
decreased body length 3 | 101
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating alkaline... 3 | 46
decreased circulating iron lev... 3 | 32
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular hem... 3 | 31
decreased startle reflex 3 | 75
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased fasted circulating g... 3 | 76
increased heart rate 3 | 23
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
abnormal snout morphology 2 | 23
cataract 2 | 92
convulsive seizures 2 | 13
decreased blood urea nitrogen ... 2 | 51
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating free fat... 2 | 31
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
decreased heart weight 2 | 27
decreased threshold for audito... 2 | 26
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased anti-nuclear antigen... 2 | 19
increased blood urea nitrogen ... 2 | 48
increased cardiac muscle contr... 2 | 8
increased circulating alkaline... 2 | 122
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased lymphocyte cell numb... 2 | 32
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
male infertility 2 | 123
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
iris synechia 1 | 3

Disease

Acquired metabolic disease 336 | 336
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 325 | 18,159
Female tissues 315 | 17,400
Digestive Tract 313 | 17,369
Skin and soft tissues 308 | 17,230
Nervous System 307 | 16,725
Male tissues 306 | 17,142
Urinary Tract 301 | 16,678
Blood and immune system 296 | 16,909
Liver and Pancreas 295 | 16,750
Respiratory system 291 | 16,393
Cardiovascular System 275 | 15,192

Target Family

Non-IDG 167 | 12,091
Enzyme 71 | 4,145
Transcription Factor 40 | 1,400
Kinase 15 | 634
GPCR 11 | 408
Transporter 11 | 473
Epigenetic 6 | 242
Ion Channel 6 | 344
Nuclear Receptor 6 | 48
oGPCR 3 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Nuclear factor erythroid 2-related factor 1 NFE2L1 Tbio Transcription Factor -1.57346 40.9 157
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610