Development Level

Tchem 47 | 1,598
Tclin 11 | 613

Collection

Kinase: IDG Consortium (Target... 10 | 125
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased lean body mass 2 | 172
abnormal behavior 1 | 298
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal response to tactile s... 1 | 17
abnormal spleen morphology 1 | 55
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased fasted circulating g... 1 | 65
decreased granulocyte number 1 | 6
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating LDL chol... 1 | 13
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 57 | 11,493
ovarian cancer 35 | 8,520
osteosarcoma 34 | 7,950
medulloblastoma, large-cell 32 | 6,241
Cancer 28 | 2,499
glioblastoma 26 | 5,792
atypical teratoid / rhabdoid tumor 22 | 5,112
ependymoma 22 | 4,679
non-small cell lung cancer 22 | 2,890
psoriasis 22 | 6,694
Breast cancer 21 | 3,578
Kidney cancer 20 | 2,613
lung cancer 20 | 4,740
adult high grade glioma 19 | 3,801
Astrocytoma, Pilocytic 18 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
malignant mesothelioma 17 | 3,232
oligodendroglioma 17 | 2,850
Renal Cell Carcinoma 16 | 214
invasive ductal carcinoma 15 | 2,951
Gastrointestinal stromal tumor 14 | 62
astrocytic glioma 14 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Pancreatic Neuroendocrine Tumor 13 | 45
lung carcinoma 13 | 2,843
primitive neuroectodermal tumor 13 | 3,035
group 4 medulloblastoma 12 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
cystic fibrosis 11 | 1,696
lung adenocarcinoma 11 | 2,716
subependymal giant cell astrocytoma 11 | 2,287
Autosomal recessive predisposition 10 | 1,442
Pick disease 10 | 1,894
group 3 medulloblastoma 10 | 4,104
interstitial cystitis 10 | 2,312
pituitary cancer 10 | 1,972
Blastic phase chronic myeloid leukemia 9 | 58
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Skin cancer 9 | 469
ductal carcinoma in situ 9 | 1,745
pancreatic cancer 9 | 2,398
tuberculosis 9 | 2,010
ulcerative colitis 9 | 1,819
Chronic phase chronic myeloid leukemia 8 | 45
Melanoma 8 | 711
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 8 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 8 | 47
acute quadriplegic myopathy 7 | 1,158
astrocytoma 7 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
spina bifida 7 | 1,074
Immune system cancer 6 | 140
Lymphoid leukemia 6 | 160
Rheumatoid arthritis 6 | 1,191
Short stature 6 | 531
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,728
juvenile dermatomyositis 6 | 1,187
non-small cell lung carcinoma 6 | 317
Alzheimer's disease 5 | 658
Breast Neoplasms 5 | 445
Carcinoma, Non-Small-Cell Lung 5 | 107
Delayed bone age 5 | 136
Dull intelligence 5 | 645
Hamman-Rich syndrome 5 | 34
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mammary Neoplasms 5 | 425
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neoplasm Invasiveness 5 | 161
Obesity 5 | 678
Poor school performance 5 | 645
adrenocortical carcinoma 5 | 1,428
medulloblastoma 5 | 720
mucosa-associated lymphoid tissue lymphoma 5 | 484
primary pancreatic ductal adenocarcinoma 5 | 1,109
progressive supranuclear palsy 5 | 676
Arthritis 4 | 290
Atopic dermatitis 4 | 952
Carcinoma, Hepatocellular 4 | 228
Delayed speech and language development 4 | 112
Diarrhea 4 | 253
Down syndrome 4 | 499
Epilepsy 4 | 792
Language Delay 4 | 112
Liver carcinoma 4 | 240
Multiple myeloma 4 | 1,332
Parkinson Disease 4 | 64
Parkinson's disease 4 | 392
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Small head 4 | 374
Speech Delay 4 | 112
Speech impairment 4 | 112
Splenomegaly 4 | 190
acute myeloid leukemia 4 | 783
primary Sjogren syndrome 4 | 735

Tissue

Endocrine System 58 | 18,159
Skin and soft tissues 58 | 17,230
Digestive Tract 57 | 17,369
Female tissues 57 | 17,400
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Urinary Tract 57 | 16,678
Blood and immune system 56 | 16,909
Respiratory system 56 | 16,393
Cardiovascular System 55 | 15,192
Liver and Pancreas 55 | 16,750

Target Family

Kinase 57 | 634
Enzyme 1 | 4,145

Ligand

CHEMBL509032 58 | 58
CHEMBL388978 200 | 200
CHEMBL603469 122 | 122
CHEMBL1230609 63 | 63
metformin 50 | 50
sunitinib 50 | 50
dasatinib 47 | 47
CHEMBL574738 44 | 44
nintedanib 44 | 44
CHEMBL288441 42 | 42
CHEMBL475251 42 | 42
CHEMBL386051 40 | 40
amifampridine 40 | 40
fampridine 40 | 40
guanidine 40 | 40
bosutinib 39 | 39
CHEMBL42 27 | 27
CHEMBL715 25 | 25
halothane 25 | 25
isoflurane 24 | 24
topiramate 24 | 24
CHEMBL495727 23 | 23
desflurane 23 | 23
dipyridamole 23 | 23
CHEMBL629 22 | 22
sevoflurane 22 | 22
CHEMBL85 21 | 21
imatinib 21 | 21
sorafenib 21 | 21
CHEMBL1112 20 | 20
chlorpromazine 20 | 20
lisuride 20 | 20
CHEMBL19611 19 | 19
clozapine 19 | 19
CHEMBL19215 18 | 18
CHEMBL2347053 18 | 18
CHEMBL249097 18 | 18
tetraethylammonium 18 | 18
thioridazine 18 | 18
CHEMBL1784637 17 | 17
CHEMBL1908395 17 | 17
CHEMBL1908397 17 | 17
CHEMBL516 17 | 17
ibrutinib 17 | 17
methoxyflurane 17 | 17
CHEMBL1909072 16 | 16
CHEMBL384304 16 | 16
CHEMBL608533 16 | 16
CHEMBL723 16 | 16
halazepam 16 | 16
metharbital 16 | 16
nilotinib 16 | 16
talbutal 16 | 16
thiamylal 16 | 16
triclofos 16 | 16
verapamil 16 | 16
CHEMBL1721885 15 | 15
CHEMBL445813 15 | 15
CHEMBL494089 15 | 15
CHEMBL708 15 | 15
bromocriptine 15 | 15
cabergoline 15 | 15
cisapride 15 | 15
haloperidol 15 | 15
staurosporine 15 | 15
zotepine 15 | 15
CHEMBL3217984 14 | 14
CHEMBL3683258 14 | 14
CHEMBL415 14 | 14
CHEMBL442 14 | 14
CHEMBL445 14 | 14
CHEMBL491473 14 | 14
CHEMBL522892 14 | 14
CHEMBL716 14 | 14
Cd2+ 14 | 14
acalabrutinib 14 | 14
ketanserin 14 | 14
mianserin 14 | 14
nafamostat 14 | 14
neratinib 14 | 14
pergolide 14 | 14
voruciclib 14 | 14
CHEMBL1201203 13 | 13
CHEMBL1241674 13 | 13
CHEMBL1980297 13 | 13
CHEMBL572878 13 | 13
CHEMBL99 13 | 13
MK-2461 13 | 13
adinazolam 13 | 13
amitriptyline 13 | 13
crizotinib 13 | 13
fospropofol 13 | 13
ilomastat 13 | 13
midostaurin 13 | 13
nifedipine 13 | 13
orphenadrine 13 | 13
quinidine 13 | 13
spiperone 13 | 13
terguride 13 | 13
triazolam 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Serine/threonine-protein kinase 32B STK32B Tchem Kinase -0.54101 2.56 98
Tyrosine-protein kinase FRK FRK Tchem Kinase -1.68365 49.2 394
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
Serine/threonine-protein kinase DCLK1 DCLK1 Tchem Kinase -2.08177 129.5 320
Non-receptor tyrosine-protein kinase TNK1 TNK1 Tchem Kinase -0.79047 7.71 293
Tyrosine-protein kinase Mer MERTK Tchem Kinase -2.27276 199.1 609
Serine/threonine-protein kinase 33 STK33 Tchem Kinase -1.15691 17.7 320
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.09841 125.5 257