Development Level

Tbio 4,015 | 10,625
Tdark 1,101 | 7,003
Tchem 791 | 1,890
Tclin 226 | 602

Collection

Eligible Kinase Proteins 61 | 134
Eligible Ion Channel Proteins 18 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 285 | 633
preweaning lethality, incomple... 100 | 260
abnormal behavior 80 | 226
embryonic lethality prior to t... 80 | 187
decreased lean body mass 78 | 195
decreased total body fat amoun... 78 | 186
embryonic lethality prior to o... 75 | 148
decreased body weight 74 | 174
decreased bone mineral content 67 | 157
decreased bone mineral density 58 | 126
increased circulating alkaline... 56 | 119
abnormal bone structure 53 | 131
decreased grip strength 50 | 123
increased or absent threshold ... 50 | 128
decreased body length 48 | 108
decreased circulating glucose ... 44 | 121
abnormal embryo size 43 | 112
increased mean corpuscular hem... 43 | 93
enlarged heart 38 | 111
increased lean body mass 38 | 107
decreased circulating triglyce... 37 | 83
hyperactivity 37 | 108
decreased circulating choleste... 35 | 85
increased fasted circulating g... 35 | 68
increased bone mineral content 34 | 92
increased grip strength 34 | 83
short tibia 34 | 82
decreased circulating HDL chol... 33 | 77
abnormal retina morphology 32 | 100
decreased circulating serum al... 31 | 79
abnormal lens morphology 30 | 73
decreased mean corpuscular vol... 30 | 50
hypoactivity 27 | 89
male infertility 27 | 62
increased mean corpuscular vol... 26 | 91
abnormal sleep behavior 25 | 63
decreased circulating insulin ... 25 | 75
impaired glucose tolerance 25 | 52
increased circulating choleste... 25 | 53
increased circulating sodium l... 25 | 71
prenatal lethality prior to he... 25 | 64
increased circulating HDL chol... 24 | 63
abnormal bone mineralization 23 | 55
abnormal retinal pigmentation 23 | 61
decreased lumbar vertebrae num... 23 | 62
decreased caudal vertebrae num... 22 | 49
decreased hemoglobin content 22 | 53
increased bone mineral density 22 | 52
decreased fasted circulating g... 21 | 49
decreased rib number 21 | 59
thrombocytopenia 21 | 46
abnormal coat/hair pigmentatio... 20 | 54
decreased circulating alanine ... 20 | 53
decreased startle reflex 20 | 48
increased exploration in new e... 20 | 56
increased leukocyte cell numbe... 20 | 37
increased sacral vertebrae num... 20 | 62
increased total body fat amoun... 20 | 57
abnormal gait 19 | 51
decreased heart weight 19 | 44
decreased prepulse inhibition 19 | 52
increased blood urea nitrogen ... 19 | 44
increased body weight 19 | 42
increased hemoglobin content 19 | 45
abnormal heart morphology 18 | 51
abnormal seminal vesicle morph... 18 | 47
decreased circulating alkaline... 18 | 41
decreased circulating fructosa... 18 | 31
decreased erythrocyte cell num... 18 | 43
decreased mean corpuscular hem... 18 | 34
improved glucose tolerance 18 | 56
decreased circulating chloride... 17 | 32
decreased circulating total pr... 17 | 41
decreased leukocyte cell numbe... 17 | 54
increased circulating chloride... 17 | 43
increased rib number 17 | 41
decreased circulating free fat... 16 | 39
increased circulating calcium ... 16 | 32
increased heart weight 16 | 37
abnormal behavioral response t... 15 | 52
abnormal eye morphology 15 | 38
abnormal testis morphology 15 | 30
increased circulating phosphat... 15 | 24
small testis 15 | 37
abnormal cranium morphology 14 | 32
abnormal epididymis morphology 14 | 31
abnormal spleen morphology 14 | 36
decreased NK T cell number 14 | 28
decreased blood urea nitrogen ... 14 | 31
decreased circulating LDL chol... 14 | 37
decreased circulating creatini... 14 | 31
decreased neutrophil cell numb... 14 | 37
increased hematocrit 14 | 36
increased startle reflex 14 | 38
abnormal neural tube closure 13 | 37
cardiovascular system phenotyp... 13 | 35
decreased circulating iron lev... 13 | 25
decreased effector memory CD8-... 13 | 24
increased circulating free fat... 13 | 17
increased erythrocyte cell num... 12 | 26

Disease

ovarian cancer 3,542 | 8,484
osteosarcoma 3,002 | 7,933
medulloblastoma, large-cell 2,317 | 6,234
psoriasis 2,303 | 6,685
glioblastoma 2,192 | 5,572
lung cancer 1,825 | 4,466
atypical teratoid / rhabdoid tumor 1,674 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,318 | 3,289
Breast cancer 1,211 | 3,094
malignant mesothelioma 1,209 | 3,162
pilocytic astrocytoma 1,163 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 1,146 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,113 | 2,956
invasive ductal carcinoma 1,104 | 2,950
primitive neuroectodermal tumor 1,088 | 3,031
oligodendroglioma 1,082 | 2,849
pediatric high grade glioma 1,046 | 2,712
non-small cell lung cancer 1,033 | 2,798
ependymoma 1,022 | 2,514
lung carcinoma 1,013 | 2,844
lung adenocarcinoma 983 | 2,713
pancreatic cancer 927 | 2,300
subependymal giant cell astrocytoma 927 | 2,287
Cancer 923 | 2,346
astrocytic glioma 869 | 2,241
Carcinoma 844 | 2,147
Multiple myeloma 842 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 840 | 1,795
Pick disease 807 | 1,893
ulcerative colitis 796 | 2,087
adult high grade glioma 754 | 2,148
group 3 medulloblastoma 752 | 2,254
interstitial cystitis 749 | 2,299
group 4 medulloblastoma 716 | 1,875
astrocytoma 695 | 1,493
diabetes mellitus 667 | 1,663
tuberculosis 646 | 1,557
pituitary cancer 618 | 1,972
cystic fibrosis 598 | 1,665
ductal carcinoma in situ 598 | 1,745
breast carcinoma 589 | 1,614
medulloblastoma 583 | 1,524
acute quadriplegic myopathy 574 | 1,157
juvenile dermatomyositis 562 | 1,189
colon cancer 541 | 1,475
primary pancreatic ductal adenocarcinoma 538 | 1,271
sonic hedgehog group medulloblastoma 532 | 1,482
dermatomyositis 526 | 933
posterior fossa group A ependymoma 523 | 1,511
Waldenstrons macroglobulinemia 497 | 765
Rheumatoid Arthritis 493 | 1,160
adrenocortical carcinoma 485 | 1,427
posterior fossa group B ependymoma 441 | 1,530
spina bifida 384 | 1,064
atypical teratoid/rhabdoid tumor 373 | 1,095
cutaneous lupus erythematosus 367 | 1,056
nasopharyngeal carcinoma 354 | 1,056
non primary Sjogren syndrome sicca 353 | 840
active Crohn's disease 347 | 918
primary Sjogren syndrome 335 | 789
gastric carcinoma 328 | 832
acute myeloid leukemia 317 | 780
esophageal adenocarcinoma 309 | 737
Atopic dermatitis 303 | 944
progressive supranuclear palsy 302 | 674
Alzheimer's disease 291 | 644
Duchenne muscular dystrophy 290 | 602
tuberculosis and treatment for 6 months 290 | 686
pancreatic carcinoma 268 | 567
aldosterone-producing adenoma 261 | 664
Intellectual disability 250 | 573
Down syndrome 245 | 548
IGA Glomerulonephritis 225 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 223 | 499
hepatocellular carcinoma 223 | 532
Obesity 221 | 616
Neurodegenerative disease 215 | 383
Amyotrophic Lateral Sclerosis 212 | 431
mucosa-associated lymphoid tissue lymphoma 199 | 480
Prostatic Neoplasms 190 | 471
gastric cancer 190 | 430
hereditary spastic paraplegia 189 | 313
Mammary Neoplasms 176 | 410
Schizophrenia 171 | 501
fibroadenoma 167 | 557
Endometriosis 163 | 535
Parkinson's disease 155 | 364
Multiple Sclerosis 153 | 498
chronic rhinosinusitis 151 | 512
active ulcerative colitis 148 | 477
Kidney disease 145 | 396
Polycystic Ovary Syndrome 143 | 332
Stomach Neoplasms 143 | 282
non-small cell lung carcinoma 142 | 413
sarcoidosis 142 | 358
inflammatory breast cancer 139 | 404
Asthma 129 | 349
Vascular disease 128 | 281
Epilepsy 126 | 346
tuberculosis and treatment for 3 months 124 | 327

Tissue

Blood and immune system 6,133 | 17,995
Female tissues 6,120 | 18,647
Nervous System 6,114 | 18,561
Digestive Tract 6,113 | 18,473
Liver and Pancreas 6,110 | 18,136
Urinary Tract 6,108 | 18,444
Endocrine System 6,106 | 18,512
Male tissues 6,103 | 17,969
Cardiovascular System 6,093 | 17,958
Respiratory system 6,071 | 17,484
Skin and soft tissues 6,018 | 18,115

Target Family

Non-IDG 3,608 | 11,971
Enzyme 1,677 | 4,146
Kinase 356 | 634
Transcription Factor 156 | 1,400
Transporter 147 | 473
Ion Channel 70 | 341
Epigenetic 58 | 242
GPCR 37 | 406
oGPCR 12 | 421
TF/Epigenetic 8 | 38
Nuclear Receptor 4 | 48

HPM Tissue

Platelets 6,133 | 6,133
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466