Development Level

Tbio 4,259 | 11,445
Tdark 965 | 6,588
Tchem 677 | 1,598
Tclin 230 | 613

Collection

RFA-RM-18-021 82 | 328
Kinase: IDG Consortium (Target... 54 | 125
Kinase: IDG Consortium (Comple... 21 | 37
Ion Channel: IDG Consortium (T... 18 | 99
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 450 | 979
preweaning lethality, incomple... 199 | 499
embryonic lethality prior to t... 122 | 278
embryonic lethality prior to o... 118 | 239
abnormal behavior 102 | 298
abnormal embryo size 87 | 220
decreased total body fat amoun... 83 | 207
abnormal bone structure 79 | 187
decreased body weight 70 | 161
decreased vertical activity 68 | 208
enlarged heart 66 | 210
decreased bone mineral content 62 | 151
increased lean body mass 61 | 172
increased circulating alkaline... 54 | 122
hyperactivity 52 | 148
decreased bone mineral density 51 | 126
increased total body fat amoun... 51 | 134
abnormal heart morphology 47 | 162
increased startle reflex 47 | 112
hypoactivity 46 | 132
decreased circulating glucose ... 45 | 126
decreased lean body mass 45 | 135
embryonic growth retardation 45 | 106
abnormal seminal vesicle morph... 42 | 114
decreased grip strength 41 | 116
male infertility 41 | 123
increased mean corpuscular hem... 40 | 96
decreased body length 39 | 101
increased or absent threshold ... 38 | 101
increased bone mineral content 37 | 108
short tibia 37 | 97
cataract 36 | 92
prenatal lethality prior to he... 36 | 87
increased fasted circulating g... 35 | 76
abnormal lens morphology 34 | 81
decreased circulating choleste... 34 | 93
decreased mean corpuscular vol... 34 | 79
decreased circulating triglyce... 32 | 79
decreased prepulse inhibition 31 | 82
decreased circulating HDL chol... 30 | 68
decreased lymphocyte cell numb... 30 | 83
increased mean corpuscular vol... 30 | 92
thrombocytopenia 29 | 56
decreased circulating serum al... 28 | 82
decreased startle reflex 28 | 75
impaired glucose tolerance 28 | 75
improved glucose tolerance 28 | 79
increased circulating HDL chol... 28 | 80
abnormal retina morphology 27 | 71
increased circulating choleste... 27 | 66
decreased circulating insulin ... 26 | 76
decreased hemoglobin content 26 | 68
decreased leukocyte cell numbe... 26 | 73
increased circulating sodium l... 26 | 71
abnormal eye morphology 25 | 68
abnormal gait 25 | 69
abnormal sleep behavior 25 | 70
decreased caudal vertebrae num... 25 | 53
decreased fasted circulating g... 25 | 65
edema 25 | 59
abnormal behavioral response t... 24 | 66
decreased erythrocyte cell num... 24 | 62
increased bone mineral density 24 | 72
increased heart weight 24 | 62
increased leukocyte cell numbe... 24 | 47
small superior vagus ganglion 24 | 74
abnormal coat-hair pigmentatio... 22 | 64
decreased circulating alkaline... 22 | 46
decreased mean corpuscular hem... 22 | 50
increased mean platelet volume 22 | 45
abnormal kidney morphology 21 | 65
small testis 21 | 58
decreased circulating total pr... 20 | 49
decreased neutrophil cell numb... 20 | 42
increased neutrophil cell numb... 20 | 46
decreased mean corpuscular hem... 19 | 31
increased blood urea nitrogen ... 19 | 48
increased circulating calcium ... 19 | 34
increased grip strength 19 | 41
abnormal skin morphology 18 | 50
abnormal spleen morphology 18 | 55
decreased blood urea nitrogen ... 18 | 51
increased hemoglobin content 18 | 45
abnormal epididymis morphology 17 | 42
abnormal testis morphology 17 | 43
decreased circulating alanine ... 17 | 47
decreased circulating chloride... 17 | 30
decreased hematocrit 17 | 46
decreased red blood cell distr... 17 | 41
increased erythrocyte cell num... 17 | 39
increased hematocrit 17 | 46
increased red blood cell distr... 17 | 34
abnormal bone mineralization 16 | 38
decreased circulating LDL chol... 16 | 38
decreased circulating creatini... 16 | 39
decreased circulating fructosa... 16 | 30
increased circulating chloride... 16 | 41
increased circulating free fat... 16 | 20
increased monocyte cell number 16 | 63
increased prepulse inhibition 16 | 32

Disease

Carcinoma 3,880 | 11,493
ovarian cancer 3,559 | 8,520
osteosarcoma 3,001 | 7,950
medulloblastoma, large-cell 2,316 | 6,241
psoriasis 2,300 | 6,694
glioblastoma 2,272 | 5,792
atypical teratoid / rhabdoid tumor 1,933 | 5,112
lung cancer 1,907 | 4,740
ependymoma 1,715 | 4,679
group 3 medulloblastoma 1,431 | 4,104
Breast cancer 1,388 | 3,578
adult high grade glioma 1,366 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,317 | 3,291
malignant mesothelioma 1,240 | 3,232
Astrocytoma, Pilocytic 1,151 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 1,144 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,110 | 2,955
invasive ductal carcinoma 1,104 | 2,951
primitive neuroectodermal tumor 1,086 | 3,035
oligodendroglioma 1,081 | 2,850
non-small cell lung cancer 1,060 | 2,890
Kidney cancer 1,054 | 2,613
astrocytic glioma 1,019 | 2,597
lung carcinoma 1,014 | 2,843
lung adenocarcinoma 982 | 2,716
Cancer 971 | 2,499
pancreatic cancer 969 | 2,398
subependymal giant cell astrocytoma 927 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 919 | 1,962
Multiple myeloma 846 | 1,332
Pick disease 807 | 1,894
tuberculosis 800 | 2,010
interstitial cystitis 748 | 2,312
group 4 medulloblastoma 720 | 1,855
diabetes mellitus 695 | 1,728
ulcerative colitis 673 | 1,819
Autosomal recessive predisposition 652 | 1,442
pituitary cancer 616 | 1,972
cystic fibrosis 610 | 1,696
breast carcinoma 604 | 1,638
ductal carcinoma in situ 597 | 1,745
acute quadriplegic myopathy 575 | 1,158
juvenile dermatomyositis 563 | 1,187
astrocytoma 546 | 1,146
colon cancer 541 | 1,478
dermatomyositis 529 | 966
Rheumatoid arthritis 501 | 1,191
Waldenstrons macroglobulinemia 496 | 765
adrenocortical carcinoma 483 | 1,428
primary pancreatic ductal adenocarcinoma 459 | 1,109
Intellectual disability 443 | 1,016
pediatric high grade glioma 434 | 1,064
Schizophrenia 431 | 1,160
spina bifida 386 | 1,074
non primary Sjogren syndrome sicca 371 | 891
cutaneous lupus erythematosus 367 | 1,057
Epilepsy 359 | 792
nasopharyngeal carcinoma 356 | 1,058
active Crohn's disease 347 | 922
Liver Cirrhosis, Experimental 334 | 769
primary Sjogren syndrome 318 | 735
acute myeloid leukemia 317 | 783
gastric carcinoma 313 | 807
Cognitive delay 312 | 608
Global developmental delay 312 | 608
Mental and motor retardation 312 | 608
Muscle hypotonia 311 | 571
Atopic dermatitis 309 | 952
esophageal adenocarcinoma 309 | 737
progressive supranuclear palsy 302 | 676
Alzheimer's disease 294 | 658
Dull intelligence 292 | 645
Low intelligence 292 | 645
Mental Retardation 292 | 645
Mental deficiency 292 | 645
Poor school performance 292 | 645
Seizures 290 | 596
Duchenne muscular dystrophy 289 | 601
Liver cancer 269 | 604
pancreatic carcinoma 267 | 562
active ulcerative colitis 265 | 764
aldosterone-producing adenoma 261 | 665
medulloblastoma 254 | 720
Obesity 245 | 678
Short stature 242 | 531
Melanoma 241 | 711
Bipolar Disorder 234 | 666
Down syndrome 231 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 231 | 510
hepatocellular carcinoma 231 | 547
Neurodegenerative disease 229 | 414
Amyotrophic lateral sclerosis 226 | 451
gastric cancer 203 | 459
mucosa-associated lymphoid tissue lymphoma 200 | 484
Prostatic Neoplasms 196 | 495
Breast Neoplasms 191 | 445
hereditary spastic paraplegia 191 | 318
Mammary Neoplasms 183 | 425
tuberculosis and treatment for 6 months 183 | 409
sonic hedgehog group medulloblastoma 180 | 467

Tissue

Endocrine System 6,044 | 18,159
Female tissues 5,971 | 17,400
Digestive Tract 5,959 | 17,369
Skin and soft tissues 5,947 | 17,230
Male tissues 5,909 | 17,142
Blood and immune system 5,906 | 16,909
Liver and Pancreas 5,868 | 16,750
Urinary Tract 5,862 | 16,678
Nervous System 5,840 | 16,725
Respiratory system 5,819 | 16,393
Cardiovascular System 5,626 | 15,192

Target Family

Non-IDG 3,603 | 12,091
Enzyme 1,677 | 4,145
Kinase 356 | 634
Transcription Factor 156 | 1,400
Transporter 147 | 473
Ion Channel 73 | 344
Epigenetic 58 | 242
GPCR 37 | 408
oGPCR 12 | 421
TF/Epigenetic 8 | 38
Nuclear Receptor 4 | 48

HPM Tissue

Platelets 6,131 | 6,131
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155