Development Level

Tbio 4,132 | 10,625
Tdark 985 | 7,003
Tchem 774 | 1,890
Tclin 195 | 602

Collection

Kinase: IDG Consortium (Targets) 39 | 125
Kinase: IDG Consortium (Complete/Control) 18 | 37
Ion Channel: IDG Consortium (Targets) 14 | 102
GPCR: IDG Consortium (Targets) 3 | 127
GPCR: IDG Consortium (Complete/Control) 1 | 26

IMPC Phenotype

preweaning lethality, complete... 319 | 633
preweaning lethality, incomple... 106 | 260
embryonic lethality prior to t... 96 | 187
decreased total body fat amoun... 89 | 186
abnormal behavior 86 | 226
decreased lean body mass 86 | 195
embryonic lethality prior to o... 85 | 148
decreased body weight 76 | 174
decreased bone mineral content 59 | 157
increased or absent threshold ... 57 | 128
abnormal bone structure 56 | 131
increased circulating alkaline... 56 | 119
abnormal embryo size 51 | 112
decreased body length 50 | 108
decreased bone mineral density 49 | 126
decreased circulating glucose ... 48 | 121
abnormal retina morphology 46 | 100
decreased grip strength 44 | 123
decreased circulating choleste... 38 | 85
hyperactivity 38 | 108
increased lean body mass 38 | 107
increased mean corpuscular hem... 38 | 93
decreased circulating HDL chol... 36 | 77
hypoactivity 36 | 89
increased grip strength 36 | 83
abnormal lens morphology 35 | 73
decreased circulating triglyce... 34 | 83
decreased mean corpuscular vol... 34 | 50
enlarged heart 34 | 111
decreased circulating serum al... 33 | 79
increased mean corpuscular vol... 32 | 91
short tibia 31 | 82
prenatal lethality prior to he... 30 | 64
increased fasted circulating g... 28 | 68
impaired glucose tolerance 25 | 52
increased bone mineral content 25 | 92
male infertility 25 | 62
abnormal bone mineralization 24 | 55
decreased circulating insulin ... 24 | 75
decreased rib number 24 | 59
abnormal retinal pigmentation 23 | 61
abnormal sleep behavior 23 | 63
decreased leukocyte cell numbe... 23 | 54
increased exploration in new e... 23 | 56
decreased hemoglobin content 22 | 53
decreased lumbar vertebrae num... 22 | 62
abnormal coat-hair pigmentatio... 21 | 54
decreased circulating total pr... 21 | 41
decreased fasted circulating g... 21 | 49
increased blood urea nitrogen ... 21 | 44
increased circulating choleste... 21 | 53
cardiovascular system phenotyp... 20 | 35
decreased caudal vertebrae num... 20 | 49
decreased prepulse inhibition 20 | 52
improved glucose tolerance 20 | 56
increased body weight 20 | 42
increased circulating HDL chol... 20 | 63
increased total body fat amoun... 20 | 57
decreased circulating alanine ... 19 | 53
decreased mean corpuscular hem... 19 | 34
abnormal gait 18 | 51
decreased circulating LDL chol... 18 | 37
decreased erythrocyte cell num... 18 | 43
increased circulating sodium l... 18 | 71
abnormal seminal vesicle morph... 17 | 47
decreased circulating fructosa... 17 | 31
increased leukocyte cell numbe... 17 | 37
increased sacral vertebrae num... 17 | 62
abnormal behavioral response t... 16 | 52
decreased circulating alkaline... 16 | 41
decreased circulating calcium ... 16 | 33
decreased heart weight 16 | 44
increased circulating chloride... 16 | 43
increased heart weight 16 | 37
increased hemoglobin content 16 | 45
thrombocytopenia 16 | 46
abnormal heart morphology 15 | 51
decreased startle reflex 15 | 48
increased bone mineral density 15 | 52
increased circulating phosphat... 15 | 24
increased hematocrit 15 | 36
increased startle reflex 15 | 38
decreased blood urea nitrogen ... 14 | 31
decreased eosinophil cell numb... 14 | 41
increased circulating potassiu... 14 | 31
small testis 14 | 37
abnormal cranium morphology 13 | 32
abnormal eye morphology 13 | 38
abnormal neural tube closure 13 | 37
decreased T cell number 13 | 31
decreased circulating free fat... 13 | 39
embryonic growth retardation 13 | 28
increased B cell number 13 | 23
increased red blood cell distr... 13 | 21
abnormal epididymis morphology 12 | 31
decreased circulating aspartat... 12 | 27
decreased circulating iron lev... 12 | 25
decreased neutrophil cell numb... 12 | 37
increased circulating calcium ... 12 | 32
vertebral fusion 12 | 23

Disease

ovarian cancer 3,647 | 8,491
osteosarcoma 2,863 | 7,933
psoriasis 2,364 | 6,685
medulloblastoma, large-cell 2,241 | 6,234
glioblastoma 2,147 | 5,572
lung cancer 1,899 | 4,473
atypical teratoid / rhabdoid tumor 1,596 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,309 | 3,289
Breast cancer 1,223 | 3,098
malignant mesothelioma 1,207 | 3,163
invasive ductal carcinoma 1,161 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 1,159 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,123 | 2,956
pilocytic astrocytoma 1,111 | 3,086
non-small cell lung cancer 1,076 | 2,798
primitive neuroectodermal tumor 1,067 | 3,031
lung adenocarcinoma 1,047 | 2,714
oligodendroglioma 1,045 | 2,849
pediatric high grade glioma 1,043 | 2,712
ependymoma 1,011 | 2,514
Cancer 967 | 2,346
lung carcinoma 958 | 2,844
pancreatic cancer 937 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 901 | 1,795
subependymal giant cell astrocytoma 899 | 2,287
Multiple myeloma 886 | 1,327
astrocytic glioma 805 | 2,241
Carcinoma 785 | 2,147
ulcerative colitis 782 | 2,087
Pick disease 780 | 1,893
group 3 medulloblastoma 780 | 2,254
astrocytoma 725 | 1,493
interstitial cystitis 709 | 2,299
adult high grade glioma 703 | 2,148
diabetes mellitus 701 | 1,663
group 4 medulloblastoma 689 | 1,875
pituitary cancer 664 | 1,972
ductal carcinoma in situ 654 | 1,745
acute quadriplegic myopathy 626 | 1,157
breast carcinoma 616 | 1,614
colon cancer 605 | 1,475
tuberculosis 601 | 1,563
cystic fibrosis 600 | 1,670
primary pancreatic ductal adenocarcinoma 590 | 1,271
juvenile dermatomyositis 589 | 1,189
sonic hedgehog group medulloblastoma 552 | 1,482
dermatomyositis 549 | 966
medulloblastoma 536 | 1,524
adrenocortical carcinoma 534 | 1,427
posterior fossa group A ependymoma 526 | 1,511
Waldenstrons macroglobulinemia 502 | 764
Rheumatoid Arthritis 469 | 1,170
posterior fossa group B ependymoma 429 | 1,530
spina bifida 408 | 1,064
atypical teratoid/rhabdoid tumor 380 | 1,095
nasopharyngeal carcinoma 380 | 1,056
non primary Sjogren syndrome sicca 350 | 840
gastric carcinoma 348 | 832
Duchenne muscular dystrophy 336 | 602
cutaneous lupus erythematosus 334 | 1,056
acute myeloid leukemia 330 | 785
esophageal adenocarcinoma 329 | 737
active Crohn's disease 322 | 918
Atopic dermatitis 313 | 944
Alzheimer's disease 277 | 644
primary Sjogren syndrome 277 | 788
progressive supranuclear palsy 272 | 674
aldosterone-producing adenoma 271 | 664
tuberculosis and treatment for 6 months 267 | 686
autosomal dominant Emery-Dreifuss muscular dystrophy 261 | 499
Down syndrome 254 | 548
Intellectual disability 253 | 573
pancreatic carcinoma 238 | 567
IGA Glomerulonephritis 230 | 454
hepatocellular carcinoma 219 | 550
Prostatic Neoplasms 218 | 471
Obesity 210 | 616
Amyotrophic Lateral Sclerosis 207 | 432
Neurodegenerative disease 203 | 383
mucosa-associated lymphoid tissue lymphoma 191 | 480
hereditary spastic paraplegia 188 | 313
Mammary Neoplasms 186 | 410
fibroadenoma 185 | 557
Endometriosis 176 | 535
gastric cancer 165 | 436
Schizophrenia 159 | 503
Polycystic Ovary Syndrome 157 | 334
Kidney disease 154 | 397
Multiple Sclerosis 149 | 498
Parkinson's disease 147 | 364
active ulcerative colitis 147 | 477
Stomach Neoplasms 146 | 282
inflammatory breast cancer 143 | 404
non-small cell lung carcinoma 138 | 413
Vascular disease 130 | 281
interstitial lung disease 128 | 292
chronic rhinosinusitis 126 | 512
glioblastoma multiforme 125 | 347
sarcoidosis 124 | 368
Becker muscular dystrophy 123 | 187

Tissue

Female tissues 6,086 | 18,646
Nervous System 6,078 | 18,560
Digestive Tract 6,064 | 18,472
Urinary Tract 6,056 | 18,443
Endocrine System 6,054 | 18,511
Blood and immune system 6,053 | 17,994
Liver and Pancreas 6,053 | 18,135
Male tissues 6,051 | 17,968
Cardiovascular System 6,038 | 17,957
Respiratory system 5,999 | 17,483
Skin and soft tissues 5,970 | 18,114

Target Family

Non-IDG 3,667 | 11,969
Enzyme 1,703 | 4,146
Kinase 267 | 634
Transcription Factor 163 | 1,400
Transporter 133 | 473
Epigenetic 70 | 242
Ion Channel 47 | 341
GPCR 19 | 408
TF/Epigenetic 8 | 38
oGPCR 7 | 421
Nuclear Receptor 2 | 48

HPM Tissue

Placenta 6,086 | 6,086
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Adult Adrenal 8,478 | 8,478
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/LRR-repeat protein 21 FBXL21 Tdark Non-IDG 0.00000 0
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Synapse differentiation-inducing gene protein 1-like SYNDIG1L Tdark Non-IDG -0.55764 3.83 4
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39