Development Level

Tbio 4,390 | 11,445
Tdark 866 | 6,588
Tchem 629 | 1,598
Tclin 198 | 613

Collection

RFA-RM-18-021 57 | 328
Kinase: IDG Consortium (Target... 39 | 125
Kinase: IDG Consortium (Comple... 18 | 37
Ion Channel: IDG Consortium (T... 15 | 99
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 509 | 979
preweaning lethality, incomple... 195 | 499
embryonic lethality prior to t... 140 | 278
embryonic lethality prior to o... 132 | 239
abnormal behavior 103 | 298
abnormal embryo size 100 | 220
decreased total body fat amoun... 83 | 207
abnormal bone structure 80 | 187
decreased body weight 72 | 161
enlarged heart 63 | 210
decreased bone mineral content 59 | 151
increased lean body mass 58 | 172
embryonic growth retardation 55 | 106
decreased circulating glucose ... 53 | 126
hypoactivity 53 | 132
increased circulating alkaline... 53 | 122
abnormal heart morphology 51 | 162
decreased bone mineral density 51 | 126
hyperactivity 48 | 148
decreased vertical activity 46 | 208
increased total body fat amoun... 46 | 134
increased startle reflex 45 | 112
decreased lean body mass 41 | 135
short tibia 41 | 97
decreased circulating choleste... 40 | 93
cataract 39 | 92
decreased grip strength 39 | 116
decreased mean corpuscular vol... 39 | 79
prenatal lethality prior to he... 39 | 87
abnormal seminal vesicle morph... 38 | 114
abnormal retina morphology 36 | 71
increased mean corpuscular hem... 36 | 96
male infertility 36 | 123
decreased body length 35 | 101
decreased circulating serum al... 34 | 82
increased mean corpuscular vol... 34 | 92
increased bone mineral content 33 | 108
decreased circulating HDL chol... 32 | 68
increased fasted circulating g... 32 | 76
increased or absent threshold ... 32 | 101
decreased circulating triglyce... 31 | 79
increased heart weight 31 | 62
abnormal lens morphology 30 | 81
edema 30 | 59
decreased prepulse inhibition 29 | 82
abnormal sleep behavior 28 | 70
decreased leukocyte cell numbe... 28 | 73
decreased lymphocyte cell numb... 28 | 83
impaired glucose tolerance 28 | 75
improved glucose tolerance 28 | 79
increased circulating HDL chol... 28 | 80
increased circulating choleste... 28 | 66
abnormal behavioral response t... 26 | 66
decreased caudal vertebrae num... 26 | 53
abnormal coat-hair pigmentatio... 25 | 64
decreased erythrocyte cell num... 25 | 62
abnormal eye morphology 24 | 68
decreased hemoglobin content 24 | 68
small testis 24 | 58
abnormal gait 23 | 69
decreased fasted circulating g... 23 | 65
decreased mean corpuscular hem... 23 | 50
decreased circulating total pr... 22 | 49
increased leukocyte cell numbe... 22 | 47
increased mean platelet volume 22 | 45
thrombocytopenia 22 | 56
cardiovascular system phenotyp... 21 | 36
increased blood urea nitrogen ... 21 | 48
increased grip strength 21 | 41
increased monocyte cell number 21 | 63
small superior vagus ganglion 21 | 74
abnormal kidney morphology 20 | 65
decreased blood urea nitrogen ... 20 | 51
decreased circulating insulin ... 20 | 76
decreased neutrophil cell numb... 20 | 42
decreased startle reflex 20 | 75
increased bone mineral density 20 | 72
increased neutrophil cell numb... 20 | 46
abnormal skin morphology 19 | 50
decreased circulating LDL chol... 19 | 38
decreased circulating alkaline... 19 | 46
increased hematocrit 19 | 46
pallor 19 | 34
abnormal pericardium morpholog... 18 | 26
decreased hematocrit 18 | 46
decreased red blood cell distr... 18 | 41
increased erythrocyte cell num... 18 | 39
abnormal embryo turning 17 | 31
abnormal testis morphology 17 | 43
decreased circulating alanine ... 17 | 47
increased circulating sodium l... 17 | 71
abnormal neural tube closure 16 | 46
decreased circulating calcium ... 16 | 36
prolonged QT interval 16 | 38
abnormal bone mineralization 15 | 38
abnormal epididymis morphology 15 | 42
abnormal spleen morphology 15 | 55
decreased circulating iron lev... 15 | 32
increased hemoglobin content 15 | 45
tremors 15 | 39

Disease

Carcinoma 3,756 | 11,493
ovarian cancer 3,656 | 8,520
osteosarcoma 2,863 | 7,950
psoriasis 2,360 | 6,694
medulloblastoma, large-cell 2,242 | 6,241
glioblastoma 2,238 | 5,792
lung cancer 1,962 | 4,740
atypical teratoid / rhabdoid tumor 1,852 | 5,112
ependymoma 1,690 | 4,679
group 3 medulloblastoma 1,444 | 4,104
Breast cancer 1,404 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,308 | 3,291
adult high grade glioma 1,289 | 3,801
malignant mesothelioma 1,237 | 3,232
invasive ductal carcinoma 1,160 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 1,158 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,119 | 2,955
Astrocytoma, Pilocytic 1,109 | 3,081
non-small cell lung cancer 1,098 | 2,890
primitive neuroectodermal tumor 1,067 | 3,035
lung adenocarcinoma 1,046 | 2,716
oligodendroglioma 1,046 | 2,850
Cancer 1,019 | 2,499
Kidney cancer 1,003 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 994 | 1,962
pancreatic cancer 977 | 2,398
lung carcinoma 960 | 2,843
astrocytic glioma 956 | 2,597
subependymal giant cell astrocytoma 901 | 2,287
Multiple myeloma 890 | 1,332
Pick disease 782 | 1,894
tuberculosis 749 | 2,010
diabetes mellitus 731 | 1,728
Autosomal recessive predisposition 716 | 1,442
interstitial cystitis 709 | 2,312
group 4 medulloblastoma 681 | 1,855
ulcerative colitis 670 | 1,819
pituitary cancer 663 | 1,972
ductal carcinoma in situ 653 | 1,745
acute quadriplegic myopathy 628 | 1,158
breast carcinoma 627 | 1,638
cystic fibrosis 609 | 1,696
colon cancer 606 | 1,478
juvenile dermatomyositis 590 | 1,187
astrocytoma 578 | 1,146
dermatomyositis 551 | 966
adrenocortical carcinoma 534 | 1,428
Waldenstrons macroglobulinemia 502 | 765
primary pancreatic ductal adenocarcinoma 498 | 1,109
Rheumatoid arthritis 470 | 1,191
pediatric high grade glioma 459 | 1,064
Intellectual disability 446 | 1,016
Schizophrenia 430 | 1,160
spina bifida 411 | 1,074
nasopharyngeal carcinoma 380 | 1,058
non primary Sjogren syndrome sicca 367 | 891
Liver Cirrhosis, Experimental 366 | 769
Epilepsy 355 | 792
gastric carcinoma 338 | 807
Duchenne muscular dystrophy 335 | 601
cutaneous lupus erythematosus 334 | 1,057
acute myeloid leukemia 332 | 783
esophageal adenocarcinoma 329 | 737
active Crohn's disease 324 | 922
Cognitive delay 318 | 608
Global developmental delay 318 | 608
Mental and motor retardation 318 | 608
Atopic dermatitis 317 | 952
Muscle hypotonia 308 | 571
Dull intelligence 300 | 645
Low intelligence 300 | 645
Mental Retardation 300 | 645
Mental deficiency 300 | 645
Poor school performance 300 | 645
Seizures 294 | 596
Alzheimer's disease 276 | 658
progressive supranuclear palsy 272 | 676
aldosterone-producing adenoma 271 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 268 | 510
primary Sjogren syndrome 262 | 735
active ulcerative colitis 257 | 764
medulloblastoma 252 | 720
Liver cancer 243 | 604
Obesity 242 | 678
Down syndrome 241 | 499
Short stature 239 | 531
pancreatic carcinoma 236 | 562
Bipolar Disorder 233 | 666
Melanoma 232 | 711
Prostatic Neoplasms 222 | 495
Neurodegenerative disease 219 | 414
Amyotrophic lateral sclerosis 216 | 451
hepatocellular carcinoma 216 | 547
Breast Neoplasms 197 | 445
hereditary spastic paraplegia 192 | 318
mucosa-associated lymphoid tissue lymphoma 192 | 484
Mammary Neoplasms 191 | 425
Failure to gain weight 187 | 365
Pediatric failure to thrive 187 | 365
sonic hedgehog group medulloblastoma 186 | 467

Tissue

Endocrine System 6,000 | 18,159
Female tissues 5,933 | 17,400
Digestive Tract 5,916 | 17,369
Skin and soft tissues 5,903 | 17,230
Male tissues 5,869 | 17,142
Blood and immune system 5,850 | 16,909
Liver and Pancreas 5,837 | 16,750
Urinary Tract 5,824 | 16,678
Nervous System 5,806 | 16,725
Respiratory system 5,778 | 16,393
Cardiovascular System 5,586 | 15,192

Target Family

Non-IDG 3,662 | 12,091
Enzyme 1,703 | 4,145
Kinase 267 | 634
Transcription Factor 163 | 1,400
Transporter 132 | 473
Epigenetic 70 | 242
Ion Channel 50 | 344
GPCR 19 | 408
TF/Epigenetic 8 | 38
oGPCR 7 | 421
Nuclear Receptor 2 | 48

HPM Tissue

Placenta 6,083 | 6,083
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3 Tbio Non-IDG -1.80776 63.4 80