Development Level

Tbio 5,352 | 10,625
Tdark 1,901 | 7,003
Tchem 977 | 1,890
Tclin 250 | 602

Collection

Kinase: IDG Consortium (Targets) 64 | 125
Ion Channel: IDG Consortium (Targets) 26 | 102
Kinase: IDG Consortium (Complete/Control) 21 | 37
GPCR: IDG Consortium (Targets) 16 | 127
GPCR: IDG Consortium (Complete/Control) 3 | 26

IMPC Phenotype

preweaning lethality, complete... 413 | 633
preweaning lethality, incomple... 130 | 260
embryonic lethality prior to t... 127 | 187
embryonic lethality prior to o... 113 | 148
abnormal behavior 106 | 226
decreased total body fat amoun... 98 | 186
decreased lean body mass 95 | 195
decreased body weight 88 | 174
abnormal embryo size 71 | 112
decreased bone mineral content 70 | 157
decreased bone mineral density 62 | 126
increased or absent threshold ... 62 | 128
abnormal bone structure 61 | 131
decreased body length 61 | 108
decreased circulating glucose ... 60 | 121
increased circulating alkaline... 59 | 119
decreased grip strength 57 | 123
increased lean body mass 55 | 107
increased mean corpuscular hem... 53 | 93
abnormal retina morphology 50 | 100
hyperactivity 50 | 108
increased bone mineral content 47 | 92
increased grip strength 46 | 83
enlarged heart 44 | 111
abnormal lens morphology 42 | 73
decreased circulating triglyce... 41 | 83
increased mean corpuscular vol... 41 | 91
decreased circulating HDL chol... 39 | 77
decreased circulating choleste... 39 | 85
short tibia 39 | 82
increased fasted circulating g... 38 | 68
decreased circulating serum al... 36 | 79
prenatal lethality prior to he... 36 | 64
increased circulating sodium l... 35 | 71
decreased circulating insulin ... 33 | 75
hypoactivity 33 | 89
decreased mean corpuscular vol... 32 | 50
abnormal retinal pigmentation 31 | 61
decreased lumbar vertebrae num... 31 | 62
abnormal bone mineralization 30 | 55
increased bone mineral density 30 | 52
male infertility 30 | 62
abnormal sleep behavior 29 | 63
decreased caudal vertebrae num... 27 | 49
decreased fasted circulating g... 27 | 49
decreased rib number 27 | 59
improved glucose tolerance 27 | 56
increased exploration in new e... 27 | 56
abnormal coat-hair pigmentatio... 26 | 54
decreased leukocyte cell numbe... 26 | 54
decreased prepulse inhibition 26 | 52
increased circulating choleste... 26 | 53
increased circulating HDL chol... 25 | 63
increased sacral vertebrae num... 25 | 62
abnormal neural tube closure 24 | 37
decreased circulating alanine ... 24 | 53
impaired glucose tolerance 24 | 52
increased blood urea nitrogen ... 24 | 44
decreased circulating LDL chol... 23 | 37
decreased startle reflex 23 | 48
increased body weight 23 | 42
increased circulating chloride... 23 | 43
thrombocytopenia 23 | 46
decreased erythrocyte cell num... 22 | 43
increased hemoglobin content 22 | 45
decreased circulating total pr... 21 | 41
decreased hemoglobin content 21 | 53
decreased mean corpuscular hem... 21 | 34
increased heart weight 21 | 37
increased rib number 21 | 41
increased total body fat amoun... 21 | 57
decreased T cell number 20 | 31
decreased neutrophil cell numb... 20 | 37
increased leukocyte cell numbe... 20 | 37
decreased circulating calcium ... 19 | 33
embryonic growth retardation 19 | 28
abnormal behavioral response t... 18 | 52
abnormal gait 18 | 51
decreased circulating fructosa... 18 | 31
decreased eosinophil cell numb... 18 | 41
decreased heart weight 18 | 44
abnormal heart morphology 17 | 51
abnormal seminal vesicle morph... 17 | 47
decreased CD4-positive, CD25-p... 17 | 24
decreased CD8-positive, alpha-... 17 | 26
decreased circulating alkaline... 17 | 41
decreased circulating aspartat... 17 | 27
small testis 17 | 37
abnormal cranium morphology 16 | 32
abnormal rib morphology 16 | 28
decreased circulating chloride... 16 | 32
decreased circulating free fat... 16 | 39
decreased threshold for audito... 16 | 32
abnormal coat appearance 15 | 25
decreased NK T cell number 15 | 28
decreased circulating iron lev... 15 | 25
decreased effector memory CD8-... 15 | 24
enlarged lymph nodes 15 | 27
increased circulating calcium ... 15 | 32
increased circulating potassiu... 15 | 31

Disease

ovarian cancer 4,740 | 8,491
osteosarcoma 4,103 | 7,933
medulloblastoma, large-cell 3,024 | 6,234
psoriasis 3,011 | 6,685
glioblastoma 2,834 | 5,572
lung cancer 2,457 | 4,473
atypical teratoid / rhabdoid tumor 2,162 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,626 | 3,289
malignant mesothelioma 1,563 | 3,163
Breast cancer 1,515 | 3,098
primitive neuroectodermal tumor 1,434 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,411 | 2,988
oligodendroglioma 1,405 | 2,849
pilocytic astrocytoma 1,399 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,354 | 2,956
invasive ductal carcinoma 1,349 | 2,950
ependymoma 1,332 | 2,514
non-small cell lung cancer 1,305 | 2,798
pediatric high grade glioma 1,292 | 2,712
lung carcinoma 1,229 | 2,844
lung adenocarcinoma 1,186 | 2,714
Cancer 1,174 | 2,346
Carcinoma 1,154 | 2,147
subependymal giant cell astrocytoma 1,148 | 2,287
group 3 medulloblastoma 1,130 | 2,254
astrocytic glioma 1,123 | 2,241
pancreatic cancer 1,078 | 2,300
Pick disease 1,055 | 1,893
Multiple myeloma 1,045 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 1,032 | 1,795
adult high grade glioma 1,021 | 2,148
ulcerative colitis 997 | 2,087
group 4 medulloblastoma 953 | 1,875
interstitial cystitis 930 | 2,299
astrocytoma 876 | 1,493
tuberculosis 816 | 1,563
diabetes mellitus 792 | 1,663
pituitary cancer 761 | 1,972
medulloblastoma 747 | 1,524
acute quadriplegic myopathy 726 | 1,157
juvenile dermatomyositis 720 | 1,189
ductal carcinoma in situ 719 | 1,745
breast carcinoma 712 | 1,614
colon cancer 687 | 1,475
cystic fibrosis 673 | 1,670
sonic hedgehog group medulloblastoma 671 | 1,482
dermatomyositis 657 | 966
Rheumatoid Arthritis 639 | 1,170
adrenocortical carcinoma 631 | 1,427
primary pancreatic ductal adenocarcinoma 630 | 1,271
posterior fossa group A ependymoma 620 | 1,511
Waldenstrons macroglobulinemia 611 | 764
posterior fossa group B ependymoma 593 | 1,530
spina bifida 517 | 1,064
cutaneous lupus erythematosus 493 | 1,056
atypical teratoid/rhabdoid tumor 485 | 1,095
acute myeloid leukemia 461 | 785
primary Sjogren syndrome 452 | 788
nasopharyngeal carcinoma 438 | 1,056
non primary Sjogren syndrome sicca 435 | 840
tuberculosis and treatment for 6 months 416 | 686
active Crohn's disease 414 | 918
progressive supranuclear palsy 394 | 674
gastric carcinoma 376 | 832
esophageal adenocarcinoma 364 | 737
Atopic dermatitis 357 | 944
Alzheimer's disease 334 | 644
aldosterone-producing adenoma 329 | 664
Intellectual disability 320 | 573
Duchenne muscular dystrophy 304 | 602
pancreatic carcinoma 301 | 567
hepatocellular carcinoma 293 | 550
Down syndrome 285 | 548
IGA Glomerulonephritis 273 | 454
Neurodegenerative disease 250 | 383
Obesity 247 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 242 | 499
Amyotrophic Lateral Sclerosis 237 | 432
gastric cancer 234 | 436
Prostatic Neoplasms 228 | 471
mucosa-associated lymphoid tissue lymphoma 224 | 480
hereditary spastic paraplegia 223 | 313
Schizophrenia 220 | 503
Mammary Neoplasms 214 | 410
Multiple Sclerosis 213 | 498
fibroadenoma 205 | 557
Endometriosis 197 | 535
sarcoidosis 181 | 368
chronic rhinosinusitis 180 | 512
Polycystic Ovary Syndrome 176 | 334
Parkinson's disease 175 | 364
active ulcerative colitis 171 | 477
inflammatory breast cancer 167 | 404
non-small cell lung carcinoma 165 | 413
Stomach Neoplasms 163 | 282
tuberculosis and treatment for 3 months 161 | 327
Crohn's disease 160 | 304
glioblastoma multiforme 157 | 347
Kidney disease 151 | 397
Asthma 143 | 349

Tissue

Blood and immune system 8,480 | 17,994
Female tissues 8,449 | 18,646
Nervous System 8,448 | 18,560
Digestive Tract 8,441 | 18,472
Liver and Pancreas 8,434 | 18,135
Endocrine System 8,427 | 18,511
Male tissues 8,427 | 17,968
Urinary Tract 8,422 | 18,443
Cardiovascular System 8,419 | 17,957
Respiratory system 8,359 | 17,483
Skin and soft tissues 8,299 | 18,114

Target Family

Non-IDG 4,857 | 11,969
Enzyme 2,163 | 4,146
Transcription Factor 597 | 1,400
Kinase 392 | 634
Epigenetic 159 | 242
Transporter 133 | 473
Ion Channel 82 | 341
GPCR 48 | 408
TF/Epigenetic 21 | 38
oGPCR 16 | 421
Nuclear Receptor 12 | 48

HPM Tissue

NK Cells 8,480 | 8,480
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
Adult Adrenal 8,478 | 8,478
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114