Development Level

Tbio 5,745 | 11,445
Tdark 1,672 | 6,588
Tchem 802 | 1,598
Tclin 256 | 613

Collection

RFA-RM-18-021 102 | 328
Kinase: IDG Consortium (Target... 64 | 125
Ion Channel: IDG Consortium (T... 26 | 99
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Targets) 16 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 662 | 979
preweaning lethality, incomple... 244 | 499
embryonic lethality prior to t... 181 | 278
embryonic lethality prior to o... 177 | 239
abnormal embryo size 135 | 220
abnormal behavior 132 | 298
decreased total body fat amoun... 102 | 207
abnormal bone structure 92 | 187
increased lean body mass 85 | 172
enlarged heart 81 | 210
decreased body weight 80 | 161
decreased vertical activity 70 | 208
embryonic growth retardation 70 | 106
decreased bone mineral content 67 | 151
decreased bone mineral density 64 | 126
decreased circulating glucose ... 63 | 126
hyperactivity 62 | 148
abnormal heart morphology 60 | 162
increased circulating alkaline... 60 | 122
increased startle reflex 60 | 112
increased total body fat amoun... 60 | 134
decreased lean body mass 59 | 135
hypoactivity 59 | 132
male infertility 56 | 123
short tibia 55 | 97
abnormal seminal vesicle morph... 52 | 114
increased or absent threshold ... 51 | 101
increased mean corpuscular hem... 50 | 96
prenatal lethality prior to he... 49 | 87
cataract 48 | 92
decreased body length 46 | 101
decreased grip strength 46 | 116
increased bone mineral content 45 | 108
decreased prepulse inhibition 44 | 82
increased mean corpuscular vol... 43 | 92
abnormal lens morphology 42 | 81
increased fasted circulating g... 42 | 76
decreased circulating choleste... 41 | 93
decreased mean corpuscular vol... 40 | 79
improved glucose tolerance 40 | 79
abnormal retina morphology 39 | 71
decreased circulating triglyce... 39 | 79
decreased circulating serum al... 36 | 82
decreased leukocyte cell numbe... 36 | 73
decreased lymphocyte cell numb... 36 | 83
impaired glucose tolerance 36 | 75
decreased circulating HDL chol... 35 | 68
small superior vagus ganglion 35 | 74
increased bone mineral density 34 | 72
decreased circulating insulin ... 33 | 76
decreased fasted circulating g... 33 | 65
decreased startle reflex 33 | 75
increased circulating HDL chol... 33 | 80
increased circulating sodium l... 32 | 71
abnormal sleep behavior 31 | 70
decreased caudal vertebrae num... 31 | 53
decreased erythrocyte cell num... 31 | 62
decreased hemoglobin content 31 | 68
increased circulating choleste... 31 | 66
increased monocyte cell number 31 | 63
thrombocytopenia 31 | 56
abnormal coat-hair pigmentatio... 30 | 64
abnormal eye morphology 30 | 68
edema 30 | 59
increased heart weight 28 | 62
small testis 28 | 58
abnormal kidney morphology 27 | 65
decreased mean corpuscular hem... 27 | 50
abnormal behavioral response t... 26 | 66
abnormal neural tube closure 26 | 46
increased grip strength 26 | 41
abnormal gait 25 | 69
decreased circulating alanine ... 25 | 47
decreased circulating total pr... 25 | 49
hydrometra 25 | 53
increased erythrocyte cell num... 25 | 39
increased leukocyte cell numbe... 25 | 47
increased mean platelet volume 25 | 45
decreased hematocrit 24 | 46
decreased neutrophil cell numb... 24 | 42
decreased blood urea nitrogen ... 23 | 51
female infertility 23 | 60
increased neutrophil cell numb... 23 | 46
pallor 23 | 34
persistence of hyaloid vascula... 23 | 33
abnormal embryo turning 22 | 31
decreased circulating LDL chol... 22 | 38
decreased circulating alkaline... 22 | 46
increased blood urea nitrogen ... 22 | 48
decreased circulating aspartat... 21 | 34
decreased circulating calcium ... 21 | 36
increased circulating chloride... 21 | 41
abnormal coat appearance 20 | 31
abnormal skin morphology 20 | 50
tremors 20 | 39
abnormal bone mineralization 19 | 38
increased circulating triglyce... 19 | 42
increased hematocrit 19 | 46
increased hemoglobin content 19 | 45
prolonged QT interval 19 | 38

Disease

Carcinoma 5,432 | 11,493
ovarian cancer 4,753 | 8,520
osteosarcoma 4,099 | 7,950
medulloblastoma, large-cell 3,022 | 6,241
psoriasis 3,008 | 6,694
glioblastoma 2,934 | 5,792
lung cancer 2,569 | 4,740
atypical teratoid / rhabdoid tumor 2,493 | 5,112
ependymoma 2,190 | 4,679
group 3 medulloblastoma 2,013 | 4,104
adult high grade glioma 1,769 | 3,801
Breast cancer 1,732 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,624 | 3,291
malignant mesothelioma 1,591 | 3,232
Kidney cancer 1,443 | 2,613
primitive neuroectodermal tumor 1,430 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 1,409 | 2,989
oligodendroglioma 1,404 | 2,850
Astrocytoma, Pilocytic 1,392 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 1,349 | 2,955
invasive ductal carcinoma 1,348 | 2,951
non-small cell lung cancer 1,329 | 2,890
astrocytic glioma 1,298 | 2,597
Cancer 1,245 | 2,499
lung carcinoma 1,229 | 2,843
lung adenocarcinoma 1,184 | 2,716
subependymal giant cell astrocytoma 1,148 | 2,287
pancreatic cancer 1,133 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1,123 | 1,962
Pick disease 1,056 | 1,894
Multiple myeloma 1,049 | 1,332
tuberculosis 1,028 | 2,010
group 4 medulloblastoma 947 | 1,855
interstitial cystitis 929 | 2,312
ulcerative colitis 860 | 1,819
diabetes mellitus 825 | 1,728
Autosomal recessive predisposition 772 | 1,442
pituitary cancer 758 | 1,972
breast carcinoma 728 | 1,638
acute quadriplegic myopathy 727 | 1,158
juvenile dermatomyositis 721 | 1,187
ductal carcinoma in situ 716 | 1,745
astrocytoma 702 | 1,146
colon cancer 687 | 1,478
cystic fibrosis 683 | 1,696
dermatomyositis 658 | 966
Rheumatoid arthritis 643 | 1,191
adrenocortical carcinoma 627 | 1,428
Waldenstrons macroglobulinemia 611 | 765
Intellectual disability 567 | 1,016
pediatric high grade glioma 543 | 1,064
primary pancreatic ductal adenocarcinoma 539 | 1,109
Schizophrenia 535 | 1,160
spina bifida 520 | 1,074
cutaneous lupus erythematosus 493 | 1,057
non primary Sjogren syndrome sicca 464 | 891
acute myeloid leukemia 460 | 783
nasopharyngeal carcinoma 436 | 1,058
primary Sjogren syndrome 425 | 735
Epilepsy 422 | 792
active Crohn's disease 415 | 922
progressive supranuclear palsy 394 | 676
Cognitive delay 390 | 608
Global developmental delay 390 | 608
Mental and motor retardation 390 | 608
Dull intelligence 376 | 645
Low intelligence 376 | 645
Mental Retardation 376 | 645
Mental deficiency 376 | 645
Poor school performance 376 | 645
Liver Cirrhosis, Experimental 372 | 769
esophageal adenocarcinoma 363 | 737
Atopic dermatitis 362 | 952
gastric carcinoma 362 | 807
Muscle hypotonia 353 | 571
Liver cancer 342 | 604
Seizures 338 | 596
Alzheimer's disease 336 | 658
Melanoma 333 | 711
medulloblastoma 333 | 720
aldosterone-producing adenoma 329 | 665
active ulcerative colitis 308 | 764
Duchenne muscular dystrophy 304 | 601
pancreatic carcinoma 298 | 562
Bipolar Disorder 292 | 666
hepatocellular carcinoma 290 | 547
Short stature 289 | 531
Obesity 277 | 678
Neurodegenerative disease 267 | 414
Down syndrome 264 | 499
tuberculosis and treatment for 6 months 257 | 409
Amyotrophic lateral sclerosis 250 | 451
autosomal dominant Emery-Dreifuss muscular dystrophy 245 | 510
gastric cancer 244 | 459
Prostatic Neoplasms 237 | 495
Multiple Sclerosis 235 | 540
Breast Neoplasms 231 | 445
mucosa-associated lymphoid tissue lymphoma 226 | 484
hereditary spastic paraplegia 224 | 318
Failure to gain weight 223 | 365

Tissue

Endocrine System 8,348 | 18,159
Female tissues 8,234 | 17,400
Digestive Tract 8,209 | 17,369
Skin and soft tissues 8,202 | 17,230
Male tissues 8,161 | 17,142
Blood and immune system 8,127 | 16,909
Liver and Pancreas 8,078 | 16,750
Nervous System 8,078 | 16,725
Urinary Tract 8,072 | 16,678
Respiratory system 8,022 | 16,393
Cardiovascular System 7,747 | 15,192

Target Family

Non-IDG 4,854 | 12,091
Enzyme 2,163 | 4,145
Transcription Factor 596 | 1,400
Kinase 392 | 634
Epigenetic 158 | 242
Transporter 132 | 473
Ion Channel 83 | 344
GPCR 48 | 408
TF/Epigenetic 21 | 38
oGPCR 16 | 421
Nuclear Receptor 12 | 48

HPM Tissue

NK Cells 8,475 | 8,475
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59