Development Level

Tbio 5,352 | 10,625
Tdark 1,901 | 7,003
Tchem 978 | 1,890
Tclin 250 | 602

Collection

Eligible Kinase Proteins 71 | 134
Eligible Ion Channel Proteins 30 | 117
Eligible non-olfactory GPCR Proteins 19 | 143

IMPC Term

preweaning lethality, complete... 413 | 633
preweaning lethality, incomple... 130 | 260
embryonic lethality prior to t... 127 | 187
embryonic lethality prior to o... 113 | 148
abnormal behavior 106 | 226
decreased total body fat amoun... 98 | 186
decreased lean body mass 95 | 195
decreased body weight 88 | 174
abnormal embryo size 71 | 112
decreased bone mineral content 70 | 157
decreased bone mineral density 62 | 126
increased or absent threshold ... 62 | 128
abnormal bone structure 61 | 131
decreased body length 61 | 108
decreased circulating glucose ... 60 | 121
increased circulating alkaline... 59 | 119
decreased grip strength 57 | 123
increased lean body mass 55 | 107
increased mean corpuscular hem... 53 | 93
abnormal retina morphology 50 | 100
hyperactivity 50 | 108
increased bone mineral content 47 | 92
increased grip strength 46 | 83
enlarged heart 44 | 111
abnormal lens morphology 42 | 73
decreased circulating triglyce... 41 | 83
increased mean corpuscular vol... 41 | 91
decreased circulating HDL chol... 39 | 77
decreased circulating choleste... 39 | 85
short tibia 39 | 82
increased fasted circulating g... 38 | 68
decreased circulating serum al... 36 | 79
prenatal lethality prior to he... 36 | 64
increased circulating sodium l... 35 | 71
decreased circulating insulin ... 33 | 75
hypoactivity 33 | 89
decreased mean corpuscular vol... 32 | 50
abnormal retinal pigmentation 31 | 61
decreased lumbar vertebrae num... 31 | 62
abnormal bone mineralization 30 | 55
increased bone mineral density 30 | 52
male infertility 30 | 62
abnormal sleep behavior 29 | 63
decreased caudal vertebrae num... 27 | 49
decreased fasted circulating g... 27 | 49
decreased rib number 27 | 59
improved glucose tolerance 27 | 56
increased exploration in new e... 27 | 56
abnormal coat/hair pigmentatio... 26 | 54
decreased leukocyte cell numbe... 26 | 54
decreased prepulse inhibition 26 | 52
increased circulating choleste... 26 | 53
increased circulating HDL chol... 25 | 63
increased sacral vertebrae num... 25 | 62
abnormal neural tube closure 24 | 37
decreased circulating alanine ... 24 | 53
impaired glucose tolerance 24 | 52
increased blood urea nitrogen ... 24 | 44
decreased circulating LDL chol... 23 | 37
decreased startle reflex 23 | 48
increased body weight 23 | 42
increased circulating chloride... 23 | 43
thrombocytopenia 23 | 46
decreased erythrocyte cell num... 22 | 43
increased hemoglobin content 22 | 45
decreased circulating total pr... 21 | 41
decreased hemoglobin content 21 | 53
decreased mean corpuscular hem... 21 | 34
increased heart weight 21 | 37
increased rib number 21 | 41
increased total body fat amoun... 21 | 57
decreased T cell number 20 | 31
decreased neutrophil cell numb... 20 | 37
increased leukocyte cell numbe... 20 | 37
decreased circulating calcium ... 19 | 33
embryonic growth retardation 19 | 28
abnormal behavioral response t... 18 | 52
abnormal gait 18 | 51
decreased circulating fructosa... 18 | 31
decreased eosinophil cell numb... 18 | 41
decreased heart weight 18 | 44
abnormal heart morphology 17 | 51
abnormal seminal vesicle morph... 17 | 47
decreased CD4-positive, CD25-p... 17 | 24
decreased CD8-positive, alpha-... 17 | 26
decreased circulating alkaline... 17 | 41
decreased circulating aspartat... 17 | 27
small testis 17 | 37
abnormal cranium morphology 16 | 32
abnormal rib morphology 16 | 28
decreased circulating chloride... 16 | 32
decreased circulating free fat... 16 | 39
decreased threshold for audito... 16 | 32
abnormal coat appearance 15 | 25
decreased NK T cell number 15 | 28
decreased circulating iron lev... 15 | 25
decreased effector memory CD8-... 15 | 24
enlarged lymph nodes 15 | 27
increased circulating calcium ... 15 | 32
increased circulating potassiu... 15 | 31

Disease

ovarian cancer 4,737 | 8,484
osteosarcoma 4,103 | 7,933
medulloblastoma, large-cell 3,024 | 6,234
psoriasis 3,011 | 6,685
glioblastoma 2,834 | 5,572
lung cancer 2,456 | 4,466
atypical teratoid / rhabdoid tumor 2,162 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,626 | 3,289
malignant mesothelioma 1,562 | 3,162
Breast cancer 1,515 | 3,094
primitive neuroectodermal tumor 1,434 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,411 | 2,988
oligodendroglioma 1,405 | 2,849
pilocytic astrocytoma 1,399 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,354 | 2,956
invasive ductal carcinoma 1,349 | 2,950
ependymoma 1,332 | 2,514
non-small cell lung cancer 1,305 | 2,798
pediatric high grade glioma 1,292 | 2,712
lung carcinoma 1,229 | 2,844
lung adenocarcinoma 1,186 | 2,713
Cancer 1,174 | 2,346
Carcinoma 1,154 | 2,147
subependymal giant cell astrocytoma 1,148 | 2,287
group 3 medulloblastoma 1,130 | 2,254
astrocytic glioma 1,123 | 2,241
pancreatic cancer 1,078 | 2,300
Pick disease 1,055 | 1,893
Multiple myeloma 1,046 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 1,032 | 1,795
adult high grade glioma 1,021 | 2,148
ulcerative colitis 997 | 2,087
group 4 medulloblastoma 953 | 1,875
interstitial cystitis 930 | 2,299
astrocytoma 876 | 1,493
tuberculosis 814 | 1,557
diabetes mellitus 792 | 1,663
pituitary cancer 761 | 1,972
medulloblastoma 747 | 1,524
acute quadriplegic myopathy 726 | 1,157
juvenile dermatomyositis 720 | 1,189
ductal carcinoma in situ 719 | 1,745
breast carcinoma 712 | 1,614
colon cancer 687 | 1,475
cystic fibrosis 672 | 1,665
sonic hedgehog group medulloblastoma 671 | 1,482
dermatomyositis 657 | 933
Rheumatoid Arthritis 639 | 1,160
adrenocortical carcinoma 631 | 1,427
primary pancreatic ductal adenocarcinoma 630 | 1,271
posterior fossa group A ependymoma 620 | 1,511
Waldenstrons macroglobulinemia 612 | 765
posterior fossa group B ependymoma 593 | 1,530
spina bifida 517 | 1,064
cutaneous lupus erythematosus 493 | 1,056
atypical teratoid/rhabdoid tumor 485 | 1,095
acute myeloid leukemia 459 | 780
primary Sjogren syndrome 453 | 789
nasopharyngeal carcinoma 438 | 1,056
non primary Sjogren syndrome sicca 435 | 840
tuberculosis and treatment for 6 months 416 | 686
active Crohn's disease 414 | 918
progressive supranuclear palsy 394 | 674
gastric carcinoma 376 | 832
esophageal adenocarcinoma 364 | 737
Atopic dermatitis 357 | 944
Alzheimer's disease 334 | 644
aldosterone-producing adenoma 329 | 664
Intellectual disability 320 | 573
Duchenne muscular dystrophy 304 | 602
pancreatic carcinoma 301 | 567
Down syndrome 285 | 548
hepatocellular carcinoma 283 | 532
IGA Glomerulonephritis 273 | 454
Neurodegenerative disease 250 | 383
Obesity 247 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 242 | 499
Amyotrophic Lateral Sclerosis 237 | 431
gastric cancer 232 | 430
Prostatic Neoplasms 228 | 471
mucosa-associated lymphoid tissue lymphoma 224 | 480
hereditary spastic paraplegia 223 | 313
Schizophrenia 218 | 501
Mammary Neoplasms 214 | 410
Multiple Sclerosis 213 | 498
fibroadenoma 205 | 557
Endometriosis 197 | 535
chronic rhinosinusitis 180 | 512
sarcoidosis 180 | 358
Parkinson's disease 175 | 364
Polycystic Ovary Syndrome 175 | 332
active ulcerative colitis 171 | 477
inflammatory breast cancer 167 | 404
non-small cell lung carcinoma 165 | 413
Stomach Neoplasms 163 | 282
tuberculosis and treatment for 3 months 161 | 327
Crohn's disease 160 | 304
glioblastoma multiforme 157 | 347
Kidney disease 151 | 396
Asthma 143 | 349

Tissue

Blood and immune system 8,481 | 17,995
Female tissues 8,450 | 18,647
Nervous System 8,449 | 18,561
Digestive Tract 8,442 | 18,473
Liver and Pancreas 8,435 | 18,136
Endocrine System 8,428 | 18,512
Male tissues 8,428 | 17,969
Urinary Tract 8,423 | 18,444
Cardiovascular System 8,420 | 17,958
Respiratory system 8,360 | 17,484
Skin and soft tissues 8,300 | 18,115

Target Family

Non-IDG 4,857 | 11,971
Enzyme 2,164 | 4,146
Transcription Factor 597 | 1,400
Kinase 392 | 634
Epigenetic 159 | 242
Transporter 133 | 473
Ion Channel 82 | 341
GPCR 48 | 406
TF/Epigenetic 21 | 38
oGPCR 16 | 421
Nuclear Receptor 12 | 48

HPM Tissue

NK Cells 8,481 | 8,481
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193