Development Level

Tbio 5,247 | 11,651
Tdark 1,224 | 6,593
Tchem 722 | 1,388
Tclin 229 | 612

Collection

RFA-RM-18-021 85 | 328
Kinase: IDG Consortium (Target... 59 | 125
Kinase: IDG Consortium (Comple... 22 | 37
Ion Channel: IDG Consortium (T... 20 | 99
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 606 | 979
preweaning lethality, incomple... 226 | 499
embryonic lethality prior to t... 166 | 278
embryonic lethality prior to o... 158 | 239
abnormal embryo size 122 | 220
abnormal behavior 118 | 298
decreased total body fat amoun... 98 | 207
abnormal bone structure 86 | 187
enlarged heart 79 | 210
decreased body weight 77 | 161
embryonic growth retardation 72 | 106
increased lean body mass 71 | 172
increased circulating alkaline... 66 | 122
abnormal heart morphology 65 | 162
decreased bone mineral content 64 | 151
decreased vertical activity 64 | 208
decreased circulating glucose ... 61 | 126
decreased bone mineral density 58 | 126
hyperactivity 57 | 148
increased total body fat amoun... 56 | 134
increased startle reflex 54 | 112
hypoactivity 53 | 132
decreased lean body mass 51 | 135
increased mean corpuscular hem... 50 | 96
decreased grip strength 49 | 116
abnormal seminal vesicle morph... 47 | 114
cataract 46 | 92
increased or absent threshold ... 45 | 101
prenatal lethality prior to he... 45 | 87
decreased mean corpuscular vol... 43 | 79
short tibia 43 | 97
male infertility 42 | 123
abnormal lens morphology 41 | 81
increased bone mineral content 41 | 108
increased mean corpuscular vol... 40 | 92
decreased circulating choleste... 39 | 93
increased fasted circulating g... 39 | 76
decreased body length 38 | 101
decreased leukocyte cell numbe... 37 | 73
decreased lymphocyte cell numb... 37 | 83
decreased circulating insulin ... 36 | 76
abnormal retina morphology 35 | 71
decreased circulating triglyce... 33 | 79
increased circulating HDL chol... 33 | 80
abnormal coat-hair pigmentatio... 32 | 64
decreased circulating HDL chol... 32 | 68
decreased circulating serum al... 32 | 82
decreased prepulse inhibition 32 | 82
increased circulating choleste... 32 | 66
edema 31 | 59
increased bone mineral density 31 | 72
abnormal eye morphology 30 | 68
decreased hemoglobin content 30 | 68
decreased startle reflex 30 | 75
small superior vagus ganglion 30 | 74
thrombocytopenia 30 | 56
abnormal behavioral response t... 29 | 66
decreased mean corpuscular hem... 29 | 50
abnormal gait 28 | 69
abnormal kidney morphology 28 | 65
decreased erythrocyte cell num... 28 | 62
impaired glucose tolerance 28 | 75
increased circulating sodium l... 28 | 71
increased heart weight 28 | 62
improved glucose tolerance 27 | 79
decreased circulating alkaline... 26 | 46
increased monocyte cell number 26 | 63
abnormal neural tube closure 25 | 46
abnormal sleep behavior 25 | 70
decreased caudal vertebrae num... 25 | 53
decreased fasted circulating g... 25 | 65
increased neutrophil cell numb... 25 | 46
small testis 25 | 58
increased blood urea nitrogen ... 24 | 48
increased mean platelet volume 24 | 45
decreased neutrophil cell numb... 23 | 42
decreased blood urea nitrogen ... 22 | 51
decreased circulating total pr... 22 | 49
decreased red blood cell distr... 22 | 41
hydrometra 22 | 53
increased erythrocyte cell num... 22 | 39
increased leukocyte cell numbe... 22 | 47
increased hemoglobin content 21 | 45
pallor 21 | 34
abnormal embryo turning 20 | 31
decreased circulating LDL chol... 20 | 38
decreased hematocrit 20 | 46
increased circulating triglyce... 20 | 42
abnormal bone mineralization 19 | 38
cardiovascular system phenotyp... 19 | 36
decreased circulating alanine ... 19 | 47
decreased circulating calcium ... 19 | 36
decreased mean corpuscular hem... 19 | 31
female infertility 19 | 60
increased prepulse inhibition 19 | 32
persistence of hyaloid vascula... 19 | 33
abnormal spleen morphology 18 | 55
increased circulating calcium ... 18 | 34
increased grip strength 18 | 41
increased hematocrit 18 | 46

Disease

Carcinoma 4,706 | 11,493
ovarian cancer 4,322 | 8,520
osteosarcoma 3,652 | 7,950
psoriasis 2,719 | 6,694
medulloblastoma, large-cell 2,690 | 6,241
glioblastoma 2,646 | 5,792
lung cancer 2,350 | 4,740
atypical teratoid / rhabdoid tumor 2,171 | 5,112
ependymoma 1,935 | 4,679
group 3 medulloblastoma 1,727 | 4,104
Breast cancer 1,549 | 3,578
adult high grade glioma 1,540 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,473 | 3,291
malignant mesothelioma 1,431 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,290 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,279 | 2,955
Astrocytoma, Pilocytic 1,263 | 3,081
invasive ductal carcinoma 1,255 | 2,951
Kidney cancer 1,243 | 2,613
non-small cell lung cancer 1,227 | 2,890
oligodendroglioma 1,225 | 2,850
primitive neuroectodermal tumor 1,215 | 3,035
astrocytic glioma 1,158 | 2,597
Cancer 1,144 | 2,499
lung carcinoma 1,129 | 2,843
lung adenocarcinoma 1,107 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 1,094 | 1,962
subependymal giant cell astrocytoma 1,074 | 2,287
pancreatic cancer 1,066 | 2,398
Multiple myeloma 1,011 | 1,332
tuberculosis 988 | 2,010
Pick disease 927 | 1,894
group 4 medulloblastoma 834 | 1,855
interstitial cystitis 822 | 2,312
diabetes mellitus 813 | 1,728
ulcerative colitis 805 | 1,819
Autosomal recessive predisposition 744 | 1,442
acute quadriplegic myopathy 719 | 1,158
juvenile dermatomyositis 705 | 1,187
pituitary cancer 681 | 1,972
astrocytoma 678 | 1,146
breast carcinoma 660 | 1,638
dermatomyositis 650 | 966
ductal carcinoma in situ 645 | 1,745
cystic fibrosis 641 | 1,696
Rheumatoid arthritis 634 | 1,191
colon cancer 630 | 1,478
Waldenstrons macroglobulinemia 597 | 765
adrenocortical carcinoma 571 | 1,428
Intellectual disability 530 | 1,016
primary pancreatic ductal adenocarcinoma 530 | 1,109
pediatric high grade glioma 512 | 1,064
Schizophrenia 475 | 1,160
cutaneous lupus erythematosus 450 | 1,057
spina bifida 440 | 1,074
non primary Sjogren syndrome sicca 434 | 891
acute myeloid leukemia 413 | 783
primary Sjogren syndrome 404 | 735
Liver Cirrhosis, Experimental 394 | 769
Epilepsy 389 | 792
nasopharyngeal carcinoma 387 | 1,058
active Crohn's disease 383 | 922
Cognitive delay 366 | 608
Global developmental delay 366 | 608
Mental and motor retardation 366 | 608
gastric carcinoma 360 | 807
esophageal adenocarcinoma 346 | 737
Muscle hypotonia 343 | 571
Dull intelligence 341 | 645
Low intelligence 341 | 645
Mental Retardation 341 | 645
Mental deficiency 341 | 645
Poor school performance 341 | 645
progressive supranuclear palsy 339 | 676
Seizures 329 | 596
Duchenne muscular dystrophy 328 | 601
Atopic dermatitis 327 | 952
Alzheimer's disease 315 | 658
aldosterone-producing adenoma 312 | 665
medulloblastoma 298 | 720
active ulcerative colitis 296 | 764
pancreatic carcinoma 285 | 562
hepatocellular carcinoma 284 | 547
Short stature 276 | 531
Liver cancer 274 | 604
Melanoma 266 | 711
Neurodegenerative disease 259 | 414
autosomal dominant Emery-Dreifuss muscular dystrophy 257 | 510
Obesity 256 | 678
Down syndrome 255 | 499
Bipolar Disorder 252 | 666
Amyotrophic lateral sclerosis 246 | 451
Prostatic Neoplasms 245 | 495
mucosa-associated lymphoid tissue lymphoma 232 | 484
hereditary spastic paraplegia 228 | 318
tuberculosis and treatment for 6 months 224 | 409
Multiple Sclerosis 221 | 540
gastric cancer 221 | 459
Breast Neoplasms 214 | 445
Small head 211 | 374

Tissue

Endocrine System 7,316 | 18,159
Digestive Tract 7,237 | 17,369
Female tissues 7,234 | 17,400
Skin and soft tissues 7,227 | 17,230
Male tissues 7,187 | 17,142
Blood and immune system 7,173 | 16,909
Liver and Pancreas 7,161 | 16,750
Urinary Tract 7,143 | 16,678
Nervous System 7,123 | 16,725
Respiratory system 7,094 | 16,393
Cardiovascular System 6,893 | 15,192

Target Family

Non-IDG 4,351 | 12,091
Enzyme 2,033 | 4,145
Kinase 384 | 634
Transcription Factor 276 | 1,400
Epigenetic 127 | 242
Transporter 125 | 473
Ion Channel 66 | 344
GPCR 27 | 408
TF/Epigenetic 15 | 38
Nuclear Receptor 13 | 48
oGPCR 5 | 421

HPM Tissue

Monocytes 7,422 | 7,422
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
HEAT repeat-containing protein 5A HEATR5A Tdark Non-IDG 0.00000 5
Protein HIDE1 C19orf38 Tdark Non-IDG 0.00000 57