Development Level

Tbio 4,838 | 10,625
Tdark 1,406 | 7,003
Tchem 957 | 1,890
Tclin 226 | 602

Collection

Eligible Kinase Proteins 66 | 134
Eligible Ion Channel Proteins 19 | 117
Eligible non-olfactory GPCR Proteins 7 | 143

IMPC Term

preweaning lethality, complete... 378 | 633
preweaning lethality, incomple... 119 | 260
embryonic lethality prior to t... 112 | 187
embryonic lethality prior to o... 98 | 148
abnormal behavior 96 | 226
decreased total body fat amoun... 96 | 186
decreased lean body mass 91 | 195
decreased body weight 86 | 174
decreased bone mineral content 72 | 157
abnormal embryo size 65 | 112
increased circulating alkaline... 62 | 119
decreased circulating glucose ... 61 | 121
abnormal bone structure 59 | 131
decreased body length 58 | 108
increased or absent threshold ... 58 | 128
decreased bone mineral density 57 | 126
decreased grip strength 53 | 123
increased mean corpuscular hem... 53 | 93
abnormal retina morphology 48 | 100
hyperactivity 45 | 108
increased lean body mass 44 | 107
increased bone mineral content 43 | 92
enlarged heart 41 | 111
abnormal lens morphology 38 | 73
decreased mean corpuscular vol... 37 | 50
decreased circulating insulin ... 36 | 75
increased fasted circulating g... 36 | 68
short tibia 35 | 82
decreased circulating HDL chol... 34 | 77
decreased circulating choleste... 34 | 85
decreased circulating serum al... 34 | 79
decreased circulating triglyce... 34 | 83
increased mean corpuscular vol... 34 | 91
increased grip strength 33 | 83
prenatal lethality prior to he... 32 | 64
abnormal retinal pigmentation 30 | 61
decreased leukocyte cell numbe... 30 | 54
hypoactivity 30 | 89
increased circulating sodium l... 30 | 71
male infertility 30 | 62
increased circulating HDL chol... 29 | 63
decreased rib number 28 | 59
increased circulating choleste... 28 | 53
abnormal coat/hair pigmentatio... 27 | 54
decreased lumbar vertebrae num... 27 | 62
increased bone mineral density 27 | 52
increased blood urea nitrogen ... 26 | 44
abnormal bone mineralization 25 | 55
increased exploration in new e... 25 | 56
decreased caudal vertebrae num... 24 | 49
impaired glucose tolerance 24 | 52
increased sacral vertebrae num... 24 | 62
thrombocytopenia 24 | 46
decreased hemoglobin content 23 | 53
abnormal gait 22 | 51
abnormal neural tube closure 22 | 37
abnormal sleep behavior 22 | 63
decreased erythrocyte cell num... 22 | 43
decreased fasted circulating g... 22 | 49
abnormal seminal vesicle morph... 21 | 47
decreased heart weight 21 | 44
decreased mean corpuscular hem... 21 | 34
increased hemoglobin content 21 | 45
decreased circulating alanine ... 20 | 53
decreased circulating alkaline... 20 | 41
decreased prepulse inhibition 20 | 52
increased circulating chloride... 20 | 43
increased leukocyte cell numbe... 20 | 37
decreased circulating total pr... 19 | 41
decreased neutrophil cell numb... 19 | 37
increased body weight 19 | 42
abnormal heart morphology 18 | 51
embryonic growth retardation 18 | 28
improved glucose tolerance 18 | 56
increased total body fat amoun... 18 | 57
abnormal eye morphology 17 | 38
decreased circulating LDL chol... 17 | 37
decreased circulating fructosa... 17 | 31
decreased startle reflex 17 | 48
increased hematocrit 17 | 36
increased startle reflex 17 | 38
abnormal behavioral response t... 16 | 52
decreased CD4-positive, CD25-p... 16 | 24
decreased circulating free fat... 16 | 39
female infertility 16 | 34
increased circulating calcium ... 16 | 32
increased circulating phosphat... 16 | 24
increased rib number 16 | 41
small testis 16 | 37
cardiovascular system phenotyp... 15 | 35
decreased NK T cell number 15 | 28
decreased T cell number 15 | 31
decreased circulating calcium ... 15 | 33
decreased circulating chloride... 15 | 32
increased circulating potassiu... 15 | 31
increased heart weight 15 | 37
abnormal rib morphology 14 | 28
abnormal spleen morphology 14 | 36
abnormal testis morphology 14 | 30
decreased eosinophil cell numb... 14 | 41

Disease

ovarian cancer 4,309 | 8,484
osteosarcoma 3,653 | 7,933
psoriasis 2,720 | 6,685
medulloblastoma, large-cell 2,690 | 6,234
glioblastoma 2,551 | 5,572
lung cancer 2,258 | 4,466
atypical teratoid / rhabdoid tumor 1,880 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,473 | 3,289
malignant mesothelioma 1,402 | 3,162
Breast cancer 1,345 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,291 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,283 | 2,956
pilocytic astrocytoma 1,269 | 3,086
invasive ductal carcinoma 1,255 | 2,950
oligodendroglioma 1,227 | 2,849
primitive neuroectodermal tumor 1,216 | 3,031
non-small cell lung cancer 1,203 | 2,798
ependymoma 1,189 | 2,514
pediatric high grade glioma 1,188 | 2,712
lung carcinoma 1,127 | 2,844
lung adenocarcinoma 1,108 | 2,713
Cancer 1,089 | 2,346
subependymal giant cell astrocytoma 1,073 | 2,287
pancreatic cancer 1,022 | 2,300
Multiple myeloma 1,008 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 1,006 | 1,795
astrocytic glioma 992 | 2,241
group 3 medulloblastoma 985 | 2,254
Carcinoma 970 | 2,147
ulcerative colitis 930 | 2,087
Pick disease 926 | 1,893
adult high grade glioma 863 | 2,148
astrocytoma 844 | 1,493
group 4 medulloblastoma 826 | 1,875
interstitial cystitis 824 | 2,299
tuberculosis 799 | 1,557
diabetes mellitus 773 | 1,663
acute quadriplegic myopathy 718 | 1,157
juvenile dermatomyositis 704 | 1,189
pituitary cancer 681 | 1,972
medulloblastoma 652 | 1,524
dermatomyositis 650 | 933
ductal carcinoma in situ 647 | 1,745
breast carcinoma 645 | 1,614
colon cancer 629 | 1,475
cystic fibrosis 629 | 1,665
Rheumatoid Arthritis 628 | 1,160
primary pancreatic ductal adenocarcinoma 617 | 1,271
Waldenstrons macroglobulinemia 598 | 765
sonic hedgehog group medulloblastoma 580 | 1,482
adrenocortical carcinoma 573 | 1,427
posterior fossa group A ependymoma 564 | 1,511
posterior fossa group B ependymoma 492 | 1,530
cutaneous lupus erythematosus 450 | 1,056
spina bifida 437 | 1,064
primary Sjogren syndrome 430 | 789
atypical teratoid/rhabdoid tumor 423 | 1,095
acute myeloid leukemia 410 | 780
non primary Sjogren syndrome sicca 407 | 840
nasopharyngeal carcinoma 385 | 1,056
active Crohn's disease 382 | 918
gastric carcinoma 376 | 832
tuberculosis and treatment for 6 months 368 | 686
esophageal adenocarcinoma 347 | 737
progressive supranuclear palsy 340 | 674
Duchenne muscular dystrophy 327 | 602
Atopic dermatitis 321 | 944
Alzheimer's disease 315 | 644
aldosterone-producing adenoma 312 | 664
Intellectual disability 292 | 573
pancreatic carcinoma 287 | 567
IGA Glomerulonephritis 279 | 454
hepatocellular carcinoma 274 | 532
Down syndrome 273 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 252 | 499
Neurodegenerative disease 240 | 383
Amyotrophic Lateral Sclerosis 236 | 431
Prostatic Neoplasms 235 | 471
mucosa-associated lymphoid tissue lymphoma 232 | 480
Obesity 226 | 616
hereditary spastic paraplegia 226 | 313
gastric cancer 206 | 430
Multiple Sclerosis 203 | 498
Mammary Neoplasms 197 | 410
Schizophrenia 191 | 501
fibroadenoma 180 | 557
Endometriosis 175 | 535
active ulcerative colitis 173 | 477
inflammatory breast cancer 172 | 404
Kidney disease 167 | 396
sarcoidosis 165 | 358
Polycystic Ovary Syndrome 163 | 332
Parkinson's disease 156 | 364
Stomach Neoplasms 154 | 282
chronic rhinosinusitis 148 | 512
Crohn's disease 147 | 304
Vascular disease 143 | 281
non-small cell lung carcinoma 143 | 413
glioblastoma multiforme 142 | 347
Asthma 141 | 349

Tissue

Blood and immune system 7,427 | 17,995
Nervous System 7,417 | 18,561
Female tissues 7,413 | 18,647
Digestive Tract 7,396 | 18,473
Liver and Pancreas 7,391 | 18,136
Urinary Tract 7,391 | 18,444
Endocrine System 7,390 | 18,512
Male tissues 7,381 | 17,969
Cardiovascular System 7,377 | 17,958
Respiratory system 7,349 | 17,484
Skin and soft tissues 7,295 | 18,115

Target Family

Non-IDG 4,354 | 11,971
Enzyme 2,035 | 4,146
Kinase 384 | 634
Transcription Factor 276 | 1,400
Epigenetic 128 | 242
Transporter 126 | 473
Ion Channel 64 | 341
GPCR 27 | 406
TF/Epigenetic 15 | 38
Nuclear Receptor 13 | 48
oGPCR 5 | 421

HPM Tissue

Monocytes 7,427 | 7,427
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682