Development Level

Tbio 5,026 | 11,178
Tdark 1,214 | 6,569
Tchem 953 | 1,885
Tclin 229 | 612

Collection

Kinase: IDG Consortium (Target... 59 | 125
Kinase: IDG Consortium (Comple... 22 | 37
Ion Channel: IDG Consortium (T... 20 | 99
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 606 | 979
preweaning lethality, incomple... 226 | 499
embryonic lethality prior to t... 166 | 278
embryonic lethality prior to o... 158 | 239
abnormal embryo size 122 | 220
abnormal behavior 118 | 298
decreased total body fat amoun... 98 | 207
abnormal bone structure 86 | 187
enlarged heart 79 | 210
decreased body weight 77 | 161
embryonic growth retardation 72 | 106
increased lean body mass 71 | 172
increased circulating alkaline... 66 | 122
abnormal heart morphology 65 | 162
decreased bone mineral content 64 | 151
decreased vertical activity 64 | 208
decreased circulating glucose ... 61 | 126
decreased bone mineral density 58 | 126
hyperactivity 57 | 148
increased total body fat amoun... 56 | 134
increased startle reflex 54 | 112
hypoactivity 53 | 132
decreased lean body mass 51 | 135
increased mean corpuscular hem... 50 | 96
decreased grip strength 49 | 116
abnormal seminal vesicle morph... 47 | 114
cataract 46 | 92
increased or absent threshold ... 45 | 101
prenatal lethality prior to he... 45 | 87
decreased mean corpuscular vol... 43 | 79
short tibia 43 | 97
male infertility 42 | 123
abnormal lens morphology 41 | 81
increased bone mineral content 41 | 108
increased mean corpuscular vol... 40 | 92
decreased circulating choleste... 39 | 93
increased fasted circulating g... 39 | 76
decreased body length 38 | 101
decreased leukocyte cell numbe... 37 | 73
decreased lymphocyte cell numb... 37 | 83
decreased circulating insulin ... 36 | 76
abnormal retina morphology 35 | 71
decreased circulating triglyce... 33 | 79
increased circulating HDL chol... 33 | 80
abnormal coat-hair pigmentatio... 32 | 64
decreased circulating HDL chol... 32 | 68
decreased circulating serum al... 32 | 82
decreased prepulse inhibition 32 | 82
increased circulating choleste... 32 | 66
edema 31 | 59
increased bone mineral density 31 | 72
abnormal eye morphology 30 | 68
decreased hemoglobin content 30 | 68
decreased startle reflex 30 | 75
small superior vagus ganglion 30 | 74
thrombocytopenia 30 | 56
abnormal behavioral response t... 29 | 66
decreased mean corpuscular hem... 29 | 50
abnormal gait 28 | 69
abnormal kidney morphology 28 | 65
decreased erythrocyte cell num... 28 | 62
impaired glucose tolerance 28 | 75
increased circulating sodium l... 28 | 71
increased heart weight 28 | 62
improved glucose tolerance 27 | 79
decreased circulating alkaline... 26 | 46
increased monocyte cell number 26 | 63
abnormal neural tube closure 25 | 46
abnormal sleep behavior 25 | 70
decreased caudal vertebrae num... 25 | 53
decreased fasted circulating g... 25 | 65
increased neutrophil cell numb... 25 | 46
small testis 25 | 58
increased blood urea nitrogen ... 24 | 48
increased mean platelet volume 24 | 45
decreased neutrophil cell numb... 23 | 42
decreased blood urea nitrogen ... 22 | 51
decreased circulating total pr... 22 | 49
decreased red blood cell distr... 22 | 41
hydrometra 22 | 53
increased erythrocyte cell num... 22 | 39
increased leukocyte cell numbe... 22 | 47
increased hemoglobin content 21 | 45
pallor 21 | 34
abnormal embryo turning 20 | 31
decreased circulating LDL chol... 20 | 38
decreased hematocrit 20 | 46
increased circulating triglyce... 20 | 42
abnormal bone mineralization 19 | 38
cardiovascular system phenotyp... 19 | 36
decreased circulating alanine ... 19 | 47
decreased circulating calcium ... 19 | 36
decreased mean corpuscular hem... 19 | 31
female infertility 19 | 60
increased prepulse inhibition 19 | 32
persistence of hyaloid vascula... 19 | 33
abnormal spleen morphology 18 | 55
increased circulating calcium ... 18 | 34
increased grip strength 18 | 41
increased hematocrit 18 | 46

Disease

Carcinoma 4,606 | 11,192
ovarian cancer 4,216 | 8,297
osteosarcoma 3,587 | 7,766
psoriasis 2,653 | 6,514
medulloblastoma, large-cell 2,631 | 6,086
glioblastoma 2,577 | 5,635
lung cancer 2,294 | 4,607
atypical teratoid / rhabdoid tumor 2,111 | 4,971
ependymoma 1,883 | 4,559
group 3 medulloblastoma 1,691 | 4,002
Breast cancer 1,514 | 3,469
adult high grade glioma 1,496 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 1,434 | 3,204
malignant mesothelioma 1,388 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 1,251 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 1,238 | 2,872
Astrocytoma, Pilocytic 1,229 | 3,006
Kidney cancer 1,222 | 2,548
invasive ductal carcinoma 1,221 | 2,867
non-small cell lung cancer 1,201 | 2,799
oligodendroglioma 1,190 | 2,768
primitive neuroectodermal tumor 1,183 | 2,957
astrocytic glioma 1,130 | 2,530
Cancer 1,100 | 2,388
lung carcinoma 1,091 | 2,755
lung adenocarcinoma 1,076 | 2,627
pancreatic ductal adenocarcinoma liver metastasis 1,067 | 1,911
subependymal giant cell astrocytoma 1,050 | 2,230
pancreatic cancer 1,040 | 2,322
Multiple myeloma 979 | 1,296
tuberculosis 970 | 1,963
Pick disease 909 | 1,856
group 4 medulloblastoma 812 | 1,806
interstitial cystitis 795 | 2,237
diabetes mellitus 789 | 1,683
ulcerative colitis 784 | 1,765
Autosomal recessive predisposition 726 | 1,407
acute quadriplegic myopathy 705 | 1,133
juvenile dermatomyositis 681 | 1,147
pituitary cancer 664 | 1,915
astrocytoma 661 | 1,113
breast carcinoma 643 | 1,589
dermatomyositis 629 | 941
ductal carcinoma in situ 620 | 1,686
cystic fibrosis 619 | 1,629
colon cancer 613 | 1,428
Rheumatoid arthritis 611 | 1,156
Waldenstrons macroglobulinemia 578 | 742
adrenocortical carcinoma 551 | 1,385
Intellectual disability 521 | 998
primary pancreatic ductal adenocarcinoma 511 | 1,071
pediatric high grade glioma 503 | 1,035
Schizophrenia 468 | 1,136
cutaneous lupus erythematosus 437 | 1,016
spina bifida 432 | 1,053
non primary Sjogren syndrome sicca 420 | 861
acute myeloid leukemia 401 | 760
primary Sjogren syndrome 392 | 710
Epilepsy 381 | 775
nasopharyngeal carcinoma 376 | 1,024
Liver Cirrhosis, Experimental 375 | 733
active Crohn's disease 367 | 882
Cognitive delay 361 | 596
Global developmental delay 361 | 596
Mental and motor retardation 361 | 596
gastric carcinoma 350 | 781
Muscle hypotonia 339 | 562
Dull intelligence 335 | 634
Low intelligence 335 | 634
Mental Retardation 335 | 634
Mental deficiency 335 | 634
Poor school performance 335 | 634
esophageal adenocarcinoma 332 | 696
progressive supranuclear palsy 329 | 656
Seizures 324 | 584
Duchenne muscular dystrophy 317 | 587
Atopic dermatitis 315 | 915
Alzheimer's disease 306 | 640
aldosterone-producing adenoma 302 | 646
medulloblastoma 289 | 702
active ulcerative colitis 286 | 736
pancreatic carcinoma 283 | 555
hepatocellular carcinoma 277 | 536
Liver cancer 271 | 589
Short stature 271 | 514
Melanoma 261 | 689
Neurodegenerative disease 251 | 402
Obesity 248 | 655
Bipolar Disorder 247 | 646
autosomal dominant Emery-Dreifuss muscular dystrophy 246 | 492
Down syndrome 245 | 480
Prostatic Neoplasms 239 | 472
Amyotrophic lateral sclerosis 238 | 437
mucosa-associated lymphoid tissue lymphoma 227 | 473
hereditary spastic paraplegia 225 | 313
tuberculosis and treatment for 6 months 218 | 399
Multiple Sclerosis 215 | 527
gastric cancer 212 | 445
Small head 209 | 366
Failure to gain weight 205 | 359

Tissue

Endocrine System 7,316 | 18,159
Digestive Tract 7,237 | 17,369
Female tissues 7,234 | 17,400
Skin and soft tissues 7,227 | 17,230
Male tissues 7,187 | 17,142
Blood and immune system 7,173 | 16,909
Liver and Pancreas 7,161 | 16,750
Urinary Tract 7,143 | 16,678
Nervous System 7,123 | 16,725
Respiratory system 7,094 | 16,393
Cardiovascular System 6,893 | 15,192

Target Family

Non-IDG 4,351 | 12,091
Enzyme 2,033 | 4,145
Kinase 384 | 634
Transcription Factor 276 | 1,400
Epigenetic 127 | 242
Transporter 125 | 473
Ion Channel 66 | 344
GPCR 27 | 408
TF/Epigenetic 15 | 38
Nuclear Receptor 13 | 48
oGPCR 5 | 421

HPM Tissue

Monocytes 7,422 | 7,422
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94