Development Level

Tbio 5,253 | 10,625
Tdark 1,536 | 7,003
Tchem 946 | 1,890
Tclin 226 | 602

Collection

Eligible Kinase Proteins 60 | 134
Eligible Ion Channel Proteins 20 | 117
Eligible non-olfactory GPCR Proteins 10 | 143

IMPC Term

preweaning lethality, complete... 421 | 633
preweaning lethality, incomple... 128 | 260
embryonic lethality prior to t... 126 | 187
abnormal behavior 117 | 226
embryonic lethality prior to o... 116 | 148
decreased total body fat amoun... 109 | 186
decreased lean body mass 101 | 195
decreased body weight 100 | 174
decreased bone mineral content 81 | 157
abnormal embryo size 72 | 112
decreased bone mineral density 67 | 126
decreased circulating glucose ... 67 | 121
decreased body length 65 | 108
abnormal bone structure 64 | 131
abnormal retina morphology 62 | 100
decreased grip strength 61 | 123
increased or absent threshold ... 61 | 128
increased circulating alkaline... 58 | 119
increased mean corpuscular hem... 55 | 93
hyperactivity 54 | 108
increased lean body mass 52 | 107
decreased circulating choleste... 46 | 85
increased mean corpuscular vol... 46 | 91
abnormal lens morphology 42 | 73
hypoactivity 42 | 89
increased grip strength 42 | 83
decreased circulating HDL chol... 41 | 77
short tibia 41 | 82
enlarged heart 40 | 111
increased bone mineral content 40 | 92
increased fasted circulating g... 40 | 68
decreased circulating triglyce... 39 | 83
decreased mean corpuscular vol... 39 | 50
prenatal lethality prior to he... 38 | 64
decreased circulating insulin ... 37 | 75
decreased circulating serum al... 36 | 79
abnormal retinal pigmentation 35 | 61
decreased leukocyte cell numbe... 31 | 54
male infertility 31 | 62
decreased lumbar vertebrae num... 30 | 62
decreased rib number 30 | 59
increased circulating sodium l... 30 | 71
thrombocytopenia 29 | 46
impaired glucose tolerance 28 | 52
abnormal behavioral response t... 27 | 52
abnormal bone mineralization 27 | 55
increased circulating HDL chol... 27 | 63
abnormal sleep behavior 26 | 63
decreased circulating alanine ... 26 | 53
decreased startle reflex 26 | 48
increased sacral vertebrae num... 26 | 62
decreased fasted circulating g... 25 | 49
abnormal coat/hair pigmentatio... 24 | 54
abnormal gait 24 | 51
decreased circulating total pr... 24 | 41
decreased eosinophil cell numb... 24 | 41
increased bone mineral density 24 | 52
increased circulating choleste... 24 | 53
increased exploration in new e... 24 | 56
decreased circulating alkaline... 23 | 41
decreased erythrocyte cell num... 23 | 43
decreased hemoglobin content 23 | 53
increased blood urea nitrogen ... 23 | 44
abnormal seminal vesicle morph... 22 | 47
cardiovascular system phenotyp... 22 | 35
decreased caudal vertebrae num... 22 | 49
decreased heart weight 22 | 44
improved glucose tolerance 22 | 56
increased circulating chloride... 22 | 43
increased leukocyte cell numbe... 22 | 37
increased body weight 21 | 42
increased hemoglobin content 21 | 45
decreased prepulse inhibition 20 | 52
increased hematocrit 20 | 36
increased total body fat amoun... 20 | 57
abnormal neural tube closure 19 | 37
decreased circulating LDL chol... 19 | 37
decreased circulating free fat... 19 | 39
decreased mean corpuscular hem... 19 | 34
female infertility 19 | 34
increased heart weight 19 | 37
small testis 19 | 37
abnormal cranium morphology 18 | 32
decreased circulating aspartat... 18 | 27
decreased circulating calcium ... 18 | 33
decreased neutrophil cell numb... 18 | 37
embryonic growth retardation 18 | 28
increased startle reflex 18 | 38
abnormal eye morphology 17 | 38
decreased blood urea nitrogen ... 17 | 31
decreased circulating fructosa... 17 | 31
decreased threshold for audito... 17 | 32
increased circulating phosphat... 17 | 24
increased circulating potassiu... 17 | 31
increased rib number 17 | 41
tremors 17 | 34
abnormal testis morphology 16 | 30
decreased circulating chloride... 16 | 32
decreased T cell number 15 | 31
decreased circulating iron lev... 15 | 25

Disease

ovarian cancer 4,680 | 8,484
osteosarcoma 3,778 | 7,933
medulloblastoma, large-cell 2,954 | 6,234
psoriasis 2,943 | 6,685
glioblastoma 2,752 | 5,572
lung cancer 2,402 | 4,466
atypical teratoid / rhabdoid tumor 2,110 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,627 | 3,289
malignant mesothelioma 1,602 | 3,162
Breast cancer 1,563 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,463 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,402 | 2,956
invasive ductal carcinoma 1,400 | 2,950
primitive neuroectodermal tumor 1,394 | 3,031
oligodendroglioma 1,391 | 2,849
pilocytic astrocytoma 1,347 | 3,086
pediatric high grade glioma 1,325 | 2,712
ependymoma 1,313 | 2,514
non-small cell lung cancer 1,274 | 2,798
lung adenocarcinoma 1,195 | 2,713
Cancer 1,153 | 2,346
subependymal giant cell astrocytoma 1,130 | 2,287
pancreatic cancer 1,110 | 2,300
group 3 medulloblastoma 1,098 | 2,254
lung carcinoma 1,094 | 2,844
astrocytic glioma 1,082 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,055 | 1,795
Carcinoma 1,051 | 2,147
Multiple myeloma 1,038 | 1,327
Pick disease 1,038 | 1,893
group 4 medulloblastoma 913 | 1,875
adult high grade glioma 910 | 2,148
ulcerative colitis 901 | 2,087
astrocytoma 890 | 1,493
interstitial cystitis 801 | 2,299
pituitary cancer 792 | 1,972
diabetes mellitus 790 | 1,663
ductal carcinoma in situ 782 | 1,745
breast carcinoma 767 | 1,614
acute quadriplegic myopathy 752 | 1,157
colon cancer 747 | 1,475
juvenile dermatomyositis 718 | 1,189
tuberculosis 717 | 1,557
sonic hedgehog group medulloblastoma 714 | 1,482
cystic fibrosis 710 | 1,665
primary pancreatic ductal adenocarcinoma 705 | 1,271
medulloblastoma 703 | 1,524
adrenocortical carcinoma 670 | 1,427
dermatomyositis 668 | 933
posterior fossa group A ependymoma 641 | 1,511
Waldenstrons macroglobulinemia 578 | 765
Rheumatoid Arthritis 567 | 1,160
posterior fossa group B ependymoma 562 | 1,530
atypical teratoid/rhabdoid tumor 487 | 1,095
spina bifida 469 | 1,064
non primary Sjogren syndrome sicca 449 | 840
nasopharyngeal carcinoma 434 | 1,056
acute myeloid leukemia 428 | 780
gastric carcinoma 401 | 832
active Crohn's disease 392 | 918
cutaneous lupus erythematosus 389 | 1,056
tuberculosis and treatment for 6 months 389 | 686
progressive supranuclear palsy 377 | 674
Duchenne muscular dystrophy 374 | 602
Atopic dermatitis 370 | 944
esophageal adenocarcinoma 361 | 737
aldosterone-producing adenoma 346 | 664
Alzheimer's disease 340 | 644
Intellectual disability 340 | 573
primary Sjogren syndrome 339 | 789
autosomal dominant Emery-Dreifuss muscular dystrophy 300 | 499
Down syndrome 296 | 548
pancreatic carcinoma 283 | 567
IGA Glomerulonephritis 263 | 454
hepatocellular carcinoma 260 | 532
Neurodegenerative disease 255 | 383
Prostatic Neoplasms 254 | 471
Amyotrophic Lateral Sclerosis 248 | 431
Obesity 246 | 616
hereditary spastic paraplegia 238 | 313
gastric cancer 220 | 430
Mammary Neoplasms 217 | 410
fibroadenoma 211 | 557
Endometriosis 209 | 535
Schizophrenia 191 | 501
active ulcerative colitis 190 | 477
mucosa-associated lymphoid tissue lymphoma 189 | 480
Polycystic Ovary Syndrome 186 | 332
chronic rhinosinusitis 179 | 512
inflammatory breast cancer 175 | 404
Parkinson's disease 172 | 364
non-small cell lung carcinoma 168 | 413
Multiple Sclerosis 164 | 498
Stomach Neoplasms 164 | 282
glioblastoma multiforme 162 | 347
Kidney disease 160 | 396
interstitial lung disease 152 | 291
tuberculosis and treatment for 3 months 147 | 327
sarcoidosis 146 | 358
Epilepsy 141 | 346

Tissue

Male tissues 7,961 | 17,969
Female tissues 7,951 | 18,647
Nervous System 7,944 | 18,561
Digestive Tract 7,940 | 18,473
Endocrine System 7,931 | 18,512
Liver and Pancreas 7,926 | 18,136
Blood and immune system 7,913 | 17,995
Urinary Tract 7,911 | 18,444
Cardiovascular System 7,907 | 17,958
Respiratory system 7,825 | 17,484
Skin and soft tissues 7,819 | 18,115

Target Family

Non-IDG 4,644 | 11,971
Enzyme 2,168 | 4,146
Transcription Factor 382 | 1,400
Kinase 370 | 634
Epigenetic 146 | 242
Transporter 130 | 473
Ion Channel 68 | 341
GPCR 28 | 406
TF/Epigenetic 12 | 38
Nuclear Receptor 8 | 48
oGPCR 5 | 421

HPM Tissue

Fetal Testis 7,961 | 7,961
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38