Development Level

Tbio 5,253 | 10,625
Tdark 1,536 | 7,003
Tchem 945 | 1,890
Tclin 226 | 602

Collection

Kinase: IDG Consortium (Targets) 53 | 125
Kinase: IDG Consortium (Complete/Control) 23 | 37
Ion Channel: IDG Consortium (Targets) 19 | 102
GPCR: IDG Consortium (Targets) 9 | 127
GPCR: IDG Consortium (Complete/Control) 3 | 26

IMPC Phenotype

preweaning lethality, complete... 421 | 633
preweaning lethality, incomple... 128 | 260
embryonic lethality prior to t... 126 | 187
abnormal behavior 117 | 226
embryonic lethality prior to o... 116 | 148
decreased total body fat amoun... 109 | 186
decreased lean body mass 101 | 195
decreased body weight 100 | 174
decreased bone mineral content 81 | 157
abnormal embryo size 72 | 112
decreased bone mineral density 67 | 126
decreased circulating glucose ... 67 | 121
decreased body length 65 | 108
abnormal bone structure 64 | 131
abnormal retina morphology 62 | 100
decreased grip strength 61 | 123
increased or absent threshold ... 61 | 128
increased circulating alkaline... 58 | 119
increased mean corpuscular hem... 55 | 93
hyperactivity 54 | 108
increased lean body mass 52 | 107
decreased circulating choleste... 46 | 85
increased mean corpuscular vol... 46 | 91
abnormal lens morphology 42 | 73
hypoactivity 42 | 89
increased grip strength 42 | 83
decreased circulating HDL chol... 41 | 77
short tibia 41 | 82
enlarged heart 40 | 111
increased bone mineral content 40 | 92
increased fasted circulating g... 40 | 68
decreased circulating triglyce... 39 | 83
decreased mean corpuscular vol... 39 | 50
prenatal lethality prior to he... 38 | 64
decreased circulating insulin ... 37 | 75
decreased circulating serum al... 36 | 79
abnormal retinal pigmentation 35 | 61
decreased leukocyte cell numbe... 31 | 54
male infertility 31 | 62
decreased lumbar vertebrae num... 30 | 62
decreased rib number 30 | 59
increased circulating sodium l... 30 | 71
thrombocytopenia 29 | 46
impaired glucose tolerance 28 | 52
abnormal behavioral response t... 27 | 52
abnormal bone mineralization 27 | 55
increased circulating HDL chol... 27 | 63
abnormal sleep behavior 26 | 63
decreased circulating alanine ... 26 | 53
decreased startle reflex 26 | 48
increased sacral vertebrae num... 26 | 62
decreased fasted circulating g... 25 | 49
abnormal coat-hair pigmentatio... 24 | 54
abnormal gait 24 | 51
decreased circulating total pr... 24 | 41
decreased eosinophil cell numb... 24 | 41
increased bone mineral density 24 | 52
increased circulating choleste... 24 | 53
increased exploration in new e... 24 | 56
decreased circulating alkaline... 23 | 41
decreased erythrocyte cell num... 23 | 43
decreased hemoglobin content 23 | 53
increased blood urea nitrogen ... 23 | 44
abnormal seminal vesicle morph... 22 | 47
cardiovascular system phenotyp... 22 | 35
decreased caudal vertebrae num... 22 | 49
decreased heart weight 22 | 44
improved glucose tolerance 22 | 56
increased circulating chloride... 22 | 43
increased leukocyte cell numbe... 22 | 37
increased body weight 21 | 42
increased hemoglobin content 21 | 45
decreased prepulse inhibition 20 | 52
increased hematocrit 20 | 36
increased total body fat amoun... 20 | 57
abnormal neural tube closure 19 | 37
decreased circulating LDL chol... 19 | 37
decreased circulating free fat... 19 | 39
decreased mean corpuscular hem... 19 | 34
female infertility 19 | 34
increased heart weight 19 | 37
small testis 19 | 37
abnormal cranium morphology 18 | 32
decreased circulating aspartat... 18 | 27
decreased circulating calcium ... 18 | 33
decreased neutrophil cell numb... 18 | 37
embryonic growth retardation 18 | 28
increased startle reflex 18 | 38
abnormal eye morphology 17 | 38
decreased blood urea nitrogen ... 17 | 31
decreased circulating fructosa... 17 | 31
decreased threshold for audito... 17 | 32
increased circulating phosphat... 17 | 24
increased circulating potassiu... 17 | 31
increased rib number 17 | 41
tremors 17 | 34
abnormal testis morphology 16 | 30
decreased circulating chloride... 16 | 32
decreased T cell number 15 | 31
decreased circulating iron lev... 15 | 25

Disease

ovarian cancer 4,685 | 8,491
osteosarcoma 3,778 | 7,933
medulloblastoma, large-cell 2,954 | 6,234
psoriasis 2,943 | 6,685
glioblastoma 2,752 | 5,572
lung cancer 2,403 | 4,473
atypical teratoid / rhabdoid tumor 2,110 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,627 | 3,289
malignant mesothelioma 1,603 | 3,163
Breast cancer 1,563 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 1,463 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,402 | 2,956
invasive ductal carcinoma 1,400 | 2,950
primitive neuroectodermal tumor 1,394 | 3,031
oligodendroglioma 1,391 | 2,849
pilocytic astrocytoma 1,347 | 3,086
pediatric high grade glioma 1,325 | 2,712
ependymoma 1,313 | 2,514
non-small cell lung cancer 1,274 | 2,798
lung adenocarcinoma 1,195 | 2,714
Cancer 1,153 | 2,346
subependymal giant cell astrocytoma 1,130 | 2,287
pancreatic cancer 1,110 | 2,300
group 3 medulloblastoma 1,098 | 2,254
lung carcinoma 1,094 | 2,844
astrocytic glioma 1,082 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,055 | 1,795
Carcinoma 1,051 | 2,147
Pick disease 1,038 | 1,893
Multiple myeloma 1,037 | 1,327
group 4 medulloblastoma 913 | 1,875
adult high grade glioma 910 | 2,148
ulcerative colitis 901 | 2,087
astrocytoma 890 | 1,493
interstitial cystitis 801 | 2,299
pituitary cancer 792 | 1,972
diabetes mellitus 790 | 1,663
ductal carcinoma in situ 782 | 1,745
breast carcinoma 767 | 1,614
acute quadriplegic myopathy 752 | 1,157
colon cancer 747 | 1,475
tuberculosis 720 | 1,563
juvenile dermatomyositis 718 | 1,189
sonic hedgehog group medulloblastoma 714 | 1,482
cystic fibrosis 711 | 1,670
primary pancreatic ductal adenocarcinoma 705 | 1,271
medulloblastoma 703 | 1,524
adrenocortical carcinoma 670 | 1,427
dermatomyositis 668 | 966
posterior fossa group A ependymoma 641 | 1,511
Waldenstrons macroglobulinemia 577 | 764
Rheumatoid Arthritis 567 | 1,170
posterior fossa group B ependymoma 562 | 1,530
atypical teratoid/rhabdoid tumor 487 | 1,095
spina bifida 469 | 1,064
non primary Sjogren syndrome sicca 449 | 840
nasopharyngeal carcinoma 434 | 1,056
acute myeloid leukemia 430 | 785
gastric carcinoma 401 | 832
active Crohn's disease 392 | 918
cutaneous lupus erythematosus 389 | 1,056
tuberculosis and treatment for 6 months 389 | 686
progressive supranuclear palsy 377 | 674
Duchenne muscular dystrophy 374 | 602
Atopic dermatitis 370 | 944
esophageal adenocarcinoma 361 | 737
aldosterone-producing adenoma 346 | 664
Alzheimer's disease 340 | 644
Intellectual disability 340 | 573
primary Sjogren syndrome 338 | 788
autosomal dominant Emery-Dreifuss muscular dystrophy 300 | 499
Down syndrome 296 | 548
pancreatic carcinoma 283 | 567
hepatocellular carcinoma 272 | 550
IGA Glomerulonephritis 263 | 454
Neurodegenerative disease 255 | 383
Prostatic Neoplasms 254 | 471
Amyotrophic Lateral Sclerosis 248 | 432
Obesity 246 | 616
hereditary spastic paraplegia 238 | 313
gastric cancer 223 | 436
Mammary Neoplasms 217 | 410
fibroadenoma 211 | 557
Endometriosis 209 | 535
Schizophrenia 193 | 503
active ulcerative colitis 190 | 477
mucosa-associated lymphoid tissue lymphoma 189 | 480
Polycystic Ovary Syndrome 187 | 334
chronic rhinosinusitis 179 | 512
inflammatory breast cancer 175 | 404
Parkinson's disease 172 | 364
non-small cell lung carcinoma 168 | 413
Multiple Sclerosis 164 | 498
Stomach Neoplasms 164 | 282
glioblastoma multiforme 162 | 347
Kidney disease 160 | 397
interstitial lung disease 153 | 292
sarcoidosis 147 | 368
tuberculosis and treatment for 3 months 147 | 327
Epilepsy 141 | 346

Tissue

Male tissues 7,960 | 17,968
Female tissues 7,950 | 18,646
Nervous System 7,943 | 18,560
Digestive Tract 7,939 | 18,472
Endocrine System 7,930 | 18,511
Liver and Pancreas 7,925 | 18,135
Blood and immune system 7,912 | 17,994
Urinary Tract 7,910 | 18,443
Cardiovascular System 7,906 | 17,957
Respiratory system 7,824 | 17,483
Skin and soft tissues 7,818 | 18,114

Target Family

Non-IDG 4,644 | 11,969
Enzyme 2,167 | 4,146
Transcription Factor 382 | 1,400
Kinase 370 | 634
Epigenetic 146 | 242
Transporter 130 | 473
Ion Channel 68 | 341
GPCR 28 | 408
TF/Epigenetic 12 | 38
Nuclear Receptor 8 | 48
oGPCR 5 | 421

HPM Tissue

Fetal Testis 7,960 | 7,960
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Adult Adrenal 8,478 | 8,478
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114