Development Level

Tbio 5,685 | 11,651
Tdark 1,336 | 6,593
Tchem 704 | 1,388
Tclin 230 | 612

Collection

RFA-RM-18-021 81 | 328
Kinase: IDG Consortium (Target... 53 | 125
Kinase: IDG Consortium (Comple... 23 | 37
Ion Channel: IDG Consortium (T... 20 | 99
GPCR: IDG Consortium (Targets) 8 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 678 | 979
preweaning lethality, incomple... 253 | 499
embryonic lethality prior to t... 188 | 278
embryonic lethality prior to o... 182 | 239
abnormal behavior 149 | 298
abnormal embryo size 139 | 220
decreased total body fat amoun... 103 | 207
decreased body weight 94 | 161
abnormal bone structure 91 | 187
enlarged heart 87 | 210
increased lean body mass 78 | 172
decreased vertical activity 76 | 208
embryonic growth retardation 75 | 106
decreased bone mineral content 72 | 151
abnormal heart morphology 69 | 162
hyperactivity 69 | 148
decreased bone mineral density 67 | 126
decreased circulating glucose ... 67 | 126
hypoactivity 66 | 132
increased startle reflex 65 | 112
increased total body fat amoun... 61 | 134
increased circulating alkaline... 57 | 122
decreased lean body mass 56 | 135
short tibia 53 | 97
decreased grip strength 52 | 116
prenatal lethality prior to he... 52 | 87
decreased circulating choleste... 51 | 93
decreased body length 50 | 101
increased mean corpuscular hem... 50 | 96
abnormal seminal vesicle morph... 49 | 114
increased mean corpuscular vol... 49 | 92
increased bone mineral content 48 | 108
male infertility 48 | 123
cataract 45 | 92
increased or absent threshold ... 45 | 101
abnormal lens morphology 44 | 81
decreased mean corpuscular vol... 44 | 79
abnormal retina morphology 43 | 71
increased fasted circulating g... 41 | 76
decreased prepulse inhibition 40 | 82
decreased circulating HDL chol... 39 | 68
decreased circulating triglyce... 39 | 79
abnormal behavioral response t... 38 | 66
decreased leukocyte cell numbe... 38 | 73
decreased startle reflex 38 | 75
decreased circulating insulin ... 37 | 76
decreased circulating serum al... 37 | 82
impaired glucose tolerance 37 | 75
edema 35 | 59
improved glucose tolerance 35 | 79
abnormal eye morphology 34 | 68
thrombocytopenia 34 | 56
decreased lymphocyte cell numb... 32 | 83
abnormal coat-hair pigmentatio... 31 | 64
abnormal gait 31 | 69
decreased erythrocyte cell num... 31 | 62
decreased fasted circulating g... 31 | 65
abnormal sleep behavior 30 | 70
increased bone mineral density 30 | 72
increased circulating choleste... 30 | 66
increased circulating sodium l... 30 | 71
increased heart weight 30 | 62
decreased caudal vertebrae num... 29 | 53
decreased circulating alkaline... 29 | 46
increased circulating HDL chol... 29 | 80
decreased circulating alanine ... 28 | 47
small testis 28 | 58
increased leukocyte cell numbe... 27 | 47
abnormal kidney morphology 26 | 65
decreased circulating total pr... 26 | 49
decreased hemoglobin content 26 | 68
abnormal skin morphology 25 | 50
decreased mean corpuscular hem... 24 | 50
increased monocyte cell number 24 | 63
small superior vagus ganglion 24 | 74
tremors 24 | 39
decreased blood urea nitrogen ... 23 | 51
decreased red blood cell distr... 23 | 41
increased blood urea nitrogen ... 23 | 48
increased mean platelet volume 23 | 45
pallor 23 | 34
abnormal embryo turning 22 | 31
decreased neutrophil cell numb... 22 | 42
female infertility 22 | 60
hydrometra 22 | 53
increased erythrocyte cell num... 22 | 39
increased grip strength 22 | 41
abnormal neural tube closure 21 | 46
cardiovascular system phenotyp... 21 | 36
decreased circulating LDL chol... 21 | 38
decreased circulating aspartat... 21 | 34
increased hematocrit 21 | 46
increased neutrophil cell numb... 21 | 46
persistence of hyaloid vascula... 21 | 33
abnormal bone mineralization 20 | 38
abnormal cranium morphology 20 | 36
abnormal epididymis morphology 20 | 42
increased circulating chloride... 20 | 41
increased circulating triglyce... 20 | 42
increased hemoglobin content 20 | 45

Disease

Carcinoma 4,962 | 11,493
ovarian cancer 4,697 | 8,520
osteosarcoma 3,780 | 7,950
medulloblastoma, large-cell 2,956 | 6,241
psoriasis 2,939 | 6,694
glioblastoma 2,865 | 5,792
lung cancer 2,493 | 4,740
atypical teratoid / rhabdoid tumor 2,441 | 5,112
ependymoma 2,168 | 4,679
group 3 medulloblastoma 1,955 | 4,104
Breast cancer 1,780 | 3,578
adult high grade glioma 1,660 | 3,801
malignant mesothelioma 1,636 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,626 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 1,461 | 2,989
invasive ductal carcinoma 1,400 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 1,397 | 2,955
primitive neuroectodermal tumor 1,392 | 3,035
oligodendroglioma 1,389 | 2,850
Astrocytoma, Pilocytic 1,345 | 3,081
Kidney cancer 1,320 | 2,613
non-small cell lung cancer 1,301 | 2,890
astrocytic glioma 1,274 | 2,597
Cancer 1,221 | 2,499
lung adenocarcinoma 1,194 | 2,716
pancreatic cancer 1,164 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1,161 | 1,962
subependymal giant cell astrocytoma 1,131 | 2,287
lung carcinoma 1,096 | 2,843
Multiple myeloma 1,042 | 1,332
Pick disease 1,040 | 1,894
tuberculosis 909 | 2,010
group 4 medulloblastoma 901 | 1,855
diabetes mellitus 821 | 1,728
Autosomal recessive predisposition 814 | 1,442
interstitial cystitis 800 | 2,312
pituitary cancer 791 | 1,972
breast carcinoma 784 | 1,638
ductal carcinoma in situ 780 | 1,745
ulcerative colitis 776 | 1,819
acute quadriplegic myopathy 753 | 1,158
colon cancer 748 | 1,478
cystic fibrosis 720 | 1,696
juvenile dermatomyositis 719 | 1,187
astrocytoma 702 | 1,146
dermatomyositis 668 | 966
adrenocortical carcinoma 667 | 1,428
primary pancreatic ductal adenocarcinoma 601 | 1,109
Intellectual disability 590 | 1,016
Rheumatoid arthritis 581 | 1,191
Waldenstrons macroglobulinemia 577 | 765
pediatric high grade glioma 576 | 1,064
Schizophrenia 489 | 1,160
spina bifida 474 | 1,074
non primary Sjogren syndrome sicca 467 | 891
Epilepsy 447 | 792
nasopharyngeal carcinoma 435 | 1,058
acute myeloid leukemia 429 | 783
Cognitive delay 405 | 608
Global developmental delay 405 | 608
Mental and motor retardation 405 | 608
active Crohn's disease 393 | 922
cutaneous lupus erythematosus 389 | 1,057
Dull intelligence 385 | 645
Liver Cirrhosis, Experimental 385 | 769
Low intelligence 385 | 645
Mental Retardation 385 | 645
Mental deficiency 385 | 645
Poor school performance 385 | 645
gastric carcinoma 385 | 807
Muscle hypotonia 381 | 571
progressive supranuclear palsy 377 | 676
Duchenne muscular dystrophy 375 | 601
Atopic dermatitis 372 | 952
Seizures 371 | 596
esophageal adenocarcinoma 361 | 737
aldosterone-producing adenoma 346 | 665
Alzheimer's disease 343 | 658
medulloblastoma 339 | 720
primary Sjogren syndrome 322 | 735
Liver cancer 320 | 604
active ulcerative colitis 314 | 764
Short stature 309 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 306 | 510
Melanoma 295 | 711
Obesity 282 | 678
pancreatic carcinoma 281 | 562
Down syndrome 277 | 499
Neurodegenerative disease 270 | 414
hepatocellular carcinoma 268 | 547
Bipolar Disorder 267 | 666
Prostatic Neoplasms 267 | 495
Amyotrophic lateral sclerosis 263 | 451
tuberculosis and treatment for 6 months 254 | 409
hereditary spastic paraplegia 241 | 318
sonic hedgehog group medulloblastoma 239 | 467
Small head 237 | 374
Failure to gain weight 236 | 365
Pediatric failure to thrive 236 | 365
Breast Neoplasms 235 | 445

Tissue

Endocrine System 7,870 | 18,159
Female tissues 7,767 | 17,400
Digestive Tract 7,745 | 17,369
Skin and soft tissues 7,744 | 17,230
Male tissues 7,710 | 17,142
Blood and immune system 7,672 | 16,909
Nervous System 7,639 | 16,725
Urinary Tract 7,639 | 16,678
Liver and Pancreas 7,638 | 16,750
Respiratory system 7,589 | 16,393
Cardiovascular System 7,373 | 15,192

Target Family

Non-IDG 4,640 | 12,091
Enzyme 2,166 | 4,145
Transcription Factor 382 | 1,400
Kinase 370 | 634
Epigenetic 145 | 242
Transporter 129 | 473
Ion Channel 70 | 344
GPCR 28 | 408
TF/Epigenetic 12 | 38
Nuclear Receptor 8 | 48
oGPCR 5 | 421

HPM Tissue

Fetal Testis 7,955 | 7,955
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66