Development Level

Tbio 6,295 | 11,651
Tdark 1,811 | 6,593
Tchem 751 | 1,388
Tclin 261 | 612

Collection

RFA-RM-18-021 94 | 328
Kinase: IDG Consortium (Target... 66 | 125
Kinase: IDG Consortium (Comple... 23 | 37
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 736 | 979
preweaning lethality, incomple... 291 | 499
embryonic lethality prior to t... 202 | 278
embryonic lethality prior to o... 196 | 239
abnormal behavior 159 | 298
abnormal embryo size 149 | 220
decreased total body fat amoun... 110 | 207
abnormal bone structure 101 | 187
decreased body weight 100 | 161
enlarged heart 92 | 210
decreased bone mineral content 91 | 151
increased lean body mass 85 | 172
embryonic growth retardation 82 | 106
decreased vertical activity 80 | 208
hyperactivity 78 | 148
decreased bone mineral density 76 | 126
abnormal heart morphology 71 | 162
increased startle reflex 71 | 112
decreased circulating glucose ... 70 | 126
hypoactivity 70 | 132
increased total body fat amoun... 70 | 134
increased circulating alkaline... 69 | 122
male infertility 69 | 123
decreased lean body mass 64 | 135
decreased grip strength 61 | 116
increased bone mineral content 61 | 108
prenatal lethality prior to he... 56 | 87
short tibia 56 | 97
abnormal seminal vesicle morph... 54 | 114
cataract 54 | 92
increased mean corpuscular hem... 54 | 96
increased or absent threshold ... 53 | 101
decreased circulating choleste... 52 | 93
increased mean corpuscular vol... 52 | 92
abnormal lens morphology 50 | 81
decreased body length 50 | 101
decreased mean corpuscular vol... 45 | 79
decreased prepulse inhibition 45 | 82
increased fasted circulating g... 45 | 76
decreased circulating serum al... 44 | 82
decreased leukocyte cell numbe... 44 | 73
abnormal retina morphology 43 | 71
increased circulating HDL chol... 42 | 80
abnormal behavioral response t... 41 | 66
decreased startle reflex 41 | 75
increased circulating choleste... 41 | 66
decreased circulating triglyce... 40 | 79
improved glucose tolerance 40 | 79
decreased circulating insulin ... 39 | 76
decreased circulating HDL chol... 38 | 68
decreased lymphocyte cell numb... 38 | 83
edema 38 | 59
impaired glucose tolerance 38 | 75
increased bone mineral density 38 | 72
abnormal coat-hair pigmentatio... 36 | 64
thrombocytopenia 36 | 56
decreased erythrocyte cell num... 35 | 62
increased circulating sodium l... 35 | 71
abnormal eye morphology 34 | 68
small testis 34 | 58
abnormal gait 33 | 69
abnormal sleep behavior 33 | 70
decreased fasted circulating g... 33 | 65
decreased hemoglobin content 33 | 68
small superior vagus ganglion 33 | 74
decreased circulating alkaline... 32 | 46
increased heart weight 32 | 62
decreased caudal vertebrae num... 30 | 53
female infertility 30 | 60
decreased blood urea nitrogen ... 29 | 51
increased leukocyte cell numbe... 29 | 47
abnormal kidney morphology 28 | 65
abnormal neural tube closure 28 | 46
decreased circulating alanine ... 28 | 47
abnormal spleen morphology 26 | 55
decreased circulating LDL chol... 26 | 38
hydrometra 26 | 53
increased blood urea nitrogen ... 26 | 48
increased mean platelet volume 26 | 45
increased monocyte cell number 26 | 63
increased neutrophil cell numb... 26 | 46
decreased circulating total pr... 25 | 49
decreased mean corpuscular hem... 25 | 50
decreased neutrophil cell numb... 25 | 42
increased erythrocyte cell num... 24 | 39
increased grip strength 24 | 41
increased hemoglobin content 24 | 45
persistence of hyaloid vascula... 24 | 33
abnormal embryo turning 23 | 31
abnormal skin morphology 23 | 50
decreased circulating aspartat... 23 | 34
increased hematocrit 23 | 46
pallor 23 | 34
tremors 23 | 39
abnormal testis morphology 22 | 43
decreased red blood cell distr... 22 | 41
increased circulating chloride... 22 | 41
decreased hematocrit 21 | 46
enlarged spleen 21 | 41
increased circulating triglyce... 21 | 42

Disease

Carcinoma 5,788 | 11,493
ovarian cancer 5,210 | 8,520
osteosarcoma 4,312 | 7,950
medulloblastoma, large-cell 3,322 | 6,241
psoriasis 3,304 | 6,694
glioblastoma 3,195 | 5,792
atypical teratoid / rhabdoid tumor 2,763 | 5,112
lung cancer 2,745 | 4,740
ependymoma 2,468 | 4,679
group 3 medulloblastoma 2,246 | 4,104
Breast cancer 1,988 | 3,578
adult high grade glioma 1,894 | 3,801
malignant mesothelioma 1,833 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,811 | 3,291
primitive neuroectodermal tumor 1,617 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 1,616 | 2,989
invasive ductal carcinoma 1,563 | 2,951
oligodendroglioma 1,548 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 1,541 | 2,955
Kidney cancer 1,540 | 2,613
Astrocytoma, Pilocytic 1,522 | 3,081
non-small cell lung cancer 1,481 | 2,890
astrocytic glioma 1,424 | 2,597
Cancer 1,334 | 2,499
lung adenocarcinoma 1,324 | 2,716
pancreatic cancer 1,262 | 2,398
lung carcinoma 1,252 | 2,843
subependymal giant cell astrocytoma 1,245 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,238 | 1,962
Pick disease 1,137 | 1,894
Multiple myeloma 1,076 | 1,332
tuberculosis 1,025 | 2,010
group 4 medulloblastoma 1,015 | 1,855
interstitial cystitis 937 | 2,312
pituitary cancer 904 | 1,972
diabetes mellitus 889 | 1,728
ductal carcinoma in situ 882 | 1,745
Autosomal recessive predisposition 878 | 1,442
breast carcinoma 873 | 1,638
ulcerative colitis 865 | 1,819
colon cancer 820 | 1,478
cystic fibrosis 800 | 1,696
acute quadriplegic myopathy 797 | 1,158
juvenile dermatomyositis 769 | 1,187
adrenocortical carcinoma 763 | 1,428
astrocytoma 756 | 1,146
dermatomyositis 693 | 966
primary pancreatic ductal adenocarcinoma 649 | 1,109
Intellectual disability 632 | 1,016
pediatric high grade glioma 629 | 1,064
Rheumatoid arthritis 617 | 1,191
Waldenstrons macroglobulinemia 602 | 765
Schizophrenia 567 | 1,160
spina bifida 560 | 1,074
nasopharyngeal carcinoma 509 | 1,058
non primary Sjogren syndrome sicca 508 | 891
acute myeloid leukemia 484 | 783
Epilepsy 470 | 792
cutaneous lupus erythematosus 455 | 1,057
active Crohn's disease 441 | 922
Cognitive delay 428 | 608
Global developmental delay 428 | 608
Mental and motor retardation 428 | 608
Atopic dermatitis 423 | 952
esophageal adenocarcinoma 420 | 737
progressive supranuclear palsy 419 | 676
gastric carcinoma 417 | 807
Liver Cirrhosis, Experimental 412 | 769
Dull intelligence 408 | 645
Low intelligence 408 | 645
Mental Retardation 408 | 645
Mental deficiency 408 | 645
Poor school performance 408 | 645
Muscle hypotonia 398 | 571
Duchenne muscular dystrophy 388 | 601
medulloblastoma 388 | 720
Seizures 386 | 596
aldosterone-producing adenoma 379 | 665
primary Sjogren syndrome 379 | 735
Alzheimer's disease 361 | 658
Liver cancer 352 | 604
active ulcerative colitis 348 | 764
Short stature 341 | 531
Melanoma 327 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 323 | 510
Obesity 310 | 678
pancreatic carcinoma 305 | 562
Bipolar Disorder 294 | 666
hepatocellular carcinoma 291 | 547
Down syndrome 289 | 499
Amyotrophic lateral sclerosis 283 | 451
Prostatic Neoplasms 281 | 495
Neurodegenerative disease 271 | 414
sonic hedgehog group medulloblastoma 266 | 467
Breast Neoplasms 264 | 445
Small head 263 | 374
tuberculosis and treatment for 6 months 261 | 409
Endometriosis 257 | 540
hereditary spastic paraplegia 250 | 318
gastric cancer 249 | 459

Tissue

Endocrine System 9,006 | 18,159
Female tissues 8,878 | 17,400
Digestive Tract 8,860 | 17,369
Skin and soft tissues 8,854 | 17,230
Male tissues 8,802 | 17,142
Blood and immune system 8,766 | 16,909
Liver and Pancreas 8,719 | 16,750
Urinary Tract 8,713 | 16,678
Nervous System 8,700 | 16,725
Respiratory system 8,646 | 16,393
Cardiovascular System 8,378 | 15,192

Target Family

Non-IDG 5,316 | 12,091
Enzyme 2,330 | 4,145
Transcription Factor 601 | 1,400
Kinase 409 | 634
Epigenetic 170 | 242
Transporter 148 | 473
Ion Channel 64 | 344
GPCR 34 | 408
TF/Epigenetic 18 | 38
Nuclear Receptor 15 | 48
oGPCR 13 | 421

HPM Tissue

Fetal Ovary 9,118 | 9,118
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19