Development Level

Tbio 5,831 | 10,625
Tdark 2,041 | 7,003
Tchem 998 | 1,890
Tclin 257 | 602

Collection

Eligible Kinase Proteins 73 | 134
Eligible Ion Channel Proteins 18 | 117
Eligible non-olfactory GPCR Proteins 11 | 143

IMPC Term

preweaning lethality, complete... 458 | 633
preweaning lethality, incomple... 146 | 260
embryonic lethality prior to t... 136 | 187
abnormal behavior 131 | 226
embryonic lethality prior to o... 125 | 148
decreased total body fat amoun... 117 | 186
decreased lean body mass 115 | 195
decreased body weight 108 | 174
decreased bone mineral content 95 | 157
abnormal embryo size 78 | 112
abnormal bone structure 75 | 131
decreased body length 74 | 108
decreased bone mineral density 73 | 126
increased circulating alkaline... 73 | 119
increased or absent threshold ... 70 | 128
decreased grip strength 67 | 123
abnormal retina morphology 64 | 100
decreased circulating glucose ... 64 | 121
hyperactivity 62 | 108
increased lean body mass 60 | 107
increased bone mineral content 57 | 92
increased mean corpuscular hem... 56 | 93
abnormal lens morphology 51 | 73
decreased circulating choleste... 50 | 85
short tibia 47 | 82
increased mean corpuscular vol... 46 | 91
decreased circulating triglyce... 45 | 83
hypoactivity 45 | 89
increased grip strength 45 | 83
enlarged heart 44 | 111
increased fasted circulating g... 43 | 68
decreased circulating HDL chol... 42 | 77
decreased circulating serum al... 41 | 79
prenatal lethality prior to he... 41 | 64
abnormal retinal pigmentation 38 | 61
decreased circulating insulin ... 38 | 75
decreased mean corpuscular vol... 38 | 50
increased circulating sodium l... 38 | 71
male infertility 38 | 62
decreased lumbar vertebrae num... 34 | 62
decreased leukocyte cell numbe... 33 | 54
decreased rib number 33 | 59
increased circulating HDL chol... 32 | 63
abnormal sleep behavior 31 | 63
increased bone mineral density 31 | 52
increased exploration in new e... 31 | 56
abnormal behavioral response t... 30 | 52
abnormal coat/hair pigmentatio... 30 | 54
decreased hemoglobin content 30 | 53
increased circulating choleste... 30 | 53
abnormal bone mineralization 29 | 55
increased sacral vertebrae num... 29 | 62
thrombocytopenia 29 | 46
increased blood urea nitrogen ... 28 | 44
decreased erythrocyte cell num... 27 | 43
impaired glucose tolerance 27 | 52
abnormal neural tube closure 26 | 37
decreased fasted circulating g... 26 | 49
improved glucose tolerance 26 | 56
increased circulating chloride... 26 | 43
increased total body fat amoun... 26 | 57
abnormal gait 25 | 51
abnormal seminal vesicle morph... 25 | 47
decreased caudal vertebrae num... 25 | 49
decreased circulating alanine ... 25 | 53
decreased prepulse inhibition 25 | 52
increased hemoglobin content 25 | 45
decreased circulating alkaline... 24 | 41
decreased circulating total pr... 24 | 41
decreased startle reflex 24 | 48
increased leukocyte cell numbe... 24 | 37
decreased circulating LDL chol... 23 | 37
decreased heart weight 23 | 44
increased body weight 23 | 42
small testis 23 | 37
decreased mean corpuscular hem... 22 | 34
embryonic growth retardation 22 | 28
increased startle reflex 22 | 38
increased heart weight 21 | 37
increased rib number 21 | 41
cardiovascular system phenotyp... 20 | 35
decreased blood urea nitrogen ... 20 | 31
decreased eosinophil cell numb... 20 | 41
increased hematocrit 20 | 36
abnormal heart morphology 19 | 51
abnormal spleen morphology 19 | 36
decreased circulating aspartat... 19 | 27
decreased circulating free fat... 19 | 39
decreased neutrophil cell numb... 19 | 37
abnormal eye morphology 18 | 38
abnormal rib morphology 18 | 28
abnormal testis morphology 18 | 30
decreased T cell number 18 | 31
decreased circulating chloride... 18 | 32
decreased circulating fructosa... 18 | 31
decreased threshold for audito... 18 | 32
female infertility 18 | 34
increased circulating potassiu... 18 | 31
tremors 18 | 34
abnormal cranium morphology 17 | 32

Disease

ovarian cancer 5,194 | 8,484
osteosarcoma 4,312 | 7,933
medulloblastoma, large-cell 3,321 | 6,234
psoriasis 3,308 | 6,685
glioblastoma 3,073 | 5,572
lung cancer 2,634 | 4,466
atypical teratoid / rhabdoid tumor 2,390 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,813 | 3,289
malignant mesothelioma 1,796 | 3,162
Breast cancer 1,744 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,618 | 2,988
primitive neuroectodermal tumor 1,618 | 3,031
invasive ductal carcinoma 1,563 | 2,950
oligodendroglioma 1,550 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 1,547 | 2,956
pilocytic astrocytoma 1,530 | 3,086
pediatric high grade glioma 1,481 | 2,712
ependymoma 1,447 | 2,514
non-small cell lung cancer 1,447 | 2,798
lung adenocarcinoma 1,325 | 2,713
Cancer 1,260 | 2,346
lung carcinoma 1,252 | 2,844
subependymal giant cell astrocytoma 1,244 | 2,287
group 3 medulloblastoma 1,243 | 2,254
Carcinoma 1,225 | 2,147
astrocytic glioma 1,224 | 2,241
pancreatic cancer 1,213 | 2,300
Pick disease 1,135 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,129 | 1,795
Multiple myeloma 1,074 | 1,327
adult high grade glioma 1,041 | 2,148
group 4 medulloblastoma 1,035 | 1,875
ulcerative colitis 1,019 | 2,087
astrocytoma 954 | 1,493
interstitial cystitis 938 | 2,299
pituitary cancer 906 | 1,972
ductal carcinoma in situ 884 | 1,745
breast carcinoma 856 | 1,614
diabetes mellitus 853 | 1,663
sonic hedgehog group medulloblastoma 822 | 1,482
colon cancer 820 | 1,475
medulloblastoma 811 | 1,524
tuberculosis 808 | 1,557
acute quadriplegic myopathy 796 | 1,157
cystic fibrosis 787 | 1,665
juvenile dermatomyositis 768 | 1,189
adrenocortical carcinoma 764 | 1,427
primary pancreatic ductal adenocarcinoma 757 | 1,271
posterior fossa group A ependymoma 744 | 1,511
dermatomyositis 693 | 933
posterior fossa group B ependymoma 671 | 1,530
Rheumatoid Arthritis 606 | 1,160
Waldenstrons macroglobulinemia 603 | 765
spina bifida 556 | 1,064
atypical teratoid/rhabdoid tumor 547 | 1,095
nasopharyngeal carcinoma 508 | 1,056
non primary Sjogren syndrome sicca 486 | 840
acute myeloid leukemia 481 | 780
cutaneous lupus erythematosus 455 | 1,056
active Crohn's disease 440 | 918
gastric carcinoma 433 | 832
Atopic dermatitis 420 | 944
esophageal adenocarcinoma 420 | 737
progressive supranuclear palsy 418 | 674
tuberculosis and treatment for 6 months 409 | 686
primary Sjogren syndrome 400 | 789
Duchenne muscular dystrophy 388 | 602
aldosterone-producing adenoma 379 | 664
Intellectual disability 358 | 573
Alzheimer's disease 357 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 316 | 499
Down syndrome 308 | 548
pancreatic carcinoma 306 | 567
IGA Glomerulonephritis 289 | 454
hepatocellular carcinoma 284 | 532
Obesity 275 | 616
Amyotrophic Lateral Sclerosis 270 | 431
Prostatic Neoplasms 266 | 471
Neurodegenerative disease 256 | 383
Endometriosis 253 | 535
hereditary spastic paraplegia 247 | 313
fibroadenoma 246 | 557
Mammary Neoplasms 239 | 410
Schizophrenia 235 | 501
gastric cancer 235 | 430
mucosa-associated lymphoid tissue lymphoma 212 | 480
chronic rhinosinusitis 204 | 512
Polycystic Ovary Syndrome 200 | 332
active ulcerative colitis 199 | 477
Multiple Sclerosis 196 | 498
inflammatory breast cancer 188 | 404
non-small cell lung carcinoma 187 | 413
Parkinson's disease 181 | 364
Stomach Neoplasms 181 | 282
glioblastoma multiforme 178 | 347
Kidney disease 170 | 396
tuberculosis and treatment for 3 months 169 | 327
interstitial lung disease 164 | 291
sarcoidosis 163 | 358
Crohn's disease 156 | 304

Tissue

Female tissues 9,127 | 18,647
Nervous System 9,105 | 18,561
Digestive Tract 9,096 | 18,473
Male tissues 9,091 | 17,969
Endocrine System 9,084 | 18,512
Liver and Pancreas 9,077 | 18,136
Blood and immune system 9,073 | 17,995
Urinary Tract 9,068 | 18,444
Cardiovascular System 9,050 | 17,958
Respiratory system 8,959 | 17,484
Skin and soft tissues 8,947 | 18,115

Target Family

Non-IDG 5,322 | 11,971
Enzyme 2,332 | 4,146
Transcription Factor 602 | 1,400
Kinase 409 | 634
Epigenetic 171 | 242
Transporter 149 | 473
Ion Channel 62 | 341
GPCR 34 | 406
TF/Epigenetic 18 | 38
Nuclear Receptor 15 | 48
oGPCR 13 | 421

HPM Tissue

Fetal Ovary 9,127 | 9,127
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89