Development Level

Tbio 5,409 | 10,625
Tdark 1,711 | 7,003
Tchem 1,028 | 1,890
Tclin 262 | 602

Collection

Eligible Kinase Proteins 71 | 134
Eligible Ion Channel Proteins 23 | 117
Eligible non-olfactory GPCR Proteins 4 | 143

IMPC Term

preweaning lethality, complete... 392 | 633
preweaning lethality, incomple... 132 | 260
embryonic lethality prior to t... 118 | 187
abnormal behavior 115 | 226
decreased total body fat amoun... 111 | 186
decreased lean body mass 107 | 195
embryonic lethality prior to o... 105 | 148
decreased body weight 102 | 174
decreased bone mineral content 84 | 157
abnormal bone structure 75 | 131
increased circulating alkaline... 74 | 119
abnormal embryo size 70 | 112
decreased body length 66 | 108
decreased bone mineral density 66 | 126
increased or absent threshold ... 65 | 128
decreased circulating glucose ... 62 | 121
abnormal retina morphology 59 | 100
increased mean corpuscular hem... 58 | 93
decreased grip strength 56 | 123
hyperactivity 56 | 108
increased lean body mass 50 | 107
increased mean corpuscular vol... 49 | 91
increased bone mineral content 48 | 92
decreased circulating serum al... 46 | 79
short tibia 46 | 82
decreased circulating choleste... 45 | 85
hypoactivity 44 | 89
decreased circulating HDL chol... 43 | 77
enlarged heart 43 | 111
decreased mean corpuscular vol... 42 | 50
increased grip strength 42 | 83
abnormal lens morphology 41 | 73
increased fasted circulating g... 41 | 68
prenatal lethality prior to he... 41 | 64
decreased circulating triglyce... 40 | 83
decreased circulating insulin ... 39 | 75
abnormal retinal pigmentation 36 | 61
abnormal bone mineralization 33 | 55
decreased lumbar vertebrae num... 33 | 62
decreased leukocyte cell numbe... 32 | 54
male infertility 32 | 62
increased circulating sodium l... 31 | 71
decreased rib number 30 | 59
increased bone mineral density 30 | 52
increased circulating HDL chol... 30 | 63
abnormal sleep behavior 29 | 63
decreased caudal vertebrae num... 29 | 49
increased circulating choleste... 29 | 53
abnormal coat/hair pigmentatio... 28 | 54
decreased circulating alanine ... 28 | 53
decreased fasted circulating g... 27 | 49
increased exploration in new e... 27 | 56
increased sacral vertebrae num... 27 | 62
cardiovascular system phenotyp... 26 | 35
decreased hemoglobin content 26 | 53
abnormal behavioral response t... 25 | 52
decreased mean corpuscular hem... 25 | 34
impaired glucose tolerance 25 | 52
increased body weight 25 | 42
increased circulating chloride... 25 | 43
increased hemoglobin content 25 | 45
thrombocytopenia 25 | 46
decreased circulating total pr... 24 | 41
increased blood urea nitrogen ... 24 | 44
increased hematocrit 24 | 36
abnormal gait 23 | 51
abnormal seminal vesicle morph... 23 | 47
decreased circulating LDL chol... 23 | 37
decreased erythrocyte cell num... 23 | 43
decreased heart weight 23 | 44
increased heart weight 23 | 37
abnormal neural tube closure 22 | 37
decreased circulating alkaline... 22 | 41
decreased circulating fructosa... 22 | 31
increased leukocyte cell numbe... 22 | 37
decreased circulating free fat... 21 | 39
decreased prepulse inhibition 21 | 52
decreased startle reflex 21 | 48
embryonic growth retardation 20 | 28
improved glucose tolerance 20 | 56
decreased circulating aspartat... 19 | 27
decreased eosinophil cell numb... 19 | 41
female infertility 19 | 34
increased startle reflex 19 | 38
increased total body fat amoun... 19 | 57
abnormal heart morphology 18 | 51
decreased circulating calcium ... 18 | 33
decreased threshold for audito... 18 | 32
increased circulating potassiu... 18 | 31
increased rib number 18 | 41
tremors 18 | 34
abnormal eye morphology 17 | 38
decreased T cell number 17 | 31
decreased circulating chloride... 17 | 32
decreased neutrophil cell numb... 17 | 37
increased mean corpuscular hem... 17 | 25
decreased CD8-positive, alpha-... 16 | 26
decreased NK T cell number 16 | 28
increased circulating phosphat... 16 | 24
small testis 16 | 37

Disease

ovarian cancer 4,762 | 8,484
osteosarcoma 3,972 | 7,933
psoriasis 3,113 | 6,685
medulloblastoma, large-cell 3,056 | 6,234
glioblastoma 2,822 | 5,572
lung cancer 2,456 | 4,466
atypical teratoid / rhabdoid tumor 2,159 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,717 | 3,289
malignant mesothelioma 1,619 | 3,162
Breast cancer 1,606 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,524 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,476 | 2,956
invasive ductal carcinoma 1,457 | 2,950
primitive neuroectodermal tumor 1,452 | 3,031
pilocytic astrocytoma 1,424 | 3,086
oligodendroglioma 1,420 | 2,849
pediatric high grade glioma 1,367 | 2,712
non-small cell lung cancer 1,366 | 2,798
ependymoma 1,318 | 2,514
lung adenocarcinoma 1,288 | 2,713
lung carcinoma 1,235 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 1,208 | 1,795
Cancer 1,196 | 2,346
pancreatic cancer 1,187 | 2,300
Carcinoma 1,156 | 2,147
group 3 medulloblastoma 1,145 | 2,254
subependymal giant cell astrocytoma 1,139 | 2,287
astrocytic glioma 1,108 | 2,241
Pick disease 1,028 | 1,893
Multiple myeloma 1,021 | 1,327
ulcerative colitis 1,012 | 2,087
adult high grade glioma 968 | 2,148
group 4 medulloblastoma 938 | 1,875
interstitial cystitis 927 | 2,299
astrocytoma 871 | 1,493
ductal carcinoma in situ 836 | 1,745
pituitary cancer 834 | 1,972
diabetes mellitus 827 | 1,663
breast carcinoma 816 | 1,614
tuberculosis 780 | 1,557
colon cancer 767 | 1,475
acute quadriplegic myopathy 755 | 1,157
cystic fibrosis 743 | 1,665
medulloblastoma 738 | 1,524
juvenile dermatomyositis 729 | 1,189
sonic hedgehog group medulloblastoma 723 | 1,482
adrenocortical carcinoma 704 | 1,427
primary pancreatic ductal adenocarcinoma 703 | 1,271
posterior fossa group A ependymoma 685 | 1,511
dermatomyositis 670 | 933
Rheumatoid Arthritis 600 | 1,160
Waldenstrons macroglobulinemia 581 | 765
posterior fossa group B ependymoma 576 | 1,530
atypical teratoid/rhabdoid tumor 521 | 1,095
spina bifida 496 | 1,064
nasopharyngeal carcinoma 472 | 1,056
non primary Sjogren syndrome sicca 457 | 840
acute myeloid leukemia 450 | 780
cutaneous lupus erythematosus 447 | 1,056
active Crohn's disease 440 | 918
Atopic dermatitis 424 | 944
gastric carcinoma 418 | 832
primary Sjogren syndrome 397 | 789
esophageal adenocarcinoma 391 | 737
progressive supranuclear palsy 382 | 674
Duchenne muscular dystrophy 372 | 602
tuberculosis and treatment for 6 months 370 | 686
Alzheimer's disease 349 | 644
aldosterone-producing adenoma 347 | 664
Intellectual disability 343 | 573
pancreatic carcinoma 315 | 567
Down syndrome 304 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 302 | 499
IGA Glomerulonephritis 283 | 454
hepatocellular carcinoma 278 | 532
Prostatic Neoplasms 270 | 471
Obesity 269 | 616
Neurodegenerative disease 253 | 383
Amyotrophic Lateral Sclerosis 252 | 431
fibroadenoma 245 | 557
Endometriosis 241 | 535
mucosa-associated lymphoid tissue lymphoma 237 | 480
gastric cancer 233 | 430
Mammary Neoplasms 229 | 410
hereditary spastic paraplegia 229 | 313
Schizophrenia 222 | 501
Polycystic Ovary Syndrome 199 | 332
active ulcerative colitis 199 | 477
Multiple Sclerosis 190 | 498
inflammatory breast cancer 188 | 404
non-small cell lung carcinoma 178 | 413
Kidney disease 177 | 396
Parkinson's disease 177 | 364
chronic rhinosinusitis 176 | 512
nephrosclerosis 175 | 329
Stomach Neoplasms 169 | 282
glioblastoma multiforme 166 | 347
tuberculosis and treatment for 3 months 161 | 327
sarcoidosis 160 | 358
interstitial lung disease 157 | 291

Tissue

Liver and Pancreas 8,410 | 18,136
Female tissues 8,389 | 18,647
Nervous System 8,387 | 18,561
Digestive Tract 8,383 | 18,473
Urinary Tract 8,371 | 18,444
Endocrine System 8,367 | 18,512
Blood and immune system 8,362 | 17,995
Male tissues 8,359 | 17,969
Cardiovascular System 8,353 | 17,958
Respiratory system 8,288 | 17,484
Skin and soft tissues 8,257 | 18,115

Target Family

Non-IDG 4,847 | 11,971
Enzyme 2,313 | 4,146
Transcription Factor 400 | 1,400
Kinase 392 | 634
Transporter 189 | 473
Epigenetic 126 | 242
Ion Channel 77 | 341
GPCR 30 | 406
TF/Epigenetic 14 | 38
oGPCR 12 | 421
Nuclear Receptor 10 | 48

HPM Tissue

Fetal Liver 8,410 | 8,410
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89