Development Level

Tbio 5,409 | 10,625
Tdark 1,711 | 7,003
Tchem 1,027 | 1,890
Tclin 262 | 602

Collection

Kinase: IDG Consortium (Targets) 62 | 125
Ion Channel: IDG Consortium (Targets) 22 | 102
Kinase: IDG Consortium (Complete/Control) 18 | 37
GPCR: IDG Consortium (Complete/Control) 5 | 26
GPCR: IDG Consortium (Targets) 5 | 127

IMPC Phenotype

preweaning lethality, complete... 392 | 633
preweaning lethality, incomple... 132 | 260
embryonic lethality prior to t... 118 | 187
abnormal behavior 115 | 226
decreased total body fat amoun... 111 | 186
decreased lean body mass 107 | 195
embryonic lethality prior to o... 105 | 148
decreased body weight 102 | 174
decreased bone mineral content 84 | 157
abnormal bone structure 75 | 131
increased circulating alkaline... 74 | 119
abnormal embryo size 70 | 112
decreased body length 66 | 108
decreased bone mineral density 66 | 126
increased or absent threshold ... 65 | 128
decreased circulating glucose ... 62 | 121
abnormal retina morphology 59 | 100
increased mean corpuscular hem... 58 | 93
decreased grip strength 56 | 123
hyperactivity 56 | 108
increased lean body mass 50 | 107
increased mean corpuscular vol... 49 | 91
increased bone mineral content 48 | 92
decreased circulating serum al... 46 | 79
short tibia 46 | 82
decreased circulating choleste... 45 | 85
hypoactivity 44 | 89
decreased circulating HDL chol... 43 | 77
enlarged heart 43 | 111
decreased mean corpuscular vol... 42 | 50
increased grip strength 42 | 83
abnormal lens morphology 41 | 73
increased fasted circulating g... 41 | 68
prenatal lethality prior to he... 41 | 64
decreased circulating triglyce... 40 | 83
decreased circulating insulin ... 39 | 75
abnormal retinal pigmentation 36 | 61
abnormal bone mineralization 33 | 55
decreased lumbar vertebrae num... 33 | 62
decreased leukocyte cell numbe... 32 | 54
male infertility 32 | 62
increased circulating sodium l... 31 | 71
decreased rib number 30 | 59
increased bone mineral density 30 | 52
increased circulating HDL chol... 30 | 63
abnormal sleep behavior 29 | 63
decreased caudal vertebrae num... 29 | 49
increased circulating choleste... 29 | 53
abnormal coat-hair pigmentatio... 28 | 54
decreased circulating alanine ... 28 | 53
decreased fasted circulating g... 27 | 49
increased exploration in new e... 27 | 56
increased sacral vertebrae num... 27 | 62
cardiovascular system phenotyp... 26 | 35
decreased hemoglobin content 26 | 53
abnormal behavioral response t... 25 | 52
decreased mean corpuscular hem... 25 | 34
impaired glucose tolerance 25 | 52
increased body weight 25 | 42
increased circulating chloride... 25 | 43
increased hemoglobin content 25 | 45
thrombocytopenia 25 | 46
decreased circulating total pr... 24 | 41
increased blood urea nitrogen ... 24 | 44
increased hematocrit 24 | 36
abnormal gait 23 | 51
abnormal seminal vesicle morph... 23 | 47
decreased circulating LDL chol... 23 | 37
decreased erythrocyte cell num... 23 | 43
decreased heart weight 23 | 44
increased heart weight 23 | 37
abnormal neural tube closure 22 | 37
decreased circulating alkaline... 22 | 41
decreased circulating fructosa... 22 | 31
increased leukocyte cell numbe... 22 | 37
decreased circulating free fat... 21 | 39
decreased prepulse inhibition 21 | 52
decreased startle reflex 21 | 48
embryonic growth retardation 20 | 28
improved glucose tolerance 20 | 56
decreased circulating aspartat... 19 | 27
decreased eosinophil cell numb... 19 | 41
female infertility 19 | 34
increased startle reflex 19 | 38
increased total body fat amoun... 19 | 57
abnormal heart morphology 18 | 51
decreased circulating calcium ... 18 | 33
decreased threshold for audito... 18 | 32
increased circulating potassiu... 18 | 31
increased rib number 18 | 41
tremors 18 | 34
abnormal eye morphology 17 | 38
decreased T cell number 17 | 31
decreased circulating chloride... 17 | 32
decreased neutrophil cell numb... 17 | 37
increased mean corpuscular hem... 17 | 25
decreased CD8-positive, alpha-... 16 | 26
decreased NK T cell number 16 | 28
increased circulating phosphat... 16 | 24
small testis 16 | 37

Disease

ovarian cancer 4,765 | 8,491
osteosarcoma 3,972 | 7,933
psoriasis 3,113 | 6,685
medulloblastoma, large-cell 3,056 | 6,234
glioblastoma 2,822 | 5,572
lung cancer 2,460 | 4,473
atypical teratoid / rhabdoid tumor 2,159 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,717 | 3,289
malignant mesothelioma 1,620 | 3,163
Breast cancer 1,607 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 1,524 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,476 | 2,956
invasive ductal carcinoma 1,457 | 2,950
primitive neuroectodermal tumor 1,452 | 3,031
pilocytic astrocytoma 1,424 | 3,086
oligodendroglioma 1,420 | 2,849
pediatric high grade glioma 1,367 | 2,712
non-small cell lung cancer 1,366 | 2,798
ependymoma 1,318 | 2,514
lung adenocarcinoma 1,288 | 2,714
lung carcinoma 1,235 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 1,208 | 1,795
Cancer 1,196 | 2,346
pancreatic cancer 1,187 | 2,300
Carcinoma 1,156 | 2,147
group 3 medulloblastoma 1,145 | 2,254
subependymal giant cell astrocytoma 1,139 | 2,287
astrocytic glioma 1,108 | 2,241
Pick disease 1,028 | 1,893
Multiple myeloma 1,020 | 1,327
ulcerative colitis 1,012 | 2,087
adult high grade glioma 968 | 2,148
group 4 medulloblastoma 938 | 1,875
interstitial cystitis 927 | 2,299
astrocytoma 871 | 1,493
ductal carcinoma in situ 836 | 1,745
pituitary cancer 834 | 1,972
diabetes mellitus 827 | 1,663
breast carcinoma 816 | 1,614
tuberculosis 784 | 1,563
colon cancer 767 | 1,475
acute quadriplegic myopathy 755 | 1,157
cystic fibrosis 746 | 1,670
medulloblastoma 738 | 1,524
juvenile dermatomyositis 729 | 1,189
sonic hedgehog group medulloblastoma 723 | 1,482
adrenocortical carcinoma 704 | 1,427
primary pancreatic ductal adenocarcinoma 703 | 1,271
posterior fossa group A ependymoma 685 | 1,511
dermatomyositis 670 | 966
Rheumatoid Arthritis 600 | 1,170
Waldenstrons macroglobulinemia 580 | 764
posterior fossa group B ependymoma 576 | 1,530
atypical teratoid/rhabdoid tumor 521 | 1,095
spina bifida 496 | 1,064
nasopharyngeal carcinoma 472 | 1,056
non primary Sjogren syndrome sicca 457 | 840
acute myeloid leukemia 452 | 785
cutaneous lupus erythematosus 447 | 1,056
active Crohn's disease 440 | 918
Atopic dermatitis 424 | 944
gastric carcinoma 418 | 832
primary Sjogren syndrome 396 | 788
esophageal adenocarcinoma 391 | 737
progressive supranuclear palsy 382 | 674
Duchenne muscular dystrophy 372 | 602
tuberculosis and treatment for 6 months 370 | 686
Alzheimer's disease 349 | 644
aldosterone-producing adenoma 347 | 664
Intellectual disability 343 | 573
pancreatic carcinoma 315 | 567
Down syndrome 304 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 302 | 499
hepatocellular carcinoma 290 | 550
IGA Glomerulonephritis 283 | 454
Prostatic Neoplasms 270 | 471
Obesity 269 | 616
Neurodegenerative disease 253 | 383
Amyotrophic Lateral Sclerosis 252 | 432
fibroadenoma 245 | 557
Endometriosis 241 | 535
gastric cancer 237 | 436
mucosa-associated lymphoid tissue lymphoma 237 | 480
Mammary Neoplasms 229 | 410
hereditary spastic paraplegia 229 | 313
Schizophrenia 223 | 503
Polycystic Ovary Syndrome 200 | 334
active ulcerative colitis 199 | 477
Multiple Sclerosis 190 | 498
inflammatory breast cancer 188 | 404
non-small cell lung carcinoma 178 | 413
Kidney disease 177 | 397
Parkinson's disease 177 | 364
chronic rhinosinusitis 176 | 512
nephrosclerosis 175 | 329
Stomach Neoplasms 169 | 282
glioblastoma multiforme 166 | 347
sarcoidosis 161 | 368
tuberculosis and treatment for 3 months 161 | 327
interstitial lung disease 158 | 292

Tissue

Liver and Pancreas 8,409 | 18,135
Female tissues 8,388 | 18,646
Nervous System 8,386 | 18,560
Digestive Tract 8,382 | 18,472
Urinary Tract 8,370 | 18,443
Endocrine System 8,366 | 18,511
Blood and immune system 8,361 | 17,994
Male tissues 8,358 | 17,968
Cardiovascular System 8,352 | 17,957
Respiratory system 8,287 | 17,483
Skin and soft tissues 8,256 | 18,114

Target Family

Non-IDG 4,847 | 11,969
Enzyme 2,312 | 4,146
Transcription Factor 400 | 1,400
Kinase 392 | 634
Transporter 189 | 473
Epigenetic 126 | 242
Ion Channel 77 | 341
GPCR 30 | 408
TF/Epigenetic 14 | 38
oGPCR 12 | 421
Nuclear Receptor 10 | 48

HPM Tissue

Fetal Liver 8,409 | 8,409
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Adult Adrenal 8,478 | 8,478
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
F-box/LRR-repeat protein 21 FBXL21 Tdark Non-IDG 0.00000 0
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66