Development Level

Tbio 5,848 | 10,625
Tdark 2,051 | 7,003
Tchem 1,051 | 1,890
Tclin 289 | 602

Collection

Eligible Kinase Proteins 82 | 134
Eligible Ion Channel Proteins 30 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 437 | 633
preweaning lethality, incomple... 155 | 260
abnormal behavior 136 | 226
embryonic lethality prior to t... 132 | 187
embryonic lethality prior to o... 118 | 148
decreased lean body mass 117 | 195
decreased total body fat amoun... 116 | 186
decreased body weight 102 | 174
decreased bone mineral content 89 | 157
increased circulating alkaline... 80 | 119
increased or absent threshold ... 79 | 128
abnormal embryo size 77 | 112
abnormal bone structure 72 | 131
decreased bone mineral density 70 | 126
decreased circulating glucose ... 69 | 121
decreased grip strength 68 | 123
decreased body length 67 | 108
abnormal retina morphology 66 | 100
hyperactivity 61 | 108
increased lean body mass 59 | 107
increased mean corpuscular hem... 58 | 93
increased bone mineral content 53 | 92
enlarged heart 52 | 111
decreased circulating choleste... 50 | 85
increased grip strength 49 | 83
decreased circulating HDL chol... 48 | 77
increased mean corpuscular vol... 48 | 91
abnormal lens morphology 47 | 73
hypoactivity 47 | 89
decreased circulating serum al... 44 | 79
short tibia 44 | 82
abnormal retinal pigmentation 42 | 61
decreased circulating insulin ... 42 | 75
increased fasted circulating g... 42 | 68
prenatal lethality prior to he... 42 | 64
decreased circulating triglyce... 41 | 83
decreased mean corpuscular vol... 41 | 50
male infertility 37 | 62
decreased lumbar vertebrae num... 36 | 62
decreased rib number 34 | 59
abnormal bone mineralization 33 | 55
decreased leukocyte cell numbe... 33 | 54
abnormal sleep behavior 32 | 63
increased circulating HDL chol... 32 | 63
increased bone mineral density 31 | 52
increased circulating sodium l... 31 | 71
increased sacral vertebrae num... 31 | 62
abnormal coat/hair pigmentatio... 30 | 54
abnormal gait 30 | 51
impaired glucose tolerance 30 | 52
increased exploration in new e... 30 | 56
thrombocytopenia 30 | 46
decreased hemoglobin content 29 | 53
decreased prepulse inhibition 29 | 52
decreased caudal vertebrae num... 28 | 49
decreased eosinophil cell numb... 28 | 41
increased blood urea nitrogen ... 28 | 44
increased circulating choleste... 28 | 53
abnormal behavioral response t... 27 | 52
increased hemoglobin content 27 | 45
decreased circulating total pr... 26 | 41
decreased erythrocyte cell num... 26 | 43
decreased fasted circulating g... 26 | 49
decreased startle reflex 26 | 48
improved glucose tolerance 26 | 56
abnormal neural tube closure 25 | 37
decreased circulating alanine ... 24 | 53
decreased heart weight 24 | 44
increased heart weight 24 | 37
decreased mean corpuscular hem... 23 | 34
increased body weight 23 | 42
increased circulating chloride... 23 | 43
abnormal cranium morphology 22 | 32
abnormal eye morphology 22 | 38
abnormal seminal vesicle morph... 22 | 47
decreased circulating alkaline... 22 | 41
decreased circulating calcium ... 22 | 33
increased hematocrit 22 | 36
increased startle reflex 22 | 38
increased total body fat amoun... 22 | 57
decreased circulating LDL chol... 21 | 37
decreased circulating free fat... 21 | 39
abnormal heart morphology 20 | 51
decreased circulating fructosa... 20 | 31
decreased threshold for audito... 20 | 32
increased leukocyte cell numbe... 20 | 37
tremors 20 | 34
abnormal spleen morphology 19 | 36
cardiovascular system phenotyp... 19 | 35
decreased T cell number 19 | 31
increased circulating phosphat... 19 | 24
decreased CD4-positive, CD25-p... 18 | 24
decreased circulating chloride... 18 | 32
decreased neutrophil cell numb... 18 | 37
increased circulating potassiu... 18 | 31
small testis 18 | 37
abnormal rib morphology 17 | 28
enlarged spleen 17 | 26
female infertility 17 | 34
increased circulating calcium ... 17 | 32

Disease

ovarian cancer 5,214 | 8,484
osteosarcoma 4,357 | 7,933
medulloblastoma, large-cell 3,423 | 6,234
psoriasis 3,368 | 6,685
glioblastoma 3,158 | 5,572
lung cancer 2,692 | 4,466
atypical teratoid / rhabdoid tumor 2,440 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,875 | 3,289
malignant mesothelioma 1,814 | 3,162
Breast cancer 1,804 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,687 | 2,988
primitive neuroectodermal tumor 1,674 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 1,636 | 2,956
invasive ductal carcinoma 1,627 | 2,950
pilocytic astrocytoma 1,624 | 3,086
oligodendroglioma 1,597 | 2,849
non-small cell lung cancer 1,516 | 2,798
pediatric high grade glioma 1,510 | 2,712
ependymoma 1,504 | 2,514
lung adenocarcinoma 1,447 | 2,713
lung carcinoma 1,374 | 2,844
Carcinoma 1,322 | 2,147
subependymal giant cell astrocytoma 1,284 | 2,287
pancreatic cancer 1,280 | 2,300
astrocytic glioma 1,266 | 2,241
Cancer 1,265 | 2,346
group 3 medulloblastoma 1,257 | 2,254
Pick disease 1,179 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,157 | 1,795
adult high grade glioma 1,109 | 2,148
group 4 medulloblastoma 1,078 | 1,875
Multiple myeloma 1,061 | 1,327
ulcerative colitis 1,060 | 2,087
interstitial cystitis 995 | 2,299
pituitary cancer 965 | 1,972
astrocytoma 951 | 1,493
ductal carcinoma in situ 927 | 1,745
breast carcinoma 906 | 1,614
diabetes mellitus 873 | 1,663
cystic fibrosis 853 | 1,665
colon cancer 849 | 1,475
medulloblastoma 841 | 1,524
acute quadriplegic myopathy 833 | 1,157
tuberculosis 817 | 1,557
sonic hedgehog group medulloblastoma 815 | 1,482
juvenile dermatomyositis 796 | 1,189
primary pancreatic ductal adenocarcinoma 796 | 1,271
adrenocortical carcinoma 768 | 1,427
posterior fossa group A ependymoma 762 | 1,511
dermatomyositis 719 | 933
posterior fossa group B ependymoma 703 | 1,530
Rheumatoid Arthritis 628 | 1,160
Waldenstrons macroglobulinemia 603 | 765
atypical teratoid/rhabdoid tumor 600 | 1,095
spina bifida 597 | 1,064
nasopharyngeal carcinoma 537 | 1,056
acute myeloid leukemia 494 | 780
non primary Sjogren syndrome sicca 485 | 840
cutaneous lupus erythematosus 474 | 1,056
active Crohn's disease 458 | 918
gastric carcinoma 450 | 832
Atopic dermatitis 446 | 944
progressive supranuclear palsy 429 | 674
esophageal adenocarcinoma 424 | 737
primary Sjogren syndrome 417 | 789
Duchenne muscular dystrophy 415 | 602
tuberculosis and treatment for 6 months 406 | 686
aldosterone-producing adenoma 385 | 664
Alzheimer's disease 371 | 644
Intellectual disability 367 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 343 | 499
Down syndrome 333 | 548
pancreatic carcinoma 323 | 567
hepatocellular carcinoma 297 | 532
Amyotrophic Lateral Sclerosis 288 | 431
Obesity 285 | 616
IGA Glomerulonephritis 280 | 454
Prostatic Neoplasms 279 | 471
Neurodegenerative disease 267 | 383
fibroadenoma 263 | 557
Endometriosis 262 | 535
hereditary spastic paraplegia 252 | 313
gastric cancer 242 | 430
Mammary Neoplasms 241 | 410
Schizophrenia 240 | 501
mucosa-associated lymphoid tissue lymphoma 233 | 480
active ulcerative colitis 229 | 477
chronic rhinosinusitis 225 | 512
Polycystic Ovary Syndrome 206 | 332
non-small cell lung carcinoma 200 | 413
Multiple Sclerosis 195 | 498
Parkinson's disease 195 | 364
glioblastoma multiforme 187 | 347
inflammatory breast cancer 185 | 404
Kidney disease 183 | 396
interstitial lung disease 177 | 291
sarcoidosis 169 | 358
tuberculosis and treatment for 3 months 168 | 327
Epilepsy 166 | 346
Stomach Neoplasms 166 | 282

Tissue

Cardiovascular System 9,239 | 17,958
Female tissues 9,218 | 18,647
Nervous System 9,209 | 18,561
Digestive Tract 9,200 | 18,473
Liver and Pancreas 9,185 | 18,136
Endocrine System 9,183 | 18,512
Male tissues 9,179 | 17,969
Urinary Tract 9,177 | 18,444
Blood and immune system 9,176 | 17,995
Respiratory system 9,085 | 17,484
Skin and soft tissues 9,062 | 18,115

Target Family

Non-IDG 5,403 | 11,971
Enzyme 2,357 | 4,146
Transcription Factor 560 | 1,400
Kinase 428 | 634
Transporter 158 | 473
Epigenetic 154 | 242
Ion Channel 83 | 341
GPCR 44 | 406
TF/Epigenetic 23 | 38
oGPCR 15 | 421
Nuclear Receptor 14 | 48

HPM Tissue

Fetal Heart 9,239 | 9,239
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209