Development Level

Tbio 5,932 | 11,445
Tdark 1,571 | 6,588
Tchem 866 | 1,598
Tclin 271 | 613

Collection

RFA-RM-18-021 113 | 328
Kinase: IDG Consortium (Target... 65 | 125
Ion Channel: IDG Consortium (T... 33 | 99
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Targets) 15 | 126
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 652 | 979
preweaning lethality, incomple... 253 | 499
embryonic lethality prior to t... 182 | 278
embryonic lethality prior to o... 164 | 239
abnormal behavior 144 | 298
abnormal embryo size 131 | 220
decreased total body fat amoun... 110 | 207
abnormal bone structure 95 | 187
enlarged heart 93 | 210
decreased body weight 92 | 161
increased lean body mass 80 | 172
decreased vertical activity 76 | 208
abnormal heart morphology 75 | 162
decreased bone mineral content 73 | 151
hyperactivity 70 | 148
increased startle reflex 69 | 112
embryonic growth retardation 68 | 106
hypoactivity 66 | 132
increased circulating alkaline... 66 | 122
decreased circulating glucose ... 65 | 126
decreased bone mineral density 61 | 126
increased total body fat amoun... 58 | 134
abnormal seminal vesicle morph... 56 | 114
cataract 55 | 92
decreased grip strength 53 | 116
prenatal lethality prior to he... 52 | 87
decreased lean body mass 51 | 135
male infertility 51 | 123
short tibia 51 | 97
increased bone mineral content 50 | 108
increased mean corpuscular vol... 50 | 92
increased or absent threshold ... 49 | 101
abnormal lens morphology 48 | 81
decreased body length 48 | 101
increased mean corpuscular hem... 48 | 96
decreased circulating choleste... 47 | 93
decreased prepulse inhibition 46 | 82
abnormal retina morphology 44 | 71
decreased mean corpuscular vol... 44 | 79
decreased circulating serum al... 43 | 82
decreased circulating triglyce... 42 | 79
decreased lymphocyte cell numb... 42 | 83
increased circulating HDL chol... 42 | 80
increased fasted circulating g... 42 | 76
decreased circulating HDL chol... 40 | 68
impaired glucose tolerance 40 | 75
decreased circulating insulin ... 39 | 76
improved glucose tolerance 39 | 79
increased circulating choleste... 39 | 66
increased heart weight 38 | 62
increased bone mineral density 37 | 72
decreased leukocyte cell numbe... 36 | 73
decreased startle reflex 36 | 75
edema 36 | 59
abnormal eye morphology 35 | 68
decreased caudal vertebrae num... 34 | 53
decreased erythrocyte cell num... 34 | 62
decreased hemoglobin content 34 | 68
abnormal coat-hair pigmentatio... 33 | 64
decreased fasted circulating g... 32 | 65
abnormal behavioral response t... 30 | 66
abnormal gait 29 | 69
abnormal sleep behavior 29 | 70
decreased circulating alkaline... 29 | 46
increased mean platelet volume 29 | 45
increased monocyte cell number 29 | 63
small superior vagus ganglion 29 | 74
small testis 28 | 58
thrombocytopenia 28 | 56
abnormal kidney morphology 27 | 65
decreased circulating alanine ... 27 | 47
increased leukocyte cell numbe... 27 | 47
increased neutrophil cell numb... 27 | 46
abnormal spleen morphology 26 | 55
decreased circulating total pr... 26 | 49
decreased mean corpuscular hem... 26 | 50
decreased blood urea nitrogen ... 25 | 51
increased blood urea nitrogen ... 25 | 48
increased circulating sodium l... 25 | 71
increased erythrocyte cell num... 25 | 39
increased grip strength 25 | 41
abnormal skin morphology 24 | 50
cardiovascular system phenotyp... 24 | 36
female infertility 24 | 60
increased hematocrit 24 | 46
abnormal neural tube closure 23 | 46
decreased neutrophil cell numb... 23 | 42
hydrometra 23 | 53
pallor 23 | 34
persistence of hyaloid vascula... 23 | 33
decreased circulating LDL chol... 22 | 38
enlarged spleen 22 | 41
increased circulating chloride... 21 | 41
increased circulating triglyce... 21 | 42
increased hemoglobin content 21 | 45
prolonged QT interval 21 | 38
decreased circulating aspartat... 20 | 34
decreased mean corpuscular hem... 20 | 31
prolonged ST segment 20 | 36
tremors 20 | 39

Disease

Carcinoma 5,535 | 11,493
ovarian cancer 4,898 | 8,520
osteosarcoma 4,035 | 7,950
psoriasis 3,222 | 6,694
medulloblastoma, large-cell 3,153 | 6,241
glioblastoma 3,070 | 5,792
lung cancer 2,664 | 4,740
atypical teratoid / rhabdoid tumor 2,628 | 5,112
ependymoma 2,337 | 4,679
group 3 medulloblastoma 2,102 | 4,104
Breast cancer 1,917 | 3,578
adult high grade glioma 1,863 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,843 | 3,291
malignant mesothelioma 1,709 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,663 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,609 | 2,955
invasive ductal carcinoma 1,555 | 2,951
primitive neuroectodermal tumor 1,528 | 3,035
Astrocytoma, Pilocytic 1,527 | 3,081
Kidney cancer 1,498 | 2,613
oligodendroglioma 1,491 | 2,850
non-small cell lung cancer 1,464 | 2,890
lung adenocarcinoma 1,374 | 2,716
pancreatic cancer 1,350 | 2,398
astrocytic glioma 1,343 | 2,597
Cancer 1,332 | 2,499
lung carcinoma 1,331 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 1,253 | 1,962
subependymal giant cell astrocytoma 1,219 | 2,287
Pick disease 1,072 | 1,894
Multiple myeloma 1,031 | 1,332
tuberculosis 1,026 | 2,010
interstitial cystitis 995 | 2,312
group 4 medulloblastoma 978 | 1,855
ulcerative colitis 939 | 1,819
pituitary cancer 926 | 1,972
diabetes mellitus 898 | 1,728
Autosomal recessive predisposition 879 | 1,442
ductal carcinoma in situ 879 | 1,745
breast carcinoma 864 | 1,638
colon cancer 858 | 1,478
cystic fibrosis 848 | 1,696
acute quadriplegic myopathy 783 | 1,158
juvenile dermatomyositis 761 | 1,187
adrenocortical carcinoma 716 | 1,428
astrocytoma 706 | 1,146
dermatomyositis 683 | 966
primary pancreatic ductal adenocarcinoma 667 | 1,109
Rheumatoid arthritis 637 | 1,191
Intellectual disability 601 | 1,016
pediatric high grade glioma 592 | 1,064
Waldenstrons macroglobulinemia 589 | 765
Schizophrenia 580 | 1,160
spina bifida 552 | 1,074
nasopharyngeal carcinoma 498 | 1,058
non primary Sjogren syndrome sicca 485 | 891
active Crohn's disease 480 | 922
cutaneous lupus erythematosus 477 | 1,057
Epilepsy 461 | 792
acute myeloid leukemia 461 | 783
Liver Cirrhosis, Experimental 446 | 769
esophageal adenocarcinoma 445 | 737
Atopic dermatitis 441 | 952
gastric carcinoma 436 | 807
Cognitive delay 413 | 608
Global developmental delay 413 | 608
Mental and motor retardation 413 | 608
Duchenne muscular dystrophy 408 | 601
Dull intelligence 394 | 645
Low intelligence 394 | 645
Mental Retardation 394 | 645
Mental deficiency 394 | 645
Poor school performance 394 | 645
primary Sjogren syndrome 393 | 735
active ulcerative colitis 389 | 764
progressive supranuclear palsy 384 | 676
Muscle hypotonia 381 | 571
Seizures 368 | 596
Liver cancer 360 | 604
aldosterone-producing adenoma 360 | 665
Alzheimer's disease 358 | 658
medulloblastoma 353 | 720
Melanoma 350 | 711
Short stature 334 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 332 | 510
Obesity 326 | 678
Bipolar Disorder 314 | 666
pancreatic carcinoma 309 | 562
Down syndrome 303 | 499
Prostatic Neoplasms 294 | 495
Amyotrophic lateral sclerosis 281 | 451
hepatocellular carcinoma 279 | 547
Neurodegenerative disease 269 | 414
fibroadenoma 259 | 559
Breast Neoplasms 255 | 445
Endometriosis 254 | 540
sonic hedgehog group medulloblastoma 254 | 467
Skin cancer 243 | 469
Mammary Neoplasms 242 | 425
Small head 241 | 374

Tissue

Endocrine System 8,512 | 18,159
Female tissues 8,404 | 17,400
Digestive Tract 8,388 | 17,369
Skin and soft tissues 8,375 | 17,230
Male tissues 8,308 | 17,142
Blood and immune system 8,280 | 16,909
Liver and Pancreas 8,248 | 16,750
Urinary Tract 8,233 | 16,678
Nervous System 8,203 | 16,725
Respiratory system 8,154 | 16,393
Cardiovascular System 7,845 | 15,192

Target Family

Non-IDG 4,982 | 12,091
Enzyme 2,240 | 4,145
Transcription Factor 528 | 1,400
Kinase 406 | 634
Transporter 185 | 473
Epigenetic 128 | 242
Ion Channel 94 | 344
GPCR 40 | 408
Nuclear Receptor 14 | 48
TF/Epigenetic 14 | 38
oGPCR 9 | 421

HPM Tissue

Fetal Gut 8,640 | 8,640
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103