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Target Filters...

Development Level

Tbio 5,580 | 11,651
Tdark 1,338 | 6,593
Tchem 668 | 1,388
Tclin 280 | 612

Collection

RFA-RM-18-021 100 | 328
Kinase: IDG Consortium (Target... 58 | 125
Ion Channel: IDG Consortium (T... 35 | 99
Kinase: IDG Consortium (Comple... 20 | 37
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 634 | 979
preweaning lethality, incomple... 260 | 499
embryonic lethality prior to t... 170 | 278
abnormal behavior 160 | 298
embryonic lethality prior to o... 159 | 239
abnormal embryo size 131 | 220
decreased total body fat amoun... 110 | 207
abnormal bone structure 102 | 187
decreased body weight 90 | 161
increased lean body mass 88 | 172
decreased bone mineral content 84 | 151
decreased vertical activity 84 | 208
hyperactivity 84 | 148
enlarged heart 73 | 210
increased circulating alkaline... 71 | 122
hypoactivity 70 | 132
increased total body fat amoun... 70 | 134
decreased bone mineral density 68 | 126
embryonic growth retardation 65 | 106
decreased circulating glucose ... 62 | 126
decreased grip strength 62 | 116
decreased lean body mass 62 | 135
increased startle reflex 60 | 112
abnormal heart morphology 58 | 162
increased bone mineral content 57 | 108
decreased body length 53 | 101
decreased circulating choleste... 53 | 93
prenatal lethality prior to he... 52 | 87
increased or absent threshold ... 51 | 101
short tibia 51 | 97
abnormal seminal vesicle morph... 50 | 114
increased mean corpuscular hem... 47 | 96
decreased prepulse inhibition 45 | 82
male infertility 45 | 123
abnormal lens morphology 43 | 81
cataract 43 | 92
decreased circulating HDL chol... 43 | 68
decreased mean corpuscular vol... 42 | 79
increased mean corpuscular vol... 42 | 92
decreased startle reflex 41 | 75
decreased circulating serum al... 40 | 82
abnormal retina morphology 39 | 71
decreased circulating triglyce... 38 | 79
abnormal gait 37 | 69
decreased circulating insulin ... 37 | 76
increased bone mineral density 37 | 72
increased fasted circulating g... 37 | 76
increased heart weight 37 | 62
abnormal behavioral response t... 36 | 66
improved glucose tolerance 35 | 79
abnormal eye morphology 34 | 68
edema 34 | 59
impaired glucose tolerance 34 | 75
increased circulating choleste... 34 | 66
decreased circulating alkaline... 33 | 46
decreased fasted circulating g... 32 | 65
decreased leukocyte cell numbe... 32 | 73
decreased lymphocyte cell numb... 32 | 83
increased circulating sodium l... 32 | 71
abnormal kidney morphology 30 | 65
increased circulating HDL chol... 30 | 80
small testis 29 | 58
decreased hemoglobin content 28 | 68
decreased neutrophil cell numb... 28 | 42
increased blood urea nitrogen ... 28 | 48
abnormal coat-hair pigmentatio... 27 | 64
decreased caudal vertebrae num... 27 | 53
decreased circulating total pr... 27 | 49
decreased erythrocyte cell num... 27 | 62
abnormal sleep behavior 26 | 70
increased mean platelet volume 26 | 45
small superior vagus ganglion 26 | 74
thrombocytopenia 26 | 56
decreased mean corpuscular hem... 25 | 50
increased monocyte cell number 25 | 63
decreased circulating alanine ... 24 | 47
increased circulating chloride... 23 | 41
increased erythrocyte cell num... 23 | 39
increased leukocyte cell numbe... 23 | 47
increased red blood cell distr... 23 | 34
pallor 23 | 34
abnormal neural tube closure 22 | 46
abnormal skin morphology 22 | 50
abnormal spleen morphology 22 | 55
decreased circulating LDL chol... 22 | 38
decreased red blood cell distr... 22 | 41
increased hematocrit 22 | 46
abnormal testis morphology 21 | 43
increased circulating triglyce... 21 | 42
increased grip strength 21 | 41
increased neutrophil cell numb... 21 | 46
limb grasping 21 | 41
tremors 21 | 39
abnormal cranium morphology 20 | 36
female infertility 20 | 60
increased hemoglobin content 20 | 45
persistence of hyaloid vascula... 20 | 33
decreased circulating aspartat... 19 | 34
decreased circulating fructosa... 19 | 30
decreased hematocrit 19 | 46

Disease

Carcinoma 5,070 | 11,493
ovarian cancer 4,526 | 8,520
osteosarcoma 3,698 | 7,950
medulloblastoma, large-cell 3,183 | 6,241
glioblastoma 3,017 | 5,792
psoriasis 2,890 | 6,694
atypical teratoid / rhabdoid tumor 2,723 | 5,112
ependymoma 2,389 | 4,679
lung cancer 2,372 | 4,740
group 3 medulloblastoma 2,063 | 4,104
adult high grade glioma 1,904 | 3,801
Breast cancer 1,745 | 3,578
oligodendroglioma 1,614 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 1,571 | 3,291
malignant mesothelioma 1,565 | 3,232
primitive neuroectodermal tumor 1,561 | 3,035
Astrocytoma, Pilocytic 1,496 | 3,081
astrocytic glioma 1,470 | 2,597
Kidney cancer 1,432 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 1,410 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,376 | 2,955
invasive ductal carcinoma 1,352 | 2,951
non-small cell lung cancer 1,275 | 2,890
subependymal giant cell astrocytoma 1,214 | 2,287
lung adenocarcinoma 1,203 | 2,716
lung carcinoma 1,193 | 2,843
Pick disease 1,158 | 1,894
Cancer 1,122 | 2,499
pancreatic cancer 1,110 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1,091 | 1,962
Multiple myeloma 971 | 1,332
group 4 medulloblastoma 928 | 1,855
tuberculosis 899 | 2,010
pituitary cancer 875 | 1,972
interstitial cystitis 821 | 2,312
diabetes mellitus 786 | 1,728
ductal carcinoma in situ 770 | 1,745
ulcerative colitis 759 | 1,819
breast carcinoma 753 | 1,638
Autosomal recessive predisposition 741 | 1,442
cystic fibrosis 736 | 1,696
colon cancer 730 | 1,478
acute quadriplegic myopathy 727 | 1,158
astrocytoma 681 | 1,146
juvenile dermatomyositis 656 | 1,187
dermatomyositis 617 | 966
Schizophrenia 612 | 1,160
adrenocortical carcinoma 612 | 1,428
Intellectual disability 609 | 1,016
Rheumatoid arthritis 576 | 1,191
primary pancreatic ductal adenocarcinoma 568 | 1,109
Waldenstrons macroglobulinemia 553 | 765
pediatric high grade glioma 550 | 1,064
Epilepsy 493 | 792
spina bifida 491 | 1,074
non primary Sjogren syndrome sicca 444 | 891
nasopharyngeal carcinoma 438 | 1,058
acute myeloid leukemia 418 | 783
Cognitive delay 403 | 608
Global developmental delay 403 | 608
Mental and motor retardation 403 | 608
gastric carcinoma 393 | 807
medulloblastoma 390 | 720
Dull intelligence 386 | 645
Low intelligence 386 | 645
Mental Retardation 386 | 645
Mental deficiency 386 | 645
Poor school performance 386 | 645
Alzheimer's disease 385 | 658
progressive supranuclear palsy 375 | 676
active Crohn's disease 372 | 922
Muscle hypotonia 371 | 571
cutaneous lupus erythematosus 365 | 1,057
Liver cancer 362 | 604
Seizures 360 | 596
esophageal adenocarcinoma 357 | 737
Liver Cirrhosis, Experimental 355 | 769
aldosterone-producing adenoma 341 | 665
Duchenne muscular dystrophy 336 | 601
Bipolar Disorder 334 | 666
Melanoma 334 | 711
Atopic dermatitis 327 | 952
primary Sjogren syndrome 308 | 735
active ulcerative colitis 302 | 764
Short stature 301 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 285 | 510
Obesity 279 | 678
Down syndrome 278 | 499
Amyotrophic lateral sclerosis 277 | 451
Neurodegenerative disease 270 | 414
pancreatic carcinoma 261 | 562
Prostatic Neoplasms 242 | 495
hepatocellular carcinoma 239 | 547
Skin cancer 236 | 469
hereditary spastic paraplegia 228 | 318
Parkinson's disease 227 | 392
fibroadenoma 226 | 559
Breast Neoplasms 224 | 445
Small head 223 | 374
sonic hedgehog group medulloblastoma 223 | 467

Tissue

Endocrine System 7,772 | 18,159
Female tissues 7,664 | 17,400
Digestive Tract 7,662 | 17,369
Skin and soft tissues 7,649 | 17,230
Male tissues 7,599 | 17,142
Nervous System 7,577 | 16,725
Blood and immune system 7,559 | 16,909
Liver and Pancreas 7,540 | 16,750
Urinary Tract 7,517 | 16,678
Respiratory system 7,474 | 16,393
Cardiovascular System 7,218 | 15,192

Target Family

Non-IDG 4,691 | 12,091
Enzyme 2,045 | 4,145
Kinase 381 | 634
Transcription Factor 278 | 1,400
Transporter 155 | 473
Epigenetic 129 | 242
Ion Channel 116 | 344
GPCR 46 | 408
TF/Epigenetic 11 | 38
Nuclear Receptor 10 | 48
oGPCR 4 | 421

HPM Tissue

Fetal Brain 7,866 | 7,866
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120