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Target Filters...

Development Level

Tbio 5,162 | 10,625
Tdark 1,528 | 7,003
Tchem 905 | 1,890
Tclin 276 | 602

Collection

Eligible Kinase Proteins 68 | 134
Eligible Ion Channel Proteins 35 | 117
Eligible non-olfactory GPCR Proteins 10 | 143

IMPC Term

preweaning lethality, complete... 389 | 633
preweaning lethality, incomple... 134 | 260
abnormal behavior 125 | 226
embryonic lethality prior to t... 113 | 187
decreased lean body mass 106 | 195
decreased body weight 103 | 174
decreased total body fat amoun... 102 | 186
embryonic lethality prior to o... 98 | 148
decreased bone mineral content 90 | 157
increased circulating alkaline... 74 | 119
abnormal bone structure 73 | 131
increased or absent threshold ... 71 | 128
decreased bone mineral density 69 | 126
decreased body length 66 | 108
decreased grip strength 65 | 123
abnormal embryo size 63 | 112
hyperactivity 62 | 108
decreased circulating glucose ... 59 | 121
increased lean body mass 55 | 107
decreased circulating choleste... 54 | 85
abnormal retina morphology 52 | 100
decreased circulating HDL chol... 52 | 77
increased mean corpuscular hem... 52 | 93
hypoactivity 44 | 89
increased bone mineral content 43 | 92
short tibia 42 | 82
prenatal lethality prior to he... 41 | 64
increased grip strength 40 | 83
abnormal lens morphology 39 | 73
decreased circulating insulin ... 39 | 75
decreased circulating triglyce... 39 | 83
enlarged heart 38 | 111
decreased circulating serum al... 37 | 79
increased fasted circulating g... 37 | 68
increased mean corpuscular vol... 36 | 91
decreased lumbar vertebrae num... 33 | 62
decreased mean corpuscular vol... 33 | 50
decreased rib number 33 | 59
abnormal retinal pigmentation 32 | 61
increased circulating sodium l... 32 | 71
decreased leukocyte cell numbe... 30 | 54
male infertility 30 | 62
abnormal gait 29 | 51
increased exploration in new e... 29 | 56
impaired glucose tolerance 28 | 52
decreased fasted circulating g... 27 | 49
increased blood urea nitrogen ... 27 | 44
increased sacral vertebrae num... 27 | 62
abnormal bone mineralization 26 | 55
abnormal sleep behavior 26 | 63
decreased circulating alanine ... 26 | 53
decreased prepulse inhibition 26 | 52
improved glucose tolerance 26 | 56
increased circulating HDL chol... 26 | 63
decreased circulating alkaline... 25 | 41
decreased startle reflex 25 | 48
increased circulating chloride... 25 | 43
increased circulating choleste... 25 | 53
abnormal behavioral response t... 24 | 52
abnormal coat/hair pigmentatio... 24 | 54
increased bone mineral density 24 | 52
increased total body fat amoun... 24 | 57
decreased caudal vertebrae num... 23 | 49
decreased eosinophil cell numb... 23 | 41
decreased hemoglobin content 23 | 53
decreased circulating LDL chol... 22 | 37
decreased heart weight 22 | 44
increased heart weight 22 | 37
increased hemoglobin content 22 | 45
decreased circulating fructosa... 21 | 31
decreased circulating total pr... 21 | 41
decreased mean corpuscular hem... 21 | 34
abnormal cranium morphology 20 | 32
abnormal neural tube closure 20 | 37
decreased circulating free fat... 20 | 39
increased startle reflex 20 | 38
abnormal seminal vesicle morph... 19 | 47
decreased circulating calcium ... 19 | 33
thrombocytopenia 19 | 46
decreased erythrocyte cell num... 18 | 43
increased body weight 18 | 42
increased rib number 18 | 41
limb grasping 18 | 35
small testis 18 | 37
decreased neutrophil cell numb... 17 | 37
increased circulating calcium ... 17 | 32
increased erythrocyte cell num... 17 | 26
abnormal eye morphology 16 | 38
abnormal heart morphology 16 | 51
abnormal testis morphology 16 | 30
decreased circulating aspartat... 16 | 27
increased hematocrit 16 | 36
increased leukocyte cell numbe... 16 | 37
abnormal locomotor activation 15 | 26
abnormal rib morphology 15 | 28
decreased circulating iron lev... 15 | 25
embryonic growth retardation 15 | 28
female infertility 15 | 34
increased circulating phosphat... 15 | 24
tremors 15 | 34

Disease

ovarian cancer 4,511 | 8,484
osteosarcoma 3,701 | 7,933
medulloblastoma, large-cell 3,184 | 6,234
glioblastoma 2,916 | 5,572
psoriasis 2,896 | 6,685
atypical teratoid / rhabdoid tumor 2,368 | 4,369
lung cancer 2,264 | 4,466
oligodendroglioma 1,615 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 1,573 | 3,289
primitive neuroectodermal tumor 1,565 | 3,031
malignant mesothelioma 1,534 | 3,162
Breast cancer 1,522 | 3,094
pilocytic astrocytoma 1,505 | 3,086
ependymoma 1,430 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 1,412 | 2,988
pediatric high grade glioma 1,411 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 1,381 | 2,956
invasive ductal carcinoma 1,353 | 2,950
non-small cell lung cancer 1,242 | 2,798
astrocytic glioma 1,229 | 2,241
subependymal giant cell astrocytoma 1,214 | 2,287
lung adenocarcinoma 1,205 | 2,713
lung carcinoma 1,193 | 2,844
Carcinoma 1,181 | 2,147
Pick disease 1,156 | 1,893
group 3 medulloblastoma 1,068 | 2,254
Cancer 1,060 | 2,346
pancreatic cancer 1,051 | 2,300
adult high grade glioma 1,044 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 995 | 1,795
Multiple myeloma 968 | 1,327
group 4 medulloblastoma 934 | 1,875
astrocytoma 919 | 1,493
pituitary cancer 877 | 1,972
ulcerative colitis 875 | 2,087
medulloblastoma 844 | 1,524
interstitial cystitis 822 | 2,299
ductal carcinoma in situ 773 | 1,745
sonic hedgehog group medulloblastoma 757 | 1,482
diabetes mellitus 754 | 1,663
breast carcinoma 742 | 1,614
colon cancer 730 | 1,475
cystic fibrosis 729 | 1,665
acute quadriplegic myopathy 726 | 1,157
tuberculosis 711 | 1,557
posterior fossa group A ependymoma 671 | 1,511
primary pancreatic ductal adenocarcinoma 664 | 1,271
juvenile dermatomyositis 655 | 1,189
posterior fossa group B ependymoma 638 | 1,530
dermatomyositis 616 | 933
adrenocortical carcinoma 615 | 1,427
Rheumatoid Arthritis 571 | 1,160
Waldenstrons macroglobulinemia 554 | 765
atypical teratoid/rhabdoid tumor 510 | 1,095
spina bifida 488 | 1,064
nasopharyngeal carcinoma 437 | 1,056
non primary Sjogren syndrome sicca 428 | 840
acute myeloid leukemia 415 | 780
gastric carcinoma 407 | 832
Alzheimer's disease 377 | 644
progressive supranuclear palsy 373 | 674
active Crohn's disease 371 | 918
Intellectual disability 367 | 573
cutaneous lupus erythematosus 365 | 1,056
esophageal adenocarcinoma 357 | 737
tuberculosis and treatment for 6 months 350 | 686
aldosterone-producing adenoma 341 | 664
Duchenne muscular dystrophy 335 | 602
Atopic dermatitis 323 | 944
primary Sjogren syndrome 323 | 789
Down syndrome 296 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 280 | 499
Schizophrenia 266 | 501
pancreatic carcinoma 263 | 567
Amyotrophic Lateral Sclerosis 259 | 431
Neurodegenerative disease 251 | 383
Obesity 249 | 616
Prostatic Neoplasms 230 | 471
hepatocellular carcinoma 230 | 532
fibroadenoma 226 | 557
hereditary spastic paraplegia 225 | 313
IGA Glomerulonephritis 221 | 454
Epilepsy 216 | 346
Parkinson's disease 213 | 364
Mammary Neoplasms 202 | 410
Endometriosis 196 | 535
active ulcerative colitis 188 | 477
chronic rhinosinusitis 188 | 512
mucosa-associated lymphoid tissue lymphoma 188 | 480
gastric cancer 187 | 430
non-small cell lung carcinoma 185 | 413
Polycystic Ovary Syndrome 173 | 332
Autistic Disorder 170 | 320
inflammatory breast cancer 165 | 404
glioblastoma multiforme 154 | 347
Multiple Sclerosis 153 | 498
Kidney disease 150 | 396
Stomach Neoplasms 149 | 282
interstitial lung disease 147 | 291
sarcoidosis 147 | 358

Tissue

Nervous System 7,871 | 18,561
Female tissues 7,862 | 18,647
Blood and immune system 7,839 | 17,995
Digestive Tract 7,838 | 18,473
Endocrine System 7,832 | 18,512
Male tissues 7,832 | 17,969
Liver and Pancreas 7,828 | 18,136
Cardiovascular System 7,825 | 17,958
Urinary Tract 7,825 | 18,444
Respiratory system 7,764 | 17,484
Skin and soft tissues 7,733 | 18,115

Target Family

Non-IDG 4,694 | 11,971
Enzyme 2,047 | 4,146
Kinase 381 | 634
Transcription Factor 278 | 1,400
Transporter 156 | 473
Epigenetic 130 | 242
Ion Channel 114 | 341
GPCR 46 | 406
TF/Epigenetic 11 | 38
Nuclear Receptor 10 | 48
oGPCR 4 | 421

HPM Tissue

Fetal Brain 7,871 | 7,871
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38