Development Level

Tbio 6,146 | 10,625
Tdark 2,315 | 7,003
Tchem 1,097 | 1,890
Tclin 290 | 602

Collection

Kinase: IDG Consortium (Targets) 84 | 125
Ion Channel: IDG Consortium (Targets) 29 | 102
Kinase: IDG Consortium (Complete/Control) 29 | 37
GPCR: IDG Consortium (Targets) 19 | 128
GPCR: IDG Consortium (Complete/Control) 4 | 24

IMPC Phenotype

preweaning lethality, complete... 476 | 633
preweaning lethality, incomple... 154 | 260
embryonic lethality prior to t... 147 | 187
abnormal behavior 141 | 226
embryonic lethality prior to o... 129 | 148
decreased lean body mass 122 | 195
decreased total body fat amoun... 122 | 186
decreased body weight 119 | 174
decreased bone mineral content 92 | 157
abnormal embryo size 83 | 112
abnormal bone structure 82 | 131
decreased bone mineral density 82 | 126
decreased body length 81 | 108
increased circulating alkaline... 78 | 119
increased or absent threshold ... 78 | 128
decreased grip strength 72 | 123
decreased circulating glucose ... 68 | 121
hyperactivity 66 | 108
abnormal retina morphology 64 | 100
increased lean body mass 61 | 107
increased bone mineral content 59 | 92
increased mean corpuscular hem... 59 | 93
decreased circulating serum al... 52 | 79
decreased circulating choleste... 50 | 85
decreased circulating triglyce... 50 | 83
enlarged heart 50 | 111
prenatal lethality prior to he... 49 | 64
short tibia 49 | 82
hypoactivity 48 | 89
abnormal lens morphology 47 | 73
decreased circulating HDL chol... 47 | 77
increased mean corpuscular vol... 47 | 91
increased grip strength 46 | 83
decreased circulating insulin ... 43 | 75
increased circulating sodium l... 43 | 71
abnormal retinal pigmentation 40 | 61
increased fasted circulating g... 40 | 68
decreased mean corpuscular vol... 38 | 50
abnormal bone mineralization 37 | 55
increased sacral vertebrae num... 36 | 62
male infertility 36 | 62
decreased hemoglobin content 35 | 53
decreased leukocyte cell numbe... 35 | 54
increased bone mineral density 35 | 52
abnormal sleep behavior 34 | 63
decreased lumbar vertebrae num... 34 | 62
increased circulating HDL chol... 34 | 63
decreased rib number 33 | 59
abnormal coat-hair pigmentatio... 32 | 54
decreased caudal vertebrae num... 32 | 49
increased circulating choleste... 31 | 53
decreased circulating total pr... 30 | 41
decreased prepulse inhibition 30 | 52
increased exploration in new e... 30 | 56
increased hemoglobin content 30 | 45
thrombocytopenia 30 | 46
decreased fasted circulating g... 29 | 49
increased circulating chloride... 29 | 43
decreased circulating LDL chol... 28 | 37
decreased circulating alanine ... 28 | 53
decreased heart weight 28 | 44
abnormal gait 27 | 51
decreased erythrocyte cell num... 27 | 43
improved glucose tolerance 27 | 56
increased blood urea nitrogen ... 27 | 44
abnormal behavioral response t... 26 | 52
abnormal neural tube closure 26 | 37
decreased startle reflex 26 | 48
increased body weight 26 | 42
increased total body fat amoun... 26 | 57
decreased circulating alkaline... 25 | 41
increased leukocyte cell numbe... 25 | 37
decreased circulating free fat... 24 | 39
embryonic growth retardation 24 | 28
impaired glucose tolerance 24 | 52
increased heart weight 24 | 37
abnormal heart morphology 23 | 51
decreased circulating fructosa... 23 | 31
decreased T cell number 22 | 31
decreased circulating calcium ... 22 | 33
decreased eosinophil cell numb... 22 | 41
decreased mean corpuscular hem... 22 | 34
increased hematocrit 22 | 36
abnormal seminal vesicle morph... 21 | 47
increased startle reflex 21 | 38
abnormal eye morphology 20 | 38
abnormal spleen morphology 20 | 36
decreased circulating aspartat... 20 | 27
decreased neutrophil cell numb... 20 | 37
increased rib number 20 | 41
small testis 20 | 37
abnormal cranium morphology 19 | 32
cardiovascular system phenotyp... 19 | 35
decreased CD4-positive, CD25-p... 19 | 24
decreased mature B cell number 19 | 25
female infertility 19 | 34
decreased NK T cell number 18 | 28
increased circulating calcium ... 18 | 32
increased circulating potassiu... 18 | 31
increased erythrocyte cell num... 18 | 26

Disease

ovarian cancer 5,465 | 8,491
osteosarcoma 4,810 | 7,933
medulloblastoma, large-cell 3,542 | 6,234
psoriasis 3,501 | 6,685
glioblastoma 3,268 | 5,572
lung cancer 2,769 | 4,473
atypical teratoid / rhabdoid tumor 2,493 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,856 | 3,289
malignant mesothelioma 1,803 | 3,163
Breast cancer 1,736 | 3,098
primitive neuroectodermal tumor 1,672 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,640 | 2,988
oligodendroglioma 1,624 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 1,590 | 2,956
pilocytic astrocytoma 1,589 | 3,086
invasive ductal carcinoma 1,574 | 2,950
ependymoma 1,549 | 2,514
pediatric high grade glioma 1,498 | 2,712
non-small cell lung cancer 1,490 | 2,798
lung carcinoma 1,412 | 2,844
lung adenocarcinoma 1,353 | 2,714
group 3 medulloblastoma 1,332 | 2,254
subependymal giant cell astrocytoma 1,332 | 2,287
Carcinoma 1,330 | 2,147
astrocytic glioma 1,306 | 2,241
Cancer 1,291 | 2,346
pancreatic cancer 1,233 | 2,300
Pick disease 1,211 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,192 | 1,795
adult high grade glioma 1,165 | 2,148
Multiple myeloma 1,127 | 1,327
ulcerative colitis 1,118 | 2,087
group 4 medulloblastoma 1,091 | 1,875
interstitial cystitis 1,083 | 2,299
astrocytoma 984 | 1,493
tuberculosis 938 | 1,563
pituitary cancer 900 | 1,972
diabetes mellitus 882 | 1,663
medulloblastoma 871 | 1,524
ductal carcinoma in situ 862 | 1,745
breast carcinoma 827 | 1,614
juvenile dermatomyositis 825 | 1,189
acute quadriplegic myopathy 821 | 1,157
cystic fibrosis 789 | 1,670
sonic hedgehog group medulloblastoma 773 | 1,482
colon cancer 771 | 1,475
Rheumatoid Arthritis 728 | 1,170
dermatomyositis 727 | 966
primary pancreatic ductal adenocarcinoma 726 | 1,271
posterior fossa group A ependymoma 709 | 1,511
posterior fossa group B ependymoma 705 | 1,530
adrenocortical carcinoma 694 | 1,427
Waldenstrons macroglobulinemia 650 | 764
spina bifida 600 | 1,064
cutaneous lupus erythematosus 566 | 1,056
atypical teratoid/rhabdoid tumor 552 | 1,095
primary Sjogren syndrome 537 | 788
acute myeloid leukemia 531 | 785
nasopharyngeal carcinoma 517 | 1,056
non primary Sjogren syndrome sicca 502 | 840
tuberculosis and treatment for 6 months 473 | 686
active Crohn's disease 460 | 918
progressive supranuclear palsy 457 | 674
gastric carcinoma 427 | 832
Atopic dermatitis 411 | 944
esophageal adenocarcinoma 403 | 737
aldosterone-producing adenoma 393 | 664
Intellectual disability 379 | 573
Alzheimer's disease 373 | 644
Duchenne muscular dystrophy 342 | 602
hepatocellular carcinoma 340 | 550
pancreatic carcinoma 337 | 567
Down syndrome 307 | 548
IGA Glomerulonephritis 293 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 289 | 499
Neurodegenerative disease 284 | 383
Obesity 284 | 616
Amyotrophic Lateral Sclerosis 278 | 432
gastric cancer 275 | 436
Schizophrenia 258 | 503
Prostatic Neoplasms 253 | 471
hereditary spastic paraplegia 251 | 313
mucosa-associated lymphoid tissue lymphoma 248 | 480
Multiple Sclerosis 241 | 498
fibroadenoma 239 | 557
chronic rhinosinusitis 227 | 512
Mammary Neoplasms 225 | 410
sarcoidosis 218 | 368
Endometriosis 215 | 535
Parkinson's disease 201 | 364
active ulcerative colitis 197 | 477
inflammatory breast cancer 196 | 404
tuberculosis and treatment for 3 months 191 | 327
Polycystic Ovary Syndrome 190 | 334
non-small cell lung carcinoma 189 | 413
Crohn's disease 183 | 304
Epilepsy 173 | 346
Stomach Neoplasms 172 | 282
Kidney disease 171 | 397
glioblastoma multiforme 170 | 347

Tissue

Blood and immune system 9,848 | 17,994
Nervous System 9,817 | 18,560
Female tissues 9,813 | 18,646
Digestive Tract 9,807 | 18,472
Liver and Pancreas 9,798 | 18,135
Male tissues 9,790 | 17,968
Endocrine System 9,788 | 18,511
Urinary Tract 9,783 | 18,443
Cardiovascular System 9,773 | 17,957
Respiratory system 9,693 | 17,483
Skin and soft tissues 9,646 | 18,114

Target Family

Non-IDG 5,621 | 11,969
Enzyme 2,520 | 4,146
Transcription Factor 680 | 1,400
Kinase 447 | 634
Transporter 184 | 473
Epigenetic 180 | 242
Ion Channel 107 | 341
GPCR 60 | 408
TF/Epigenetic 21 | 38
Nuclear Receptor 15 | 48
oGPCR 13 | 421

HPM Tissue

CD8 Cells 9,848 | 9,848
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Adult Adrenal 8,478 | 8,478
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39