Development Level

Tbio 6,675 | 11,651
Tdark 2,045 | 6,593
Tchem 826 | 1,388
Tclin 294 | 612

Collection

RFA-RM-18-021 130 | 328
Kinase: IDG Consortium (Target... 84 | 125
Ion Channel: IDG Consortium (T... 30 | 99
Kinase: IDG Consortium (Comple... 29 | 37
GPCR: IDG Consortium (Targets) 19 | 126
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 756 | 979
preweaning lethality, incomple... 303 | 499
embryonic lethality prior to t... 219 | 278
embryonic lethality prior to o... 203 | 239
abnormal behavior 173 | 298
abnormal embryo size 163 | 220
decreased total body fat amoun... 124 | 207
abnormal bone structure 115 | 187
decreased body weight 112 | 161
enlarged heart 103 | 210
increased lean body mass 101 | 172
decreased vertical activity 86 | 208
embryonic growth retardation 86 | 106
decreased bone mineral content 85 | 151
hyperactivity 85 | 148
abnormal heart morphology 81 | 162
decreased bone mineral density 79 | 126
increased circulating alkaline... 79 | 122
increased startle reflex 76 | 112
hypoactivity 75 | 132
increased total body fat amoun... 74 | 134
decreased lean body mass 73 | 135
prenatal lethality prior to he... 70 | 87
decreased circulating glucose ... 69 | 126
male infertility 66 | 123
increased or absent threshold ... 65 | 101
decreased grip strength 64 | 116
decreased body length 62 | 101
short tibia 61 | 97
increased bone mineral content 58 | 108
cataract 57 | 92
abnormal seminal vesicle morph... 55 | 114
decreased circulating choleste... 55 | 93
abnormal lens morphology 53 | 81
increased mean corpuscular hem... 53 | 96
decreased prepulse inhibition 52 | 82
decreased circulating serum al... 51 | 82
decreased circulating triglyce... 49 | 79
decreased mean corpuscular vol... 49 | 79
decreased lymphocyte cell numb... 48 | 83
increased mean corpuscular vol... 48 | 92
decreased leukocyte cell numbe... 47 | 73
abnormal retina morphology 46 | 71
decreased hemoglobin content 46 | 68
increased bone mineral density 46 | 72
increased fasted circulating g... 45 | 76
decreased circulating insulin ... 42 | 76
decreased startle reflex 42 | 75
increased circulating HDL chol... 42 | 80
decreased circulating HDL chol... 41 | 68
increased circulating sodium l... 41 | 71
small superior vagus ganglion 41 | 74
impaired glucose tolerance 40 | 75
increased circulating choleste... 40 | 66
thrombocytopenia 40 | 56
abnormal gait 38 | 69
decreased erythrocyte cell num... 38 | 62
improved glucose tolerance 38 | 79
abnormal coat-hair pigmentatio... 37 | 64
abnormal eye morphology 37 | 68
abnormal sleep behavior 37 | 70
decreased caudal vertebrae num... 37 | 53
decreased fasted circulating g... 37 | 65
edema 37 | 59
increased heart weight 37 | 62
increased monocyte cell number 36 | 63
abnormal behavioral response t... 35 | 66
decreased circulating total pr... 34 | 49
small testis 33 | 58
abnormal kidney morphology 32 | 65
decreased circulating alkaline... 32 | 46
decreased mean corpuscular hem... 32 | 50
female infertility 32 | 60
increased erythrocyte cell num... 32 | 39
hydrometra 30 | 53
increased neutrophil cell numb... 30 | 46
abnormal neural tube closure 29 | 46
decreased circulating alanine ... 29 | 47
decreased hematocrit 29 | 46
increased hemoglobin content 29 | 45
decreased blood urea nitrogen ... 28 | 51
increased leukocyte cell numbe... 28 | 47
increased mean platelet volume 28 | 45
abnormal bone mineralization 27 | 38
decreased circulating LDL chol... 27 | 38
increased grip strength 27 | 41
increased hematocrit 27 | 46
persistence of hyaloid vascula... 27 | 33
decreased circulating calcium ... 26 | 36
increased circulating chloride... 26 | 41
abnormal embryo turning 25 | 31
abnormal spleen morphology 25 | 55
decreased neutrophil cell numb... 25 | 42
decreased red blood cell distr... 25 | 41
increased blood urea nitrogen ... 25 | 48
increased red blood cell distr... 25 | 34
pallor 25 | 34
abnormal skin morphology 24 | 50
corneal opacity 24 | 32
decreased circulating aspartat... 24 | 34

Disease

Carcinoma 6,379 | 11,493
ovarian cancer 5,479 | 8,520
osteosarcoma 4,807 | 7,950
medulloblastoma, large-cell 3,540 | 6,241
psoriasis 3,497 | 6,694
glioblastoma 3,375 | 5,792
lung cancer 2,901 | 4,740
atypical teratoid / rhabdoid tumor 2,865 | 5,112
ependymoma 2,558 | 4,679
group 3 medulloblastoma 2,328 | 4,104
adult high grade glioma 2,025 | 3,801
Breast cancer 1,977 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,854 | 3,291
malignant mesothelioma 1,833 | 3,232
primitive neuroectodermal tumor 1,669 | 3,035
Kidney cancer 1,639 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 1,637 | 2,989
oligodendroglioma 1,623 | 2,850
Astrocytoma, Pilocytic 1,587 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 1,584 | 2,955
invasive ductal carcinoma 1,573 | 2,951
non-small cell lung cancer 1,526 | 2,890
astrocytic glioma 1,516 | 2,597
lung carcinoma 1,411 | 2,843
Cancer 1,372 | 2,499
lung adenocarcinoma 1,350 | 2,716
subependymal giant cell astrocytoma 1,333 | 2,287
pancreatic cancer 1,290 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1,289 | 1,962
Pick disease 1,211 | 1,894
tuberculosis 1,182 | 2,010
Multiple myeloma 1,130 | 1,332
group 4 medulloblastoma 1,101 | 1,855
interstitial cystitis 1,084 | 2,312
ulcerative colitis 966 | 1,819
diabetes mellitus 918 | 1,728
pituitary cancer 897 | 1,972
Autosomal recessive predisposition 883 | 1,442
ductal carcinoma in situ 859 | 1,745
breast carcinoma 844 | 1,638
juvenile dermatomyositis 826 | 1,187
acute quadriplegic myopathy 822 | 1,158
cystic fibrosis 801 | 1,696
astrocytoma 774 | 1,146
colon cancer 770 | 1,478
Rheumatoid arthritis 739 | 1,191
dermatomyositis 728 | 966
adrenocortical carcinoma 692 | 1,428
Intellectual disability 652 | 1,016
Waldenstrons macroglobulinemia 650 | 765
pediatric high grade glioma 638 | 1,064
primary pancreatic ductal adenocarcinoma 628 | 1,109
Schizophrenia 607 | 1,160
spina bifida 603 | 1,074
cutaneous lupus erythematosus 566 | 1,057
non primary Sjogren syndrome sicca 538 | 891
acute myeloid leukemia 530 | 783
nasopharyngeal carcinoma 517 | 1,058
primary Sjogren syndrome 503 | 735
Epilepsy 489 | 792
active Crohn's disease 461 | 922
progressive supranuclear palsy 456 | 676
Cognitive delay 433 | 608
Global developmental delay 433 | 608
Mental and motor retardation 433 | 608
Atopic dermatitis 418 | 952
Liver Cirrhosis, Experimental 416 | 769
gastric carcinoma 414 | 807
Dull intelligence 407 | 645
Low intelligence 407 | 645
Mental Retardation 407 | 645
Mental deficiency 407 | 645
Poor school performance 407 | 645
esophageal adenocarcinoma 402 | 737
Muscle hypotonia 396 | 571
aldosterone-producing adenoma 393 | 665
medulloblastoma 386 | 720
Liver cancer 378 | 604
Seizures 377 | 596
Alzheimer's disease 375 | 658
Melanoma 367 | 711
active ulcerative colitis 348 | 764
Duchenne muscular dystrophy 343 | 601
hepatocellular carcinoma 336 | 547
Bipolar Disorder 335 | 666
pancreatic carcinoma 334 | 562
Short stature 333 | 531
Obesity 325 | 678
Neurodegenerative disease 302 | 414
tuberculosis and treatment for 6 months 299 | 409
Amyotrophic lateral sclerosis 294 | 451
autosomal dominant Emery-Dreifuss muscular dystrophy 293 | 510
gastric cancer 284 | 459
Down syndrome 281 | 499
Prostatic Neoplasms 266 | 495
Small head 264 | 374
Multiple Sclerosis 263 | 540
Failure to gain weight 255 | 365
Pediatric failure to thrive 255 | 365
sonic hedgehog group medulloblastoma 255 | 467

Tissue

Endocrine System 9,708 | 18,159
Female tissues 9,581 | 17,400
Digestive Tract 9,551 | 17,369
Skin and soft tissues 9,546 | 17,230
Male tissues 9,492 | 17,142
Blood and immune system 9,465 | 16,909
Liver and Pancreas 9,416 | 16,750
Nervous System 9,404 | 16,725
Urinary Tract 9,400 | 16,678
Respiratory system 9,333 | 16,393
Cardiovascular System 9,047 | 15,192

Target Family

Non-IDG 5,614 | 12,091
Enzyme 2,519 | 4,145
Transcription Factor 679 | 1,400
Kinase 447 | 634
Transporter 183 | 473
Epigenetic 179 | 242
Ion Channel 110 | 344
GPCR 60 | 408
TF/Epigenetic 21 | 38
Nuclear Receptor 15 | 48
oGPCR 13 | 421

HPM Tissue

CD8 Cells 9,840 | 9,840
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123