Development Level

Tbio 6,146 | 10,625
Tdark 2,315 | 7,003
Tchem 1,098 | 1,890
Tclin 290 | 602

Collection

Eligible Kinase Proteins 87 | 134
Eligible Ion Channel Proteins 30 | 117
Eligible non-olfactory GPCR Proteins 20 | 143

IMPC Term

preweaning lethality, complete... 476 | 633
preweaning lethality, incomple... 154 | 260
embryonic lethality prior to t... 147 | 187
abnormal behavior 141 | 226
embryonic lethality prior to o... 129 | 148
decreased lean body mass 122 | 195
decreased total body fat amoun... 122 | 186
decreased body weight 119 | 174
decreased bone mineral content 92 | 157
abnormal embryo size 83 | 112
abnormal bone structure 82 | 131
decreased bone mineral density 82 | 126
decreased body length 81 | 108
increased circulating alkaline... 78 | 119
increased or absent threshold ... 78 | 128
decreased grip strength 72 | 123
decreased circulating glucose ... 68 | 121
hyperactivity 66 | 108
abnormal retina morphology 64 | 100
increased lean body mass 61 | 107
increased bone mineral content 59 | 92
increased mean corpuscular hem... 59 | 93
decreased circulating serum al... 52 | 79
decreased circulating choleste... 50 | 85
decreased circulating triglyce... 50 | 83
enlarged heart 50 | 111
prenatal lethality prior to he... 49 | 64
short tibia 49 | 82
hypoactivity 48 | 89
abnormal lens morphology 47 | 73
decreased circulating HDL chol... 47 | 77
increased mean corpuscular vol... 47 | 91
increased grip strength 46 | 83
decreased circulating insulin ... 43 | 75
increased circulating sodium l... 43 | 71
abnormal retinal pigmentation 40 | 61
increased fasted circulating g... 40 | 68
decreased mean corpuscular vol... 38 | 50
abnormal bone mineralization 37 | 55
increased sacral vertebrae num... 36 | 62
male infertility 36 | 62
decreased hemoglobin content 35 | 53
decreased leukocyte cell numbe... 35 | 54
increased bone mineral density 35 | 52
abnormal sleep behavior 34 | 63
decreased lumbar vertebrae num... 34 | 62
increased circulating HDL chol... 34 | 63
decreased rib number 33 | 59
abnormal coat/hair pigmentatio... 32 | 54
decreased caudal vertebrae num... 32 | 49
increased circulating choleste... 31 | 53
decreased circulating total pr... 30 | 41
decreased prepulse inhibition 30 | 52
increased exploration in new e... 30 | 56
increased hemoglobin content 30 | 45
thrombocytopenia 30 | 46
decreased fasted circulating g... 29 | 49
increased circulating chloride... 29 | 43
decreased circulating LDL chol... 28 | 37
decreased circulating alanine ... 28 | 53
decreased heart weight 28 | 44
abnormal gait 27 | 51
decreased erythrocyte cell num... 27 | 43
improved glucose tolerance 27 | 56
increased blood urea nitrogen ... 27 | 44
abnormal behavioral response t... 26 | 52
abnormal neural tube closure 26 | 37
decreased startle reflex 26 | 48
increased body weight 26 | 42
increased total body fat amoun... 26 | 57
decreased circulating alkaline... 25 | 41
increased leukocyte cell numbe... 25 | 37
decreased circulating free fat... 24 | 39
embryonic growth retardation 24 | 28
impaired glucose tolerance 24 | 52
increased heart weight 24 | 37
abnormal heart morphology 23 | 51
decreased circulating fructosa... 23 | 31
decreased T cell number 22 | 31
decreased circulating calcium ... 22 | 33
decreased eosinophil cell numb... 22 | 41
decreased mean corpuscular hem... 22 | 34
increased hematocrit 22 | 36
abnormal seminal vesicle morph... 21 | 47
increased startle reflex 21 | 38
abnormal eye morphology 20 | 38
abnormal spleen morphology 20 | 36
decreased circulating aspartat... 20 | 27
decreased neutrophil cell numb... 20 | 37
increased rib number 20 | 41
small testis 20 | 37
abnormal cranium morphology 19 | 32
cardiovascular system phenotyp... 19 | 35
decreased CD4-positive, CD25-p... 19 | 24
decreased mature B cell number 19 | 25
female infertility 19 | 34
decreased NK T cell number 18 | 28
increased circulating calcium ... 18 | 32
increased circulating potassiu... 18 | 31
increased erythrocyte cell num... 18 | 26

Disease

ovarian cancer 5,462 | 8,484
osteosarcoma 4,810 | 7,933
medulloblastoma, large-cell 3,542 | 6,234
psoriasis 3,501 | 6,685
glioblastoma 3,268 | 5,572
lung cancer 2,765 | 4,466
atypical teratoid / rhabdoid tumor 2,493 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,856 | 3,289
malignant mesothelioma 1,802 | 3,162
Breast cancer 1,734 | 3,094
primitive neuroectodermal tumor 1,672 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,640 | 2,988
oligodendroglioma 1,624 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 1,590 | 2,956
pilocytic astrocytoma 1,589 | 3,086
invasive ductal carcinoma 1,574 | 2,950
ependymoma 1,549 | 2,514
pediatric high grade glioma 1,498 | 2,712
non-small cell lung cancer 1,490 | 2,798
lung carcinoma 1,412 | 2,844
lung adenocarcinoma 1,352 | 2,713
group 3 medulloblastoma 1,332 | 2,254
subependymal giant cell astrocytoma 1,332 | 2,287
Carcinoma 1,330 | 2,147
astrocytic glioma 1,306 | 2,241
Cancer 1,291 | 2,346
pancreatic cancer 1,233 | 2,300
Pick disease 1,211 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,192 | 1,795
adult high grade glioma 1,165 | 2,148
Multiple myeloma 1,128 | 1,327
ulcerative colitis 1,118 | 2,087
group 4 medulloblastoma 1,091 | 1,875
interstitial cystitis 1,083 | 2,299
astrocytoma 984 | 1,493
tuberculosis 935 | 1,557
pituitary cancer 900 | 1,972
diabetes mellitus 882 | 1,663
medulloblastoma 871 | 1,524
ductal carcinoma in situ 862 | 1,745
breast carcinoma 827 | 1,614
juvenile dermatomyositis 825 | 1,189
acute quadriplegic myopathy 821 | 1,157
cystic fibrosis 788 | 1,665
sonic hedgehog group medulloblastoma 773 | 1,482
colon cancer 771 | 1,475
Rheumatoid Arthritis 728 | 1,160
dermatomyositis 727 | 933
primary pancreatic ductal adenocarcinoma 726 | 1,271
posterior fossa group A ependymoma 709 | 1,511
posterior fossa group B ependymoma 705 | 1,530
adrenocortical carcinoma 694 | 1,427
Waldenstrons macroglobulinemia 651 | 765
spina bifida 600 | 1,064
cutaneous lupus erythematosus 566 | 1,056
atypical teratoid/rhabdoid tumor 552 | 1,095
primary Sjogren syndrome 538 | 789
acute myeloid leukemia 529 | 780
nasopharyngeal carcinoma 517 | 1,056
non primary Sjogren syndrome sicca 502 | 840
tuberculosis and treatment for 6 months 473 | 686
active Crohn's disease 460 | 918
progressive supranuclear palsy 457 | 674
gastric carcinoma 427 | 832
Atopic dermatitis 411 | 944
esophageal adenocarcinoma 403 | 737
aldosterone-producing adenoma 393 | 664
Intellectual disability 379 | 573
Alzheimer's disease 373 | 644
Duchenne muscular dystrophy 342 | 602
pancreatic carcinoma 337 | 567
hepatocellular carcinoma 330 | 532
Down syndrome 307 | 548
IGA Glomerulonephritis 293 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 289 | 499
Neurodegenerative disease 284 | 383
Obesity 284 | 616
Amyotrophic Lateral Sclerosis 278 | 431
gastric cancer 273 | 430
Schizophrenia 256 | 501
Prostatic Neoplasms 253 | 471
hereditary spastic paraplegia 251 | 313
mucosa-associated lymphoid tissue lymphoma 248 | 480
Multiple Sclerosis 241 | 498
fibroadenoma 239 | 557
chronic rhinosinusitis 227 | 512
Mammary Neoplasms 225 | 410
sarcoidosis 217 | 358
Endometriosis 215 | 535
Parkinson's disease 201 | 364
active ulcerative colitis 197 | 477
inflammatory breast cancer 196 | 404
tuberculosis and treatment for 3 months 191 | 327
Polycystic Ovary Syndrome 189 | 332
non-small cell lung carcinoma 189 | 413
Crohn's disease 183 | 304
Epilepsy 173 | 346
Stomach Neoplasms 172 | 282
Kidney disease 171 | 396
glioblastoma multiforme 170 | 347

Tissue

Blood and immune system 9,849 | 17,995
Nervous System 9,818 | 18,561
Female tissues 9,814 | 18,647
Digestive Tract 9,808 | 18,473
Liver and Pancreas 9,799 | 18,136
Male tissues 9,791 | 17,969
Endocrine System 9,789 | 18,512
Urinary Tract 9,784 | 18,444
Cardiovascular System 9,774 | 17,958
Respiratory system 9,694 | 17,484
Skin and soft tissues 9,647 | 18,115

Target Family

Non-IDG 5,621 | 11,971
Enzyme 2,521 | 4,146
Transcription Factor 680 | 1,400
Kinase 447 | 634
Transporter 184 | 473
Epigenetic 180 | 242
Ion Channel 107 | 341
GPCR 60 | 406
TF/Epigenetic 21 | 38
Nuclear Receptor 15 | 48
oGPCR 13 | 421

HPM Tissue

CD8 Cells 9,849 | 9,849
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193