Development Level

Tbio 5,061 | 10,625
Tdark 1,594 | 7,003
Tchem 906 | 1,890
Tclin 218 | 602

Collection

Eligible Kinase Proteins 65 | 134
Eligible Ion Channel Proteins 21 | 117
Eligible non-olfactory GPCR Proteins 14 | 145

IMPC Term

preweaning lethality, complete... 412 | 633
embryonic lethality prior to t... 127 | 187
preweaning lethality, incomple... 123 | 260
embryonic lethality prior to o... 117 | 148
abnormal behavior 113 | 226
decreased total body fat amoun... 96 | 186
decreased lean body mass 92 | 195
decreased body weight 90 | 174
decreased bone mineral content 73 | 157
abnormal embryo size 68 | 112
abnormal bone structure 65 | 131
increased circulating alkaline... 64 | 119
increased or absent threshold ... 57 | 128
decreased body length 54 | 108
decreased bone mineral density 54 | 126
decreased circulating glucose ... 53 | 121
increased lean body mass 53 | 107
hyperactivity 51 | 108
decreased grip strength 49 | 123
increased mean corpuscular hem... 49 | 93
increased bone mineral content 48 | 92
abnormal retina morphology 47 | 100
enlarged heart 40 | 111
abnormal lens morphology 39 | 73
decreased circulating choleste... 39 | 85
decreased circulating triglyce... 37 | 83
decreased circulating HDL chol... 36 | 77
increased grip strength 36 | 83
abnormal retinal pigmentation 35 | 61
decreased circulating insulin ... 35 | 75
increased mean corpuscular vol... 35 | 91
prenatal lethality prior to he... 35 | 64
decreased mean corpuscular vol... 34 | 50
male infertility 34 | 62
increased fasted circulating g... 33 | 68
decreased circulating serum al... 32 | 79
hypoactivity 32 | 89
short tibia 32 | 82
decreased lumbar vertebrae num... 31 | 62
decreased leukocyte cell numbe... 29 | 54
increased circulating sodium l... 29 | 71
decreased rib number 28 | 59
abnormal sleep behavior 27 | 63
decreased caudal vertebrae num... 27 | 49
increased circulating HDL chol... 27 | 63
increased sacral vertebrae num... 27 | 62
abnormal bone mineralization 26 | 55
decreased circulating alanine ... 26 | 53
abnormal coat/hair pigmentatio... 25 | 54
decreased fasted circulating g... 25 | 49
increased bone mineral density 25 | 52
increased circulating choleste... 25 | 53
decreased hemoglobin content 23 | 53
decreased startle reflex 23 | 48
increased exploration in new e... 23 | 56
impaired glucose tolerance 22 | 52
increased blood urea nitrogen ... 22 | 44
increased body weight 22 | 42
increased hemoglobin content 22 | 45
abnormal behavioral response t... 20 | 52
abnormal neural tube closure 20 | 37
decreased circulating LDL chol... 20 | 37
decreased circulating alkaline... 20 | 41
decreased erythrocyte cell num... 20 | 43
decreased neutrophil cell numb... 20 | 37
increased heart weight 20 | 37
increased total body fat amoun... 20 | 57
decreased circulating total pr... 19 | 41
decreased mean corpuscular hem... 19 | 34
decreased prepulse inhibition 19 | 52
female infertility 19 | 34
increased leukocyte cell numbe... 19 | 37
small testis 19 | 37
thrombocytopenia 19 | 46
abnormal seminal vesicle morph... 18 | 47
decreased CD4-positive, CD25-p... 18 | 24
decreased circulating fructosa... 18 | 31
decreased heart weight 18 | 44
embryonic growth retardation 18 | 28
improved glucose tolerance 18 | 56
increased circulating chloride... 18 | 43
increased hematocrit 18 | 36
increased rib number 18 | 41
abnormal gait 17 | 51
cardiovascular system phenotyp... 17 | 35
decreased T cell number 17 | 31
decreased circulating calcium ... 17 | 33
increased erythrocyte cell num... 17 | 26
abnormal heart morphology 16 | 51
abnormal testis morphology 16 | 30
decreased CD8-positive, alpha-... 16 | 26
decreased circulating free fat... 16 | 39
decreased effector memory CD8-... 16 | 24
decreased eosinophil cell numb... 16 | 41
decreased NK T cell number 15 | 28
decreased circulating aspartat... 15 | 27
decreased threshold for audito... 15 | 32
increased circulating calcium ... 15 | 32
increased startle reflex 15 | 38
abnormal spleen morphology 14 | 36

Disease

ovarian cancer 4,490 | 8,492
osteosarcoma 3,801 | 7,933
medulloblastoma, large-cell 2,777 | 6,234
psoriasis 2,747 | 6,685
glioblastoma 2,587 | 5,572
lung cancer 2,270 | 4,473
atypical teratoid / rhabdoid tumor 1,967 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,459 | 3,289
malignant mesothelioma 1,427 | 3,163
Breast cancer 1,349 | 3,099
primitive neuroectodermal tumor 1,292 | 3,031
oligodendroglioma 1,287 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,271 | 2,988
ependymoma 1,233 | 2,514
pilocytic astrocytoma 1,226 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,204 | 2,956
invasive ductal carcinoma 1,204 | 2,950
pediatric high grade glioma 1,180 | 2,712
non-small cell lung cancer 1,134 | 2,798
subependymal giant cell astrocytoma 1,071 | 2,287
group 3 medulloblastoma 1,057 | 2,254
Cancer 1,052 | 2,346
lung adenocarcinoma 1,047 | 2,714
astrocytic glioma 1,037 | 2,241
Multiple myeloma 1,032 | 1,328
lung carcinoma 1,032 | 2,844
Carcinoma 1,004 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 980 | 1,795
Pick disease 962 | 1,893
pancreatic cancer 940 | 2,300
adult high grade glioma 908 | 2,148
ulcerative colitis 866 | 2,087
group 4 medulloblastoma 845 | 1,875
astrocytoma 823 | 1,493
interstitial cystitis 775 | 2,299
diabetes mellitus 751 | 1,663
tuberculosis 740 | 1,563
acute quadriplegic myopathy 706 | 1,157
medulloblastoma 684 | 1,524
juvenile dermatomyositis 674 | 1,189
pituitary cancer 659 | 1,972
dermatomyositis 644 | 967
ductal carcinoma in situ 625 | 1,745
sonic hedgehog group medulloblastoma 615 | 1,482
Waldenstrons macroglobulinemia 603 | 765
breast carcinoma 602 | 1,614
colon cancer 598 | 1,475
cystic fibrosis 594 | 1,670
Rheumatoid Arthritis 591 | 1,171
primary pancreatic ductal adenocarcinoma 573 | 1,271
posterior fossa group A ependymoma 546 | 1,511
posterior fossa group B ependymoma 518 | 1,530
adrenocortical carcinoma 511 | 1,427
spina bifida 462 | 1,064
acute myeloid leukemia 450 | 785
atypical teratoid/rhabdoid tumor 436 | 1,095
cutaneous lupus erythematosus 425 | 1,056
non primary Sjogren syndrome sicca 419 | 840
primary Sjogren syndrome 414 | 789
tuberculosis and treatment for 6 months 392 | 686
nasopharyngeal carcinoma 371 | 1,056
active Crohn's disease 362 | 918
progressive supranuclear palsy 351 | 674
gastric carcinoma 333 | 832
Intellectual disability 326 | 573
esophageal adenocarcinoma 316 | 737
aldosterone-producing adenoma 297 | 664
Alzheimer's disease 292 | 644
Atopic dermatitis 282 | 944
hepatocellular carcinoma 271 | 550
Duchenne muscular dystrophy 268 | 602
Down syndrome 264 | 548
pancreatic carcinoma 258 | 567
IGA Glomerulonephritis 249 | 454
Neurodegenerative disease 246 | 383
hereditary spastic paraplegia 222 | 313
Amyotrophic Lateral Sclerosis 218 | 432
Obesity 218 | 616
Prostatic Neoplasms 215 | 471
gastric cancer 214 | 436
autosomal dominant Emery-Dreifuss muscular dystrophy 210 | 499
Schizophrenia 190 | 503
Mammary Neoplasms 187 | 410
Multiple Sclerosis 180 | 498
sarcoidosis 175 | 368
Endometriosis 173 | 535
mucosa-associated lymphoid tissue lymphoma 167 | 480
fibroadenoma 160 | 557
Crohn's disease 158 | 304
Parkinson's disease 158 | 364
Polycystic Ovary Syndrome 155 | 335
active ulcerative colitis 150 | 477
Stomach Neoplasms 144 | 282
inflammatory breast cancer 144 | 404
chronic rhinosinusitis 140 | 512
glioblastoma multiforme 139 | 347
tuberculosis and treatment for 3 months 137 | 327
non-small cell lung carcinoma 134 | 413
Kidney disease 133 | 397
Epilepsy 132 | 346

Tissue

Blood and immune system 7,779 | 17,995
Female tissues 7,758 | 18,647
Nervous System 7,757 | 18,561
Digestive Tract 7,746 | 18,473
Endocrine System 7,734 | 18,512
Liver and Pancreas 7,734 | 18,136
Male tissues 7,732 | 17,969
Cardiovascular System 7,728 | 17,958
Urinary Tract 7,728 | 18,444
Respiratory system 7,664 | 17,484
Skin and soft tissues 7,625 | 18,115

Target Family

Non-IDG 4,507 | 11,969
Enzyme 2,090 | 4,146
Transcription Factor 385 | 1,400
Kinase 371 | 634
Epigenetic 162 | 242
Transporter 120 | 473
Ion Channel 68 | 341
GPCR 36 | 408
TF/Epigenetic 21 | 38
Nuclear Receptor 10 | 48
oGPCR 9 | 421

HPM Tissue

CD4 Cells 7,779 | 7,779
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57