Development Level

Tbio 5,406 | 11,445
Tdark 1,395 | 6,588
Tchem 749 | 1,598
Tclin 223 | 613

Collection

RFA-RM-18-021 95 | 328
Kinase: IDG Consortium (Target... 59 | 125
Ion Channel: IDG Consortium (T... 23 | 99
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Targets) 14 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 679 | 979
preweaning lethality, incomple... 237 | 499
embryonic lethality prior to t... 192 | 278
embryonic lethality prior to o... 183 | 239
abnormal behavior 140 | 298
abnormal embryo size 133 | 220
decreased total body fat amoun... 99 | 207
abnormal bone structure 93 | 187
enlarged heart 82 | 210
increased lean body mass 81 | 172
decreased body weight 79 | 161
embryonic growth retardation 74 | 106
increased circulating alkaline... 73 | 122
decreased bone mineral content 69 | 151
hyperactivity 66 | 148
abnormal heart morphology 65 | 162
decreased vertical activity 65 | 208
decreased bone mineral density 61 | 126
increased startle reflex 61 | 112
increased total body fat amoun... 60 | 134
decreased circulating glucose ... 59 | 126
decreased lean body mass 59 | 135
hypoactivity 57 | 132
male infertility 54 | 123
prenatal lethality prior to he... 52 | 87
cataract 50 | 92
increased bone mineral content 47 | 108
decreased grip strength 46 | 116
increased mean corpuscular hem... 46 | 96
abnormal lens morphology 45 | 81
abnormal seminal vesicle morph... 44 | 114
decreased circulating choleste... 44 | 93
increased or absent threshold ... 44 | 101
decreased prepulse inhibition 41 | 82
short tibia 41 | 97
decreased circulating triglyce... 38 | 79
increased mean corpuscular vol... 38 | 92
abnormal retina morphology 37 | 71
decreased body length 37 | 101
decreased mean corpuscular vol... 37 | 79
small superior vagus ganglion 37 | 74
decreased leukocyte cell numbe... 36 | 73
increased fasted circulating g... 36 | 76
decreased circulating serum al... 35 | 82
decreased circulating HDL chol... 34 | 68
decreased circulating insulin ... 34 | 76
decreased startle reflex 33 | 75
edema 33 | 59
impaired glucose tolerance 33 | 75
increased circulating choleste... 32 | 66
increased bone mineral density 31 | 72
increased heart weight 31 | 62
small testis 31 | 58
abnormal behavioral response t... 30 | 66
abnormal coat-hair pigmentatio... 30 | 64
decreased lymphocyte cell numb... 30 | 83
increased circulating sodium l... 30 | 71
decreased caudal vertebrae num... 29 | 53
increased circulating HDL chol... 29 | 80
decreased erythrocyte cell num... 28 | 62
decreased fasted circulating g... 28 | 65
decreased hemoglobin content 27 | 68
improved glucose tolerance 27 | 79
thrombocytopenia 27 | 56
abnormal gait 26 | 69
abnormal sleep behavior 26 | 70
decreased mean corpuscular hem... 26 | 50
female infertility 26 | 60
abnormal eye morphology 25 | 68
decreased circulating alkaline... 25 | 46
hydrometra 25 | 53
increased erythrocyte cell num... 25 | 39
increased mean platelet volume 25 | 45
abnormal kidney morphology 24 | 65
decreased circulating alanine ... 24 | 47
decreased neutrophil cell numb... 24 | 42
increased monocyte cell number 24 | 63
pallor 24 | 34
abnormal neural tube closure 23 | 46
decreased blood urea nitrogen ... 23 | 51
decreased circulating LDL chol... 23 | 38
decreased circulating total pr... 23 | 49
decreased red blood cell distr... 23 | 41
increased hematocrit 23 | 46
increased neutrophil cell numb... 22 | 46
persistence of hyaloid vascula... 22 | 33
abnormal skin morphology 21 | 50
decreased circulating calcium ... 21 | 36
increased hemoglobin content 21 | 45
increased leukocyte cell numbe... 21 | 47
abnormal embryo turning 20 | 31
increased grip strength 20 | 41
abnormal bone mineralization 19 | 38
abnormal pericardium morpholog... 19 | 26
abnormal spleen morphology 19 | 55
decreased circulating aspartat... 19 | 34
increased body length 19 | 32
tremors 19 | 39
cardiovascular system phenotyp... 18 | 36
increased prepulse inhibition 18 | 32

Disease

Carcinoma 4,872 | 11,493
ovarian cancer 4,504 | 8,520
osteosarcoma 3,799 | 7,950
medulloblastoma, large-cell 2,778 | 6,241
psoriasis 2,745 | 6,694
glioblastoma 2,682 | 5,792
lung cancer 2,359 | 4,740
atypical teratoid / rhabdoid tumor 2,261 | 5,112
ependymoma 1,991 | 4,679
group 3 medulloblastoma 1,851 | 4,104
adult high grade glioma 1,575 | 3,801
Breast cancer 1,530 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,459 | 3,291
malignant mesothelioma 1,450 | 3,232
primitive neuroectodermal tumor 1,291 | 3,035
oligodendroglioma 1,287 | 2,850
Kidney cancer 1,276 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 1,270 | 2,989
Astrocytoma, Pilocytic 1,223 | 3,081
astrocytic glioma 1,209 | 2,597
invasive ductal carcinoma 1,203 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 1,199 | 2,955
non-small cell lung cancer 1,157 | 2,890
Cancer 1,112 | 2,499
subependymal giant cell astrocytoma 1,072 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,062 | 1,962
lung adenocarcinoma 1,045 | 2,716
Multiple myeloma 1,032 | 1,332
lung carcinoma 1,032 | 2,843
pancreatic cancer 987 | 2,398
Pick disease 962 | 1,894
tuberculosis 927 | 2,010
group 4 medulloblastoma 847 | 1,855
diabetes mellitus 780 | 1,728
interstitial cystitis 776 | 2,312
ulcerative colitis 749 | 1,819
Autosomal recessive predisposition 745 | 1,442
acute quadriplegic myopathy 708 | 1,158
juvenile dermatomyositis 675 | 1,187
pituitary cancer 656 | 1,972
astrocytoma 654 | 1,146
dermatomyositis 643 | 966
ductal carcinoma in situ 623 | 1,745
breast carcinoma 618 | 1,638
Waldenstrons macroglobulinemia 602 | 765
cystic fibrosis 601 | 1,696
Rheumatoid arthritis 600 | 1,191
colon cancer 598 | 1,478
Intellectual disability 570 | 1,016
pediatric high grade glioma 515 | 1,064
adrenocortical carcinoma 511 | 1,428
primary pancreatic ductal adenocarcinoma 492 | 1,109
Schizophrenia 482 | 1,160
spina bifida 463 | 1,074
acute myeloid leukemia 449 | 783
non primary Sjogren syndrome sicca 442 | 891
cutaneous lupus erythematosus 425 | 1,057
Epilepsy 413 | 792
primary Sjogren syndrome 392 | 735
Cognitive delay 389 | 608
Global developmental delay 389 | 608
Mental and motor retardation 389 | 608
nasopharyngeal carcinoma 370 | 1,058
Dull intelligence 369 | 645
Low intelligence 369 | 645
Mental Retardation 369 | 645
Mental deficiency 369 | 645
Poor school performance 369 | 645
active Crohn's disease 363 | 922
Muscle hypotonia 355 | 571
progressive supranuclear palsy 350 | 676
Liver Cirrhosis, Experimental 341 | 769
Seizures 340 | 596
gastric carcinoma 323 | 807
esophageal adenocarcinoma 315 | 737
medulloblastoma 312 | 720
aldosterone-producing adenoma 297 | 665
Alzheimer's disease 295 | 658
Atopic dermatitis 289 | 952
Liver cancer 284 | 604
Short stature 279 | 531
Duchenne muscular dystrophy 268 | 601
hepatocellular carcinoma 267 | 547
active ulcerative colitis 266 | 764
Neurodegenerative disease 263 | 414
Bipolar Disorder 261 | 666
Melanoma 260 | 711
pancreatic carcinoma 256 | 562
Obesity 249 | 678
Down syndrome 247 | 499
tuberculosis and treatment for 6 months 242 | 409
Amyotrophic lateral sclerosis 231 | 451
Failure to gain weight 231 | 365
Pediatric failure to thrive 231 | 365
Small head 229 | 374
Prostatic Neoplasms 225 | 495
hereditary spastic paraplegia 223 | 318
gastric cancer 221 | 459
autosomal dominant Emery-Dreifuss muscular dystrophy 212 | 510
Breast Neoplasms 206 | 445

Tissue

Endocrine System 7,664 | 18,159
Female tissues 7,572 | 17,400
Digestive Tract 7,551 | 17,369
Skin and soft tissues 7,537 | 17,230
Male tissues 7,519 | 17,142
Blood and immune system 7,485 | 16,909
Liver and Pancreas 7,458 | 16,750
Urinary Tract 7,449 | 16,678
Nervous System 7,447 | 16,725
Respiratory system 7,406 | 16,393
Cardiovascular System 7,215 | 15,192

Target Family

Non-IDG 4,503 | 12,091
Enzyme 2,089 | 4,145
Transcription Factor 384 | 1,400
Kinase 371 | 634
Epigenetic 161 | 242
Transporter 119 | 473
Ion Channel 70 | 344
GPCR 36 | 408
TF/Epigenetic 21 | 38
Nuclear Receptor 10 | 48
oGPCR 9 | 421

HPM Tissue

CD4 Cells 7,773 | 7,773
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28