Development Level

Tbio 5,761 | 10,625
Tdark 2,051 | 7,003
Tchem 1,025 | 1,890
Tclin 253 | 602

Collection

Kinase: IDG Consortium (Targets) 69 | 125
Kinase: IDG Consortium (Complete/Control) 26 | 37
Ion Channel: IDG Consortium (Targets) 25 | 102
GPCR: IDG Consortium (Targets) 14 | 127
GPCR: IDG Consortium (Complete/Control) 5 | 26

IMPC Phenotype

preweaning lethality, complete... 452 | 633
preweaning lethality, incomple... 150 | 260
embryonic lethality prior to t... 140 | 187
embryonic lethality prior to o... 122 | 148
abnormal behavior 116 | 226
decreased total body fat amoun... 109 | 186
decreased body weight 108 | 174
decreased lean body mass 107 | 195
decreased bone mineral content 79 | 157
abnormal bone structure 72 | 131
abnormal embryo size 71 | 112
increased or absent threshold ... 71 | 128
decreased body length 69 | 108
decreased circulating glucose ... 69 | 121
decreased grip strength 69 | 123
decreased bone mineral density 66 | 126
increased circulating alkaline... 66 | 119
abnormal retina morphology 59 | 100
increased bone mineral content 58 | 92
increased lean body mass 57 | 107
increased mean corpuscular hem... 57 | 93
hyperactivity 55 | 108
decreased circulating triglyce... 47 | 83
enlarged heart 47 | 111
decreased circulating serum al... 46 | 79
decreased circulating choleste... 44 | 85
prenatal lethality prior to he... 44 | 64
abnormal lens morphology 42 | 73
increased grip strength 42 | 83
short tibia 42 | 82
increased fasted circulating g... 41 | 68
decreased circulating HDL chol... 40 | 77
increased circulating sodium l... 39 | 71
increased mean corpuscular vol... 39 | 91
hypoactivity 37 | 89
increased circulating HDL chol... 35 | 63
abnormal bone mineralization 34 | 55
abnormal retinal pigmentation 34 | 61
decreased circulating insulin ... 34 | 75
decreased leukocyte cell numbe... 34 | 54
abnormal sleep behavior 33 | 63
decreased lumbar vertebrae num... 33 | 62
decreased mean corpuscular vol... 33 | 50
increased sacral vertebrae num... 33 | 62
increased bone mineral density 32 | 52
male infertility 32 | 62
decreased caudal vertebrae num... 31 | 49
decreased rib number 31 | 59
increased circulating choleste... 31 | 53
decreased prepulse inhibition 29 | 52
abnormal coat-hair pigmentatio... 28 | 54
decreased circulating alkaline... 28 | 41
decreased circulating alanine ... 27 | 53
decreased circulating total pr... 27 | 41
decreased heart weight 27 | 44
decreased hemoglobin content 27 | 53
thrombocytopenia 27 | 46
decreased fasted circulating g... 26 | 49
increased exploration in new e... 26 | 56
increased hemoglobin content 26 | 45
impaired glucose tolerance 25 | 52
improved glucose tolerance 25 | 56
increased body weight 25 | 42
abnormal behavioral response t... 24 | 52
decreased erythrocyte cell num... 24 | 43
decreased startle reflex 24 | 48
increased blood urea nitrogen ... 24 | 44
increased circulating chloride... 24 | 43
decreased circulating LDL chol... 23 | 37
increased heart weight 23 | 37
abnormal neural tube closure 22 | 37
abnormal seminal vesicle morph... 22 | 47
decreased circulating fructosa... 22 | 31
increased total body fat amoun... 22 | 57
decreased circulating creatini... 21 | 31
decreased neutrophil cell numb... 21 | 37
increased hematocrit 21 | 36
increased leukocyte cell numbe... 21 | 37
abnormal eye morphology 20 | 38
abnormal spleen morphology 20 | 36
decreased eosinophil cell numb... 20 | 41
abnormal gait 19 | 51
cardiovascular system phenotyp... 19 | 35
decreased CD4-positive, CD25-p... 19 | 24
decreased circulating calcium ... 19 | 33
decreased mature B cell number 19 | 25
decreased mean corpuscular hem... 19 | 34
embryonic growth retardation 19 | 28
increased circulating calcium ... 19 | 32
increased startle reflex 19 | 38
abnormal heart morphology 18 | 51
decreased T cell number 18 | 31
decreased circulating chloride... 18 | 32
increased rib number 18 | 41
small testis 18 | 37
abnormal cranium morphology 17 | 32
decreased NK T cell number 17 | 28
decreased blood urea nitrogen ... 17 | 31
increased circulating potassiu... 17 | 31
thrombocytosis 17 | 23

Disease

ovarian cancer 5,113 | 8,491
osteosarcoma 4,478 | 7,933
medulloblastoma, large-cell 3,280 | 6,234
psoriasis 3,213 | 6,685
glioblastoma 3,040 | 5,572
lung cancer 2,614 | 4,473
atypical teratoid / rhabdoid tumor 2,324 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,698 | 3,289
malignant mesothelioma 1,676 | 3,163
Breast cancer 1,606 | 3,098
primitive neuroectodermal tumor 1,529 | 3,031
oligodendroglioma 1,515 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,500 | 2,988
pilocytic astrocytoma 1,478 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,450 | 2,956
ependymoma 1,443 | 2,514
invasive ductal carcinoma 1,418 | 2,950
pediatric high grade glioma 1,399 | 2,712
non-small cell lung cancer 1,345 | 2,798
lung carcinoma 1,287 | 2,844
Cancer 1,229 | 2,346
subependymal giant cell astrocytoma 1,228 | 2,287
lung adenocarcinoma 1,225 | 2,714
group 3 medulloblastoma 1,213 | 2,254
Carcinoma 1,210 | 2,147
astrocytic glioma 1,209 | 2,241
Pick disease 1,141 | 1,893
pancreatic cancer 1,106 | 2,300
Multiple myeloma 1,098 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 1,091 | 1,795
adult high grade glioma 1,066 | 2,148
group 4 medulloblastoma 1,043 | 1,875
ulcerative colitis 1,034 | 2,087
interstitial cystitis 977 | 2,299
astrocytoma 941 | 1,493
tuberculosis 879 | 1,563
diabetes mellitus 829 | 1,663
medulloblastoma 817 | 1,524
pituitary cancer 812 | 1,972
juvenile dermatomyositis 777 | 1,189
acute quadriplegic myopathy 761 | 1,157
ductal carcinoma in situ 741 | 1,745
sonic hedgehog group medulloblastoma 731 | 1,482
breast carcinoma 728 | 1,614
colon cancer 715 | 1,475
cystic fibrosis 709 | 1,670
Rheumatoid Arthritis 700 | 1,170
dermatomyositis 694 | 966
primary pancreatic ductal adenocarcinoma 668 | 1,271
posterior fossa group A ependymoma 656 | 1,511
Waldenstrons macroglobulinemia 649 | 764
adrenocortical carcinoma 646 | 1,427
posterior fossa group B ependymoma 632 | 1,530
spina bifida 546 | 1,064
cutaneous lupus erythematosus 531 | 1,056
atypical teratoid/rhabdoid tumor 514 | 1,095
primary Sjogren syndrome 513 | 788
acute myeloid leukemia 512 | 785
non primary Sjogren syndrome sicca 473 | 840
nasopharyngeal carcinoma 456 | 1,056
tuberculosis and treatment for 6 months 445 | 686
active Crohn's disease 427 | 918
progressive supranuclear palsy 426 | 674
gastric carcinoma 392 | 832
esophageal adenocarcinoma 365 | 737
aldosterone-producing adenoma 363 | 664
Intellectual disability 362 | 573
Atopic dermatitis 360 | 944
Alzheimer's disease 358 | 644
hepatocellular carcinoma 327 | 550
Duchenne muscular dystrophy 324 | 602
pancreatic carcinoma 322 | 567
Down syndrome 307 | 548
IGA Glomerulonephritis 284 | 454
Neurodegenerative disease 275 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 265 | 499
gastric cancer 258 | 436
Amyotrophic Lateral Sclerosis 252 | 432
Obesity 252 | 616
hereditary spastic paraplegia 252 | 313
Prostatic Neoplasms 239 | 471
Schizophrenia 228 | 503
mucosa-associated lymphoid tissue lymphoma 220 | 480
Mammary Neoplasms 219 | 410
Multiple Sclerosis 217 | 498
fibroadenoma 202 | 557
chronic rhinosinusitis 197 | 512
sarcoidosis 196 | 368
Endometriosis 194 | 535
active ulcerative colitis 189 | 477
Parkinson's disease 187 | 364
inflammatory breast cancer 183 | 404
Polycystic Ovary Syndrome 178 | 334
tuberculosis and treatment for 3 months 173 | 327
Crohn's disease 171 | 304
non-small cell lung carcinoma 170 | 413
Epilepsy 163 | 346
glioblastoma multiforme 162 | 347
Kidney disease 160 | 397
Stomach Neoplasms 158 | 282

Tissue

Blood and immune system 9,090 | 17,994
Female tissues 9,065 | 18,646
Nervous System 9,063 | 18,560
Digestive Tract 9,057 | 18,472
Liver and Pancreas 9,049 | 18,135
Male tissues 9,049 | 17,968
Endocrine System 9,043 | 18,511
Urinary Tract 9,037 | 18,443
Cardiovascular System 9,023 | 17,957
Respiratory system 8,966 | 17,483
Skin and soft tissues 8,914 | 18,114

Target Family

Non-IDG 5,207 | 11,969
Enzyme 2,299 | 4,146
Transcription Factor 644 | 1,400
Kinase 418 | 634
Epigenetic 177 | 242
Transporter 157 | 473
Ion Channel 90 | 341
GPCR 48 | 408
TF/Epigenetic 22 | 38
Nuclear Receptor 18 | 48
oGPCR 10 | 421

HPM Tissue

B Cells 9,090 | 9,090
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Adult Adrenal 8,478 | 8,478
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130