Development Level

Tbio 5,761 | 10,625
Tdark 2,051 | 7,003
Tchem 1,026 | 1,890
Tclin 253 | 602

Collection

Eligible Kinase Proteins 73 | 134
Eligible Ion Channel Proteins 26 | 117
Eligible non-olfactory GPCR Proteins 16 | 143

IMPC Term

preweaning lethality, complete... 452 | 633
preweaning lethality, incomple... 150 | 260
embryonic lethality prior to t... 140 | 187
embryonic lethality prior to o... 122 | 148
abnormal behavior 116 | 226
decreased total body fat amoun... 109 | 186
decreased body weight 108 | 174
decreased lean body mass 107 | 195
decreased bone mineral content 79 | 157
abnormal bone structure 72 | 131
abnormal embryo size 71 | 112
increased or absent threshold ... 71 | 128
decreased body length 69 | 108
decreased circulating glucose ... 69 | 121
decreased grip strength 69 | 123
decreased bone mineral density 66 | 126
increased circulating alkaline... 66 | 119
abnormal retina morphology 59 | 100
increased bone mineral content 58 | 92
increased lean body mass 57 | 107
increased mean corpuscular hem... 57 | 93
hyperactivity 55 | 108
decreased circulating triglyce... 47 | 83
enlarged heart 47 | 111
decreased circulating serum al... 46 | 79
decreased circulating choleste... 44 | 85
prenatal lethality prior to he... 44 | 64
abnormal lens morphology 42 | 73
increased grip strength 42 | 83
short tibia 42 | 82
increased fasted circulating g... 41 | 68
decreased circulating HDL chol... 40 | 77
increased circulating sodium l... 39 | 71
increased mean corpuscular vol... 39 | 91
hypoactivity 37 | 89
increased circulating HDL chol... 35 | 63
abnormal bone mineralization 34 | 55
abnormal retinal pigmentation 34 | 61
decreased circulating insulin ... 34 | 75
decreased leukocyte cell numbe... 34 | 54
abnormal sleep behavior 33 | 63
decreased lumbar vertebrae num... 33 | 62
decreased mean corpuscular vol... 33 | 50
increased sacral vertebrae num... 33 | 62
increased bone mineral density 32 | 52
male infertility 32 | 62
decreased caudal vertebrae num... 31 | 49
decreased rib number 31 | 59
increased circulating choleste... 31 | 53
decreased prepulse inhibition 29 | 52
abnormal coat/hair pigmentatio... 28 | 54
decreased circulating alkaline... 28 | 41
decreased circulating alanine ... 27 | 53
decreased circulating total pr... 27 | 41
decreased heart weight 27 | 44
decreased hemoglobin content 27 | 53
thrombocytopenia 27 | 46
decreased fasted circulating g... 26 | 49
increased exploration in new e... 26 | 56
increased hemoglobin content 26 | 45
impaired glucose tolerance 25 | 52
improved glucose tolerance 25 | 56
increased body weight 25 | 42
abnormal behavioral response t... 24 | 52
decreased erythrocyte cell num... 24 | 43
decreased startle reflex 24 | 48
increased blood urea nitrogen ... 24 | 44
increased circulating chloride... 24 | 43
decreased circulating LDL chol... 23 | 37
increased heart weight 23 | 37
abnormal neural tube closure 22 | 37
abnormal seminal vesicle morph... 22 | 47
decreased circulating fructosa... 22 | 31
increased total body fat amoun... 22 | 57
decreased circulating creatini... 21 | 31
decreased neutrophil cell numb... 21 | 37
increased hematocrit 21 | 36
increased leukocyte cell numbe... 21 | 37
abnormal eye morphology 20 | 38
abnormal spleen morphology 20 | 36
decreased eosinophil cell numb... 20 | 41
abnormal gait 19 | 51
cardiovascular system phenotyp... 19 | 35
decreased CD4-positive, CD25-p... 19 | 24
decreased circulating calcium ... 19 | 33
decreased mature B cell number 19 | 25
decreased mean corpuscular hem... 19 | 34
embryonic growth retardation 19 | 28
increased circulating calcium ... 19 | 32
increased startle reflex 19 | 38
abnormal heart morphology 18 | 51
decreased T cell number 18 | 31
decreased circulating chloride... 18 | 32
increased rib number 18 | 41
small testis 18 | 37
abnormal cranium morphology 17 | 32
decreased NK T cell number 17 | 28
decreased blood urea nitrogen ... 17 | 31
increased circulating potassiu... 17 | 31
thrombocytosis 17 | 23

Disease

ovarian cancer 5,111 | 8,484
osteosarcoma 4,478 | 7,933
medulloblastoma, large-cell 3,280 | 6,234
psoriasis 3,213 | 6,685
glioblastoma 3,040 | 5,572
lung cancer 2,611 | 4,466
atypical teratoid / rhabdoid tumor 2,324 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,698 | 3,289
malignant mesothelioma 1,675 | 3,162
Breast cancer 1,604 | 3,094
primitive neuroectodermal tumor 1,529 | 3,031
oligodendroglioma 1,515 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,500 | 2,988
pilocytic astrocytoma 1,478 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,450 | 2,956
ependymoma 1,443 | 2,514
invasive ductal carcinoma 1,418 | 2,950
pediatric high grade glioma 1,399 | 2,712
non-small cell lung cancer 1,345 | 2,798
lung carcinoma 1,287 | 2,844
Cancer 1,229 | 2,346
subependymal giant cell astrocytoma 1,228 | 2,287
lung adenocarcinoma 1,225 | 2,713
group 3 medulloblastoma 1,213 | 2,254
Carcinoma 1,210 | 2,147
astrocytic glioma 1,209 | 2,241
Pick disease 1,141 | 1,893
pancreatic cancer 1,106 | 2,300
Multiple myeloma 1,099 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 1,091 | 1,795
adult high grade glioma 1,066 | 2,148
group 4 medulloblastoma 1,043 | 1,875
ulcerative colitis 1,034 | 2,087
interstitial cystitis 977 | 2,299
astrocytoma 941 | 1,493
tuberculosis 877 | 1,557
diabetes mellitus 829 | 1,663
medulloblastoma 817 | 1,524
pituitary cancer 812 | 1,972
juvenile dermatomyositis 777 | 1,189
acute quadriplegic myopathy 761 | 1,157
ductal carcinoma in situ 741 | 1,745
sonic hedgehog group medulloblastoma 731 | 1,482
breast carcinoma 728 | 1,614
colon cancer 715 | 1,475
cystic fibrosis 706 | 1,665
Rheumatoid Arthritis 700 | 1,160
dermatomyositis 694 | 933
primary pancreatic ductal adenocarcinoma 668 | 1,271
posterior fossa group A ependymoma 656 | 1,511
Waldenstrons macroglobulinemia 650 | 765
adrenocortical carcinoma 646 | 1,427
posterior fossa group B ependymoma 632 | 1,530
spina bifida 546 | 1,064
cutaneous lupus erythematosus 531 | 1,056
atypical teratoid/rhabdoid tumor 514 | 1,095
primary Sjogren syndrome 514 | 789
acute myeloid leukemia 509 | 780
non primary Sjogren syndrome sicca 473 | 840
nasopharyngeal carcinoma 456 | 1,056
tuberculosis and treatment for 6 months 445 | 686
active Crohn's disease 427 | 918
progressive supranuclear palsy 426 | 674
gastric carcinoma 392 | 832
esophageal adenocarcinoma 365 | 737
aldosterone-producing adenoma 363 | 664
Intellectual disability 362 | 573
Atopic dermatitis 360 | 944
Alzheimer's disease 358 | 644
Duchenne muscular dystrophy 324 | 602
pancreatic carcinoma 322 | 567
hepatocellular carcinoma 318 | 532
Down syndrome 307 | 548
IGA Glomerulonephritis 284 | 454
Neurodegenerative disease 275 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 265 | 499
gastric cancer 255 | 430
Amyotrophic Lateral Sclerosis 252 | 431
Obesity 252 | 616
hereditary spastic paraplegia 252 | 313
Prostatic Neoplasms 239 | 471
Schizophrenia 226 | 501
mucosa-associated lymphoid tissue lymphoma 220 | 480
Mammary Neoplasms 219 | 410
Multiple Sclerosis 217 | 498
fibroadenoma 202 | 557
chronic rhinosinusitis 197 | 512
sarcoidosis 195 | 358
Endometriosis 194 | 535
active ulcerative colitis 189 | 477
Parkinson's disease 187 | 364
inflammatory breast cancer 183 | 404
Polycystic Ovary Syndrome 177 | 332
tuberculosis and treatment for 3 months 173 | 327
Crohn's disease 171 | 304
non-small cell lung carcinoma 170 | 413
Epilepsy 163 | 346
glioblastoma multiforme 162 | 347
Kidney disease 160 | 396
Stomach Neoplasms 158 | 282

Tissue

Blood and immune system 9,091 | 17,995
Female tissues 9,066 | 18,647
Nervous System 9,064 | 18,561
Digestive Tract 9,058 | 18,473
Liver and Pancreas 9,050 | 18,136
Male tissues 9,050 | 17,969
Endocrine System 9,044 | 18,512
Urinary Tract 9,038 | 18,444
Cardiovascular System 9,024 | 17,958
Respiratory system 8,967 | 17,484
Skin and soft tissues 8,915 | 18,115

Target Family

Non-IDG 5,207 | 11,971
Enzyme 2,300 | 4,146
Transcription Factor 644 | 1,400
Kinase 418 | 634
Epigenetic 177 | 242
Transporter 157 | 473
Ion Channel 90 | 341
GPCR 48 | 406
TF/Epigenetic 22 | 38
Nuclear Receptor 18 | 48
oGPCR 10 | 421

HPM Tissue

B Cells 9,091 | 9,091
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89