Development Level

Tbio 6,230 | 11,651
Tdark 1,822 | 6,593
Tchem 777 | 1,388
Tclin 257 | 612

Collection

RFA-RM-18-021 108 | 328
Kinase: IDG Consortium (Target... 69 | 125
Ion Channel: IDG Consortium (T... 26 | 99
Kinase: IDG Consortium (Comple... 26 | 37
GPCR: IDG Consortium (Targets) 14 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 714 | 979
preweaning lethality, incomple... 284 | 499
embryonic lethality prior to t... 206 | 278
embryonic lethality prior to o... 194 | 239
abnormal embryo size 151 | 220
abnormal behavior 145 | 298
decreased total body fat amoun... 119 | 207
abnormal bone structure 103 | 187
decreased body weight 98 | 161
increased lean body mass 97 | 172
enlarged heart 90 | 210
decreased vertical activity 83 | 208
embryonic growth retardation 79 | 106
decreased bone mineral content 75 | 151
abnormal heart morphology 72 | 162
hyperactivity 72 | 148
increased total body fat amoun... 72 | 134
decreased circulating glucose ... 70 | 126
decreased bone mineral density 69 | 126
decreased lean body mass 67 | 135
increased circulating alkaline... 66 | 122
increased startle reflex 65 | 112
hypoactivity 64 | 132
male infertility 62 | 123
decreased grip strength 61 | 116
prenatal lethality prior to he... 60 | 87
decreased body length 58 | 101
short tibia 56 | 97
increased bone mineral content 55 | 108
increased mean corpuscular hem... 54 | 96
abnormal seminal vesicle morph... 53 | 114
increased or absent threshold ... 53 | 101
decreased prepulse inhibition 50 | 82
cataract 48 | 92
decreased circulating triglyce... 48 | 79
decreased circulating choleste... 47 | 93
increased fasted circulating g... 47 | 76
abnormal lens morphology 46 | 81
decreased circulating serum al... 46 | 82
decreased leukocyte cell numbe... 44 | 73
decreased mean corpuscular vol... 44 | 79
increased bone mineral density 43 | 72
increased circulating HDL chol... 42 | 80
increased mean corpuscular vol... 42 | 92
abnormal retina morphology 41 | 71
impaired glucose tolerance 41 | 75
increased circulating choleste... 39 | 66
small superior vagus ganglion 39 | 74
decreased lymphocyte cell numb... 38 | 83
decreased startle reflex 38 | 75
increased circulating sodium l... 38 | 71
decreased hemoglobin content 37 | 68
decreased circulating HDL chol... 35 | 68
decreased erythrocyte cell num... 35 | 62
improved glucose tolerance 35 | 79
thrombocytopenia 35 | 56
abnormal behavioral response t... 34 | 66
abnormal sleep behavior 34 | 70
decreased circulating insulin ... 34 | 76
abnormal coat-hair pigmentatio... 33 | 64
abnormal eye morphology 33 | 68
decreased caudal vertebrae num... 33 | 53
decreased circulating alkaline... 32 | 46
increased heart weight 32 | 62
decreased circulating total pr... 31 | 49
decreased fasted circulating g... 31 | 65
edema 31 | 59
small testis 31 | 58
abnormal kidney morphology 29 | 65
decreased mean corpuscular hem... 29 | 50
hydrometra 29 | 53
increased erythrocyte cell num... 29 | 39
increased mean platelet volume 29 | 45
abnormal gait 28 | 69
decreased hematocrit 28 | 46
increased monocyte cell number 28 | 63
abnormal neural tube closure 27 | 46
female infertility 27 | 60
decreased circulating alanine ... 26 | 47
decreased red blood cell distr... 26 | 41
increased hematocrit 26 | 46
abnormal bone mineralization 25 | 38
abnormal spleen morphology 25 | 55
decreased blood urea nitrogen ... 25 | 51
increased grip strength 25 | 41
increased neutrophil cell numb... 25 | 46
pallor 25 | 34
abnormal embryo turning 24 | 31
decreased circulating calcium ... 24 | 36
decreased neutrophil cell numb... 24 | 42
increased hemoglobin content 24 | 45
increased leukocyte cell numbe... 24 | 47
abnormal skin morphology 23 | 50
decreased circulating LDL chol... 23 | 38
increased circulating triglyce... 23 | 42
increased blood urea nitrogen ... 22 | 48
increased body length 22 | 32
increased circulating chloride... 22 | 41
increased red blood cell distr... 22 | 34
decreased circulating fructosa... 21 | 30

Disease

Carcinoma 5,868 | 11,493
ovarian cancer 5,125 | 8,520
osteosarcoma 4,476 | 7,950
medulloblastoma, large-cell 3,280 | 6,241
psoriasis 3,211 | 6,694
glioblastoma 3,146 | 5,792
lung cancer 2,726 | 4,740
atypical teratoid / rhabdoid tumor 2,677 | 5,112
ependymoma 2,355 | 4,679
group 3 medulloblastoma 2,156 | 4,104
adult high grade glioma 1,863 | 3,801
Breast cancer 1,841 | 3,578
malignant mesothelioma 1,704 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,698 | 3,291
primitive neuroectodermal tumor 1,528 | 3,035
Kidney cancer 1,514 | 2,613
oligodendroglioma 1,514 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 1,499 | 2,989
Astrocytoma, Pilocytic 1,474 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 1,446 | 2,955
invasive ductal carcinoma 1,417 | 2,951
astrocytic glioma 1,401 | 2,597
non-small cell lung cancer 1,373 | 2,890
Cancer 1,302 | 2,499
lung carcinoma 1,287 | 2,843
subependymal giant cell astrocytoma 1,229 | 2,287
lung adenocarcinoma 1,223 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 1,182 | 1,962
pancreatic cancer 1,158 | 2,398
Pick disease 1,141 | 1,894
tuberculosis 1,112 | 2,010
Multiple myeloma 1,102 | 1,332
group 4 medulloblastoma 1,044 | 1,855
interstitial cystitis 977 | 2,312
ulcerative colitis 899 | 1,819
diabetes mellitus 865 | 1,728
Autosomal recessive predisposition 816 | 1,442
pituitary cancer 810 | 1,972
juvenile dermatomyositis 778 | 1,187
acute quadriplegic myopathy 761 | 1,158
astrocytoma 752 | 1,146
breast carcinoma 745 | 1,638
ductal carcinoma in situ 738 | 1,745
cystic fibrosis 722 | 1,696
colon cancer 715 | 1,478
Rheumatoid arthritis 709 | 1,191
dermatomyositis 695 | 966
Waldenstrons macroglobulinemia 649 | 765
adrenocortical carcinoma 645 | 1,428
Intellectual disability 623 | 1,016
pediatric high grade glioma 603 | 1,064
primary pancreatic ductal adenocarcinoma 577 | 1,109
Schizophrenia 564 | 1,160
spina bifida 550 | 1,074
cutaneous lupus erythematosus 531 | 1,057
acute myeloid leukemia 510 | 783
non primary Sjogren syndrome sicca 508 | 891
primary Sjogren syndrome 480 | 735
Epilepsy 467 | 792
nasopharyngeal carcinoma 455 | 1,058
active Crohn's disease 428 | 922
progressive supranuclear palsy 425 | 676
Cognitive delay 422 | 608
Global developmental delay 422 | 608
Mental and motor retardation 422 | 608
Dull intelligence 397 | 645
Low intelligence 397 | 645
Mental Retardation 397 | 645
Mental deficiency 397 | 645
Poor school performance 397 | 645
Liver Cirrhosis, Experimental 394 | 769
Muscle hypotonia 394 | 571
gastric carcinoma 378 | 807
medulloblastoma 375 | 720
Seizures 367 | 596
Atopic dermatitis 366 | 952
esophageal adenocarcinoma 364 | 737
aldosterone-producing adenoma 363 | 665
Alzheimer's disease 356 | 658
Liver cancer 349 | 604
Duchenne muscular dystrophy 325 | 601
Short stature 325 | 531
active ulcerative colitis 325 | 764
hepatocellular carcinoma 325 | 547
Melanoma 324 | 711
pancreatic carcinoma 320 | 562
Bipolar Disorder 302 | 666
Neurodegenerative disease 293 | 414
Obesity 285 | 678
Down syndrome 283 | 499
tuberculosis and treatment for 6 months 278 | 409
autosomal dominant Emery-Dreifuss muscular dystrophy 268 | 510
gastric cancer 268 | 459
Amyotrophic lateral sclerosis 265 | 451
hereditary spastic paraplegia 255 | 318
Small head 252 | 374
Prostatic Neoplasms 251 | 495
Failure to gain weight 243 | 365
Pediatric failure to thrive 243 | 365
Breast Neoplasms 241 | 445

Tissue

Endocrine System 8,971 | 18,159
Female tissues 8,842 | 17,400
Digestive Tract 8,829 | 17,369
Skin and soft tissues 8,829 | 17,230
Male tissues 8,791 | 17,142
Blood and immune system 8,754 | 16,909
Liver and Pancreas 8,718 | 16,750
Nervous System 8,714 | 16,725
Urinary Tract 8,700 | 16,678
Respiratory system 8,656 | 16,393
Cardiovascular System 8,377 | 15,192

Target Family

Non-IDG 5,205 | 12,091
Enzyme 2,298 | 4,145
Transcription Factor 643 | 1,400
Kinase 418 | 634
Epigenetic 176 | 242
Transporter 156 | 473
Ion Channel 92 | 344
GPCR 48 | 408
TF/Epigenetic 22 | 38
Nuclear Receptor 18 | 48
oGPCR 10 | 421

HPM Tissue

B Cells 9,086 | 9,086
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123