Development Level

Tbio 5,292 | 11,445
Tdark 1,201 | 6,588
Tchem 838 | 1,598
Tclin 261 | 613

Collection

RFA-RM-18-021 92 | 328
Kinase: IDG Consortium (Target... 55 | 125
Ion Channel: IDG Consortium (T... 23 | 99
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Targets) 13 | 126
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 575 | 979
preweaning lethality, incomple... 245 | 499
embryonic lethality prior to t... 153 | 278
embryonic lethality prior to o... 142 | 239
abnormal behavior 132 | 298
abnormal embryo size 118 | 220
decreased total body fat amoun... 99 | 207
abnormal bone structure 92 | 187
decreased body weight 84 | 161
enlarged heart 78 | 210
increased lean body mass 76 | 172
decreased bone mineral content 75 | 151
decreased vertical activity 73 | 208
hyperactivity 68 | 148
decreased circulating glucose ... 67 | 126
embryonic growth retardation 62 | 106
hypoactivity 62 | 132
increased circulating alkaline... 62 | 122
increased total body fat amoun... 62 | 134
increased startle reflex 60 | 112
decreased bone mineral density 58 | 126
abnormal heart morphology 57 | 162
decreased lean body mass 55 | 135
decreased grip strength 54 | 116
male infertility 52 | 123
decreased body length 50 | 101
increased bone mineral content 49 | 108
cataract 48 | 92
increased or absent threshold ... 48 | 101
short tibia 48 | 97
abnormal seminal vesicle morph... 47 | 114
decreased circulating choleste... 47 | 93
decreased mean corpuscular vol... 46 | 79
prenatal lethality prior to he... 45 | 87
increased mean corpuscular hem... 44 | 96
abnormal lens morphology 42 | 81
decreased circulating serum al... 42 | 82
decreased prepulse inhibition 42 | 82
increased mean corpuscular vol... 39 | 92
abnormal retina morphology 37 | 71
decreased startle reflex 37 | 75
increased fasted circulating g... 37 | 76
decreased circulating insulin ... 36 | 76
improved glucose tolerance 36 | 79
abnormal behavioral response t... 35 | 66
decreased circulating HDL chol... 35 | 68
decreased circulating triglyce... 33 | 79
decreased lymphocyte cell numb... 33 | 83
increased circulating choleste... 33 | 66
increased heart weight 33 | 62
abnormal sleep behavior 32 | 70
impaired glucose tolerance 32 | 75
increased circulating HDL chol... 32 | 80
abnormal coat-hair pigmentatio... 31 | 64
abnormal eye morphology 31 | 68
decreased fasted circulating g... 31 | 65
decreased leukocyte cell numbe... 31 | 73
increased bone mineral density 31 | 72
thrombocytopenia 31 | 56
edema 30 | 59
increased circulating sodium l... 29 | 71
abnormal gait 28 | 69
abnormal kidney morphology 28 | 65
increased monocyte cell number 28 | 63
decreased hemoglobin content 27 | 68
abnormal skin morphology 26 | 50
decreased caudal vertebrae num... 26 | 53
decreased circulating total pr... 26 | 49
decreased mean corpuscular hem... 26 | 50
increased leukocyte cell numbe... 26 | 47
small superior vagus ganglion 26 | 74
small testis 26 | 58
decreased blood urea nitrogen ... 25 | 51
increased hematocrit 25 | 46
increased hemoglobin content 24 | 45
decreased neutrophil cell numb... 23 | 42
increased blood urea nitrogen ... 23 | 48
increased erythrocyte cell num... 23 | 39
increased mean platelet volume 23 | 45
decreased circulating alkaline... 22 | 46
decreased mean corpuscular hem... 22 | 31
increased grip strength 22 | 41
cardiovascular system phenotyp... 21 | 36
decreased circulating LDL chol... 21 | 38
decreased circulating alanine ... 21 | 47
decreased circulating calcium ... 21 | 36
decreased red blood cell distr... 21 | 41
increased circulating triglyce... 21 | 42
persistence of hyaloid vascula... 21 | 33
abnormal bone mineralization 20 | 38
decreased erythrocyte cell num... 20 | 62
decreased hematocrit 20 | 46
limb grasping 20 | 41
abnormal epididymis morphology 19 | 42
abnormal spleen morphology 19 | 55
abnormal testis morphology 19 | 43
decreased circulating aspartat... 19 | 34
increased neutrophil cell numb... 19 | 46
pallor 19 | 34
tremors 19 | 39

Disease

Carcinoma 4,847 | 11,493
ovarian cancer 4,461 | 8,520
osteosarcoma 3,608 | 7,950
psoriasis 2,943 | 6,694
medulloblastoma, large-cell 2,854 | 6,241
glioblastoma 2,816 | 5,792
lung cancer 2,401 | 4,740
atypical teratoid / rhabdoid tumor 2,335 | 5,112
ependymoma 2,127 | 4,679
group 3 medulloblastoma 1,832 | 4,104
Breast cancer 1,765 | 3,578
adult high grade glioma 1,696 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,646 | 3,291
malignant mesothelioma 1,556 | 3,232
invasive ductal carcinoma 1,480 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 1,471 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,448 | 2,955
Astrocytoma, Pilocytic 1,442 | 3,081
non-small cell lung cancer 1,372 | 2,890
oligodendroglioma 1,363 | 2,850
primitive neuroectodermal tumor 1,330 | 3,035
Kidney cancer 1,293 | 2,613
astrocytic glioma 1,259 | 2,597
lung adenocarcinoma 1,256 | 2,716
lung carcinoma 1,224 | 2,843
pancreatic cancer 1,217 | 2,398
Cancer 1,211 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 1,159 | 1,962
subependymal giant cell astrocytoma 1,141 | 2,287
Pick disease 985 | 1,894
Multiple myeloma 962 | 1,332
interstitial cystitis 939 | 2,312
tuberculosis 925 | 2,010
group 4 medulloblastoma 868 | 1,855
ductal carcinoma in situ 831 | 1,745
diabetes mellitus 830 | 1,728
ulcerative colitis 828 | 1,819
breast carcinoma 824 | 1,638
pituitary cancer 823 | 1,972
Autosomal recessive predisposition 811 | 1,442
cystic fibrosis 806 | 1,696
colon cancer 783 | 1,478
acute quadriplegic myopathy 730 | 1,158
juvenile dermatomyositis 707 | 1,187
astrocytoma 673 | 1,146
adrenocortical carcinoma 657 | 1,428
dermatomyositis 646 | 966
primary pancreatic ductal adenocarcinoma 627 | 1,109
Rheumatoid arthritis 592 | 1,191
Waldenstrons macroglobulinemia 568 | 765
pediatric high grade glioma 548 | 1,064
Intellectual disability 542 | 1,016
Schizophrenia 519 | 1,160
spina bifida 510 | 1,074
nasopharyngeal carcinoma 458 | 1,058
cutaneous lupus erythematosus 448 | 1,057
Atopic dermatitis 437 | 952
Epilepsy 426 | 792
non primary Sjogren syndrome sicca 426 | 891
gastric carcinoma 421 | 807
Liver Cirrhosis, Experimental 419 | 769
active Crohn's disease 418 | 922
esophageal adenocarcinoma 417 | 737
acute myeloid leukemia 411 | 783
Duchenne muscular dystrophy 401 | 601
Cognitive delay 377 | 608
Global developmental delay 377 | 608
Mental and motor retardation 377 | 608
Muscle hypotonia 362 | 571
Dull intelligence 361 | 645
Low intelligence 361 | 645
Mental Retardation 361 | 645
Mental deficiency 361 | 645
Poor school performance 361 | 645
primary Sjogren syndrome 361 | 735
progressive supranuclear palsy 355 | 676
active ulcerative colitis 342 | 764
aldosterone-producing adenoma 339 | 665
Alzheimer's disease 338 | 658
Seizures 337 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 328 | 510
Liver cancer 316 | 604
medulloblastoma 304 | 720
Melanoma 303 | 711
Obesity 296 | 678
Short stature 294 | 531
Down syndrome 290 | 499
Bipolar Disorder 285 | 666
pancreatic carcinoma 279 | 562
Neurodegenerative disease 271 | 414
Amyotrophic lateral sclerosis 270 | 451
fibroadenoma 270 | 559
hepatocellular carcinoma 253 | 547
Prostatic Neoplasms 251 | 495
sonic hedgehog group medulloblastoma 240 | 467
hereditary spastic paraplegia 234 | 318
Breast Neoplasms 229 | 445
mucosa-associated lymphoid tissue lymphoma 227 | 484
Failure to gain weight 218 | 365
Pediatric failure to thrive 218 | 365

Tissue

Endocrine System 7,489 | 18,159
Female tissues 7,398 | 17,400
Digestive Tract 7,387 | 17,369
Skin and soft tissues 7,372 | 17,230
Male tissues 7,328 | 17,142
Blood and immune system 7,313 | 16,909
Liver and Pancreas 7,295 | 16,750
Urinary Tract 7,277 | 16,678
Nervous System 7,242 | 16,725
Respiratory system 7,218 | 16,393
Cardiovascular System 7,004 | 15,192

Target Family

Non-IDG 4,526 | 12,091
Enzyme 2,064 | 4,145
Kinase 388 | 634
Transcription Factor 241 | 1,400
Transporter 134 | 473
Epigenetic 92 | 242
Ion Channel 83 | 344
GPCR 36 | 408
TF/Epigenetic 11 | 38
Nuclear Receptor 9 | 48
oGPCR 8 | 421

HPM Tissue

Adult Urinary Bladder 7,592 | 7,592
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155