Development Level

Tbio 7,298 | 11,651
Tdark 2,334 | 6,593
Tchem 898 | 1,388
Tclin 306 | 612

Collection

RFA-RM-18-021 141 | 328
Kinase: IDG Consortium (Target... 91 | 125
Ion Channel: IDG Consortium (T... 33 | 99
Kinase: IDG Consortium (Comple... 29 | 37
GPCR: IDG Consortium (Targets) 16 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 776 | 979
preweaning lethality, incomple... 344 | 499
embryonic lethality prior to t... 217 | 278
embryonic lethality prior to o... 210 | 239
abnormal behavior 197 | 298
abnormal embryo size 158 | 220
decreased total body fat amoun... 134 | 207
abnormal bone structure 132 | 187
decreased body weight 117 | 161
increased lean body mass 112 | 172
enlarged heart 106 | 210
decreased vertical activity 101 | 208
hyperactivity 99 | 148
decreased bone mineral content 98 | 151
abnormal heart morphology 88 | 162
increased circulating alkaline... 88 | 122
increased total body fat amoun... 88 | 134
hypoactivity 87 | 132
male infertility 87 | 123
decreased lean body mass 86 | 135
decreased bone mineral density 83 | 126
embryonic growth retardation 82 | 106
decreased circulating glucose ... 81 | 126
decreased grip strength 79 | 116
increased startle reflex 75 | 112
decreased body length 68 | 101
increased bone mineral content 68 | 108
decreased circulating choleste... 67 | 93
short tibia 67 | 97
increased mean corpuscular hem... 65 | 96
prenatal lethality prior to he... 64 | 87
cataract 62 | 92
increased or absent threshold ... 62 | 101
increased mean corpuscular vol... 61 | 92
decreased mean corpuscular vol... 60 | 79
increased circulating HDL chol... 57 | 80
abnormal seminal vesicle morph... 56 | 114
abnormal lens morphology 54 | 81
decreased prepulse inhibition 53 | 82
abnormal behavioral response t... 52 | 66
decreased circulating serum al... 52 | 82
decreased circulating triglyce... 51 | 79
impaired glucose tolerance 51 | 75
increased fasted circulating g... 51 | 76
abnormal sleep behavior 50 | 70
decreased leukocyte cell numbe... 50 | 73
increased circulating choleste... 49 | 66
abnormal retina morphology 48 | 71
decreased circulating HDL chol... 47 | 68
decreased startle reflex 47 | 75
improved glucose tolerance 47 | 79
decreased lymphocyte cell numb... 46 | 83
increased bone mineral density 46 | 72
increased heart weight 46 | 62
increased circulating sodium l... 45 | 71
decreased erythrocyte cell num... 44 | 62
decreased hemoglobin content 44 | 68
abnormal eye morphology 43 | 68
abnormal gait 43 | 69
decreased circulating insulin ... 43 | 76
abnormal coat-hair pigmentatio... 42 | 64
decreased fasted circulating g... 41 | 65
thrombocytopenia 40 | 56
decreased caudal vertebrae num... 38 | 53
decreased circulating alkaline... 38 | 46
edema 38 | 59
female infertility 36 | 60
small testis 36 | 58
decreased circulating total pr... 35 | 49
increased blood urea nitrogen ... 35 | 48
increased hematocrit 35 | 46
small superior vagus ganglion 35 | 74
decreased mean corpuscular hem... 34 | 50
increased monocyte cell number 34 | 63
increased hemoglobin content 33 | 45
increased neutrophil cell numb... 33 | 46
abnormal kidney morphology 32 | 65
decreased circulating alanine ... 32 | 47
increased circulating chloride... 32 | 41
increased erythrocyte cell num... 32 | 39
increased leukocyte cell numbe... 32 | 47
increased mean platelet volume 32 | 45
abnormal skin morphology 31 | 50
decreased blood urea nitrogen ... 31 | 51
decreased circulating LDL chol... 31 | 38
abnormal spleen morphology 30 | 55
decreased neutrophil cell numb... 30 | 42
increased circulating triglyce... 30 | 42
increased grip strength 29 | 41
tremors 29 | 39
decreased hematocrit 28 | 46
decreased red blood cell distr... 27 | 41
hydrometra 27 | 53
persistence of hyaloid vascula... 27 | 33
abnormal embryo turning 26 | 31
decreased circulating aspartat... 26 | 34
decreased circulating calcium ... 26 | 36
decreased mean corpuscular hem... 25 | 31
increased red blood cell distr... 25 | 34
prolonged QT interval 25 | 38

Disease

Carcinoma 6,950 | 11,493
ovarian cancer 5,928 | 8,520
osteosarcoma 5,031 | 7,950
medulloblastoma, large-cell 3,960 | 6,241
psoriasis 3,920 | 6,694
glioblastoma 3,713 | 5,792
atypical teratoid / rhabdoid tumor 3,225 | 5,112
lung cancer 3,141 | 4,740
ependymoma 2,953 | 4,679
group 3 medulloblastoma 2,646 | 4,104
Breast cancer 2,313 | 3,578
adult high grade glioma 2,282 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 2,121 | 3,291
malignant mesothelioma 2,098 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,919 | 2,989
primitive neuroectodermal tumor 1,889 | 3,035
invasive ductal carcinoma 1,865 | 2,951
Astrocytoma, Pilocytic 1,843 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 1,842 | 2,955
oligodendroglioma 1,816 | 2,850
Kidney cancer 1,800 | 2,613
non-small cell lung cancer 1,766 | 2,890
astrocytic glioma 1,681 | 2,597
lung adenocarcinoma 1,617 | 2,716
lung carcinoma 1,570 | 2,843
Cancer 1,511 | 2,499
pancreatic cancer 1,501 | 2,398
subependymal giant cell astrocytoma 1,475 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,448 | 1,962
Pick disease 1,322 | 1,894
tuberculosis 1,210 | 2,010
group 4 medulloblastoma 1,200 | 1,855
interstitial cystitis 1,156 | 2,312
Multiple myeloma 1,138 | 1,332
pituitary cancer 1,119 | 1,972
ductal carcinoma in situ 1,073 | 1,745
ulcerative colitis 1,052 | 1,819
breast carcinoma 1,035 | 1,638
Autosomal recessive predisposition 1,001 | 1,442
diabetes mellitus 991 | 1,728
cystic fibrosis 982 | 1,696
colon cancer 937 | 1,478
adrenocortical carcinoma 913 | 1,428
acute quadriplegic myopathy 897 | 1,158
juvenile dermatomyositis 881 | 1,187
astrocytoma 828 | 1,146
dermatomyositis 779 | 966
primary pancreatic ductal adenocarcinoma 759 | 1,109
Rheumatoid arthritis 746 | 1,191
Intellectual disability 724 | 1,016
pediatric high grade glioma 704 | 1,064
spina bifida 678 | 1,074
Schizophrenia 671 | 1,160
Waldenstrons macroglobulinemia 637 | 765
nasopharyngeal carcinoma 616 | 1,058
non primary Sjogren syndrome sicca 569 | 891
Epilepsy 566 | 792
cutaneous lupus erythematosus 558 | 1,057
Atopic dermatitis 556 | 952
active Crohn's disease 549 | 922
acute myeloid leukemia 538 | 783
gastric carcinoma 507 | 807
Liver Cirrhosis, Experimental 490 | 769
progressive supranuclear palsy 487 | 676
Cognitive delay 477 | 608
Global developmental delay 477 | 608
Mental and motor retardation 477 | 608
esophageal adenocarcinoma 466 | 737
Dull intelligence 461 | 645
Low intelligence 461 | 645
Mental Retardation 461 | 645
Mental deficiency 461 | 645
Poor school performance 461 | 645
primary Sjogren syndrome 456 | 735
Duchenne muscular dystrophy 454 | 601
medulloblastoma 450 | 720
Seizures 442 | 596
Muscle hypotonia 440 | 571
aldosterone-producing adenoma 440 | 665
Alzheimer's disease 430 | 658
active ulcerative colitis 428 | 764
Melanoma 419 | 711
Liver cancer 416 | 604
Short stature 378 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 375 | 510
pancreatic carcinoma 374 | 562
Obesity 372 | 678
Bipolar Disorder 366 | 666
hepatocellular carcinoma 351 | 547
Down syndrome 341 | 499
Amyotrophic lateral sclerosis 339 | 451
Neurodegenerative disease 332 | 414
Prostatic Neoplasms 321 | 495
Endometriosis 313 | 540
fibroadenoma 305 | 559
sonic hedgehog group medulloblastoma 302 | 467
Small head 295 | 374
gastric cancer 292 | 459
tuberculosis and treatment for 6 months 292 | 409
chronic rhinosinusitis 285 | 512

Tissue

Endocrine System 10,686 | 18,159
Female tissues 10,429 | 17,400
Digestive Tract 10,395 | 17,369
Skin and soft tissues 10,384 | 17,230
Male tissues 10,354 | 17,142
Blood and immune system 10,269 | 16,909
Liver and Pancreas 10,218 | 16,750
Nervous System 10,215 | 16,725
Urinary Tract 10,198 | 16,678
Respiratory system 10,136 | 16,393
Cardiovascular System 9,732 | 15,192

Target Family

Non-IDG 6,385 | 12,091
Enzyme 2,739 | 4,145
Transcription Factor 594 | 1,400
Kinase 503 | 634
Transporter 213 | 473
Epigenetic 177 | 242
Ion Channel 117 | 344
GPCR 57 | 408
TF/Epigenetic 20 | 38
Nuclear Receptor 16 | 48
oGPCR 15 | 421

HPM Tissue

Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275