Development Level

Tbio 6,742 | 10,625
Tdark 2,591 | 7,003
Tchem 1,209 | 1,890
Tclin 301 | 602

Collection

Eligible Kinase Proteins 99 | 134
Eligible Ion Channel Proteins 33 | 117
Eligible non-olfactory GPCR Proteins 16 | 143

IMPC Term

preweaning lethality, complete... 486 | 633
preweaning lethality, incomple... 176 | 260
abnormal behavior 161 | 226
embryonic lethality prior to t... 151 | 187
decreased lean body mass 145 | 195
decreased total body fat amoun... 134 | 186
decreased body weight 128 | 174
embryonic lethality prior to o... 127 | 148
decreased bone mineral content 107 | 157
abnormal bone structure 93 | 131
increased circulating alkaline... 91 | 119
decreased grip strength 89 | 123
decreased body length 88 | 108
decreased bone mineral density 87 | 126
abnormal embryo size 84 | 112
decreased circulating glucose ... 80 | 121
increased or absent threshold ... 78 | 128
hyperactivity 76 | 108
abnormal retina morphology 68 | 100
increased bone mineral content 67 | 92
increased lean body mass 66 | 107
increased mean corpuscular hem... 66 | 93
decreased circulating choleste... 64 | 85
increased mean corpuscular vol... 61 | 91
decreased circulating HDL chol... 59 | 77
hypoactivity 59 | 89
short tibia 58 | 82
decreased circulating triglyce... 57 | 83
abnormal lens morphology 56 | 73
increased grip strength 52 | 83
decreased circulating serum al... 51 | 79
enlarged heart 50 | 111
increased circulating sodium l... 47 | 71
decreased circulating insulin ... 45 | 75
decreased mean corpuscular vol... 45 | 50
prenatal lethality prior to he... 45 | 64
abnormal sleep behavior 43 | 63
increased circulating HDL chol... 43 | 63
increased fasted circulating g... 43 | 68
decreased lumbar vertebrae num... 42 | 62
male infertility 42 | 62
abnormal behavioral response t... 40 | 52
abnormal retinal pigmentation 40 | 61
decreased leukocyte cell numbe... 40 | 54
increased sacral vertebrae num... 39 | 62
decreased hemoglobin content 38 | 53
increased circulating choleste... 38 | 53
abnormal bone mineralization 37 | 55
decreased rib number 37 | 59
decreased caudal vertebrae num... 36 | 49
impaired glucose tolerance 36 | 52
abnormal coat/hair pigmentatio... 35 | 54
increased bone mineral density 35 | 52
increased circulating chloride... 34 | 43
thrombocytopenia 34 | 46
abnormal gait 33 | 51
decreased circulating total pr... 33 | 41
increased hemoglobin content 33 | 45
increased total body fat amoun... 33 | 57
decreased circulating alanine ... 32 | 53
decreased erythrocyte cell num... 32 | 43
improved glucose tolerance 32 | 56
increased blood urea nitrogen ... 32 | 44
decreased circulating alkaline... 31 | 41
decreased fasted circulating g... 31 | 49
decreased heart weight 31 | 44
decreased prepulse inhibition 31 | 52
decreased circulating LDL chol... 30 | 37
increased body weight 30 | 42
increased exploration in new e... 30 | 56
decreased eosinophil cell numb... 28 | 41
decreased startle reflex 28 | 48
increased hematocrit 27 | 36
increased leukocyte cell numbe... 27 | 37
abnormal eye morphology 26 | 38
increased heart weight 26 | 37
abnormal heart morphology 25 | 51
abnormal neural tube closure 25 | 37
abnormal seminal vesicle morph... 25 | 47
decreased mean corpuscular hem... 25 | 34
increased rib number 25 | 41
increased startle reflex 25 | 38
abnormal cranium morphology 24 | 32
cardiovascular system phenotyp... 24 | 35
decreased circulating calcium ... 24 | 33
decreased circulating free fat... 24 | 39
decreased neutrophil cell numb... 23 | 37
embryonic growth retardation 23 | 28
tremors 23 | 34
decreased circulating aspartat... 22 | 27
decreased circulating fructosa... 22 | 31
increased circulating potassiu... 22 | 31
small testis 22 | 37
abnormal spleen morphology 21 | 36
decreased circulating chloride... 21 | 32
increased erythrocyte cell num... 21 | 26
decreased NK T cell number 20 | 28
decreased blood urea nitrogen ... 20 | 31
decreased circulating creatini... 20 | 31
increased circulating calcium ... 20 | 32

Disease

ovarian cancer 5,905 | 8,484
osteosarcoma 5,033 | 7,933
medulloblastoma, large-cell 3,957 | 6,234
psoriasis 3,922 | 6,685
glioblastoma 3,577 | 5,572
lung cancer 3,003 | 4,466
atypical teratoid / rhabdoid tumor 2,760 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,121 | 3,289
malignant mesothelioma 2,053 | 3,162
Breast cancer 2,022 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,919 | 2,988
primitive neuroectodermal tumor 1,889 | 3,031
invasive ductal carcinoma 1,865 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,847 | 2,956
pilocytic astrocytoma 1,844 | 3,086
oligodendroglioma 1,816 | 2,849
non-small cell lung cancer 1,723 | 2,798
pediatric high grade glioma 1,722 | 2,712
ependymoma 1,698 | 2,514
lung adenocarcinoma 1,617 | 2,713
lung carcinoma 1,569 | 2,844
subependymal giant cell astrocytoma 1,473 | 2,287
group 3 medulloblastoma 1,465 | 2,254
astrocytic glioma 1,452 | 2,241
Carcinoma 1,443 | 2,147
pancreatic cancer 1,437 | 2,300
Cancer 1,428 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 1,329 | 1,795
Pick disease 1,320 | 1,893
adult high grade glioma 1,262 | 2,148
group 4 medulloblastoma 1,230 | 1,875
ulcerative colitis 1,226 | 2,087
interstitial cystitis 1,155 | 2,299
Multiple myeloma 1,135 | 1,327
pituitary cancer 1,120 | 1,972
ductal carcinoma in situ 1,075 | 1,745
astrocytoma 1,054 | 1,493
breast carcinoma 1,015 | 1,614
cystic fibrosis 964 | 1,665
medulloblastoma 953 | 1,524
tuberculosis 952 | 1,557
diabetes mellitus 951 | 1,663
sonic hedgehog group medulloblastoma 943 | 1,482
colon cancer 936 | 1,475
adrenocortical carcinoma 912 | 1,427
acute quadriplegic myopathy 895 | 1,157
posterior fossa group B ependymoma 883 | 1,530
juvenile dermatomyositis 880 | 1,189
primary pancreatic ductal adenocarcinoma 875 | 1,271
posterior fossa group A ependymoma 869 | 1,511
dermatomyositis 778 | 933
Rheumatoid Arthritis 733 | 1,160
atypical teratoid/rhabdoid tumor 677 | 1,095
spina bifida 671 | 1,064
Waldenstrons macroglobulinemia 638 | 765
nasopharyngeal carcinoma 616 | 1,056
cutaneous lupus erythematosus 558 | 1,056
Atopic dermatitis 549 | 944
active Crohn's disease 547 | 918
non primary Sjogren syndrome sicca 544 | 840
acute myeloid leukemia 537 | 780
gastric carcinoma 522 | 832
progressive supranuclear palsy 486 | 674
primary Sjogren syndrome 480 | 789
esophageal adenocarcinoma 466 | 737
tuberculosis and treatment for 6 months 466 | 686
Duchenne muscular dystrophy 454 | 602
aldosterone-producing adenoma 440 | 664
Alzheimer's disease 423 | 644
Intellectual disability 415 | 573
pancreatic carcinoma 377 | 567
Down syndrome 369 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 367 | 499
hepatocellular carcinoma 342 | 532
IGA Glomerulonephritis 332 | 454
Obesity 331 | 616
Amyotrophic Lateral Sclerosis 320 | 431
Neurodegenerative disease 312 | 383
Endometriosis 309 | 535
Prostatic Neoplasms 307 | 471
fibroadenoma 304 | 557
chronic rhinosinusitis 285 | 512
Schizophrenia 277 | 501
gastric cancer 277 | 430
mucosa-associated lymphoid tissue lymphoma 269 | 480
hereditary spastic paraplegia 265 | 313
active ulcerative colitis 255 | 477
Mammary Neoplasms 252 | 410
Multiple Sclerosis 251 | 498
Polycystic Ovary Syndrome 226 | 332
Parkinson's disease 224 | 364
inflammatory breast cancer 221 | 404
non-small cell lung carcinoma 219 | 413
Kidney disease 207 | 396
Epilepsy 206 | 346
glioblastoma multiforme 206 | 347
sarcoidosis 206 | 358
tuberculosis and treatment for 3 months 205 | 327
interstitial lung disease 200 | 291
Vascular disease 189 | 281

Tissue

Male tissues 10,843 | 17,969
Female tissues 10,805 | 18,647
Nervous System 10,781 | 18,561
Endocrine System 10,771 | 18,512
Digestive Tract 10,768 | 18,473
Liver and Pancreas 10,738 | 18,136
Urinary Tract 10,730 | 18,444
Blood and immune system 10,716 | 17,995
Cardiovascular System 10,693 | 17,958
Skin and soft tissues 10,585 | 18,115
Respiratory system 10,566 | 17,484

Target Family

Non-IDG 6,390 | 11,971
Enzyme 2,741 | 4,146
Transcription Factor 595 | 1,400
Kinase 503 | 634
Transporter 214 | 473
Epigenetic 178 | 242
Ion Channel 114 | 341
GPCR 57 | 406
TF/Epigenetic 20 | 38
Nuclear Receptor 16 | 48
oGPCR 15 | 421

HPM Tissue

Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248