Development Level

Tbio 4,952 | 10,625
Tdark 1,400 | 7,003
Tchem 968 | 1,890
Tclin 279 | 602

Collection

Eligible Kinase Proteins 69 | 134
Eligible Ion Channel Proteins 33 | 117
Eligible non-olfactory GPCR Proteins 12 | 145

IMPC Term

preweaning lethality, complete... 347 | 633
preweaning lethality, incomple... 132 | 260
abnormal behavior 126 | 226
decreased lean body mass 117 | 195
decreased total body fat amoun... 105 | 186
decreased body weight 104 | 174
embryonic lethality prior to t... 91 | 187
decreased bone mineral content 89 | 157
embryonic lethality prior to o... 83 | 148
increased circulating alkaline... 75 | 119
abnormal bone structure 73 | 131
decreased body length 65 | 108
increased or absent threshold ... 60 | 128
abnormal embryo size 59 | 112
decreased circulating glucose ... 58 | 121
decreased bone mineral density 57 | 126
decreased grip strength 57 | 123
hyperactivity 57 | 108
increased mean corpuscular hem... 54 | 93
abnormal retina morphology 52 | 100
increased lean body mass 51 | 107
abnormal lens morphology 46 | 73
increased bone mineral content 46 | 92
decreased circulating triglyce... 45 | 83
short tibia 44 | 82
decreased circulating insulin ... 42 | 75
increased fasted circulating g... 41 | 68
decreased circulating HDL chol... 40 | 77
hypoactivity 40 | 89
decreased circulating choleste... 39 | 85
decreased circulating serum al... 39 | 79
increased mean corpuscular vol... 38 | 91
increased grip strength 37 | 83
decreased mean corpuscular vol... 36 | 50
enlarged heart 35 | 111
increased circulating HDL chol... 33 | 63
prenatal lethality prior to he... 33 | 64
abnormal sleep behavior 32 | 63
increased total body fat amoun... 32 | 57
decreased lumbar vertebrae num... 30 | 62
increased circulating choleste... 30 | 53
increased circulating sodium l... 30 | 71
decreased rib number 29 | 59
impaired glucose tolerance 29 | 52
male infertility 29 | 62
abnormal retinal pigmentation 27 | 61
increased sacral vertebrae num... 27 | 62
abnormal coat/hair pigmentatio... 26 | 54
decreased caudal vertebrae num... 26 | 49
decreased fasted circulating g... 26 | 49
decreased hemoglobin content 26 | 53
abnormal bone mineralization 25 | 55
decreased circulating alanine ... 25 | 53
decreased circulating alkaline... 25 | 41
decreased prepulse inhibition 25 | 52
increased blood urea nitrogen ... 25 | 44
thrombocytopenia 25 | 46
abnormal gait 24 | 51
decreased leukocyte cell numbe... 24 | 54
increased body weight 24 | 42
increased hemoglobin content 24 | 45
abnormal behavioral response t... 23 | 52
decreased circulating total pr... 23 | 41
decreased erythrocyte cell num... 23 | 43
decreased startle reflex 23 | 48
increased circulating chloride... 23 | 43
increased exploration in new e... 23 | 56
decreased circulating LDL chol... 22 | 37
decreased eosinophil cell numb... 22 | 41
increased bone mineral density 22 | 52
cardiovascular system phenotyp... 21 | 35
decreased heart weight 21 | 44
decreased mean corpuscular hem... 21 | 34
increased heart weight 21 | 37
abnormal cranium morphology 20 | 32
abnormal neural tube closure 20 | 37
improved glucose tolerance 20 | 56
increased hematocrit 19 | 36
increased startle reflex 19 | 38
decreased circulating aspartat... 18 | 27
decreased circulating fructosa... 18 | 31
decreased neutrophil cell numb... 18 | 37
increased leukocyte cell numbe... 18 | 37
decreased circulating creatini... 17 | 31
decreased circulating free fat... 17 | 39
decreased threshold for audito... 17 | 32
increased circulating calcium ... 17 | 32
increased circulating phosphat... 17 | 24
increased rib number 17 | 41
abnormal seminal vesicle morph... 16 | 47
decreased circulating calcium ... 16 | 33
increased erythrocyte cell num... 16 | 26
limb grasping 16 | 35
tremors 16 | 34
abnormal heart morphology 15 | 51
decreased T cell number 15 | 31
decreased blood urea nitrogen ... 15 | 31
decreased circulating chloride... 15 | 32
decreased mean corpuscular hem... 15 | 19
enlarged lymph nodes 15 | 27

Disease

ovarian cancer 4,354 | 8,492
osteosarcoma 3,532 | 7,933
medulloblastoma, large-cell 3,023 | 6,234
psoriasis 2,939 | 6,685
glioblastoma 2,785 | 5,572
lung cancer 2,271 | 4,473
atypical teratoid / rhabdoid tumor 2,117 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,618 | 3,289
pilocytic astrocytoma 1,516 | 3,086
Breast cancer 1,514 | 3,099
malignant mesothelioma 1,514 | 3,163
oligodendroglioma 1,478 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,476 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,445 | 2,956
invasive ductal carcinoma 1,440 | 2,950
primitive neuroectodermal tumor 1,434 | 3,031
pediatric high grade glioma 1,372 | 2,712
ependymoma 1,343 | 2,514
non-small cell lung cancer 1,304 | 2,798
lung carcinoma 1,292 | 2,844
lung adenocarcinoma 1,265 | 2,714
subependymal giant cell astrocytoma 1,240 | 2,287
astrocytic glioma 1,152 | 2,241
pancreatic cancer 1,124 | 2,300
Cancer 1,098 | 2,346
Carcinoma 1,085 | 2,147
Pick disease 1,072 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,029 | 1,795
group 3 medulloblastoma 987 | 2,254
adult high grade glioma 981 | 2,148
ulcerative colitis 965 | 2,087
Multiple myeloma 935 | 1,328
interstitial cystitis 919 | 2,299
group 4 medulloblastoma 916 | 1,875
astrocytoma 881 | 1,493
pituitary cancer 858 | 1,972
ductal carcinoma in situ 827 | 1,745
breast carcinoma 794 | 1,614
colon cancer 781 | 1,475
diabetes mellitus 773 | 1,663
cystic fibrosis 767 | 1,670
tuberculosis 752 | 1,563
medulloblastoma 750 | 1,524
sonic hedgehog group medulloblastoma 718 | 1,482
primary pancreatic ductal adenocarcinoma 710 | 1,271
acute quadriplegic myopathy 700 | 1,157
posterior fossa group A ependymoma 687 | 1,511
adrenocortical carcinoma 676 | 1,427
juvenile dermatomyositis 669 | 1,189
dermatomyositis 626 | 967
posterior fossa group B ependymoma 594 | 1,530
Rheumatoid Arthritis 572 | 1,171
atypical teratoid/rhabdoid tumor 542 | 1,095
Waldenstrons macroglobulinemia 532 | 765
spina bifida 464 | 1,064
cutaneous lupus erythematosus 452 | 1,056
nasopharyngeal carcinoma 439 | 1,056
active Crohn's disease 430 | 918
Duchenne muscular dystrophy 399 | 602
gastric carcinoma 399 | 832
Atopic dermatitis 398 | 944
non primary Sjogren syndrome sicca 394 | 840
acute myeloid leukemia 382 | 785
progressive supranuclear palsy 379 | 674
esophageal adenocarcinoma 373 | 737
primary Sjogren syndrome 373 | 789
Alzheimer's disease 363 | 644
Down syndrome 344 | 548
aldosterone-producing adenoma 334 | 664
Intellectual disability 332 | 573
tuberculosis and treatment for 6 months 325 | 686
autosomal dominant Emery-Dreifuss muscular dystrophy 312 | 499
Neurodegenerative disease 275 | 383
Obesity 275 | 616
pancreatic carcinoma 272 | 567
Amyotrophic Lateral Sclerosis 264 | 432
fibroadenoma 261 | 557
hepatocellular carcinoma 248 | 550
mucosa-associated lymphoid tissue lymphoma 240 | 480
IGA Glomerulonephritis 235 | 454
Prostatic Neoplasms 234 | 471
Schizophrenia 233 | 503
hereditary spastic paraplegia 225 | 313
Mammary Neoplasms 210 | 410
Multiple Sclerosis 210 | 498
gastric cancer 208 | 436
active ulcerative colitis 207 | 477
Endometriosis 194 | 535
chronic rhinosinusitis 194 | 512
Parkinson's disease 188 | 364
Epilepsy 185 | 346
Polycystic Ovary Syndrome 184 | 335
Kidney disease 178 | 397
inflammatory breast cancer 176 | 404
non-small cell lung carcinoma 174 | 413
sarcoidosis 161 | 368
glioblastoma multiforme 160 | 347
nephrosclerosis 160 | 329
Stomach Neoplasms 154 | 282
interstitial lung disease 152 | 292

Tissue

Nervous System 7,599 | 18,561
Female tissues 7,584 | 18,647
Digestive Tract 7,575 | 18,473
Male tissues 7,568 | 17,969
Blood and immune system 7,566 | 17,995
Liver and Pancreas 7,566 | 18,136
Urinary Tract 7,563 | 18,444
Cardiovascular System 7,552 | 17,958
Endocrine System 7,552 | 18,512
Respiratory system 7,494 | 17,484
Skin and soft tissues 7,456 | 18,115

Target Family

Non-IDG 4,513 | 11,969
Enzyme 2,097 | 4,146
Kinase 367 | 634
Transcription Factor 193 | 1,400
Transporter 171 | 473
Ion Channel 112 | 341
Epigenetic 80 | 242
GPCR 43 | 408
TF/Epigenetic 9 | 38
oGPCR 8 | 421
Nuclear Receptor 6 | 48

HPM Tissue

Adult Spinal Cord 7,599 | 7,599
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53