Development Level

Tbio 4,952 | 10,625
Tdark 1,400 | 7,003
Tchem 967 | 1,890
Tclin 279 | 602

Collection

Kinase: IDG Consortium (Targets) 61 | 125
Ion Channel: IDG Consortium (Targets) 31 | 102
Kinase: IDG Consortium (Complete/Control) 22 | 37
GPCR: IDG Consortium (Targets) 13 | 128
GPCR: IDG Consortium (Complete/Control) 2 | 24

IMPC Phenotype

preweaning lethality, complete... 347 | 633
preweaning lethality, incomple... 132 | 260
abnormal behavior 126 | 226
decreased lean body mass 117 | 195
decreased total body fat amoun... 105 | 186
decreased body weight 104 | 174
embryonic lethality prior to t... 91 | 187
decreased bone mineral content 89 | 157
embryonic lethality prior to o... 83 | 148
increased circulating alkaline... 75 | 119
abnormal bone structure 73 | 131
decreased body length 65 | 108
increased or absent threshold ... 60 | 128
abnormal embryo size 59 | 112
decreased circulating glucose ... 58 | 121
decreased bone mineral density 57 | 126
decreased grip strength 57 | 123
hyperactivity 57 | 108
increased mean corpuscular hem... 54 | 93
abnormal retina morphology 52 | 100
increased lean body mass 51 | 107
abnormal lens morphology 46 | 73
increased bone mineral content 46 | 92
decreased circulating triglyce... 45 | 83
short tibia 44 | 82
decreased circulating insulin ... 42 | 75
increased fasted circulating g... 41 | 68
decreased circulating HDL chol... 40 | 77
hypoactivity 40 | 89
decreased circulating choleste... 39 | 85
decreased circulating serum al... 39 | 79
increased mean corpuscular vol... 38 | 91
increased grip strength 37 | 83
decreased mean corpuscular vol... 36 | 50
enlarged heart 35 | 111
increased circulating HDL chol... 33 | 63
prenatal lethality prior to he... 33 | 64
abnormal sleep behavior 32 | 63
increased total body fat amoun... 32 | 57
decreased lumbar vertebrae num... 30 | 62
increased circulating choleste... 30 | 53
increased circulating sodium l... 30 | 71
decreased rib number 29 | 59
impaired glucose tolerance 29 | 52
male infertility 29 | 62
abnormal retinal pigmentation 27 | 61
increased sacral vertebrae num... 27 | 62
abnormal coat-hair pigmentatio... 26 | 54
decreased caudal vertebrae num... 26 | 49
decreased fasted circulating g... 26 | 49
decreased hemoglobin content 26 | 53
abnormal bone mineralization 25 | 55
decreased circulating alanine ... 25 | 53
decreased circulating alkaline... 25 | 41
decreased prepulse inhibition 25 | 52
increased blood urea nitrogen ... 25 | 44
thrombocytopenia 25 | 46
abnormal gait 24 | 51
decreased leukocyte cell numbe... 24 | 54
increased body weight 24 | 42
increased hemoglobin content 24 | 45
abnormal behavioral response t... 23 | 52
decreased circulating total pr... 23 | 41
decreased erythrocyte cell num... 23 | 43
decreased startle reflex 23 | 48
increased circulating chloride... 23 | 43
increased exploration in new e... 23 | 56
decreased circulating LDL chol... 22 | 37
decreased eosinophil cell numb... 22 | 41
increased bone mineral density 22 | 52
cardiovascular system phenotyp... 21 | 35
decreased heart weight 21 | 44
decreased mean corpuscular hem... 21 | 34
increased heart weight 21 | 37
abnormal cranium morphology 20 | 32
abnormal neural tube closure 20 | 37
improved glucose tolerance 20 | 56
increased hematocrit 19 | 36
increased startle reflex 19 | 38
decreased circulating aspartat... 18 | 27
decreased circulating fructosa... 18 | 31
decreased neutrophil cell numb... 18 | 37
increased leukocyte cell numbe... 18 | 37
decreased circulating creatini... 17 | 31
decreased circulating free fat... 17 | 39
decreased threshold for audito... 17 | 32
increased circulating calcium ... 17 | 32
increased circulating phosphat... 17 | 24
increased rib number 17 | 41
abnormal seminal vesicle morph... 16 | 47
decreased circulating calcium ... 16 | 33
increased erythrocyte cell num... 16 | 26
limb grasping 16 | 35
tremors 16 | 34
abnormal heart morphology 15 | 51
decreased T cell number 15 | 31
decreased blood urea nitrogen ... 15 | 31
decreased circulating chloride... 15 | 32
decreased mean corpuscular hem... 15 | 19
enlarged lymph nodes 15 | 27

Disease

ovarian cancer 4,353 | 8,491
osteosarcoma 3,532 | 7,933
medulloblastoma, large-cell 3,023 | 6,234
psoriasis 2,939 | 6,685
glioblastoma 2,785 | 5,572
lung cancer 2,271 | 4,473
atypical teratoid / rhabdoid tumor 2,117 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,618 | 3,289
pilocytic astrocytoma 1,516 | 3,086
malignant mesothelioma 1,514 | 3,163
Breast cancer 1,513 | 3,098
oligodendroglioma 1,478 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,476 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,445 | 2,956
invasive ductal carcinoma 1,440 | 2,950
primitive neuroectodermal tumor 1,434 | 3,031
pediatric high grade glioma 1,372 | 2,712
ependymoma 1,343 | 2,514
non-small cell lung cancer 1,304 | 2,798
lung carcinoma 1,292 | 2,844
lung adenocarcinoma 1,265 | 2,714
subependymal giant cell astrocytoma 1,240 | 2,287
astrocytic glioma 1,152 | 2,241
pancreatic cancer 1,124 | 2,300
Cancer 1,098 | 2,346
Carcinoma 1,085 | 2,147
Pick disease 1,072 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,029 | 1,795
group 3 medulloblastoma 987 | 2,254
adult high grade glioma 981 | 2,148
ulcerative colitis 965 | 2,087
Multiple myeloma 934 | 1,327
interstitial cystitis 919 | 2,299
group 4 medulloblastoma 916 | 1,875
astrocytoma 881 | 1,493
pituitary cancer 858 | 1,972
ductal carcinoma in situ 827 | 1,745
breast carcinoma 794 | 1,614
colon cancer 781 | 1,475
diabetes mellitus 773 | 1,663
cystic fibrosis 767 | 1,670
tuberculosis 752 | 1,563
medulloblastoma 750 | 1,524
sonic hedgehog group medulloblastoma 718 | 1,482
primary pancreatic ductal adenocarcinoma 710 | 1,271
acute quadriplegic myopathy 700 | 1,157
posterior fossa group A ependymoma 687 | 1,511
adrenocortical carcinoma 676 | 1,427
juvenile dermatomyositis 669 | 1,189
dermatomyositis 625 | 966
posterior fossa group B ependymoma 594 | 1,530
Rheumatoid Arthritis 571 | 1,170
atypical teratoid/rhabdoid tumor 542 | 1,095
Waldenstrons macroglobulinemia 531 | 764
spina bifida 464 | 1,064
cutaneous lupus erythematosus 452 | 1,056
nasopharyngeal carcinoma 439 | 1,056
active Crohn's disease 430 | 918
Duchenne muscular dystrophy 399 | 602
gastric carcinoma 399 | 832
Atopic dermatitis 398 | 944
non primary Sjogren syndrome sicca 394 | 840
acute myeloid leukemia 382 | 785
progressive supranuclear palsy 379 | 674
esophageal adenocarcinoma 373 | 737
primary Sjogren syndrome 372 | 788
Alzheimer's disease 363 | 644
Down syndrome 344 | 548
aldosterone-producing adenoma 334 | 664
Intellectual disability 332 | 573
tuberculosis and treatment for 6 months 325 | 686
autosomal dominant Emery-Dreifuss muscular dystrophy 312 | 499
Neurodegenerative disease 275 | 383
Obesity 275 | 616
pancreatic carcinoma 272 | 567
Amyotrophic Lateral Sclerosis 264 | 432
fibroadenoma 261 | 557
hepatocellular carcinoma 248 | 550
mucosa-associated lymphoid tissue lymphoma 240 | 480
IGA Glomerulonephritis 235 | 454
Prostatic Neoplasms 234 | 471
Schizophrenia 233 | 503
hereditary spastic paraplegia 225 | 313
Mammary Neoplasms 210 | 410
Multiple Sclerosis 210 | 498
gastric cancer 208 | 436
active ulcerative colitis 207 | 477
Endometriosis 194 | 535
chronic rhinosinusitis 194 | 512
Parkinson's disease 188 | 364
Epilepsy 185 | 346
Polycystic Ovary Syndrome 183 | 334
Kidney disease 178 | 397
inflammatory breast cancer 176 | 404
non-small cell lung carcinoma 174 | 413
sarcoidosis 161 | 368
glioblastoma multiforme 160 | 347
nephrosclerosis 160 | 329
Stomach Neoplasms 154 | 282
interstitial lung disease 152 | 292

Tissue

Nervous System 7,598 | 18,560
Female tissues 7,583 | 18,646
Digestive Tract 7,574 | 18,472
Male tissues 7,567 | 17,968
Blood and immune system 7,565 | 17,994
Liver and Pancreas 7,565 | 18,135
Urinary Tract 7,562 | 18,443
Cardiovascular System 7,551 | 17,957
Endocrine System 7,551 | 18,511
Respiratory system 7,493 | 17,483
Skin and soft tissues 7,455 | 18,114

Target Family

Non-IDG 4,513 | 11,969
Enzyme 2,096 | 4,146
Kinase 367 | 634
Transcription Factor 193 | 1,400
Transporter 171 | 473
Ion Channel 112 | 341
Epigenetic 80 | 242
GPCR 43 | 408
TF/Epigenetic 9 | 38
oGPCR 8 | 421
Nuclear Receptor 6 | 48

HPM Tissue

Adult Spinal Cord 7,598 | 7,598
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Adult Adrenal 8,478 | 8,478
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114
Sorting nexin-32 SNX32 Tdark Non-IDG 0.60 0.07 75
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.7 122