Development Level

Tbio 5,259 | 11,445
Tdark 1,242 | 6,588
Tchem 809 | 1,598
Tclin 284 | 613

Collection

RFA-RM-18-021 106 | 328
Kinase: IDG Consortium (Target... 61 | 125
Ion Channel: IDG Consortium (T... 31 | 99
Kinase: IDG Consortium (Comple... 22 | 37
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 555 | 979
preweaning lethality, incomple... 256 | 499
abnormal behavior 150 | 298
embryonic lethality prior to t... 137 | 278
embryonic lethality prior to o... 134 | 239
abnormal embryo size 102 | 220
decreased total body fat amoun... 100 | 207
abnormal bone structure 97 | 187
decreased body weight 91 | 161
decreased bone mineral content 83 | 151
increased lean body mass 75 | 172
increased total body fat amoun... 73 | 134
decreased vertical activity 70 | 208
hyperactivity 70 | 148
increased circulating alkaline... 69 | 122
enlarged heart 68 | 210
decreased lean body mass 66 | 135
decreased bone mineral density 65 | 126
hypoactivity 62 | 132
decreased circulating glucose ... 59 | 126
decreased grip strength 58 | 116
increased startle reflex 58 | 112
increased bone mineral content 53 | 108
abnormal heart morphology 52 | 162
embryonic growth retardation 50 | 106
cataract 49 | 92
decreased body length 48 | 101
male infertility 48 | 123
short tibia 48 | 97
abnormal lens morphology 47 | 81
abnormal seminal vesicle morph... 45 | 114
increased mean corpuscular hem... 45 | 96
decreased prepulse inhibition 44 | 82
increased fasted circulating g... 43 | 76
increased or absent threshold ... 43 | 101
decreased circulating choleste... 42 | 93
prenatal lethality prior to he... 42 | 87
increased circulating choleste... 41 | 66
decreased mean corpuscular vol... 40 | 79
increased mean corpuscular vol... 40 | 92
decreased circulating triglyce... 39 | 79
decreased circulating insulin ... 38 | 76
increased circulating HDL chol... 38 | 80
decreased circulating serum al... 37 | 82
decreased startle reflex 37 | 75
decreased circulating HDL chol... 35 | 68
abnormal behavioral response t... 34 | 66
increased heart weight 34 | 62
abnormal retina morphology 33 | 71
decreased lymphocyte cell numb... 33 | 83
impaired glucose tolerance 33 | 75
abnormal gait 32 | 69
abnormal coat-hair pigmentatio... 31 | 64
decreased leukocyte cell numbe... 31 | 73
increased bone mineral density 31 | 72
thrombocytopenia 31 | 56
abnormal sleep behavior 30 | 70
decreased fasted circulating g... 30 | 65
decreased hemoglobin content 30 | 68
edema 30 | 59
improved glucose tolerance 30 | 79
decreased caudal vertebrae num... 29 | 53
decreased circulating total pr... 29 | 49
increased circulating sodium l... 29 | 71
increased mean platelet volume 29 | 45
decreased erythrocyte cell num... 27 | 62
abnormal eye morphology 26 | 68
decreased circulating alanine ... 26 | 47
decreased mean corpuscular hem... 26 | 50
increased blood urea nitrogen ... 26 | 48
increased hematocrit 26 | 46
decreased circulating alkaline... 25 | 46
decreased neutrophil cell numb... 25 | 42
increased leukocyte cell numbe... 24 | 47
small superior vagus ganglion 24 | 74
decreased hematocrit 23 | 46
increased erythrocyte cell num... 23 | 39
increased neutrophil cell numb... 23 | 46
decreased circulating LDL chol... 22 | 38
decreased mean corpuscular hem... 22 | 31
increased circulating chloride... 22 | 41
increased hemoglobin content 22 | 45
cardiovascular system phenotyp... 21 | 36
decreased blood urea nitrogen ... 21 | 51
decreased circulating aspartat... 21 | 34
persistence of hyaloid vascula... 21 | 33
small testis 21 | 58
decreased red blood cell distr... 20 | 41
hydrometra 20 | 53
increased monocyte cell number 20 | 63
increased prepulse inhibition 20 | 32
tremors 20 | 39
abnormal cranium morphology 19 | 36
abnormal neural tube closure 19 | 46
abnormal skin morphology 19 | 50
enlarged lymph nodes 19 | 37
increased circulating creatini... 19 | 38
increased grip strength 19 | 41
increased red blood cell distr... 19 | 34
limb grasping 19 | 41

Disease

Carcinoma 4,880 | 11,493
ovarian cancer 4,363 | 8,520
osteosarcoma 3,530 | 7,950
medulloblastoma, large-cell 3,023 | 6,241
psoriasis 2,937 | 6,694
glioblastoma 2,895 | 5,792
atypical teratoid / rhabdoid tumor 2,516 | 5,112
lung cancer 2,370 | 4,740
ependymoma 2,274 | 4,679
group 3 medulloblastoma 1,933 | 4,104
adult high grade glioma 1,820 | 3,801
Breast cancer 1,736 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,617 | 3,291
malignant mesothelioma 1,553 | 3,232
Astrocytoma, Pilocytic 1,515 | 3,081
oligodendroglioma 1,477 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 1,475 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,442 | 2,955
invasive ductal carcinoma 1,439 | 2,951
primitive neuroectodermal tumor 1,434 | 3,035
astrocytic glioma 1,361 | 2,597
Kidney cancer 1,339 | 2,613
non-small cell lung cancer 1,335 | 2,890
lung carcinoma 1,293 | 2,843
lung adenocarcinoma 1,264 | 2,716
subependymal giant cell astrocytoma 1,241 | 2,287
pancreatic cancer 1,178 | 2,398
Cancer 1,153 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 1,127 | 1,962
Pick disease 1,073 | 1,894
tuberculosis 941 | 2,010
Multiple myeloma 937 | 1,332
interstitial cystitis 918 | 2,312
group 4 medulloblastoma 891 | 1,855
pituitary cancer 857 | 1,972
Autosomal recessive predisposition 831 | 1,442
ductal carcinoma in situ 826 | 1,745
ulcerative colitis 816 | 1,819
breast carcinoma 808 | 1,638
diabetes mellitus 805 | 1,728
colon cancer 782 | 1,478
cystic fibrosis 781 | 1,696
acute quadriplegic myopathy 701 | 1,158
adrenocortical carcinoma 675 | 1,428
astrocytoma 673 | 1,146
juvenile dermatomyositis 670 | 1,187
dermatomyositis 625 | 966
primary pancreatic ductal adenocarcinoma 614 | 1,109
Schizophrenia 590 | 1,160
Rheumatoid arthritis 578 | 1,191
Intellectual disability 576 | 1,016
pediatric high grade glioma 534 | 1,064
Waldenstrons macroglobulinemia 531 | 765
Epilepsy 477 | 792
spina bifida 471 | 1,074
cutaneous lupus erythematosus 452 | 1,057
nasopharyngeal carcinoma 440 | 1,058
active Crohn's disease 433 | 922
Liver Cirrhosis, Experimental 422 | 769
non primary Sjogren syndrome sicca 416 | 891
Atopic dermatitis 400 | 952
Duchenne muscular dystrophy 398 | 601
Cognitive delay 389 | 608
Global developmental delay 389 | 608
Mental and motor retardation 389 | 608
gastric carcinoma 385 | 807
acute myeloid leukemia 383 | 783
progressive supranuclear palsy 381 | 676
Dull intelligence 380 | 645
Low intelligence 380 | 645
Mental Retardation 380 | 645
Mental deficiency 380 | 645
Poor school performance 380 | 645
esophageal adenocarcinoma 373 | 737
Seizures 371 | 596
Muscle hypotonia 366 | 571
Alzheimer's disease 360 | 658
active ulcerative colitis 356 | 764
primary Sjogren syndrome 352 | 735
aldosterone-producing adenoma 334 | 665
medulloblastoma 330 | 720
Liver cancer 328 | 604
Down syndrome 326 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 319 | 510
Bipolar Disorder 316 | 666
Melanoma 310 | 711
Obesity 310 | 678
Short stature 295 | 531
Neurodegenerative disease 292 | 414
Amyotrophic lateral sclerosis 278 | 451
pancreatic carcinoma 270 | 562
fibroadenoma 262 | 559
hepatocellular carcinoma 244 | 547
Prostatic Neoplasms 243 | 495
mucosa-associated lymphoid tissue lymphoma 239 | 484
Multiple Sclerosis 227 | 540
hereditary spastic paraplegia 227 | 318
Breast Neoplasms 226 | 445
Skin cancer 226 | 469
Small head 223 | 374

Tissue

Endocrine System 7,480 | 18,159
Female tissues 7,382 | 17,400
Digestive Tract 7,371 | 17,369
Skin and soft tissues 7,367 | 17,230
Male tissues 7,311 | 17,142
Blood and immune system 7,283 | 16,909
Liver and Pancreas 7,264 | 16,750
Nervous System 7,256 | 16,725
Urinary Tract 7,241 | 16,678
Respiratory system 7,174 | 16,393
Cardiovascular System 6,948 | 15,192

Target Family

Non-IDG 4,507 | 12,091
Enzyme 2,095 | 4,145
Kinase 367 | 634
Transcription Factor 193 | 1,400
Transporter 171 | 473
Ion Channel 115 | 344
Epigenetic 80 | 242
GPCR 43 | 408
TF/Epigenetic 9 | 38
oGPCR 8 | 421
Nuclear Receptor 6 | 48

HPM Tissue

Adult Spinal Cord 7,594 | 7,594
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141