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Target Filters...

Development Level

Tbio 6,795 | 11,445
Tdark 2,013 | 6,588
Tchem 967 | 1,598
Tclin 340 | 613

Collection

RFA-RM-18-021 137 | 328
Kinase: IDG Consortium (Target... 79 | 125
Ion Channel: IDG Consortium (T... 42 | 99
Kinase: IDG Consortium (Comple... 27 | 37
GPCR: IDG Consortium (Targets) 15 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 737 | 979
preweaning lethality, incomple... 323 | 499
embryonic lethality prior to t... 205 | 278
abnormal behavior 198 | 298
embryonic lethality prior to o... 193 | 239
abnormal embryo size 147 | 220
decreased total body fat amoun... 137 | 207
abnormal bone structure 120 | 187
decreased body weight 112 | 161
enlarged heart 108 | 210
increased lean body mass 104 | 172
hyperactivity 97 | 148
decreased vertical activity 96 | 208
decreased bone mineral content 93 | 151
increased total body fat amoun... 88 | 134
decreased bone mineral density 84 | 126
increased circulating alkaline... 83 | 122
abnormal heart morphology 81 | 162
decreased lean body mass 80 | 135
decreased circulating glucose ... 79 | 126
decreased grip strength 79 | 116
hypoactivity 79 | 132
increased startle reflex 78 | 112
embryonic growth retardation 77 | 106
male infertility 70 | 123
decreased body length 65 | 101
decreased circulating choleste... 64 | 93
short tibia 64 | 97
increased or absent threshold ... 63 | 101
cataract 62 | 92
prenatal lethality prior to he... 62 | 87
abnormal seminal vesicle morph... 61 | 114
increased bone mineral content 61 | 108
increased mean corpuscular hem... 59 | 96
abnormal lens morphology 56 | 81
decreased prepulse inhibition 56 | 82
increased mean corpuscular vol... 56 | 92
abnormal retina morphology 53 | 71
decreased circulating triglyce... 50 | 79
decreased startle reflex 50 | 75
decreased circulating serum al... 47 | 82
decreased leukocyte cell numbe... 47 | 73
decreased lymphocyte cell numb... 46 | 83
decreased mean corpuscular vol... 46 | 79
increased fasted circulating g... 46 | 76
decreased circulating HDL chol... 45 | 68
impaired glucose tolerance 44 | 75
abnormal gait 43 | 69
abnormal behavioral response t... 42 | 66
abnormal eye morphology 42 | 68
decreased hemoglobin content 41 | 68
increased circulating HDL chol... 41 | 80
decreased circulating insulin ... 40 | 76
decreased fasted circulating g... 40 | 65
increased heart weight 40 | 62
decreased circulating alkaline... 39 | 46
decreased erythrocyte cell num... 39 | 62
increased bone mineral density 39 | 72
small superior vagus ganglion 39 | 74
abnormal coat-hair pigmentatio... 38 | 64
decreased caudal vertebrae num... 38 | 53
improved glucose tolerance 38 | 79
increased circulating choleste... 38 | 66
abnormal sleep behavior 37 | 70
thrombocytopenia 37 | 56
increased circulating sodium l... 36 | 71
edema 35 | 59
decreased circulating total pr... 34 | 49
increased mean platelet volume 34 | 45
decreased circulating alanine ... 31 | 47
increased circulating chloride... 31 | 41
increased monocyte cell number 31 | 63
abnormal kidney morphology 30 | 65
decreased circulating LDL chol... 30 | 38
decreased neutrophil cell numb... 30 | 42
increased hemoglobin content 30 | 45
increased leukocyte cell numbe... 30 | 47
tremors 30 | 39
abnormal spleen morphology 29 | 55
increased hematocrit 29 | 46
increased neutrophil cell numb... 29 | 46
small testis 29 | 58
abnormal skin morphology 28 | 50
decreased mean corpuscular hem... 28 | 50
female infertility 28 | 60
hydrometra 28 | 53
increased blood urea nitrogen ... 28 | 48
decreased red blood cell distr... 27 | 41
increased grip strength 27 | 41
limb grasping 27 | 41
decreased hematocrit 26 | 46
increased erythrocyte cell num... 26 | 39
increased prepulse inhibition 26 | 32
abnormal neural tube closure 25 | 46
decreased circulating aspartat... 25 | 34
persistence of hyaloid vascula... 25 | 33
abnormal bone mineralization 24 | 38
cardiovascular system phenotyp... 24 | 36
enlarged spleen 24 | 41
prolonged QT interval 24 | 38

Disease

Carcinoma 6,594 | 11,493
ovarian cancer 5,590 | 8,520
osteosarcoma 4,746 | 7,950
medulloblastoma, large-cell 3,950 | 6,241
glioblastoma 3,683 | 5,792
psoriasis 3,673 | 6,694
atypical teratoid / rhabdoid tumor 3,256 | 5,112
lung cancer 2,986 | 4,740
ependymoma 2,937 | 4,679
group 3 medulloblastoma 2,604 | 4,104
adult high grade glioma 2,289 | 3,801
Breast cancer 2,161 | 3,578
malignant mesothelioma 1,992 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,960 | 3,291
oligodendroglioma 1,874 | 2,850
primitive neuroectodermal tumor 1,872 | 3,035
Astrocytoma, Pilocytic 1,839 | 3,081
Kidney cancer 1,790 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 1,760 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,758 | 2,955
astrocytic glioma 1,739 | 2,597
invasive ductal carcinoma 1,708 | 2,951
non-small cell lung cancer 1,581 | 2,890
lung carcinoma 1,542 | 2,843
subependymal giant cell astrocytoma 1,503 | 2,287
lung adenocarcinoma 1,478 | 2,716
pancreatic cancer 1,387 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1,365 | 1,962
Pick disease 1,352 | 1,894
Cancer 1,347 | 2,499
group 4 medulloblastoma 1,175 | 1,855
tuberculosis 1,147 | 2,010
Multiple myeloma 1,095 | 1,332
interstitial cystitis 1,087 | 2,312
pituitary cancer 1,087 | 1,972
Autosomal recessive predisposition 988 | 1,442
ulcerative colitis 954 | 1,819
ductal carcinoma in situ 952 | 1,745
breast carcinoma 932 | 1,638
diabetes mellitus 930 | 1,728
cystic fibrosis 908 | 1,696
colon cancer 884 | 1,478
acute quadriplegic myopathy 850 | 1,158
adrenocortical carcinoma 813 | 1,428
astrocytoma 810 | 1,146
juvenile dermatomyositis 801 | 1,187
Intellectual disability 753 | 1,016
dermatomyositis 739 | 966
Schizophrenia 735 | 1,160
Rheumatoid arthritis 718 | 1,191
primary pancreatic ductal adenocarcinoma 703 | 1,109
pediatric high grade glioma 694 | 1,064
spina bifida 647 | 1,074
Waldenstrons macroglobulinemia 606 | 765
Epilepsy 600 | 792
non primary Sjogren syndrome sicca 553 | 891
nasopharyngeal carcinoma 540 | 1,058
cutaneous lupus erythematosus 529 | 1,057
acute myeloid leukemia 518 | 783
active Crohn's disease 504 | 922
progressive supranuclear palsy 490 | 676
Dull intelligence 489 | 645
Low intelligence 489 | 645
Mental Retardation 489 | 645
Mental deficiency 489 | 645
Poor school performance 489 | 645
Cognitive delay 468 | 608
Global developmental delay 468 | 608
Mental and motor retardation 468 | 608
Atopic dermatitis 459 | 952
gastric carcinoma 457 | 807
Seizures 445 | 596
medulloblastoma 444 | 720
Muscle hypotonia 443 | 571
Liver Cirrhosis, Experimental 441 | 769
Alzheimer's disease 440 | 658
esophageal adenocarcinoma 433 | 737
Liver cancer 427 | 604
aldosterone-producing adenoma 418 | 665
Melanoma 411 | 711
Bipolar Disorder 405 | 666
primary Sjogren syndrome 405 | 735
active ulcerative colitis 401 | 764
Duchenne muscular dystrophy 391 | 601
Obesity 367 | 678
Short stature 360 | 531
Down syndrome 341 | 499
pancreatic carcinoma 340 | 562
hepatocellular carcinoma 336 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 334 | 510
Neurodegenerative disease 333 | 414
Amyotrophic lateral sclerosis 326 | 451
Prostatic Neoplasms 300 | 495
Skin cancer 291 | 469
gastric cancer 284 | 459
sonic hedgehog group medulloblastoma 284 | 467
Small head 281 | 374
tuberculosis and treatment for 6 months 273 | 409
fibroadenoma 270 | 559
Failure to gain weight 268 | 365

Tissue

Endocrine System 9,979 | 18,159
Female tissues 9,806 | 17,400
Digestive Tract 9,800 | 17,369
Skin and soft tissues 9,783 | 17,230
Male tissues 9,739 | 17,142
Blood and immune system 9,677 | 16,909
Nervous System 9,674 | 16,725
Liver and Pancreas 9,631 | 16,750
Urinary Tract 9,623 | 16,678
Respiratory system 9,542 | 16,393
Cardiovascular System 9,186 | 15,192

Target Family

Non-IDG 5,831 | 12,091
Enzyme 2,565 | 4,145
Transcription Factor 546 | 1,400
Kinase 462 | 634
Transporter 253 | 473
Epigenetic 169 | 242
Ion Channel 164 | 344
GPCR 75 | 408
TF/Epigenetic 22 | 38
Nuclear Receptor 18 | 48
oGPCR 10 | 421

HPM Tissue

Adult Retina 10,115 | 10,115
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190