Development Level

Tbio 6,366 | 10,625
Tdark 2,277 | 7,003
Tchem 1,147 | 1,890
Tclin 334 | 602

Collection

Eligible Kinase Proteins 83 | 134
Eligible Ion Channel Proteins 47 | 117
Eligible non-olfactory GPCR Proteins 18 | 143

IMPC Term

preweaning lethality, complete... 458 | 633
preweaning lethality, incomple... 170 | 260
abnormal behavior 156 | 226
decreased lean body mass 137 | 195
embryonic lethality prior to t... 136 | 187
decreased total body fat amoun... 131 | 186
decreased body weight 118 | 174
embryonic lethality prior to o... 117 | 148
decreased bone mineral content 104 | 157
decreased grip strength 88 | 123
increased circulating alkaline... 87 | 119
abnormal bone structure 85 | 131
increased or absent threshold ... 83 | 128
hyperactivity 77 | 108
decreased bone mineral density 76 | 126
decreased body length 75 | 108
abnormal embryo size 74 | 112
decreased circulating glucose ... 72 | 121
increased lean body mass 71 | 107
abnormal retina morphology 67 | 100
increased mean corpuscular hem... 61 | 93
decreased circulating choleste... 60 | 85
increased bone mineral content 58 | 92
decreased circulating HDL chol... 56 | 77
enlarged heart 56 | 111
increased mean corpuscular vol... 54 | 91
abnormal lens morphology 52 | 73
hypoactivity 52 | 89
increased grip strength 52 | 83
short tibia 52 | 82
decreased circulating triglyce... 51 | 83
decreased circulating serum al... 48 | 79
abnormal retinal pigmentation 44 | 61
decreased circulating insulin ... 44 | 75
prenatal lethality prior to he... 44 | 64
increased fasted circulating g... 43 | 68
male infertility 41 | 62
increased circulating sodium l... 40 | 71
abnormal sleep behavior 38 | 63
decreased leukocyte cell numbe... 38 | 54
decreased mean corpuscular vol... 38 | 50
impaired glucose tolerance 36 | 52
decreased lumbar vertebrae num... 35 | 62
abnormal bone mineralization 34 | 55
abnormal gait 34 | 51
decreased caudal vertebrae num... 34 | 49
decreased hemoglobin content 34 | 53
decreased rib number 34 | 59
increased total body fat amoun... 34 | 57
decreased prepulse inhibition 32 | 52
increased body weight 32 | 42
increased bone mineral density 32 | 52
increased circulating HDL chol... 32 | 63
increased sacral vertebrae num... 32 | 62
decreased circulating alanine ... 31 | 53
decreased fasted circulating g... 31 | 49
increased blood urea nitrogen ... 31 | 44
increased circulating chloride... 31 | 43
increased circulating choleste... 31 | 53
increased hemoglobin content 31 | 45
abnormal coat/hair pigmentatio... 30 | 54
decreased circulating LDL chol... 30 | 37
decreased circulating alkaline... 30 | 41
decreased startle reflex 30 | 48
abnormal behavioral response t... 29 | 52
decreased erythrocyte cell num... 29 | 43
increased exploration in new e... 29 | 56
thrombocytopenia 29 | 46
decreased heart weight 28 | 44
decreased circulating total pr... 27 | 41
improved glucose tolerance 26 | 56
increased startle reflex 26 | 38
decreased eosinophil cell numb... 25 | 41
increased leukocyte cell numbe... 25 | 37
tremors 25 | 34
abnormal heart morphology 24 | 51
abnormal seminal vesicle morph... 24 | 47
cardiovascular system phenotyp... 24 | 35
decreased mean corpuscular hem... 24 | 34
increased heart weight 24 | 37
increased hematocrit 24 | 36
increased rib number 24 | 41
abnormal cranium morphology 23 | 32
abnormal neural tube closure 23 | 37
decreased neutrophil cell numb... 23 | 37
decreased circulating free fat... 22 | 39
decreased circulating fructosa... 22 | 31
abnormal eye morphology 21 | 38
abnormal spleen morphology 21 | 36
decreased circulating aspartat... 21 | 27
decreased circulating calcium ... 21 | 33
limb grasping 21 | 35
decreased circulating chloride... 20 | 32
increased circulating phosphat... 20 | 24
increased mean corpuscular hem... 20 | 25
abnormal rib morphology 19 | 28
decreased circulating creatini... 19 | 31
increased circulating calcium ... 19 | 32
increased erythrocyte cell num... 18 | 26
small testis 18 | 37

Disease

ovarian cancer 5,571 | 8,484
osteosarcoma 4,748 | 7,933
medulloblastoma, large-cell 3,948 | 6,234
psoriasis 3,676 | 6,685
glioblastoma 3,552 | 5,572
lung cancer 2,832 | 4,466
atypical teratoid / rhabdoid tumor 2,789 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,959 | 3,289
malignant mesothelioma 1,954 | 3,162
Breast cancer 1,884 | 3,094
oligodendroglioma 1,874 | 2,849
primitive neuroectodermal tumor 1,872 | 3,031
pilocytic astrocytoma 1,846 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,763 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 1,760 | 2,988
pediatric high grade glioma 1,714 | 2,712
invasive ductal carcinoma 1,708 | 2,950
ependymoma 1,704 | 2,514
non-small cell lung cancer 1,545 | 2,798
lung carcinoma 1,542 | 2,844
subependymal giant cell astrocytoma 1,502 | 2,287
astrocytic glioma 1,493 | 2,241
lung adenocarcinoma 1,481 | 2,713
Carcinoma 1,458 | 2,147
group 3 medulloblastoma 1,403 | 2,254
Pick disease 1,350 | 1,893
pancreatic cancer 1,323 | 2,300
Cancer 1,275 | 2,346
adult high grade glioma 1,267 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 1,257 | 1,795
group 4 medulloblastoma 1,193 | 1,875
ulcerative colitis 1,108 | 2,087
Multiple myeloma 1,093 | 1,327
pituitary cancer 1,089 | 1,972
interstitial cystitis 1,086 | 2,299
astrocytoma 1,051 | 1,493
medulloblastoma 987 | 1,524
ductal carcinoma in situ 954 | 1,745
sonic hedgehog group medulloblastoma 919 | 1,482
breast carcinoma 914 | 1,614
cystic fibrosis 893 | 1,665
diabetes mellitus 893 | 1,663
tuberculosis 890 | 1,557
colon cancer 883 | 1,475
acute quadriplegic myopathy 848 | 1,157
posterior fossa group A ependymoma 846 | 1,511
posterior fossa group B ependymoma 844 | 1,530
adrenocortical carcinoma 814 | 1,427
primary pancreatic ductal adenocarcinoma 809 | 1,271
juvenile dermatomyositis 800 | 1,189
dermatomyositis 738 | 933
Rheumatoid Arthritis 702 | 1,160
atypical teratoid/rhabdoid tumor 661 | 1,095
spina bifida 643 | 1,064
Waldenstrons macroglobulinemia 607 | 765
nasopharyngeal carcinoma 539 | 1,056
cutaneous lupus erythematosus 530 | 1,056
non primary Sjogren syndrome sicca 529 | 840
acute myeloid leukemia 514 | 780
active Crohn's disease 502 | 918
progressive supranuclear palsy 489 | 674
gastric carcinoma 472 | 832
tuberculosis and treatment for 6 months 458 | 686
Atopic dermatitis 454 | 944
Alzheimer's disease 433 | 644
esophageal adenocarcinoma 433 | 737
primary Sjogren syndrome 428 | 789
Intellectual disability 424 | 573
aldosterone-producing adenoma 418 | 664
Duchenne muscular dystrophy 390 | 602
Down syndrome 365 | 548
pancreatic carcinoma 342 | 567
autosomal dominant Emery-Dreifuss muscular dystrophy 327 | 499
hepatocellular carcinoma 327 | 532
Neurodegenerative disease 315 | 383
Obesity 311 | 616
Amyotrophic Lateral Sclerosis 308 | 431
Schizophrenia 302 | 501
Prostatic Neoplasms 288 | 471
IGA Glomerulonephritis 286 | 454
fibroadenoma 269 | 557
gastric cancer 269 | 430
hereditary spastic paraplegia 257 | 313
chronic rhinosinusitis 255 | 512
Epilepsy 251 | 346
Endometriosis 248 | 535
mucosa-associated lymphoid tissue lymphoma 248 | 480
active ulcerative colitis 244 | 477
Multiple Sclerosis 241 | 498
Mammary Neoplasms 237 | 410
Parkinson's disease 230 | 364
inflammatory breast cancer 219 | 404
non-small cell lung carcinoma 215 | 413
Polycystic Ovary Syndrome 196 | 332
Autistic Disorder 195 | 320
glioblastoma multiforme 194 | 347
Kidney disease 191 | 396
sarcoidosis 191 | 358
interstitial lung disease 184 | 291
tuberculosis and treatment for 3 months 181 | 327

Tissue

Nervous System 10,124 | 18,561
Female tissues 10,097 | 18,647
Digestive Tract 10,091 | 18,473
Male tissues 10,074 | 17,969
Endocrine System 10,072 | 18,512
Blood and immune system 10,068 | 17,995
Liver and Pancreas 10,068 | 18,136
Urinary Tract 10,062 | 18,444
Cardiovascular System 10,051 | 17,958
Respiratory system 9,955 | 17,484
Skin and soft tissues 9,936 | 18,115

Target Family

Non-IDG 5,837 | 11,971
Enzyme 2,567 | 4,146
Transcription Factor 547 | 1,400
Kinase 462 | 634
Transporter 254 | 473
Epigenetic 170 | 242
Ion Channel 162 | 341
GPCR 75 | 406
TF/Epigenetic 22 | 38
Nuclear Receptor 18 | 48
oGPCR 10 | 421

HPM Tissue

Adult Retina 10,124 | 10,124
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48