Development Level

Tbio 5,743 | 10,625
Tdark 1,819 | 7,003
Tchem 1,124 | 1,890
Tclin 277 | 602

Collection

Eligible Kinase Proteins 71 | 134
Eligible Ion Channel Proteins 30 | 117
Eligible non-olfactory GPCR Proteins 9 | 143

IMPC Term

preweaning lethality, complete... 402 | 633
preweaning lethality, incomple... 146 | 260
abnormal behavior 128 | 226
embryonic lethality prior to t... 122 | 187
decreased lean body mass 117 | 195
decreased total body fat amoun... 111 | 186
embryonic lethality prior to o... 108 | 148
decreased body weight 103 | 174
decreased bone mineral content 91 | 157
increased circulating alkaline... 76 | 119
abnormal bone structure 74 | 131
decreased body length 70 | 108
increased or absent threshold ... 70 | 128
abnormal embryo size 69 | 112
decreased bone mineral density 68 | 126
decreased grip strength 68 | 123
abnormal retina morphology 65 | 100
decreased circulating glucose ... 63 | 121
hyperactivity 62 | 108
increased lean body mass 58 | 107
increased mean corpuscular hem... 55 | 93
increased bone mineral content 53 | 92
hypoactivity 52 | 89
short tibia 51 | 82
abnormal lens morphology 49 | 73
increased grip strength 48 | 83
decreased circulating choleste... 46 | 85
increased fasted circulating g... 45 | 68
decreased circulating HDL chol... 44 | 77
decreased circulating serum al... 44 | 79
increased mean corpuscular vol... 44 | 91
decreased circulating triglyce... 42 | 83
decreased circulating insulin ... 41 | 75
enlarged heart 41 | 111
decreased mean corpuscular vol... 38 | 50
increased circulating sodium l... 37 | 71
prenatal lethality prior to he... 37 | 64
abnormal retinal pigmentation 36 | 61
decreased lumbar vertebrae num... 35 | 62
abnormal sleep behavior 34 | 63
decreased leukocyte cell numbe... 31 | 54
male infertility 31 | 62
decreased rib number 30 | 59
impaired glucose tolerance 30 | 52
abnormal bone mineralization 29 | 55
decreased fasted circulating g... 29 | 49
increased circulating HDL chol... 29 | 63
increased circulating choleste... 29 | 53
increased exploration in new e... 29 | 56
increased total body fat amoun... 29 | 57
increased blood urea nitrogen ... 28 | 44
increased bone mineral density 28 | 52
increased sacral vertebrae num... 28 | 62
decreased caudal vertebrae num... 27 | 49
decreased hemoglobin content 27 | 53
thrombocytopenia 27 | 46
abnormal coat/hair pigmentatio... 26 | 54
abnormal gait 26 | 51
decreased circulating alanine ... 26 | 53
increased hemoglobin content 26 | 45
abnormal behavioral response t... 25 | 52
increased body weight 25 | 42
decreased circulating LDL chol... 24 | 37
decreased circulating total pr... 24 | 41
decreased eosinophil cell numb... 24 | 41
decreased erythrocyte cell num... 24 | 43
decreased prepulse inhibition 24 | 52
increased circulating chloride... 24 | 43
increased hematocrit 24 | 36
decreased circulating alkaline... 23 | 41
decreased circulating calcium ... 23 | 33
decreased mean corpuscular hem... 23 | 34
decreased startle reflex 23 | 48
improved glucose tolerance 23 | 56
cardiovascular system phenotyp... 22 | 35
increased rib number 22 | 41
abnormal neural tube closure 21 | 37
decreased circulating free fat... 21 | 39
decreased heart weight 21 | 44
increased heart weight 21 | 37
abnormal seminal vesicle morph... 20 | 47
increased circulating phosphat... 20 | 24
increased leukocyte cell numbe... 20 | 37
abnormal eye morphology 19 | 38
decreased circulating aspartat... 19 | 27
decreased circulating fructosa... 19 | 31
increased circulating calcium ... 19 | 32
increased circulating potassiu... 19 | 31
increased startle reflex 19 | 38
abnormal cranium morphology 17 | 32
decreased neutrophil cell numb... 17 | 37
decreased threshold for audito... 17 | 32
small testis 17 | 37
tremors 17 | 34
abnormal heart morphology 16 | 51
abnormal testis morphology 16 | 30
decreased circulating creatini... 16 | 31
female infertility 16 | 34
decreased NK T cell number 15 | 28
decreased circulating iron lev... 15 | 25

Disease

ovarian cancer 5,112 | 8,484
osteosarcoma 4,251 | 7,933
psoriasis 3,392 | 6,685
medulloblastoma, large-cell 3,330 | 6,234
glioblastoma 3,103 | 5,572
lung cancer 2,674 | 4,466
atypical teratoid / rhabdoid tumor 2,350 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,917 | 3,289
malignant mesothelioma 1,787 | 3,162
Breast cancer 1,771 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,737 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,715 | 2,956
invasive ductal carcinoma 1,705 | 2,950
pilocytic astrocytoma 1,653 | 3,086
non-small cell lung cancer 1,571 | 2,798
primitive neuroectodermal tumor 1,566 | 3,031
oligodendroglioma 1,559 | 2,849
pediatric high grade glioma 1,500 | 2,712
lung adenocarcinoma 1,482 | 2,713
lung carcinoma 1,460 | 2,844
ependymoma 1,438 | 2,514
pancreatic cancer 1,373 | 2,300
subependymal giant cell astrocytoma 1,316 | 2,287
Cancer 1,314 | 2,346
Carcinoma 1,238 | 2,147
astrocytic glioma 1,216 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,195 | 1,795
group 3 medulloblastoma 1,167 | 2,254
ulcerative colitis 1,149 | 2,087
Pick disease 1,134 | 1,893
interstitial cystitis 1,121 | 2,299
adult high grade glioma 1,097 | 2,148
group 4 medulloblastoma 1,063 | 1,875
Multiple myeloma 1,042 | 1,327
pituitary cancer 1,001 | 1,972
astrocytoma 976 | 1,493
ductal carcinoma in situ 962 | 1,745
breast carcinoma 934 | 1,614
colon cancer 897 | 1,475
diabetes mellitus 893 | 1,663
cystic fibrosis 889 | 1,665
primary pancreatic ductal adenocarcinoma 842 | 1,271
tuberculosis 832 | 1,557
acute quadriplegic myopathy 830 | 1,157
sonic hedgehog group medulloblastoma 807 | 1,482
medulloblastoma 801 | 1,524
juvenile dermatomyositis 797 | 1,189
posterior fossa group A ependymoma 783 | 1,511
adrenocortical carcinoma 774 | 1,427
dermatomyositis 710 | 933
posterior fossa group B ependymoma 679 | 1,530
Rheumatoid Arthritis 653 | 1,160
Waldenstrons macroglobulinemia 609 | 765
spina bifida 589 | 1,064
atypical teratoid/rhabdoid tumor 578 | 1,095
nasopharyngeal carcinoma 522 | 1,056
cutaneous lupus erythematosus 521 | 1,056
active Crohn's disease 503 | 918
gastric carcinoma 495 | 832
Atopic dermatitis 481 | 944
non primary Sjogren syndrome sicca 476 | 840
acute myeloid leukemia 469 | 780
esophageal adenocarcinoma 458 | 737
Duchenne muscular dystrophy 446 | 602
primary Sjogren syndrome 444 | 789
progressive supranuclear palsy 406 | 674
aldosterone-producing adenoma 392 | 664
tuberculosis and treatment for 6 months 384 | 686
Alzheimer's disease 371 | 644
Down syndrome 363 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 360 | 499
Intellectual disability 346 | 573
pancreatic carcinoma 319 | 567
fibroadenoma 311 | 557
Obesity 305 | 616
Prostatic Neoplasms 292 | 471
IGA Glomerulonephritis 291 | 454
hepatocellular carcinoma 284 | 532
Amyotrophic Lateral Sclerosis 283 | 431
Neurodegenerative disease 277 | 383
mucosa-associated lymphoid tissue lymphoma 273 | 480
Endometriosis 254 | 535
Mammary Neoplasms 245 | 410
active ulcerative colitis 244 | 477
gastric cancer 242 | 430
Schizophrenia 236 | 501
hereditary spastic paraplegia 236 | 313
Multiple Sclerosis 222 | 498
chronic rhinosinusitis 219 | 512
Parkinson's disease 206 | 364
Kidney disease 203 | 396
inflammatory breast cancer 202 | 404
non-small cell lung carcinoma 194 | 413
glioblastoma multiforme 188 | 347
Polycystic Ovary Syndrome 186 | 332
sarcoidosis 185 | 358
interstitial lung disease 183 | 291
Stomach Neoplasms 175 | 282
nephrosclerosis 175 | 329
urothelial carcinoma 175 | 318

Tissue

Male tissues 8,963 | 17,969
Nervous System 8,950 | 18,561
Digestive Tract 8,947 | 18,473
Female tissues 8,947 | 18,647
Liver and Pancreas 8,936 | 18,136
Blood and immune system 8,934 | 17,995
Endocrine System 8,928 | 18,512
Urinary Tract 8,927 | 18,444
Cardiovascular System 8,913 | 17,958
Respiratory system 8,856 | 17,484
Skin and soft tissues 8,802 | 18,115

Target Family

Non-IDG 5,264 | 11,971
Enzyme 2,371 | 4,146
Transcription Factor 431 | 1,400
Kinase 421 | 634
Transporter 179 | 473
Epigenetic 135 | 242
Ion Channel 90 | 341
GPCR 41 | 406
TF/Epigenetic 13 | 38
Nuclear Receptor 10 | 48
oGPCR 8 | 421

HPM Tissue

Adult Prostate 8,963 | 8,963
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48