Development Level

Tbio 6,217 | 11,651
Tdark 1,616 | 6,593
Tchem 838 | 1,388
Tclin 281 | 612

Collection

RFA-RM-18-021 104 | 328
Kinase: IDG Consortium (Target... 65 | 125
Ion Channel: IDG Consortium (T... 29 | 99
Kinase: IDG Consortium (Comple... 23 | 37
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 660 | 979
preweaning lethality, incomple... 288 | 499
embryonic lethality prior to t... 177 | 278
embryonic lethality prior to o... 168 | 239
abnormal behavior 159 | 298
abnormal embryo size 133 | 220
decreased total body fat amoun... 111 | 207
abnormal bone structure 106 | 187
decreased body weight 89 | 161
decreased bone mineral content 84 | 151
enlarged heart 83 | 210
decreased vertical activity 82 | 208
increased lean body mass 82 | 172
hyperactivity 78 | 148
hypoactivity 77 | 132
increased total body fat amoun... 73 | 134
increased circulating alkaline... 71 | 122
embryonic growth retardation 70 | 106
decreased circulating glucose ... 66 | 126
increased startle reflex 66 | 112
decreased bone mineral density 65 | 126
abnormal heart morphology 62 | 162
decreased grip strength 62 | 116
decreased lean body mass 61 | 135
male infertility 61 | 123
short tibia 61 | 97
increased bone mineral content 55 | 108
decreased body length 54 | 101
cataract 53 | 92
increased or absent threshold ... 52 | 101
prenatal lethality prior to he... 52 | 87
abnormal seminal vesicle morph... 51 | 114
decreased circulating choleste... 51 | 93
increased mean corpuscular hem... 50 | 96
abnormal lens morphology 48 | 81
abnormal retina morphology 46 | 71
decreased prepulse inhibition 46 | 82
increased fasted circulating g... 46 | 76
decreased mean corpuscular vol... 44 | 79
increased mean corpuscular vol... 44 | 92
decreased circulating serum al... 43 | 82
decreased startle reflex 42 | 75
decreased circulating insulin ... 40 | 76
impaired glucose tolerance 40 | 75
increased circulating HDL chol... 40 | 80
decreased leukocyte cell numbe... 39 | 73
increased bone mineral density 38 | 72
decreased lymphocyte cell numb... 37 | 83
increased heart weight 37 | 62
abnormal eye morphology 36 | 68
abnormal sleep behavior 36 | 70
decreased circulating HDL chol... 36 | 68
improved glucose tolerance 36 | 79
increased circulating choleste... 36 | 66
abnormal behavioral response t... 35 | 66
abnormal coat-hair pigmentatio... 35 | 64
decreased circulating triglyce... 35 | 79
decreased fasted circulating g... 34 | 65
edema 34 | 59
increased circulating sodium l... 34 | 71
abnormal gait 33 | 69
decreased caudal vertebrae num... 32 | 53
decreased erythrocyte cell num... 32 | 62
small superior vagus ganglion 32 | 74
increased hematocrit 31 | 46
thrombocytopenia 31 | 56
decreased hemoglobin content 30 | 68
decreased mean corpuscular hem... 29 | 50
increased monocyte cell number 29 | 63
decreased circulating alkaline... 28 | 46
increased mean platelet volume 28 | 45
small testis 28 | 58
abnormal kidney morphology 27 | 65
decreased circulating total pr... 27 | 49
female infertility 27 | 60
increased leukocyte cell numbe... 27 | 47
decreased neutrophil cell numb... 26 | 42
increased blood urea nitrogen ... 26 | 48
increased erythrocyte cell num... 26 | 39
increased grip strength 26 | 41
increased hemoglobin content 26 | 45
abnormal skin morphology 25 | 50
decreased circulating LDL chol... 25 | 38
decreased circulating alanine ... 25 | 47
decreased circulating aspartat... 24 | 34
decreased circulating calcium ... 24 | 36
increased neutrophil cell numb... 24 | 46
cardiovascular system phenotyp... 23 | 36
increased circulating triglyce... 23 | 42
tremors 23 | 39
increased circulating calcium ... 22 | 34
persistence of hyaloid vascula... 22 | 33
abnormal spleen morphology 21 | 55
decreased blood urea nitrogen ... 21 | 51
decreased mean corpuscular hem... 21 | 31
decreased red blood cell distr... 21 | 41
hydrometra 21 | 53
increased circulating chloride... 21 | 41
increased circulating phosphat... 21 | 26
abnormal bone mineralization 20 | 38

Disease

Carcinoma 5,763 | 11,493
ovarian cancer 5,126 | 8,520
osteosarcoma 4,245 | 7,950
psoriasis 3,389 | 6,694
medulloblastoma, large-cell 3,330 | 6,241
glioblastoma 3,236 | 5,792
lung cancer 2,780 | 4,740
atypical teratoid / rhabdoid tumor 2,746 | 5,112
ependymoma 2,475 | 4,679
group 3 medulloblastoma 2,169 | 4,104
Breast cancer 2,038 | 3,578
adult high grade glioma 1,971 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,915 | 3,291
malignant mesothelioma 1,829 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,736 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,710 | 2,955
invasive ductal carcinoma 1,705 | 2,951
Astrocytoma, Pilocytic 1,646 | 3,081
non-small cell lung cancer 1,605 | 2,890
primitive neuroectodermal tumor 1,565 | 3,035
oligodendroglioma 1,559 | 2,850
Kidney cancer 1,527 | 2,613
lung adenocarcinoma 1,480 | 2,716
lung carcinoma 1,460 | 2,843
astrocytic glioma 1,432 | 2,597
pancreatic cancer 1,425 | 2,398
Cancer 1,383 | 2,499
subependymal giant cell astrocytoma 1,317 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,311 | 1,962
Pick disease 1,136 | 1,894
interstitial cystitis 1,122 | 2,312
tuberculosis 1,047 | 2,010
Multiple myeloma 1,045 | 1,332
group 4 medulloblastoma 1,028 | 1,855
pituitary cancer 999 | 1,972
ulcerative colitis 982 | 1,819
ductal carcinoma in situ 960 | 1,745
breast carcinoma 950 | 1,638
diabetes mellitus 928 | 1,728
Autosomal recessive predisposition 906 | 1,442
cystic fibrosis 904 | 1,696
colon cancer 898 | 1,478
acute quadriplegic myopathy 832 | 1,158
juvenile dermatomyositis 798 | 1,187
adrenocortical carcinoma 773 | 1,428
astrocytoma 764 | 1,146
primary pancreatic ductal adenocarcinoma 728 | 1,109
dermatomyositis 711 | 966
Rheumatoid arthritis 662 | 1,191
pediatric high grade glioma 628 | 1,064
Intellectual disability 617 | 1,016
Schizophrenia 614 | 1,160
Waldenstrons macroglobulinemia 608 | 765
spina bifida 595 | 1,074
nasopharyngeal carcinoma 522 | 1,058
cutaneous lupus erythematosus 520 | 1,057
active Crohn's disease 505 | 922
non primary Sjogren syndrome sicca 499 | 891
Atopic dermatitis 489 | 952
Epilepsy 484 | 792
gastric carcinoma 480 | 807
Liver Cirrhosis, Experimental 478 | 769
acute myeloid leukemia 472 | 783
esophageal adenocarcinoma 458 | 737
Duchenne muscular dystrophy 445 | 601
primary Sjogren syndrome 422 | 735
Cognitive delay 420 | 608
Global developmental delay 420 | 608
Mental and motor retardation 420 | 608
Dull intelligence 408 | 645
Low intelligence 408 | 645
Mental Retardation 408 | 645
Mental deficiency 408 | 645
Poor school performance 408 | 645
active ulcerative colitis 408 | 764
progressive supranuclear palsy 406 | 676
Muscle hypotonia 398 | 571
Seizures 394 | 596
aldosterone-producing adenoma 392 | 665
Alzheimer's disease 379 | 658
Liver cancer 378 | 604
medulloblastoma 376 | 720
autosomal dominant Emery-Dreifuss muscular dystrophy 368 | 510
Melanoma 362 | 711
Down syndrome 337 | 499
Obesity 337 | 678
Short stature 334 | 531
Bipolar Disorder 318 | 666
pancreatic carcinoma 316 | 562
fibroadenoma 312 | 559
Prostatic Neoplasms 304 | 495
Neurodegenerative disease 300 | 414
Amyotrophic lateral sclerosis 295 | 451
hepatocellular carcinoma 291 | 547
mucosa-associated lymphoid tissue lymphoma 273 | 484
sonic hedgehog group medulloblastoma 268 | 467
Breast Neoplasms 267 | 445
Endometriosis 258 | 540
gastric cancer 257 | 459
Mammary Neoplasms 252 | 425

Tissue

Endocrine System 8,841 | 18,159
Female tissues 8,721 | 17,400
Digestive Tract 8,705 | 17,369
Skin and soft tissues 8,692 | 17,230
Male tissues 8,652 | 17,142
Blood and immune system 8,616 | 16,909
Liver and Pancreas 8,596 | 16,750
Urinary Tract 8,578 | 16,678
Nervous System 8,560 | 16,725
Respiratory system 8,510 | 16,393
Cardiovascular System 8,214 | 15,192

Target Family

Non-IDG 5,254 | 12,091
Enzyme 2,370 | 4,145
Transcription Factor 430 | 1,400
Kinase 421 | 634
Transporter 178 | 473
Epigenetic 134 | 242
Ion Channel 93 | 344
GPCR 41 | 408
TF/Epigenetic 13 | 38
Nuclear Receptor 10 | 48
oGPCR 8 | 421

HPM Tissue

Adult Prostate 8,952 | 8,952
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19