Development Level

Tbio 5,743 | 10,625
Tdark 1,819 | 7,003
Tchem 1,123 | 1,890
Tclin 277 | 602

Collection

Kinase: IDG Consortium (Targets) 65 | 125
Ion Channel: IDG Consortium (Targets) 29 | 102
Kinase: IDG Consortium (Complete/Control) 23 | 37
GPCR: IDG Consortium (Targets) 10 | 127
GPCR: IDG Consortium (Complete/Control) 4 | 26

IMPC Phenotype

preweaning lethality, complete... 402 | 633
preweaning lethality, incomple... 146 | 260
abnormal behavior 128 | 226
embryonic lethality prior to t... 122 | 187
decreased lean body mass 117 | 195
decreased total body fat amoun... 111 | 186
embryonic lethality prior to o... 108 | 148
decreased body weight 103 | 174
decreased bone mineral content 91 | 157
increased circulating alkaline... 76 | 119
abnormal bone structure 74 | 131
decreased body length 70 | 108
increased or absent threshold ... 70 | 128
abnormal embryo size 69 | 112
decreased bone mineral density 68 | 126
decreased grip strength 68 | 123
abnormal retina morphology 65 | 100
decreased circulating glucose ... 63 | 121
hyperactivity 62 | 108
increased lean body mass 58 | 107
increased mean corpuscular hem... 55 | 93
increased bone mineral content 53 | 92
hypoactivity 52 | 89
short tibia 51 | 82
abnormal lens morphology 49 | 73
increased grip strength 48 | 83
decreased circulating choleste... 46 | 85
increased fasted circulating g... 45 | 68
decreased circulating HDL chol... 44 | 77
decreased circulating serum al... 44 | 79
increased mean corpuscular vol... 44 | 91
decreased circulating triglyce... 42 | 83
decreased circulating insulin ... 41 | 75
enlarged heart 41 | 111
decreased mean corpuscular vol... 38 | 50
increased circulating sodium l... 37 | 71
prenatal lethality prior to he... 37 | 64
abnormal retinal pigmentation 36 | 61
decreased lumbar vertebrae num... 35 | 62
abnormal sleep behavior 34 | 63
decreased leukocyte cell numbe... 31 | 54
male infertility 31 | 62
decreased rib number 30 | 59
impaired glucose tolerance 30 | 52
abnormal bone mineralization 29 | 55
decreased fasted circulating g... 29 | 49
increased circulating HDL chol... 29 | 63
increased circulating choleste... 29 | 53
increased exploration in new e... 29 | 56
increased total body fat amoun... 29 | 57
increased blood urea nitrogen ... 28 | 44
increased bone mineral density 28 | 52
increased sacral vertebrae num... 28 | 62
decreased caudal vertebrae num... 27 | 49
decreased hemoglobin content 27 | 53
thrombocytopenia 27 | 46
abnormal coat-hair pigmentatio... 26 | 54
abnormal gait 26 | 51
decreased circulating alanine ... 26 | 53
increased hemoglobin content 26 | 45
abnormal behavioral response t... 25 | 52
increased body weight 25 | 42
decreased circulating LDL chol... 24 | 37
decreased circulating total pr... 24 | 41
decreased eosinophil cell numb... 24 | 41
decreased erythrocyte cell num... 24 | 43
decreased prepulse inhibition 24 | 52
increased circulating chloride... 24 | 43
increased hematocrit 24 | 36
decreased circulating alkaline... 23 | 41
decreased circulating calcium ... 23 | 33
decreased mean corpuscular hem... 23 | 34
decreased startle reflex 23 | 48
improved glucose tolerance 23 | 56
cardiovascular system phenotyp... 22 | 35
increased rib number 22 | 41
abnormal neural tube closure 21 | 37
decreased circulating free fat... 21 | 39
decreased heart weight 21 | 44
increased heart weight 21 | 37
abnormal seminal vesicle morph... 20 | 47
increased circulating phosphat... 20 | 24
increased leukocyte cell numbe... 20 | 37
abnormal eye morphology 19 | 38
decreased circulating aspartat... 19 | 27
decreased circulating fructosa... 19 | 31
increased circulating calcium ... 19 | 32
increased circulating potassiu... 19 | 31
increased startle reflex 19 | 38
abnormal cranium morphology 17 | 32
decreased neutrophil cell numb... 17 | 37
decreased threshold for audito... 17 | 32
small testis 17 | 37
tremors 17 | 34
abnormal heart morphology 16 | 51
abnormal testis morphology 16 | 30
decreased circulating creatini... 16 | 31
female infertility 16 | 34
decreased NK T cell number 15 | 28
decreased circulating iron lev... 15 | 25

Disease

ovarian cancer 5,115 | 8,491
osteosarcoma 4,251 | 7,933
psoriasis 3,392 | 6,685
medulloblastoma, large-cell 3,330 | 6,234
glioblastoma 3,103 | 5,572
lung cancer 2,676 | 4,473
atypical teratoid / rhabdoid tumor 2,350 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,917 | 3,289
malignant mesothelioma 1,788 | 3,163
Breast cancer 1,771 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 1,737 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,715 | 2,956
invasive ductal carcinoma 1,705 | 2,950
pilocytic astrocytoma 1,653 | 3,086
non-small cell lung cancer 1,571 | 2,798
primitive neuroectodermal tumor 1,566 | 3,031
oligodendroglioma 1,559 | 2,849
pediatric high grade glioma 1,500 | 2,712
lung adenocarcinoma 1,482 | 2,714
lung carcinoma 1,460 | 2,844
ependymoma 1,438 | 2,514
pancreatic cancer 1,373 | 2,300
subependymal giant cell astrocytoma 1,316 | 2,287
Cancer 1,314 | 2,346
Carcinoma 1,238 | 2,147
astrocytic glioma 1,216 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,195 | 1,795
group 3 medulloblastoma 1,167 | 2,254
ulcerative colitis 1,149 | 2,087
Pick disease 1,134 | 1,893
interstitial cystitis 1,121 | 2,299
adult high grade glioma 1,097 | 2,148
group 4 medulloblastoma 1,063 | 1,875
Multiple myeloma 1,041 | 1,327
pituitary cancer 1,001 | 1,972
astrocytoma 976 | 1,493
ductal carcinoma in situ 962 | 1,745
breast carcinoma 934 | 1,614
colon cancer 897 | 1,475
diabetes mellitus 893 | 1,663
cystic fibrosis 890 | 1,670
primary pancreatic ductal adenocarcinoma 842 | 1,271
tuberculosis 834 | 1,563
acute quadriplegic myopathy 830 | 1,157
sonic hedgehog group medulloblastoma 807 | 1,482
medulloblastoma 801 | 1,524
juvenile dermatomyositis 797 | 1,189
posterior fossa group A ependymoma 783 | 1,511
adrenocortical carcinoma 774 | 1,427
dermatomyositis 710 | 966
posterior fossa group B ependymoma 679 | 1,530
Rheumatoid Arthritis 653 | 1,170
Waldenstrons macroglobulinemia 608 | 764
spina bifida 589 | 1,064
atypical teratoid/rhabdoid tumor 578 | 1,095
nasopharyngeal carcinoma 522 | 1,056
cutaneous lupus erythematosus 521 | 1,056
active Crohn's disease 503 | 918
gastric carcinoma 495 | 832
Atopic dermatitis 481 | 944
non primary Sjogren syndrome sicca 476 | 840
acute myeloid leukemia 471 | 785
esophageal adenocarcinoma 458 | 737
Duchenne muscular dystrophy 446 | 602
primary Sjogren syndrome 443 | 788
progressive supranuclear palsy 406 | 674
aldosterone-producing adenoma 392 | 664
tuberculosis and treatment for 6 months 384 | 686
Alzheimer's disease 371 | 644
Down syndrome 363 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 360 | 499
Intellectual disability 346 | 573
pancreatic carcinoma 319 | 567
fibroadenoma 311 | 557
Obesity 305 | 616
hepatocellular carcinoma 297 | 550
Prostatic Neoplasms 292 | 471
IGA Glomerulonephritis 291 | 454
Amyotrophic Lateral Sclerosis 283 | 432
Neurodegenerative disease 277 | 383
mucosa-associated lymphoid tissue lymphoma 273 | 480
Endometriosis 254 | 535
Mammary Neoplasms 245 | 410
gastric cancer 245 | 436
active ulcerative colitis 244 | 477
Schizophrenia 238 | 503
hereditary spastic paraplegia 236 | 313
Multiple Sclerosis 222 | 498
chronic rhinosinusitis 219 | 512
Parkinson's disease 206 | 364
Kidney disease 203 | 397
inflammatory breast cancer 202 | 404
non-small cell lung carcinoma 194 | 413
glioblastoma multiforme 188 | 347
Polycystic Ovary Syndrome 187 | 334
sarcoidosis 186 | 368
interstitial lung disease 184 | 292
Stomach Neoplasms 175 | 282
nephrosclerosis 175 | 329
urothelial carcinoma 175 | 318

Tissue

Male tissues 8,962 | 17,968
Nervous System 8,949 | 18,560
Digestive Tract 8,946 | 18,472
Female tissues 8,946 | 18,646
Liver and Pancreas 8,935 | 18,135
Blood and immune system 8,933 | 17,994
Endocrine System 8,927 | 18,511
Urinary Tract 8,926 | 18,443
Cardiovascular System 8,912 | 17,957
Respiratory system 8,855 | 17,483
Skin and soft tissues 8,801 | 18,114

Target Family

Non-IDG 5,264 | 11,969
Enzyme 2,370 | 4,146
Transcription Factor 431 | 1,400
Kinase 421 | 634
Transporter 179 | 473
Epigenetic 135 | 242
Ion Channel 90 | 341
GPCR 41 | 408
TF/Epigenetic 13 | 38
Nuclear Receptor 10 | 48
oGPCR 8 | 421

HPM Tissue

Adult Prostate 8,962 | 8,962
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Adult Adrenal 8,478 | 8,478
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
F-box/LRR-repeat protein 21 FBXL21 Tdark Non-IDG 0.00000 0
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130