Development Level

Tbio 6,403 | 11,651
Tdark 1,633 | 6,593
Tchem 847 | 1,388
Tclin 285 | 612

Collection

RFA-RM-18-021 105 | 328
Kinase: IDG Consortium (Target... 67 | 125
Kinase: IDG Consortium (Comple... 27 | 37
Ion Channel: IDG Consortium (T... 24 | 99
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 708 | 979
preweaning lethality, incomple... 287 | 499
embryonic lethality prior to t... 194 | 278
embryonic lethality prior to o... 192 | 239
abnormal behavior 163 | 298
abnormal embryo size 142 | 220
decreased total body fat amoun... 123 | 207
abnormal bone structure 113 | 187
decreased body weight 96 | 161
enlarged heart 94 | 210
increased lean body mass 94 | 172
decreased vertical activity 89 | 208
decreased bone mineral content 84 | 151
hyperactivity 82 | 148
abnormal heart morphology 78 | 162
hypoactivity 78 | 132
increased total body fat amoun... 76 | 134
embryonic growth retardation 75 | 106
increased circulating alkaline... 73 | 122
decreased circulating glucose ... 71 | 126
decreased bone mineral density 70 | 126
decreased lean body mass 67 | 135
increased startle reflex 66 | 112
increased bone mineral content 64 | 108
decreased grip strength 63 | 116
prenatal lethality prior to he... 61 | 87
short tibia 60 | 97
decreased circulating choleste... 59 | 93
male infertility 59 | 123
increased or absent threshold ... 57 | 101
decreased body length 54 | 101
cataract 53 | 92
abnormal seminal vesicle morph... 51 | 114
decreased prepulse inhibition 51 | 82
decreased mean corpuscular vol... 50 | 79
increased mean corpuscular hem... 49 | 96
abnormal lens morphology 48 | 81
abnormal retina morphology 47 | 71
increased mean corpuscular vol... 47 | 92
decreased circulating serum al... 46 | 82
decreased fasted circulating g... 44 | 65
impaired glucose tolerance 44 | 75
increased fasted circulating g... 44 | 76
decreased circulating HDL chol... 43 | 68
decreased circulating triglyce... 43 | 79
decreased startle reflex 43 | 75
increased circulating HDL chol... 43 | 80
increased circulating choleste... 43 | 66
decreased leukocyte cell numbe... 42 | 73
increased bone mineral density 42 | 72
decreased lymphocyte cell numb... 41 | 83
abnormal behavioral response t... 40 | 66
decreased circulating insulin ... 39 | 76
abnormal sleep behavior 38 | 70
abnormal eye morphology 37 | 68
abnormal gait 37 | 69
improved glucose tolerance 37 | 79
abnormal coat-hair pigmentatio... 36 | 64
increased heart weight 36 | 62
small superior vagus ganglion 36 | 74
decreased circulating alkaline... 35 | 46
decreased caudal vertebrae num... 34 | 53
decreased erythrocyte cell num... 34 | 62
increased circulating sodium l... 34 | 71
decreased hemoglobin content 33 | 68
edema 33 | 59
thrombocytopenia 33 | 56
abnormal kidney morphology 32 | 65
decreased mean corpuscular hem... 32 | 50
increased hematocrit 30 | 46
small testis 30 | 58
increased erythrocyte cell num... 29 | 39
abnormal skin morphology 28 | 50
decreased circulating total pr... 28 | 49
decreased neutrophil cell numb... 28 | 42
increased mean platelet volume 28 | 45
decreased circulating LDL chol... 27 | 38
decreased circulating alanine ... 27 | 47
increased neutrophil cell numb... 27 | 46
tremors 27 | 39
abnormal bone mineralization 26 | 38
female infertility 26 | 60
increased blood urea nitrogen ... 26 | 48
increased circulating chloride... 26 | 41
increased hemoglobin content 26 | 45
hydrometra 25 | 53
increased circulating triglyce... 25 | 42
increased leukocyte cell numbe... 25 | 47
decreased red blood cell distr... 24 | 41
increased monocyte cell number 24 | 63
pallor 24 | 34
abnormal neural tube closure 23 | 46
decreased blood urea nitrogen ... 23 | 51
decreased circulating calcium ... 23 | 36
increased grip strength 23 | 41
increased red blood cell distr... 23 | 34
decreased circulating aspartat... 22 | 34
decreased hematocrit 21 | 46
decreased mean corpuscular hem... 21 | 31
persistence of hyaloid vascula... 21 | 33

Disease

Carcinoma 5,896 | 11,493
ovarian cancer 5,329 | 8,520
osteosarcoma 4,407 | 7,950
medulloblastoma, large-cell 3,418 | 6,241
psoriasis 3,417 | 6,694
glioblastoma 3,291 | 5,792
lung cancer 2,852 | 4,740
atypical teratoid / rhabdoid tumor 2,794 | 5,112
ependymoma 2,528 | 4,679
group 3 medulloblastoma 2,216 | 4,104
Breast cancer 2,035 | 3,578
adult high grade glioma 1,988 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,946 | 3,291
malignant mesothelioma 1,855 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 1,779 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1,771 | 2,989
invasive ductal carcinoma 1,704 | 2,951
Astrocytoma, Pilocytic 1,670 | 3,081
oligodendroglioma 1,596 | 2,850
non-small cell lung cancer 1,592 | 2,890
primitive neuroectodermal tumor 1,588 | 3,035
Kidney cancer 1,556 | 2,613
lung carcinoma 1,490 | 2,843
astrocytic glioma 1,470 | 2,597
lung adenocarcinoma 1,467 | 2,716
pancreatic cancer 1,461 | 2,398
Cancer 1,396 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 1,370 | 1,962
subependymal giant cell astrocytoma 1,328 | 2,287
Pick disease 1,169 | 1,894
interstitial cystitis 1,108 | 2,312
tuberculosis 1,108 | 2,010
Multiple myeloma 1,080 | 1,332
group 4 medulloblastoma 1,052 | 1,855
ulcerative colitis 977 | 1,819
pituitary cancer 971 | 1,972
ductal carcinoma in situ 970 | 1,745
diabetes mellitus 960 | 1,728
breast carcinoma 950 | 1,638
Autosomal recessive predisposition 915 | 1,442
cystic fibrosis 907 | 1,696
colon cancer 866 | 1,478
acute quadriplegic myopathy 834 | 1,158
juvenile dermatomyositis 809 | 1,187
adrenocortical carcinoma 785 | 1,428
astrocytoma 774 | 1,146
primary pancreatic ductal adenocarcinoma 746 | 1,109
dermatomyositis 736 | 966
Rheumatoid arthritis 680 | 1,191
Intellectual disability 649 | 1,016
pediatric high grade glioma 631 | 1,064
spina bifida 615 | 1,074
Schizophrenia 613 | 1,160
Waldenstrons macroglobulinemia 611 | 765
non primary Sjogren syndrome sicca 520 | 891
nasopharyngeal carcinoma 515 | 1,058
cutaneous lupus erythematosus 514 | 1,057
active Crohn's disease 504 | 922
Epilepsy 503 | 792
gastric carcinoma 499 | 807
acute myeloid leukemia 488 | 783
Atopic dermatitis 480 | 952
Liver Cirrhosis, Experimental 477 | 769
esophageal adenocarcinoma 458 | 737
progressive supranuclear palsy 441 | 676
Cognitive delay 438 | 608
Global developmental delay 438 | 608
Mental and motor retardation 438 | 608
Duchenne muscular dystrophy 437 | 601
primary Sjogren syndrome 424 | 735
Dull intelligence 418 | 645
Low intelligence 418 | 645
Mental Retardation 418 | 645
Mental deficiency 418 | 645
Poor school performance 418 | 645
aldosterone-producing adenoma 407 | 665
active ulcerative colitis 403 | 764
Seizures 396 | 596
Alzheimer's disease 394 | 658
Muscle hypotonia 391 | 571
medulloblastoma 382 | 720
Melanoma 377 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 367 | 510
Liver cancer 363 | 604
Obesity 356 | 678
Bipolar Disorder 349 | 666
Short stature 344 | 531
Down syndrome 343 | 499
pancreatic carcinoma 334 | 562
fibroadenoma 316 | 559
Amyotrophic lateral sclerosis 306 | 451
hepatocellular carcinoma 304 | 547
Prostatic Neoplasms 300 | 495
Neurodegenerative disease 297 | 414
sonic hedgehog group medulloblastoma 277 | 467
mucosa-associated lymphoid tissue lymphoma 270 | 484
gastric cancer 265 | 459
Breast Neoplasms 260 | 445
tuberculosis and treatment for 6 months 258 | 409
Small head 256 | 374

Tissue

Endocrine System 9,058 | 18,159
Female tissues 8,949 | 17,400
Digestive Tract 8,940 | 17,369
Skin and soft tissues 8,929 | 17,230
Male tissues 8,876 | 17,142
Blood and immune system 8,860 | 16,909
Liver and Pancreas 8,858 | 16,750
Urinary Tract 8,828 | 16,678
Nervous System 8,800 | 16,725
Respiratory system 8,771 | 16,393
Cardiovascular System 8,493 | 15,192

Target Family

Non-IDG 5,395 | 12,091
Enzyme 2,463 | 4,145
Kinase 439 | 634
Transcription Factor 375 | 1,400
Transporter 176 | 473
Epigenetic 142 | 242
Ion Channel 96 | 344
GPCR 41 | 408
Nuclear Receptor 16 | 48
TF/Epigenetic 16 | 38
oGPCR 9 | 421

HPM Tissue

Adult Pancreas 9,168 | 9,168
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418