Development Level

Tbio 5,923 | 10,625
Tdark 1,848 | 7,003
Tchem 1,123 | 1,890
Tclin 281 | 602

Collection

Eligible Kinase Proteins 73 | 134
Eligible Ion Channel Proteins 24 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 437 | 633
preweaning lethality, incomple... 151 | 260
embryonic lethality prior to t... 130 | 187
decreased total body fat amoun... 126 | 186
abnormal behavior 124 | 226
embryonic lethality prior to o... 119 | 148
decreased lean body mass 117 | 195
decreased body weight 105 | 174
decreased bone mineral content 87 | 157
abnormal bone structure 81 | 131
increased circulating alkaline... 80 | 119
increased or absent threshold ... 75 | 128
abnormal embryo size 73 | 112
decreased body length 73 | 108
decreased grip strength 70 | 123
decreased circulating glucose ... 69 | 121
decreased bone mineral density 67 | 126
increased lean body mass 65 | 107
abnormal retina morphology 62 | 100
hyperactivity 62 | 108
increased bone mineral content 62 | 92
decreased circulating choleste... 54 | 85
short tibia 53 | 82
increased mean corpuscular hem... 52 | 93
hypoactivity 51 | 89
decreased circulating HDL chol... 50 | 77
decreased circulating serum al... 48 | 79
abnormal lens morphology 47 | 73
enlarged heart 47 | 111
increased grip strength 47 | 83
decreased circulating triglyce... 44 | 83
prenatal lethality prior to he... 44 | 64
decreased mean corpuscular vol... 43 | 50
increased fasted circulating g... 43 | 68
increased mean corpuscular vol... 43 | 91
abnormal retinal pigmentation 42 | 61
decreased circulating insulin ... 42 | 75
decreased fasted circulating g... 36 | 49
decreased lumbar vertebrae num... 36 | 62
abnormal bone mineralization 35 | 55
abnormal sleep behavior 35 | 63
increased circulating HDL chol... 35 | 63
increased circulating sodium l... 35 | 71
increased circulating choleste... 34 | 53
decreased leukocyte cell numbe... 33 | 54
decreased caudal vertebrae num... 32 | 49
decreased rib number 32 | 59
impaired glucose tolerance 32 | 52
increased bone mineral density 32 | 52
male infertility 32 | 62
decreased hemoglobin content 30 | 53
decreased prepulse inhibition 30 | 52
increased exploration in new e... 29 | 56
abnormal coat/hair pigmentatio... 28 | 54
increased sacral vertebrae num... 28 | 62
abnormal behavioral response t... 27 | 52
abnormal gait 27 | 51
decreased circulating alanine ... 27 | 53
decreased circulating alkaline... 27 | 41
decreased startle reflex 27 | 48
increased circulating chloride... 27 | 43
increased hemoglobin content 27 | 45
thrombocytopenia 27 | 46
increased blood urea nitrogen ... 26 | 44
increased total body fat amoun... 26 | 57
decreased circulating LDL chol... 25 | 37
decreased erythrocyte cell num... 25 | 43
improved glucose tolerance 25 | 56
increased body weight 25 | 42
decreased eosinophil cell numb... 24 | 41
decreased heart weight 24 | 44
decreased mean corpuscular hem... 24 | 34
increased hematocrit 24 | 36
abnormal heart morphology 23 | 51
decreased circulating total pr... 23 | 41
decreased neutrophil cell numb... 23 | 37
abnormal seminal vesicle morph... 22 | 47
decreased circulating free fat... 22 | 39
increased heart weight 22 | 37
increased rib number 22 | 41
abnormal neural tube closure 21 | 37
increased leukocyte cell numbe... 21 | 37
tremors 21 | 34
abnormal cranium morphology 20 | 32
decreased circulating calcium ... 19 | 33
decreased CD4-positive, CD25-p... 18 | 24
decreased circulating chloride... 18 | 32
decreased circulating fructosa... 18 | 31
decreased threshold for audito... 18 | 32
embryonic growth retardation 18 | 28
increased circulating potassiu... 18 | 31
increased startle reflex 18 | 38
small testis 18 | 37
abnormal eye morphology 17 | 38
cardiovascular system phenotyp... 17 | 35
decreased circulating aspartat... 17 | 27
decreased circulating creatini... 17 | 31
female infertility 17 | 34
increased erythrocyte cell num... 17 | 26
increased circulating calcium ... 16 | 32

Disease

ovarian cancer 5,313 | 8,484
osteosarcoma 4,410 | 7,933
psoriasis 3,420 | 6,685
medulloblastoma, large-cell 3,417 | 6,234
glioblastoma 3,160 | 5,572
lung cancer 2,740 | 4,466
atypical teratoid / rhabdoid tumor 2,403 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,947 | 3,289
malignant mesothelioma 1,812 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 1,784 | 2,956
Breast cancer 1,781 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,772 | 2,988
invasive ductal carcinoma 1,704 | 2,950
pilocytic astrocytoma 1,674 | 3,086
oligodendroglioma 1,596 | 2,849
primitive neuroectodermal tumor 1,588 | 3,031
non-small cell lung cancer 1,554 | 2,798
pediatric high grade glioma 1,527 | 2,712
lung carcinoma 1,488 | 2,844
ependymoma 1,483 | 2,514
lung adenocarcinoma 1,468 | 2,713
pancreatic cancer 1,406 | 2,300
Cancer 1,327 | 2,346
subependymal giant cell astrocytoma 1,326 | 2,287
astrocytic glioma 1,250 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,245 | 1,795
Carcinoma 1,240 | 2,147
group 3 medulloblastoma 1,220 | 2,254
Pick disease 1,168 | 1,893
ulcerative colitis 1,141 | 2,087
interstitial cystitis 1,108 | 2,299
adult high grade glioma 1,089 | 2,148
group 4 medulloblastoma 1,077 | 1,875
Multiple myeloma 1,076 | 1,327
astrocytoma 990 | 1,493
pituitary cancer 972 | 1,972
ductal carcinoma in situ 971 | 1,745
breast carcinoma 933 | 1,614
diabetes mellitus 921 | 1,663
cystic fibrosis 891 | 1,665
tuberculosis 884 | 1,557
primary pancreatic ductal adenocarcinoma 870 | 1,271
colon cancer 865 | 1,475
acute quadriplegic myopathy 832 | 1,157
medulloblastoma 817 | 1,524
juvenile dermatomyositis 808 | 1,189
sonic hedgehog group medulloblastoma 808 | 1,482
adrenocortical carcinoma 786 | 1,427
posterior fossa group A ependymoma 779 | 1,511
dermatomyositis 735 | 933
posterior fossa group B ependymoma 687 | 1,530
Rheumatoid Arthritis 667 | 1,160
Waldenstrons macroglobulinemia 612 | 765
spina bifida 608 | 1,064
atypical teratoid/rhabdoid tumor 572 | 1,095
nasopharyngeal carcinoma 515 | 1,056
cutaneous lupus erythematosus 514 | 1,056
gastric carcinoma 512 | 832
active Crohn's disease 501 | 918
non primary Sjogren syndrome sicca 497 | 840
acute myeloid leukemia 485 | 780
Atopic dermatitis 474 | 944
esophageal adenocarcinoma 459 | 737
primary Sjogren syndrome 446 | 789
progressive supranuclear palsy 441 | 674
Duchenne muscular dystrophy 436 | 602
aldosterone-producing adenoma 407 | 664
tuberculosis and treatment for 6 months 401 | 686
Alzheimer's disease 389 | 644
Intellectual disability 371 | 573
Down syndrome 366 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 359 | 499
pancreatic carcinoma 336 | 567
Obesity 316 | 616
fibroadenoma 315 | 557
IGA Glomerulonephritis 298 | 454
hepatocellular carcinoma 295 | 532
Amyotrophic Lateral Sclerosis 293 | 431
Prostatic Neoplasms 286 | 471
Neurodegenerative disease 275 | 383
mucosa-associated lymphoid tissue lymphoma 269 | 480
gastric cancer 252 | 430
hereditary spastic paraplegia 247 | 313
Schizophrenia 246 | 501
Endometriosis 241 | 535
active ulcerative colitis 240 | 477
Mammary Neoplasms 237 | 410
chronic rhinosinusitis 222 | 512
Multiple Sclerosis 217 | 498
Kidney disease 214 | 396
Parkinson's disease 202 | 364
non-small cell lung carcinoma 201 | 413
interstitial lung disease 199 | 291
Polycystic Ovary Syndrome 198 | 332
inflammatory breast cancer 195 | 404
sarcoidosis 189 | 358
Epilepsy 187 | 346
glioblastoma multiforme 185 | 347
nephrosclerosis 183 | 329
Stomach Neoplasms 178 | 282

Tissue

Liver and Pancreas 9,175 | 18,136
Digestive Tract 9,161 | 18,473
Nervous System 9,159 | 18,561
Female tissues 9,154 | 18,647
Male tissues 9,153 | 17,969
Blood and immune system 9,140 | 17,995
Endocrine System 9,139 | 18,512
Urinary Tract 9,133 | 18,444
Cardiovascular System 9,123 | 17,958
Respiratory system 9,074 | 17,484
Skin and soft tissues 9,018 | 18,115

Target Family

Non-IDG 5,402 | 11,971
Enzyme 2,465 | 4,146
Kinase 439 | 634
Transcription Factor 375 | 1,400
Transporter 177 | 473
Epigenetic 143 | 242
Ion Channel 92 | 341
GPCR 41 | 406
Nuclear Receptor 16 | 48
TF/Epigenetic 16 | 38
oGPCR 9 | 421

HPM Tissue

Adult Pancreas 9,175 | 9,175
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193