Development Level

Tbio 6,413 | 10,625
Tdark 2,330 | 7,003
Tchem 1,152 | 1,890
Tclin 306 | 602

Collection

Eligible Kinase Proteins 82 | 134
Eligible Ion Channel Proteins 36 | 117
Eligible non-olfactory GPCR Proteins 18 | 143

IMPC Term

preweaning lethality, complete... 463 | 633
preweaning lethality, incomple... 167 | 260
abnormal behavior 149 | 226
embryonic lethality prior to t... 143 | 187
decreased lean body mass 133 | 195
decreased total body fat amoun... 133 | 186
embryonic lethality prior to o... 121 | 148
decreased body weight 120 | 174
decreased bone mineral content 101 | 157
increased circulating alkaline... 89 | 119
abnormal embryo size 82 | 112
decreased body length 82 | 108
decreased grip strength 80 | 123
abnormal bone structure 78 | 131
decreased bone mineral density 78 | 126
increased or absent threshold ... 74 | 128
decreased circulating glucose ... 73 | 121
hyperactivity 72 | 108
abnormal retina morphology 67 | 100
increased lean body mass 67 | 107
increased mean corpuscular hem... 63 | 93
increased bone mineral content 60 | 92
decreased circulating choleste... 55 | 85
hypoactivity 55 | 89
decreased circulating HDL chol... 53 | 77
increased mean corpuscular vol... 53 | 91
enlarged heart 51 | 111
short tibia 50 | 82
decreased circulating serum al... 49 | 79
abnormal lens morphology 48 | 73
decreased circulating insulin ... 48 | 75
increased fasted circulating g... 48 | 68
increased grip strength 48 | 83
decreased circulating triglyce... 46 | 83
decreased mean corpuscular vol... 43 | 50
prenatal lethality prior to he... 43 | 64
abnormal retinal pigmentation 42 | 61
male infertility 42 | 62
increased circulating HDL chol... 41 | 63
abnormal sleep behavior 40 | 63
decreased lumbar vertebrae num... 37 | 62
increased circulating choleste... 37 | 53
increased circulating sodium l... 37 | 71
decreased leukocyte cell numbe... 35 | 54
decreased rib number 35 | 59
impaired glucose tolerance 35 | 52
abnormal bone mineralization 34 | 55
increased bone mineral density 34 | 52
increased total body fat amoun... 34 | 57
thrombocytopenia 34 | 46
abnormal coat/hair pigmentatio... 33 | 54
decreased caudal vertebrae num... 33 | 49
increased hemoglobin content 33 | 45
abnormal gait 32 | 51
decreased fasted circulating g... 32 | 49
increased sacral vertebrae num... 31 | 62
abnormal behavioral response t... 30 | 52
decreased prepulse inhibition 30 | 52
improved glucose tolerance 30 | 56
decreased erythrocyte cell num... 29 | 43
decreased hemoglobin content 29 | 53
increased blood urea nitrogen ... 29 | 44
increased exploration in new e... 29 | 56
decreased circulating alanine ... 28 | 53
decreased circulating total pr... 28 | 41
decreased eosinophil cell numb... 28 | 41
increased body weight 28 | 42
cardiovascular system phenotyp... 27 | 35
decreased heart weight 27 | 44
increased circulating chloride... 27 | 43
increased hematocrit 27 | 36
abnormal seminal vesicle morph... 26 | 47
decreased circulating LDL chol... 26 | 37
increased leukocyte cell numbe... 26 | 37
abnormal neural tube closure 25 | 37
decreased circulating alkaline... 25 | 41
decreased startle reflex 25 | 48
increased heart weight 24 | 37
abnormal cranium morphology 23 | 32
decreased circulating free fat... 23 | 39
decreased mean corpuscular hem... 23 | 34
increased startle reflex 23 | 38
abnormal heart morphology 22 | 51
decreased circulating calcium ... 22 | 33
embryonic growth retardation 22 | 28
increased rib number 22 | 41
abnormal eye morphology 21 | 38
abnormal spleen morphology 21 | 36
decreased circulating fructosa... 21 | 31
increased erythrocyte cell num... 21 | 26
small testis 21 | 37
tremors 21 | 34
decreased blood urea nitrogen ... 20 | 31
decreased neutrophil cell numb... 20 | 37
increased circulating calcium ... 20 | 32
increased circulating phosphat... 20 | 24
increased circulating potassiu... 20 | 31
limb grasping 20 | 35
decreased T cell number 19 | 31
decreased circulating aspartat... 19 | 27

Disease

ovarian cancer 5,622 | 8,484
osteosarcoma 4,754 | 7,933
medulloblastoma, large-cell 3,753 | 6,234
psoriasis 3,689 | 6,685
glioblastoma 3,445 | 5,572
lung cancer 2,891 | 4,466
atypical teratoid / rhabdoid tumor 2,659 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,033 | 3,289
malignant mesothelioma 1,959 | 3,162
Breast cancer 1,919 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,838 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,815 | 2,956
primitive neuroectodermal tumor 1,812 | 3,031
invasive ductal carcinoma 1,800 | 2,950
pilocytic astrocytoma 1,780 | 3,086
oligodendroglioma 1,758 | 2,849
pediatric high grade glioma 1,660 | 2,712
non-small cell lung cancer 1,640 | 2,798
ependymoma 1,638 | 2,514
lung carcinoma 1,545 | 2,844
lung adenocarcinoma 1,521 | 2,713
subependymal giant cell astrocytoma 1,411 | 2,287
pancreatic cancer 1,400 | 2,300
Cancer 1,396 | 2,346
Carcinoma 1,396 | 2,147
astrocytic glioma 1,378 | 2,241
group 3 medulloblastoma 1,345 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 1,266 | 1,795
Pick disease 1,261 | 1,893
group 4 medulloblastoma 1,206 | 1,875
adult high grade glioma 1,200 | 2,148
ulcerative colitis 1,176 | 2,087
interstitial cystitis 1,112 | 2,299
Multiple myeloma 1,093 | 1,327
pituitary cancer 1,086 | 1,972
ductal carcinoma in situ 1,024 | 1,745
astrocytoma 1,023 | 1,493
breast carcinoma 990 | 1,614
cystic fibrosis 935 | 1,665
tuberculosis 930 | 1,557
diabetes mellitus 929 | 1,663
colon cancer 912 | 1,475
sonic hedgehog group medulloblastoma 904 | 1,482
medulloblastoma 894 | 1,524
primary pancreatic ductal adenocarcinoma 871 | 1,271
acute quadriplegic myopathy 866 | 1,157
adrenocortical carcinoma 859 | 1,427
juvenile dermatomyositis 854 | 1,189
posterior fossa group A ependymoma 838 | 1,511
posterior fossa group B ependymoma 803 | 1,530
dermatomyositis 753 | 933
Rheumatoid Arthritis 701 | 1,160
atypical teratoid/rhabdoid tumor 650 | 1,095
Waldenstrons macroglobulinemia 622 | 765
spina bifida 611 | 1,064
nasopharyngeal carcinoma 561 | 1,056
non primary Sjogren syndrome sicca 528 | 840
cutaneous lupus erythematosus 526 | 1,056
acute myeloid leukemia 519 | 780
active Crohn's disease 518 | 918
gastric carcinoma 513 | 832
Atopic dermatitis 500 | 944
primary Sjogren syndrome 459 | 789
Duchenne muscular dystrophy 451 | 602
esophageal adenocarcinoma 451 | 737
tuberculosis and treatment for 6 months 448 | 686
progressive supranuclear palsy 447 | 674
aldosterone-producing adenoma 428 | 664
Intellectual disability 413 | 573
Alzheimer's disease 401 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 370 | 499
Down syndrome 364 | 548
pancreatic carcinoma 357 | 567
Obesity 328 | 616
hepatocellular carcinoma 323 | 532
fibroadenoma 322 | 557
Amyotrophic Lateral Sclerosis 317 | 431
Neurodegenerative disease 306 | 383
IGA Glomerulonephritis 303 | 454
Prostatic Neoplasms 289 | 471
Endometriosis 272 | 535
Schizophrenia 269 | 501
gastric cancer 268 | 430
mucosa-associated lymphoid tissue lymphoma 268 | 480
hereditary spastic paraplegia 264 | 313
chronic rhinosinusitis 258 | 512
Multiple Sclerosis 247 | 498
Mammary Neoplasms 244 | 410
active ulcerative colitis 238 | 477
Parkinson's disease 225 | 364
inflammatory breast cancer 222 | 404
non-small cell lung carcinoma 212 | 413
Polycystic Ovary Syndrome 209 | 332
Kidney disease 204 | 396
interstitial lung disease 200 | 291
sarcoidosis 198 | 358
Epilepsy 196 | 346
glioblastoma multiforme 196 | 347
tuberculosis and treatment for 3 months 187 | 327
Crohn's disease 183 | 304

Tissue

Female tissues 10,201 | 18,647
Male tissues 10,160 | 17,969
Nervous System 10,158 | 18,561
Endocrine System 10,138 | 18,512
Digestive Tract 10,130 | 18,473
Blood and immune system 10,124 | 17,995
Urinary Tract 10,107 | 18,444
Liver and Pancreas 10,104 | 18,136
Cardiovascular System 10,077 | 17,958
Respiratory system 9,979 | 17,484
Skin and soft tissues 9,969 | 18,115

Target Family

Non-IDG 5,966 | 11,971
Enzyme 2,558 | 4,146
Transcription Factor 633 | 1,400
Kinase 463 | 634
Transporter 194 | 473
Epigenetic 162 | 242
Ion Channel 111 | 341
GPCR 58 | 406
Nuclear Receptor 24 | 48
TF/Epigenetic 19 | 38
oGPCR 13 | 421

HPM Tissue

Adult Ovary 10,201 | 10,201
Adult Testis 10,843 | 10,843
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27