Development Level

Tbio 6,857 | 11,445
Tdark 2,062 | 6,588
Tchem 961 | 1,598
Tclin 312 | 613

Collection

RFA-RM-18-021 128 | 328
Kinase: IDG Consortium (Target... 74 | 125
Ion Channel: IDG Consortium (T... 36 | 99
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Targets) 18 | 126
GPCR: IDG Consortium (Complete... 6 | 25

IMPC Phenotype

preweaning lethality, complete... 747 | 979
preweaning lethality, incomple... 317 | 499
embryonic lethality prior to t... 209 | 278
embryonic lethality prior to o... 194 | 239
abnormal behavior 187 | 298
abnormal embryo size 151 | 220
decreased total body fat amoun... 131 | 207
abnormal bone structure 112 | 187
decreased body weight 110 | 161
enlarged heart 107 | 210
increased lean body mass 100 | 172
decreased vertical activity 98 | 208
decreased bone mineral content 94 | 151
hyperactivity 93 | 148
increased circulating alkaline... 87 | 122
abnormal heart morphology 81 | 162
hypoactivity 81 | 132
decreased circulating glucose ... 80 | 126
increased total body fat amoun... 80 | 134
decreased bone mineral density 79 | 126
embryonic growth retardation 79 | 106
increased startle reflex 77 | 112
decreased lean body mass 75 | 135
male infertility 73 | 123
decreased grip strength 70 | 116
decreased body length 66 | 101
increased bone mineral content 64 | 108
short tibia 64 | 97
abnormal seminal vesicle morph... 61 | 114
increased mean corpuscular hem... 61 | 96
decreased circulating choleste... 60 | 93
prenatal lethality prior to he... 60 | 87
decreased mean corpuscular vol... 56 | 79
cataract 55 | 92
decreased prepulse inhibition 55 | 82
increased mean corpuscular vol... 55 | 92
increased or absent threshold ... 55 | 101
abnormal lens morphology 52 | 81
decreased circulating serum al... 51 | 82
increased fasted circulating g... 50 | 76
increased circulating HDL chol... 49 | 80
abnormal retina morphology 48 | 71
increased bone mineral density 48 | 72
decreased circulating insulin ... 47 | 76
decreased leukocyte cell numbe... 47 | 73
decreased lymphocyte cell numb... 47 | 83
impaired glucose tolerance 47 | 75
decreased circulating triglyce... 46 | 79
improved glucose tolerance 46 | 79
increased circulating choleste... 46 | 66
decreased circulating HDL chol... 43 | 68
abnormal sleep behavior 41 | 70
decreased startle reflex 41 | 75
increased heart weight 41 | 62
small superior vagus ganglion 41 | 74
abnormal behavioral response t... 40 | 66
abnormal gait 40 | 69
decreased erythrocyte cell num... 40 | 62
thrombocytopenia 40 | 56
abnormal eye morphology 39 | 68
edema 39 | 59
abnormal coat-hair pigmentatio... 38 | 64
decreased fasted circulating g... 38 | 65
decreased caudal vertebrae num... 37 | 53
increased circulating sodium l... 36 | 71
decreased hemoglobin content 35 | 68
increased hematocrit 34 | 46
increased monocyte cell number 34 | 63
hydrometra 33 | 53
decreased circulating alkaline... 32 | 46
decreased mean corpuscular hem... 32 | 50
increased leukocyte cell numbe... 32 | 47
increased neutrophil cell numb... 32 | 46
small testis 32 | 58
abnormal skin morphology 31 | 50
decreased blood urea nitrogen ... 31 | 51
increased hemoglobin content 31 | 45
increased mean platelet volume 31 | 45
abnormal kidney morphology 30 | 65
decreased circulating total pr... 30 | 49
decreased circulating alanine ... 29 | 47
female infertility 28 | 60
increased blood urea nitrogen ... 28 | 48
increased erythrocyte cell num... 28 | 39
abnormal spleen morphology 27 | 55
decreased circulating LDL chol... 27 | 38
increased circulating triglyce... 27 | 42
persistence of hyaloid vascula... 27 | 33
abnormal neural tube closure 26 | 46
cardiovascular system phenotyp... 26 | 36
decreased circulating calcium ... 26 | 36
decreased red blood cell distr... 26 | 41
pallor 26 | 34
tremors 26 | 39
abnormal cranium morphology 25 | 36
decreased neutrophil cell numb... 25 | 42
increased circulating chloride... 25 | 41
limb grasping 25 | 41
abnormal bone mineralization 24 | 38
increased grip strength 24 | 41

Disease

Carcinoma 6,577 | 11,493
ovarian cancer 5,642 | 8,520
osteosarcoma 4,755 | 7,950
medulloblastoma, large-cell 3,755 | 6,241
psoriasis 3,688 | 6,694
glioblastoma 3,576 | 5,792
atypical teratoid / rhabdoid tumor 3,103 | 5,112
lung cancer 3,026 | 4,740
ependymoma 2,811 | 4,679
group 3 medulloblastoma 2,484 | 4,104
Breast cancer 2,212 | 3,578
adult high grade glioma 2,151 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 2,034 | 3,291
malignant mesothelioma 2,004 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,838 | 2,989
primitive neuroectodermal tumor 1,812 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 1,810 | 2,955
invasive ductal carcinoma 1,800 | 2,951
Astrocytoma, Pilocytic 1,779 | 3,081
oligodendroglioma 1,757 | 2,850
Kidney cancer 1,748 | 2,613
non-small cell lung cancer 1,682 | 2,890
astrocytic glioma 1,604 | 2,597
lung carcinoma 1,546 | 2,843
lung adenocarcinoma 1,518 | 2,716
Cancer 1,470 | 2,499
pancreatic cancer 1,463 | 2,398
subependymal giant cell astrocytoma 1,412 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,385 | 1,962
Pick disease 1,263 | 1,894
tuberculosis 1,173 | 2,010
group 4 medulloblastoma 1,151 | 1,855
interstitial cystitis 1,112 | 2,312
Multiple myeloma 1,096 | 1,332
pituitary cancer 1,085 | 1,972
ductal carcinoma in situ 1,022 | 1,745
ulcerative colitis 1,016 | 1,819
breast carcinoma 1,009 | 1,638
Autosomal recessive predisposition 977 | 1,442
diabetes mellitus 964 | 1,728
cystic fibrosis 949 | 1,696
colon cancer 913 | 1,478
acute quadriplegic myopathy 868 | 1,158
adrenocortical carcinoma 858 | 1,428
juvenile dermatomyositis 855 | 1,187
astrocytoma 800 | 1,146
dermatomyositis 754 | 966
primary pancreatic ductal adenocarcinoma 754 | 1,109
Rheumatoid arthritis 718 | 1,191
pediatric high grade glioma 711 | 1,064
Intellectual disability 702 | 1,016
Schizophrenia 675 | 1,160
Waldenstrons macroglobulinemia 621 | 765
spina bifida 619 | 1,074
nasopharyngeal carcinoma 561 | 1,058
non primary Sjogren syndrome sicca 550 | 891
Epilepsy 532 | 792
cutaneous lupus erythematosus 526 | 1,057
acute myeloid leukemia 522 | 783
active Crohn's disease 520 | 922
Atopic dermatitis 505 | 952
gastric carcinoma 497 | 807
Liver Cirrhosis, Experimental 479 | 769
Cognitive delay 460 | 608
Global developmental delay 460 | 608
Mental and motor retardation 460 | 608
Dull intelligence 453 | 645
Low intelligence 453 | 645
Mental Retardation 453 | 645
Mental deficiency 453 | 645
Poor school performance 453 | 645
Duchenne muscular dystrophy 451 | 601
esophageal adenocarcinoma 451 | 737
progressive supranuclear palsy 447 | 676
primary Sjogren syndrome 438 | 735
Muscle hypotonia 429 | 571
aldosterone-producing adenoma 428 | 665
medulloblastoma 426 | 720
Seizures 418 | 596
Alzheimer's disease 405 | 658
Liver cancer 405 | 604
active ulcerative colitis 398 | 764
Melanoma 390 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 378 | 510
Short stature 371 | 531
Obesity 364 | 678
Bipolar Disorder 360 | 666
pancreatic carcinoma 354 | 562
Down syndrome 336 | 499
hepatocellular carcinoma 333 | 547
Amyotrophic lateral sclerosis 332 | 451
fibroadenoma 323 | 559
Neurodegenerative disease 322 | 414
Prostatic Neoplasms 303 | 495
sonic hedgehog group medulloblastoma 294 | 467
gastric cancer 283 | 459
tuberculosis and treatment for 6 months 283 | 409
Small head 278 | 374
Endometriosis 277 | 540
Skin cancer 272 | 469

Tissue

Endocrine System 10,044 | 18,159
Female tissues 9,837 | 17,400
Digestive Tract 9,822 | 17,369
Skin and soft tissues 9,807 | 17,230
Male tissues 9,766 | 17,142
Blood and immune system 9,713 | 16,909
Nervous System 9,654 | 16,725
Liver and Pancreas 9,648 | 16,750
Urinary Tract 9,635 | 16,678
Respiratory system 9,573 | 16,393
Cardiovascular System 9,232 | 15,192

Target Family

Non-IDG 5,960 | 12,091
Enzyme 2,555 | 4,145
Transcription Factor 632 | 1,400
Kinase 463 | 634
Transporter 193 | 473
Epigenetic 161 | 242
Ion Channel 114 | 344
GPCR 58 | 408
Nuclear Receptor 24 | 48
TF/Epigenetic 19 | 38
oGPCR 13 | 421

HPM Tissue

Adult Ovary 10,192 | 10,192
Adult Testis 10,836 | 10,836
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Latexin LXN Tbio Enzyme -2.54426 344.4 419
Tensin-1 TNS1 Tbio Non-IDG -2.74141 354.5 133
Lysosomal Pro-X carboxypeptidase PRCP Tchem Enzyme -1.87633 85.9 165
Y-box-binding protein 2 YBX2 Tbio Transcription Factor -1.99119 94.8 236
Patched domain-containing protein 1 PTCHD1 Tbio Non-IDG -0.84569 7.72 81