Development Level

Tbio 4,504 | 11,178
Tdark 1,055 | 6,569
Tchem 869 | 1,885
Tclin 235 | 612

Collection

Kinase: IDG Consortium (Target... 45 | 125
Ion Channel: IDG Consortium (T... 19 | 99
Kinase: IDG Consortium (Comple... 18 | 37
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 515 | 979
preweaning lethality, incomple... 202 | 499
embryonic lethality prior to o... 137 | 239
embryonic lethality prior to t... 132 | 278
abnormal behavior 112 | 298
abnormal embryo size 91 | 220
decreased total body fat amoun... 87 | 207
abnormal bone structure 76 | 187
decreased body weight 74 | 161
enlarged heart 71 | 210
increased lean body mass 62 | 172
hyperactivity 56 | 148
increased circulating alkaline... 56 | 122
abnormal heart morphology 55 | 162
decreased bone mineral content 55 | 151
decreased circulating glucose ... 55 | 126
decreased vertical activity 54 | 208
hypoactivity 53 | 132
embryonic growth retardation 51 | 106
decreased lean body mass 49 | 135
increased total body fat amoun... 48 | 134
decreased bone mineral density 47 | 126
increased startle reflex 45 | 112
increased bone mineral content 43 | 108
short tibia 42 | 97
decreased grip strength 41 | 116
decreased mean corpuscular vol... 41 | 79
abnormal seminal vesicle morph... 40 | 114
decreased circulating choleste... 40 | 93
male infertility 40 | 123
increased mean corpuscular hem... 39 | 96
increased mean corpuscular vol... 38 | 92
prenatal lethality prior to he... 38 | 87
cataract 37 | 92
decreased body length 37 | 101
decreased circulating serum al... 37 | 82
increased fasted circulating g... 35 | 76
abnormal lens morphology 34 | 81
increased circulating choleste... 34 | 66
decreased prepulse inhibition 33 | 82
increased circulating HDL chol... 33 | 80
increased or absent threshold ... 33 | 101
decreased circulating insulin ... 32 | 76
thrombocytopenia 32 | 56
abnormal retina morphology 30 | 71
decreased circulating HDL chol... 30 | 68
decreased circulating triglyce... 30 | 79
decreased lymphocyte cell numb... 30 | 83
abnormal coat-hair pigmentatio... 29 | 64
decreased leukocyte cell numbe... 29 | 73
abnormal eye morphology 28 | 68
decreased fasted circulating g... 28 | 65
impaired glucose tolerance 28 | 75
increased heart weight 28 | 62
abnormal sleep behavior 27 | 70
decreased startle reflex 27 | 75
edema 27 | 59
increased bone mineral density 27 | 72
abnormal gait 26 | 69
decreased erythrocyte cell num... 26 | 62
abnormal kidney morphology 25 | 65
decreased circulating total pr... 25 | 49
increased leukocyte cell numbe... 25 | 47
abnormal behavioral response t... 24 | 66
decreased caudal vertebrae num... 24 | 53
small testis 24 | 58
decreased hemoglobin content 23 | 68
increased blood urea nitrogen ... 23 | 48
increased circulating sodium l... 23 | 71
improved glucose tolerance 22 | 79
small superior vagus ganglion 22 | 74
decreased circulating alanine ... 21 | 47
decreased mean corpuscular hem... 21 | 50
increased hematocrit 21 | 46
abnormal skin morphology 20 | 50
decreased blood urea nitrogen ... 20 | 51
decreased circulating LDL chol... 20 | 38
decreased circulating aspartat... 19 | 34
decreased neutrophil cell numb... 19 | 42
increased circulating chloride... 19 | 41
increased erythrocyte cell num... 19 | 39
increased monocyte cell number 19 | 63
decreased circulating alkaline... 18 | 46
decreased hematocrit 18 | 46
decreased mean corpuscular hem... 18 | 31
increased mean platelet volume 18 | 45
increased neutrophil cell numb... 18 | 46
pallor 18 | 34
abnormal embryo turning 17 | 31
abnormal testis morphology 17 | 43
hydrometra 17 | 53
increased circulating creatini... 17 | 38
increased grip strength 17 | 41
decreased circulating calcium ... 16 | 36
decreased circulating creatini... 16 | 39
decreased red blood cell distr... 16 | 41
increased circulating triglyce... 16 | 42
increased hemoglobin content 16 | 45
increased mean corpuscular hem... 16 | 36
increased prepulse inhibition 16 | 32

Disease

Carcinoma 4,084 | 11,192
ovarian cancer 3,789 | 8,297
osteosarcoma 3,064 | 7,766
psoriasis 2,516 | 6,514
glioblastoma 2,386 | 5,635
medulloblastoma, large-cell 2,357 | 6,086
lung cancer 2,103 | 4,607
atypical teratoid / rhabdoid tumor 1,972 | 4,971
ependymoma 1,777 | 4,559
group 3 medulloblastoma 1,529 | 4,002
Breast cancer 1,518 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 1,407 | 3,204
adult high grade glioma 1,402 | 3,701
malignant mesothelioma 1,333 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 1,251 | 2,902
invasive ductal carcinoma 1,242 | 2,867
Astrocytoma, Pilocytic 1,236 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 1,230 | 2,872
non-small cell lung cancer 1,212 | 2,799
lung adenocarcinoma 1,140 | 2,627
lung carcinoma 1,124 | 2,755
Kidney cancer 1,112 | 2,548
oligodendroglioma 1,111 | 2,768
primitive neuroectodermal tumor 1,109 | 2,957
pancreatic cancer 1,080 | 2,322
Cancer 1,056 | 2,388
pancreatic ductal adenocarcinoma liver metastasis 1,034 | 1,911
astrocytic glioma 1,007 | 2,530
subependymal giant cell astrocytoma 942 | 2,230
Multiple myeloma 878 | 1,296
tuberculosis 837 | 1,963
Pick disease 802 | 1,856
interstitial cystitis 783 | 2,237
diabetes mellitus 743 | 1,683
ulcerative colitis 739 | 1,765
group 4 medulloblastoma 725 | 1,806
Autosomal recessive predisposition 718 | 1,407
ductal carcinoma in situ 706 | 1,686
pituitary cancer 696 | 1,915
breast carcinoma 683 | 1,589
cystic fibrosis 674 | 1,629
colon cancer 633 | 1,428
acute quadriplegic myopathy 630 | 1,133
juvenile dermatomyositis 608 | 1,147
astrocytoma 574 | 1,113
dermatomyositis 572 | 941
adrenocortical carcinoma 560 | 1,385
primary pancreatic ductal adenocarcinoma 528 | 1,071
Waldenstrons macroglobulinemia 516 | 742
Rheumatoid arthritis 506 | 1,156
pediatric high grade glioma 475 | 1,035
Schizophrenia 465 | 1,136
Intellectual disability 458 | 998
spina bifida 409 | 1,053
nasopharyngeal carcinoma 403 | 1,024
cutaneous lupus erythematosus 402 | 1,016
Liver Cirrhosis, Experimental 389 | 733
Epilepsy 375 | 775
non primary Sjogren syndrome sicca 375 | 861
Duchenne muscular dystrophy 370 | 587
active Crohn's disease 368 | 882
Atopic dermatitis 359 | 915
gastric carcinoma 357 | 781
esophageal adenocarcinoma 353 | 696
acute myeloid leukemia 334 | 760
Cognitive delay 326 | 596
Global developmental delay 326 | 596
Mental and motor retardation 326 | 596
primary Sjogren syndrome 326 | 710
Dull intelligence 312 | 634
Low intelligence 312 | 634
Mental Retardation 312 | 634
Mental deficiency 312 | 634
Poor school performance 312 | 634
Muscle hypotonia 311 | 562
active ulcerative colitis 305 | 736
Seizures 298 | 584
aldosterone-producing adenoma 294 | 646
progressive supranuclear palsy 292 | 656
Alzheimer's disease 281 | 640
autosomal dominant Emery-Dreifuss muscular dystrophy 279 | 492
Melanoma 269 | 689
medulloblastoma 262 | 702
Liver cancer 260 | 589
pancreatic carcinoma 258 | 555
Down syndrome 251 | 480
Bipolar Disorder 250 | 646
Obesity 249 | 655
Short stature 246 | 514
hepatocellular carcinoma 242 | 536
Neurodegenerative disease 236 | 402
Prostatic Neoplasms 231 | 472
Amyotrophic lateral sclerosis 224 | 437
mucosa-associated lymphoid tissue lymphoma 223 | 473
fibroadenoma 215 | 538
Failure to gain weight 204 | 359
Pediatric failure to thrive 204 | 359
hereditary spastic paraplegia 199 | 313
gastric cancer 198 | 445
Skin cancer 193 | 451

Tissue

Endocrine System 6,560 | 18,159
Female tissues 6,474 | 17,400
Digestive Tract 6,462 | 17,369
Skin and soft tissues 6,456 | 17,230
Male tissues 6,415 | 17,142
Blood and immune system 6,401 | 16,909
Liver and Pancreas 6,383 | 16,750
Urinary Tract 6,362 | 16,678
Nervous System 6,346 | 16,725
Respiratory system 6,315 | 16,393
Cardiovascular System 6,091 | 15,192

Target Family

Non-IDG 3,909 | 12,091
Enzyme 1,854 | 4,145
Transcription Factor 302 | 1,400
Kinase 297 | 634
Transporter 109 | 473
Epigenetic 74 | 242
Ion Channel 69 | 344
GPCR 31 | 408
TF/Epigenetic 10 | 38
oGPCR 6 | 421
Nuclear Receptor 2 | 48

HPM Tissue

Adult Lung 6,663 | 6,663
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779