Development Level

Tbio 4,360 | 10,625
Tdark 1,203 | 7,003
Tchem 874 | 1,890
Tclin 232 | 602

Collection

Eligible Kinase Proteins 49 | 134
Eligible Ion Channel Proteins 22 | 117
Eligible non-olfactory GPCR Proteins 10 | 143

IMPC Term

preweaning lethality, complete... 325 | 633
preweaning lethality, incomple... 105 | 260
embryonic lethality prior to t... 91 | 187
decreased total body fat amoun... 89 | 186
abnormal behavior 88 | 226
decreased lean body mass 87 | 195
embryonic lethality prior to o... 84 | 148
decreased body weight 79 | 174
decreased bone mineral content 64 | 157
increased circulating alkaline... 55 | 119
abnormal bone structure 54 | 131
decreased bone mineral density 53 | 126
decreased body length 50 | 108
decreased circulating glucose ... 50 | 121
abnormal embryo size 48 | 112
increased or absent threshold ... 47 | 128
hyperactivity 44 | 108
increased lean body mass 44 | 107
decreased grip strength 43 | 123
increased mean corpuscular hem... 43 | 93
abnormal retina morphology 42 | 100
enlarged heart 40 | 111
decreased circulating serum al... 38 | 79
abnormal lens morphology 37 | 73
decreased circulating choleste... 37 | 85
decreased circulating triglyce... 36 | 83
decreased mean corpuscular vol... 36 | 50
increased bone mineral content 35 | 92
increased mean corpuscular vol... 35 | 91
decreased circulating insulin ... 34 | 75
short tibia 34 | 82
decreased circulating HDL chol... 33 | 77
hypoactivity 33 | 89
increased fasted circulating g... 32 | 68
increased grip strength 32 | 83
abnormal sleep behavior 28 | 63
prenatal lethality prior to he... 28 | 64
thrombocytopenia 28 | 46
increased exploration in new e... 27 | 56
increased circulating sodium l... 25 | 71
abnormal coat/hair pigmentatio... 24 | 54
abnormal retinal pigmentation 24 | 61
decreased rib number 24 | 59
impaired glucose tolerance 24 | 52
increased bone mineral density 24 | 52
increased circulating choleste... 24 | 53
decreased fasted circulating g... 23 | 49
decreased hemoglobin content 23 | 53
decreased lumbar vertebrae num... 23 | 62
increased circulating HDL chol... 22 | 63
male infertility 22 | 62
abnormal bone mineralization 21 | 55
decreased circulating total pr... 21 | 41
increased blood urea nitrogen ... 21 | 44
increased heart weight 21 | 37
decreased caudal vertebrae num... 20 | 49
decreased erythrocyte cell num... 20 | 43
decreased leukocyte cell numbe... 20 | 54
decreased prepulse inhibition 20 | 52
increased sacral vertebrae num... 20 | 62
abnormal gait 19 | 51
abnormal heart morphology 19 | 51
decreased circulating LDL chol... 19 | 37
decreased circulating alanine ... 19 | 53
decreased mean corpuscular hem... 19 | 34
increased body weight 19 | 42
increased circulating chloride... 19 | 43
increased leukocyte cell numbe... 19 | 37
increased total body fat amoun... 19 | 57
decreased circulating fructosa... 18 | 31
increased hematocrit 18 | 36
abnormal eye morphology 17 | 38
decreased startle reflex 17 | 48
increased hemoglobin content 17 | 45
abnormal neural tube closure 16 | 37
abnormal seminal vesicle morph... 16 | 47
decreased blood urea nitrogen ... 16 | 31
decreased heart weight 16 | 44
improved glucose tolerance 16 | 56
abnormal behavioral response t... 15 | 52
decreased circulating aspartat... 15 | 27
decreased circulating creatini... 15 | 31
increased circulating creatini... 15 | 29
small testis 15 | 37
abnormal cranium morphology 14 | 32
abnormal kidney morphology 14 | 30
abnormal rib morphology 14 | 28
cardiovascular system phenotyp... 14 | 35
decreased NK T cell number 14 | 28
decreased neutrophil cell numb... 14 | 37
decreased threshold for audito... 14 | 32
increased circulating calcium ... 14 | 32
increased circulating potassiu... 14 | 31
increased mean corpuscular hem... 14 | 25
abnormal testis morphology 13 | 30
decreased eosinophil cell numb... 13 | 41
decreased hematocrit 13 | 25
immune system phenotype 13 | 17
increased circulating phosphat... 13 | 24
increased rib number 13 | 41

Disease

ovarian cancer 3,880 | 8,484
osteosarcoma 3,137 | 7,933
psoriasis 2,594 | 6,685
medulloblastoma, large-cell 2,401 | 6,234
glioblastoma 2,357 | 5,572
lung cancer 2,081 | 4,466
atypical teratoid / rhabdoid tumor 1,711 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,454 | 3,289
Breast cancer 1,363 | 3,094
malignant mesothelioma 1,334 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 1,291 | 2,988
invasive ductal carcinoma 1,282 | 2,950
pilocytic astrocytoma 1,277 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,270 | 2,956
non-small cell lung cancer 1,220 | 2,798
lung adenocarcinoma 1,180 | 2,713
lung carcinoma 1,167 | 2,844
oligodendroglioma 1,141 | 2,849
primitive neuroectodermal tumor 1,140 | 3,031
pediatric high grade glioma 1,127 | 2,712
ependymoma 1,082 | 2,514
pancreatic cancer 1,075 | 2,300
Cancer 1,046 | 2,346
subependymal giant cell astrocytoma 972 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 953 | 1,795
Carcinoma 904 | 2,147
Multiple myeloma 903 | 1,327
ulcerative colitis 899 | 2,087
astrocytic glioma 870 | 2,241
group 3 medulloblastoma 836 | 2,254
interstitial cystitis 820 | 2,299
Pick disease 815 | 1,893
adult high grade glioma 797 | 2,148
group 4 medulloblastoma 759 | 1,875
astrocytoma 747 | 1,493
diabetes mellitus 733 | 1,663
ductal carcinoma in situ 733 | 1,745
pituitary cancer 714 | 1,972
breast carcinoma 695 | 1,614
tuberculosis 692 | 1,557
cystic fibrosis 685 | 1,665
primary pancreatic ductal adenocarcinoma 653 | 1,271
colon cancer 651 | 1,475
acute quadriplegic myopathy 639 | 1,157
juvenile dermatomyositis 627 | 1,189
sonic hedgehog group medulloblastoma 592 | 1,482
dermatomyositis 586 | 933
posterior fossa group A ependymoma 583 | 1,511
medulloblastoma 582 | 1,524
adrenocortical carcinoma 579 | 1,427
Waldenstrons macroglobulinemia 535 | 765
Rheumatoid Arthritis 518 | 1,160
posterior fossa group B ependymoma 468 | 1,530
atypical teratoid/rhabdoid tumor 437 | 1,095
cutaneous lupus erythematosus 420 | 1,056
nasopharyngeal carcinoma 420 | 1,056
spina bifida 418 | 1,064
gastric carcinoma 385 | 832
active Crohn's disease 384 | 918
Duchenne muscular dystrophy 379 | 602
esophageal adenocarcinoma 377 | 737
non primary Sjogren syndrome sicca 371 | 840
Atopic dermatitis 367 | 944
primary Sjogren syndrome 361 | 789
acute myeloid leukemia 343 | 780
aldosterone-producing adenoma 301 | 664
progressive supranuclear palsy 300 | 674
Alzheimer's disease 298 | 644
tuberculosis and treatment for 6 months 284 | 686
autosomal dominant Emery-Dreifuss muscular dystrophy 283 | 499
Down syndrome 275 | 548
pancreatic carcinoma 262 | 567
Intellectual disability 249 | 573
IGA Glomerulonephritis 239 | 454
hepatocellular carcinoma 238 | 532
Prostatic Neoplasms 234 | 471
Obesity 229 | 616
mucosa-associated lymphoid tissue lymphoma 227 | 480
fibroadenoma 225 | 557
Neurodegenerative disease 223 | 383
Amyotrophic Lateral Sclerosis 219 | 431
hereditary spastic paraplegia 198 | 313
gastric cancer 190 | 430
Mammary Neoplasms 185 | 410
active ulcerative colitis 185 | 477
Multiple Sclerosis 181 | 498
Endometriosis 178 | 535
Schizophrenia 177 | 501
Kidney disease 169 | 396
inflammatory breast cancer 169 | 404
non-small cell lung carcinoma 161 | 413
chronic rhinosinusitis 157 | 512
Polycystic Ovary Syndrome 156 | 332
Parkinson's disease 154 | 364
interstitial lung disease 150 | 291
nephrosclerosis 150 | 329
Stomach Neoplasms 149 | 282
sarcoidosis 147 | 358
Vascular disease 144 | 281
urothelial carcinoma 140 | 318

Tissue

Respiratory system 6,669 | 17,484
Female tissues 6,660 | 18,647
Blood and immune system 6,656 | 17,995
Digestive Tract 6,655 | 18,473
Nervous System 6,655 | 18,561
Liver and Pancreas 6,654 | 18,136
Male tissues 6,650 | 17,969
Urinary Tract 6,650 | 18,444
Endocrine System 6,649 | 18,512
Cardiovascular System 6,642 | 17,958
Skin and soft tissues 6,544 | 18,115

Target Family

Non-IDG 3,913 | 11,971
Enzyme 1,855 | 4,146
Transcription Factor 303 | 1,400
Kinase 297 | 634
Transporter 110 | 473
Epigenetic 75 | 242
Ion Channel 67 | 341
GPCR 31 | 406
TF/Epigenetic 10 | 38
oGPCR 6 | 421
Nuclear Receptor 2 | 48

HPM Tissue

Adult Lung 6,669 | 6,669
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209