Development Level

Tbio 4,712 | 11,651
Tdark 1,064 | 6,593
Tchem 652 | 1,388
Tclin 235 | 612

Collection

RFA-RM-18-021 74 | 328
Kinase: IDG Consortium (Target... 45 | 125
Ion Channel: IDG Consortium (T... 19 | 99
Kinase: IDG Consortium (Comple... 18 | 37
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 515 | 979
preweaning lethality, incomple... 202 | 499
embryonic lethality prior to o... 137 | 239
embryonic lethality prior to t... 132 | 278
abnormal behavior 112 | 298
abnormal embryo size 91 | 220
decreased total body fat amoun... 87 | 207
abnormal bone structure 76 | 187
decreased body weight 74 | 161
enlarged heart 71 | 210
increased lean body mass 62 | 172
hyperactivity 56 | 148
increased circulating alkaline... 56 | 122
abnormal heart morphology 55 | 162
decreased bone mineral content 55 | 151
decreased circulating glucose ... 55 | 126
decreased vertical activity 54 | 208
hypoactivity 53 | 132
embryonic growth retardation 51 | 106
decreased lean body mass 49 | 135
increased total body fat amoun... 48 | 134
decreased bone mineral density 47 | 126
increased startle reflex 45 | 112
increased bone mineral content 43 | 108
short tibia 42 | 97
decreased grip strength 41 | 116
decreased mean corpuscular vol... 41 | 79
abnormal seminal vesicle morph... 40 | 114
decreased circulating choleste... 40 | 93
male infertility 40 | 123
increased mean corpuscular hem... 39 | 96
increased mean corpuscular vol... 38 | 92
prenatal lethality prior to he... 38 | 87
cataract 37 | 92
decreased body length 37 | 101
decreased circulating serum al... 37 | 82
increased fasted circulating g... 35 | 76
abnormal lens morphology 34 | 81
increased circulating choleste... 34 | 66
decreased prepulse inhibition 33 | 82
increased circulating HDL chol... 33 | 80
increased or absent threshold ... 33 | 101
decreased circulating insulin ... 32 | 76
thrombocytopenia 32 | 56
abnormal retina morphology 30 | 71
decreased circulating HDL chol... 30 | 68
decreased circulating triglyce... 30 | 79
decreased lymphocyte cell numb... 30 | 83
abnormal coat-hair pigmentatio... 29 | 64
decreased leukocyte cell numbe... 29 | 73
abnormal eye morphology 28 | 68
decreased fasted circulating g... 28 | 65
impaired glucose tolerance 28 | 75
increased heart weight 28 | 62
abnormal sleep behavior 27 | 70
decreased startle reflex 27 | 75
edema 27 | 59
increased bone mineral density 27 | 72
abnormal gait 26 | 69
decreased erythrocyte cell num... 26 | 62
abnormal kidney morphology 25 | 65
decreased circulating total pr... 25 | 49
increased leukocyte cell numbe... 25 | 47
abnormal behavioral response t... 24 | 66
decreased caudal vertebrae num... 24 | 53
small testis 24 | 58
decreased hemoglobin content 23 | 68
increased blood urea nitrogen ... 23 | 48
increased circulating sodium l... 23 | 71
improved glucose tolerance 22 | 79
small superior vagus ganglion 22 | 74
decreased circulating alanine ... 21 | 47
decreased mean corpuscular hem... 21 | 50
increased hematocrit 21 | 46
abnormal skin morphology 20 | 50
decreased blood urea nitrogen ... 20 | 51
decreased circulating LDL chol... 20 | 38
decreased circulating aspartat... 19 | 34
decreased neutrophil cell numb... 19 | 42
increased circulating chloride... 19 | 41
increased erythrocyte cell num... 19 | 39
increased monocyte cell number 19 | 63
decreased circulating alkaline... 18 | 46
decreased hematocrit 18 | 46
decreased mean corpuscular hem... 18 | 31
increased mean platelet volume 18 | 45
increased neutrophil cell numb... 18 | 46
pallor 18 | 34
abnormal embryo turning 17 | 31
abnormal testis morphology 17 | 43
hydrometra 17 | 53
increased circulating creatini... 17 | 38
increased grip strength 17 | 41
decreased circulating calcium ... 16 | 36
decreased circulating creatini... 16 | 39
decreased red blood cell distr... 16 | 41
increased circulating triglyce... 16 | 42
increased hemoglobin content 16 | 45
increased mean corpuscular hem... 16 | 36
increased prepulse inhibition 16 | 32

Disease

Carcinoma 4,189 | 11,493
ovarian cancer 3,890 | 8,520
osteosarcoma 3,135 | 7,950
psoriasis 2,590 | 6,694
glioblastoma 2,449 | 5,792
medulloblastoma, large-cell 2,403 | 6,241
lung cancer 2,167 | 4,740
atypical teratoid / rhabdoid tumor 2,019 | 5,112
ependymoma 1,826 | 4,679
Breast cancer 1,566 | 3,578
group 3 medulloblastoma 1,564 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 1,453 | 3,291
adult high grade glioma 1,439 | 3,801
malignant mesothelioma 1,370 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,290 | 2,989
invasive ductal carcinoma 1,281 | 2,951
Astrocytoma, Pilocytic 1,274 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 1,265 | 2,955
non-small cell lung cancer 1,251 | 2,890
lung adenocarcinoma 1,178 | 2,716
lung carcinoma 1,167 | 2,843
oligodendroglioma 1,140 | 2,850
primitive neuroectodermal tumor 1,138 | 3,035
Kidney cancer 1,136 | 2,613
pancreatic cancer 1,113 | 2,398
Cancer 1,104 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 1,056 | 1,962
astrocytic glioma 1,027 | 2,597
subependymal giant cell astrocytoma 972 | 2,287
Multiple myeloma 906 | 1,332
tuberculosis 859 | 2,010
interstitial cystitis 819 | 2,312
Pick disease 816 | 1,894
diabetes mellitus 765 | 1,728
ulcerative colitis 764 | 1,819
group 4 medulloblastoma 740 | 1,855
Autosomal recessive predisposition 733 | 1,442
ductal carcinoma in situ 730 | 1,745
pituitary cancer 711 | 1,972
breast carcinoma 706 | 1,638
cystic fibrosis 697 | 1,696
colon cancer 651 | 1,478
acute quadriplegic myopathy 640 | 1,158
juvenile dermatomyositis 628 | 1,187
astrocytoma 593 | 1,146
dermatomyositis 588 | 966
adrenocortical carcinoma 576 | 1,428
primary pancreatic ductal adenocarcinoma 550 | 1,109
Waldenstrons macroglobulinemia 534 | 765
Rheumatoid arthritis 519 | 1,191
pediatric high grade glioma 485 | 1,064
Schizophrenia 475 | 1,160
Intellectual disability 465 | 1,016
cutaneous lupus erythematosus 420 | 1,057
nasopharyngeal carcinoma 420 | 1,058
spina bifida 419 | 1,074
Liver Cirrhosis, Experimental 413 | 769
non primary Sjogren syndrome sicca 388 | 891
active Crohn's disease 384 | 922
Duchenne muscular dystrophy 379 | 601
Epilepsy 379 | 792
esophageal adenocarcinoma 376 | 737
Atopic dermatitis 374 | 952
gastric carcinoma 371 | 807
primary Sjogren syndrome 345 | 735
acute myeloid leukemia 343 | 783
Cognitive delay 331 | 608
Global developmental delay 331 | 608
Mental and motor retardation 331 | 608
Dull intelligence 318 | 645
Low intelligence 318 | 645
Mental Retardation 318 | 645
Mental deficiency 318 | 645
Poor school performance 318 | 645
active ulcerative colitis 318 | 764
Muscle hypotonia 315 | 571
aldosterone-producing adenoma 301 | 665
Seizures 300 | 596
progressive supranuclear palsy 300 | 676
Alzheimer's disease 293 | 658
autosomal dominant Emery-Dreifuss muscular dystrophy 289 | 510
Melanoma 277 | 711
medulloblastoma 270 | 720
Liver cancer 267 | 604
Obesity 261 | 678
pancreatic carcinoma 261 | 562
Down syndrome 259 | 499
Bipolar Disorder 258 | 666
Short stature 253 | 531
hepatocellular carcinoma 246 | 547
Neurodegenerative disease 244 | 414
Prostatic Neoplasms 241 | 495
Amyotrophic lateral sclerosis 231 | 451
mucosa-associated lymphoid tissue lymphoma 228 | 484
fibroadenoma 225 | 559
Failure to gain weight 208 | 365
Pediatric failure to thrive 208 | 365
gastric cancer 202 | 459
Skin cancer 201 | 469
hereditary spastic paraplegia 201 | 318

Tissue

Endocrine System 6,560 | 18,159
Female tissues 6,474 | 17,400
Digestive Tract 6,462 | 17,369
Skin and soft tissues 6,456 | 17,230
Male tissues 6,415 | 17,142
Blood and immune system 6,401 | 16,909
Liver and Pancreas 6,383 | 16,750
Urinary Tract 6,362 | 16,678
Nervous System 6,346 | 16,725
Respiratory system 6,315 | 16,393
Cardiovascular System 6,091 | 15,192

Target Family

Non-IDG 3,909 | 12,091
Enzyme 1,854 | 4,145
Transcription Factor 302 | 1,400
Kinase 297 | 634
Transporter 109 | 473
Epigenetic 74 | 242
Ion Channel 69 | 344
GPCR 31 | 408
TF/Epigenetic 10 | 38
oGPCR 6 | 421
Nuclear Receptor 2 | 48

HPM Tissue

Adult Lung 6,663 | 6,663
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18