Development Level

Tbio 6,258 | 11,651
Tdark 1,743 | 6,593
Tchem 822 | 1,388
Tclin 290 | 612

Collection

RFA-RM-18-021 115 | 328
Kinase: IDG Consortium (Target... 67 | 125
Ion Channel: IDG Consortium (T... 30 | 99
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Targets) 20 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 667 | 979
preweaning lethality, incomple... 282 | 499
embryonic lethality prior to t... 186 | 278
embryonic lethality prior to o... 179 | 239
abnormal behavior 158 | 298
abnormal embryo size 139 | 220
decreased total body fat amoun... 110 | 207
abnormal bone structure 105 | 187
enlarged heart 101 | 210
decreased body weight 98 | 161
decreased vertical activity 87 | 208
hypoactivity 81 | 132
abnormal heart morphology 80 | 162
increased lean body mass 79 | 172
hyperactivity 78 | 148
decreased bone mineral content 77 | 151
decreased bone mineral density 74 | 126
decreased circulating glucose ... 73 | 126
increased circulating alkaline... 72 | 122
embryonic growth retardation 70 | 106
decreased lean body mass 67 | 135
increased total body fat amoun... 66 | 134
increased startle reflex 65 | 112
decreased grip strength 62 | 116
short tibia 62 | 97
male infertility 60 | 123
decreased body length 58 | 101
abnormal seminal vesicle morph... 56 | 114
cataract 54 | 92
decreased circulating choleste... 54 | 93
decreased mean corpuscular vol... 54 | 79
increased mean corpuscular hem... 54 | 96
increased or absent threshold ... 53 | 101
prenatal lethality prior to he... 53 | 87
increased mean corpuscular vol... 50 | 92
increased bone mineral content 49 | 108
decreased circulating serum al... 48 | 82
abnormal lens morphology 47 | 81
decreased prepulse inhibition 46 | 82
increased fasted circulating g... 45 | 76
increased circulating choleste... 43 | 66
abnormal retina morphology 42 | 71
decreased circulating triglyce... 42 | 79
decreased lymphocyte cell numb... 42 | 83
decreased circulating insulin ... 41 | 76
decreased leukocyte cell numbe... 41 | 73
improved glucose tolerance 41 | 79
decreased circulating HDL chol... 40 | 68
decreased startle reflex 40 | 75
increased circulating HDL chol... 40 | 80
impaired glucose tolerance 39 | 75
increased heart weight 39 | 62
increased bone mineral density 38 | 72
abnormal coat-hair pigmentatio... 37 | 64
abnormal eye morphology 37 | 68
thrombocytopenia 37 | 56
decreased caudal vertebrae num... 35 | 53
decreased erythrocyte cell num... 35 | 62
decreased fasted circulating g... 35 | 65
small superior vagus ganglion 35 | 74
abnormal behavioral response t... 34 | 66
abnormal gait 34 | 69
edema 33 | 59
increased circulating sodium l... 33 | 71
decreased circulating alkaline... 32 | 46
decreased circulating total pr... 32 | 49
small testis 32 | 58
abnormal kidney morphology 31 | 65
decreased hemoglobin content 30 | 68
hydrometra 30 | 53
increased monocyte cell number 30 | 63
decreased mean corpuscular hem... 29 | 50
increased mean platelet volume 29 | 45
abnormal sleep behavior 28 | 70
decreased circulating alanine ... 27 | 47
decreased neutrophil cell numb... 27 | 42
increased blood urea nitrogen ... 27 | 48
abnormal skin morphology 26 | 50
decreased circulating LDL chol... 26 | 38
female infertility 26 | 60
increased leukocyte cell numbe... 26 | 47
abnormal bone mineralization 25 | 38
decreased blood urea nitrogen ... 25 | 51
increased hematocrit 25 | 46
increased hemoglobin content 25 | 45
cardiovascular system phenotyp... 24 | 36
increased neutrophil cell numb... 24 | 46
abnormal neural tube closure 23 | 46
abnormal spleen morphology 23 | 55
abnormal testis morphology 23 | 43
decreased circulating aspartat... 23 | 34
decreased circulating calcium ... 23 | 36
enlarged lymph nodes 23 | 37
enlarged spleen 23 | 41
increased circulating triglyce... 23 | 42
prolonged QT interval 23 | 38
increased circulating chloride... 22 | 41
increased erythrocyte cell num... 22 | 39
increased grip strength 22 | 41
pallor 22 | 34

Disease

Carcinoma 5,965 | 11,493
ovarian cancer 5,110 | 8,520
osteosarcoma 4,255 | 7,950
psoriasis 3,372 | 6,694
medulloblastoma, large-cell 3,314 | 6,241
glioblastoma 3,207 | 5,792
lung cancer 2,784 | 4,740
atypical teratoid / rhabdoid tumor 2,729 | 5,112
ependymoma 2,451 | 4,679
group 3 medulloblastoma 2,139 | 4,104
Breast cancer 1,941 | 3,578
adult high grade glioma 1,907 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,843 | 3,291
malignant mesothelioma 1,776 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,651 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,633 | 2,955
invasive ductal carcinoma 1,596 | 2,951
Kidney cancer 1,590 | 2,613
Astrocytoma, Pilocytic 1,584 | 3,081
primitive neuroectodermal tumor 1,535 | 3,035
oligodendroglioma 1,527 | 2,850
non-small cell lung cancer 1,514 | 2,890
lung carcinoma 1,432 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 1,431 | 1,962
lung adenocarcinoma 1,414 | 2,716
astrocytic glioma 1,403 | 2,597
pancreatic cancer 1,327 | 2,398
Cancer 1,293 | 2,499
subependymal giant cell astrocytoma 1,285 | 2,287
Pick disease 1,112 | 1,894
tuberculosis 1,087 | 2,010
Multiple myeloma 1,058 | 1,332
interstitial cystitis 1,054 | 2,312
group 4 medulloblastoma 1,006 | 1,855
ulcerative colitis 973 | 1,819
Autosomal recessive predisposition 938 | 1,442
pituitary cancer 935 | 1,972
diabetes mellitus 933 | 1,728
ductal carcinoma in situ 906 | 1,745
cystic fibrosis 856 | 1,696
breast carcinoma 855 | 1,638
colon cancer 833 | 1,478
acute quadriplegic myopathy 802 | 1,158
juvenile dermatomyositis 750 | 1,187
adrenocortical carcinoma 726 | 1,428
astrocytoma 718 | 1,146
dermatomyositis 704 | 966
Rheumatoid arthritis 689 | 1,191
Intellectual disability 649 | 1,016
primary pancreatic ductal adenocarcinoma 632 | 1,109
Schizophrenia 617 | 1,160
pediatric high grade glioma 610 | 1,064
Waldenstrons macroglobulinemia 598 | 765
spina bifida 594 | 1,074
cutaneous lupus erythematosus 534 | 1,057
non primary Sjogren syndrome sicca 528 | 891
nasopharyngeal carcinoma 519 | 1,058
Epilepsy 509 | 792
active Crohn's disease 489 | 922
Liver Cirrhosis, Experimental 470 | 769
acute myeloid leukemia 454 | 783
Atopic dermatitis 446 | 952
Cognitive delay 440 | 608
Global developmental delay 440 | 608
Mental and motor retardation 440 | 608
gastric carcinoma 439 | 807
Dull intelligence 432 | 645
Low intelligence 432 | 645
Mental Retardation 432 | 645
Mental deficiency 432 | 645
Poor school performance 432 | 645
esophageal adenocarcinoma 428 | 737
Muscle hypotonia 408 | 571
primary Sjogren syndrome 408 | 735
progressive supranuclear palsy 403 | 676
Seizures 401 | 596
Melanoma 392 | 711
aldosterone-producing adenoma 392 | 665
Duchenne muscular dystrophy 386 | 601
Liver cancer 379 | 604
active ulcerative colitis 378 | 764
Alzheimer's disease 375 | 658
medulloblastoma 365 | 720
Short stature 340 | 531
Obesity 339 | 678
pancreatic carcinoma 329 | 562
Bipolar Disorder 325 | 666
autosomal dominant Emery-Dreifuss muscular dystrophy 325 | 510
hepatocellular carcinoma 317 | 547
Down syndrome 308 | 499
Prostatic Neoplasms 308 | 495
Neurodegenerative disease 295 | 414
Amyotrophic lateral sclerosis 289 | 451
mucosa-associated lymphoid tissue lymphoma 272 | 484
fibroadenoma 266 | 559
Skin cancer 264 | 469
gastric cancer 264 | 459
Small head 262 | 374
Failure to gain weight 261 | 365
Pediatric failure to thrive 261 | 365

Tissue

Endocrine System 8,951 | 18,159
Female tissues 8,821 | 17,400
Digestive Tract 8,812 | 17,369
Skin and soft tissues 8,808 | 17,230
Male tissues 8,730 | 17,142
Blood and immune system 8,708 | 16,909
Liver and Pancreas 8,689 | 16,750
Urinary Tract 8,667 | 16,678
Nervous System 8,637 | 16,725
Respiratory system 8,571 | 16,393
Cardiovascular System 8,226 | 15,192

Target Family

Non-IDG 5,212 | 12,091
Enzyme 2,463 | 4,145
Transcription Factor 460 | 1,400
Kinase 412 | 634
Transporter 231 | 473
Epigenetic 123 | 242
Ion Channel 95 | 344
GPCR 61 | 408
oGPCR 22 | 421
Nuclear Receptor 18 | 48
TF/Epigenetic 16 | 38

HPM Tissue

Adult Liver 9,113 | 9,113
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275