Development Level

Tbio 5,770 | 10,625
Tdark 1,954 | 7,003
Tchem 1,111 | 1,890
Tclin 287 | 602

Collection

Eligible Kinase Proteins 74 | 134
Eligible Ion Channel Proteins 28 | 117
Eligible non-olfactory GPCR Proteins 21 | 143

IMPC Term

preweaning lethality, complete... 426 | 633
preweaning lethality, incomple... 146 | 260
abnormal behavior 130 | 226
embryonic lethality prior to t... 127 | 187
decreased lean body mass 120 | 195
embryonic lethality prior to o... 110 | 148
decreased total body fat amoun... 109 | 186
decreased body weight 105 | 174
decreased bone mineral content 88 | 157
abnormal bone structure 73 | 131
decreased bone mineral density 73 | 126
increased circulating alkaline... 73 | 119
abnormal embryo size 72 | 112
decreased body length 71 | 108
decreased circulating glucose ... 70 | 121
increased or absent threshold ... 69 | 128
decreased grip strength 65 | 123
hyperactivity 60 | 108
increased mean corpuscular hem... 59 | 93
abnormal retina morphology 57 | 100
increased lean body mass 56 | 107
hypoactivity 51 | 89
increased bone mineral content 49 | 92
enlarged heart 48 | 111
short tibia 48 | 82
abnormal lens morphology 47 | 73
decreased circulating choleste... 47 | 85
decreased circulating serum al... 47 | 79
increased mean corpuscular vol... 47 | 91
decreased circulating HDL chol... 44 | 77
decreased circulating insulin ... 42 | 75
increased fasted circulating g... 42 | 68
increased grip strength 41 | 83
decreased circulating triglyce... 40 | 83
decreased lumbar vertebrae num... 40 | 62
decreased mean corpuscular vol... 39 | 50
prenatal lethality prior to he... 38 | 64
decreased rib number 37 | 59
increased sacral vertebrae num... 37 | 62
increased circulating HDL chol... 36 | 63
increased circulating sodium l... 35 | 71
abnormal bone mineralization 34 | 55
decreased leukocyte cell numbe... 33 | 54
increased circulating choleste... 33 | 53
abnormal retinal pigmentation 32 | 61
impaired glucose tolerance 32 | 52
increased bone mineral density 32 | 52
abnormal coat/hair pigmentatio... 31 | 54
decreased caudal vertebrae num... 31 | 49
abnormal sleep behavior 30 | 63
improved glucose tolerance 30 | 56
male infertility 30 | 62
thrombocytopenia 30 | 46
increased exploration in new e... 29 | 56
decreased fasted circulating g... 28 | 49
abnormal seminal vesicle morph... 27 | 47
decreased circulating alanine ... 27 | 53
decreased circulating total pr... 27 | 41
decreased prepulse inhibition 27 | 52
increased body weight 27 | 42
abnormal eye morphology 26 | 38
increased hemoglobin content 26 | 45
abnormal gait 25 | 51
abnormal heart morphology 25 | 51
decreased circulating alkaline... 25 | 41
decreased eosinophil cell numb... 25 | 41
decreased heart weight 25 | 44
decreased hemoglobin content 25 | 53
decreased startle reflex 25 | 48
increased circulating chloride... 25 | 43
decreased circulating LDL chol... 24 | 37
increased blood urea nitrogen ... 24 | 44
increased total body fat amoun... 24 | 57
decreased circulating free fat... 23 | 39
decreased circulating fructosa... 23 | 31
decreased mean corpuscular hem... 23 | 34
increased heart weight 23 | 37
increased rib number 23 | 41
increased startle reflex 23 | 38
abnormal behavioral response t... 22 | 52
abnormal neural tube closure 22 | 37
abnormal cranium morphology 21 | 32
cardiovascular system phenotyp... 21 | 35
decreased erythrocyte cell num... 21 | 43
increased circulating potassiu... 21 | 31
increased hematocrit 21 | 36
increased leukocyte cell numbe... 21 | 37
small testis 21 | 37
decreased circulating calcium ... 20 | 33
decreased neutrophil cell numb... 20 | 37
decreased circulating chloride... 19 | 32
enlarged lymph nodes 19 | 27
abnormal testis morphology 18 | 30
increased circulating phosphat... 18 | 24
abnormal kidney morphology 17 | 30
abnormal rib morphology 17 | 28
abnormal spleen morphology 17 | 36
decreased circulating aspartat... 17 | 27
decreased circulating creatini... 17 | 31
tremors 17 | 34

Disease

ovarian cancer 5,096 | 8,484
osteosarcoma 4,259 | 7,933
psoriasis 3,375 | 6,685
medulloblastoma, large-cell 3,315 | 6,234
glioblastoma 3,091 | 5,572
lung cancer 2,658 | 4,466
atypical teratoid / rhabdoid tumor 2,338 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,845 | 3,289
malignant mesothelioma 1,740 | 3,162
Breast cancer 1,694 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,653 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,638 | 2,956
invasive ductal carcinoma 1,596 | 2,950
pilocytic astrocytoma 1,592 | 3,086
primitive neuroectodermal tumor 1,538 | 3,031
oligodendroglioma 1,529 | 2,849
non-small cell lung cancer 1,476 | 2,798
ependymoma 1,439 | 2,514
pediatric high grade glioma 1,436 | 2,712
lung carcinoma 1,431 | 2,844
lung adenocarcinoma 1,417 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 1,318 | 1,795
subependymal giant cell astrocytoma 1,284 | 2,287
Carcinoma 1,271 | 2,147
pancreatic cancer 1,270 | 2,300
Cancer 1,230 | 2,346
astrocytic glioma 1,211 | 2,241
group 3 medulloblastoma 1,166 | 2,254
ulcerative colitis 1,132 | 2,087
Pick disease 1,111 | 1,893
adult high grade glioma 1,081 | 2,148
Multiple myeloma 1,057 | 1,327
interstitial cystitis 1,055 | 2,299
group 4 medulloblastoma 1,016 | 1,875
pituitary cancer 937 | 1,972
astrocytoma 909 | 1,493
ductal carcinoma in situ 908 | 1,745
diabetes mellitus 899 | 1,663
tuberculosis 861 | 1,557
breast carcinoma 838 | 1,614
cystic fibrosis 837 | 1,665
colon cancer 832 | 1,475
medulloblastoma 817 | 1,524
acute quadriplegic myopathy 801 | 1,157
sonic hedgehog group medulloblastoma 772 | 1,482
juvenile dermatomyositis 749 | 1,189
primary pancreatic ductal adenocarcinoma 744 | 1,271
posterior fossa group A ependymoma 734 | 1,511
adrenocortical carcinoma 730 | 1,427
dermatomyositis 703 | 933
posterior fossa group B ependymoma 687 | 1,530
Rheumatoid Arthritis 677 | 1,160
Waldenstrons macroglobulinemia 599 | 765
spina bifida 587 | 1,064
atypical teratoid/rhabdoid tumor 569 | 1,095
cutaneous lupus erythematosus 534 | 1,056
nasopharyngeal carcinoma 518 | 1,056
non primary Sjogren syndrome sicca 504 | 840
active Crohn's disease 487 | 918
gastric carcinoma 456 | 832
acute myeloid leukemia 453 | 780
Atopic dermatitis 438 | 944
primary Sjogren syndrome 431 | 789
esophageal adenocarcinoma 429 | 737
progressive supranuclear palsy 404 | 674
tuberculosis and treatment for 6 months 400 | 686
aldosterone-producing adenoma 392 | 664
Duchenne muscular dystrophy 385 | 602
Alzheimer's disease 367 | 644
Intellectual disability 357 | 573
pancreatic carcinoma 332 | 567
Down syndrome 330 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 319 | 499
Obesity 309 | 616
hepatocellular carcinoma 307 | 532
Prostatic Neoplasms 296 | 471
IGA Glomerulonephritis 283 | 454
Neurodegenerative disease 279 | 383
Amyotrophic Lateral Sclerosis 275 | 431
mucosa-associated lymphoid tissue lymphoma 272 | 480
fibroadenoma 265 | 557
gastric cancer 249 | 430
Schizophrenia 248 | 501
Endometriosis 245 | 535
hereditary spastic paraplegia 242 | 313
chronic rhinosinusitis 241 | 512
Mammary Neoplasms 234 | 410
active ulcerative colitis 219 | 477
Multiple Sclerosis 216 | 498
non-small cell lung carcinoma 216 | 413
inflammatory breast cancer 204 | 404
nephrosclerosis 198 | 329
Parkinson's disease 196 | 364
Polycystic Ovary Syndrome 194 | 332
Kidney disease 191 | 396
sarcoidosis 188 | 358
Epilepsy 183 | 346
Stomach Neoplasms 183 | 282
glioblastoma multiforme 172 | 347
tuberculosis and treatment for 3 months 172 | 327

Tissue

Liver and Pancreas 9,122 | 18,136
Female tissues 9,098 | 18,647
Nervous System 9,093 | 18,561
Digestive Tract 9,092 | 18,473
Urinary Tract 9,081 | 18,444
Endocrine System 9,075 | 18,512
Blood and immune system 9,056 | 17,995
Male tissues 9,054 | 17,969
Cardiovascular System 9,031 | 17,958
Respiratory system 8,955 | 17,484
Skin and soft tissues 8,948 | 18,115

Target Family

Non-IDG 5,218 | 11,971
Enzyme 2,466 | 4,146
Transcription Factor 461 | 1,400
Kinase 412 | 634
Transporter 232 | 473
Epigenetic 124 | 242
Ion Channel 92 | 341
GPCR 61 | 406
oGPCR 22 | 421
Nuclear Receptor 18 | 48
TF/Epigenetic 16 | 38

HPM Tissue

Adult Liver 9,122 | 9,122
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193