Development Level

Tbio 4,319 | 10,625
Tdark 1,334 | 7,003
Tchem 845 | 1,890
Tclin 230 | 602

Collection

Eligible Kinase Proteins 50 | 134
Eligible Ion Channel Proteins 20 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 306 | 633
preweaning lethality, incomple... 99 | 260
embryonic lethality prior to t... 96 | 187
abnormal behavior 86 | 226
embryonic lethality prior to o... 85 | 148
decreased lean body mass 80 | 195
decreased total body fat amoun... 79 | 186
decreased body weight 78 | 174
increased circulating alkaline... 56 | 119
abnormal embryo size 54 | 112
decreased bone mineral content 54 | 157
increased or absent threshold ... 49 | 128
abnormal bone structure 48 | 131
hyperactivity 48 | 108
decreased body length 45 | 108
decreased bone mineral density 43 | 126
decreased circulating glucose ... 43 | 121
decreased grip strength 42 | 123
enlarged heart 40 | 111
abnormal retina morphology 39 | 100
increased lean body mass 39 | 107
abnormal lens morphology 38 | 73
increased mean corpuscular hem... 38 | 93
decreased circulating choleste... 37 | 85
decreased circulating triglyce... 36 | 83
increased bone mineral content 36 | 92
decreased circulating HDL chol... 33 | 77
increased fasted circulating g... 33 | 68
decreased mean corpuscular vol... 32 | 50
hypoactivity 32 | 89
decreased circulating serum al... 31 | 79
short tibia 30 | 82
increased mean corpuscular vol... 29 | 91
decreased circulating insulin ... 27 | 75
increased grip strength 27 | 83
abnormal sleep behavior 26 | 63
decreased lumbar vertebrae num... 25 | 62
increased bone mineral density 25 | 52
prenatal lethality prior to he... 25 | 64
increased circulating sodium l... 24 | 71
impaired glucose tolerance 23 | 52
increased blood urea nitrogen ... 23 | 44
abnormal bone mineralization 22 | 55
decreased hemoglobin content 22 | 53
decreased leukocyte cell numbe... 22 | 54
increased circulating HDL chol... 22 | 63
increased circulating choleste... 22 | 53
thrombocytopenia 22 | 46
abnormal gait 21 | 51
abnormal neural tube closure 21 | 37
decreased prepulse inhibition 21 | 52
male infertility 21 | 62
abnormal coat/hair pigmentatio... 20 | 54
abnormal seminal vesicle morph... 20 | 47
decreased fasted circulating g... 20 | 49
decreased rib number 20 | 59
abnormal behavioral response t... 19 | 52
abnormal heart morphology 19 | 51
decreased caudal vertebrae num... 19 | 49
decreased circulating total pr... 19 | 41
increased circulating chloride... 19 | 43
increased sacral vertebrae num... 19 | 62
decreased circulating alanine ... 18 | 53
decreased circulating alkaline... 18 | 41
decreased circulating fructosa... 18 | 31
decreased mean corpuscular hem... 18 | 34
decreased startle reflex 18 | 48
increased body weight 18 | 42
increased hematocrit 18 | 36
increased leukocyte cell numbe... 18 | 37
abnormal retinal pigmentation 17 | 61
decreased heart weight 17 | 44
increased circulating creatini... 17 | 29
increased exploration in new e... 17 | 56
increased heart weight 17 | 37
increased hemoglobin content 17 | 45
cardiovascular system phenotyp... 16 | 35
decreased circulating LDL chol... 16 | 37
small testis 16 | 37
decreased eosinophil cell numb... 15 | 41
decreased neutrophil cell numb... 15 | 37
improved glucose tolerance 15 | 56
limb grasping 15 | 35
abnormal testis morphology 14 | 30
decreased circulating aspartat... 14 | 27
decreased erythrocyte cell num... 14 | 43
decreased threshold for audito... 14 | 32
embryonic growth retardation 14 | 28
increased total body fat amoun... 14 | 57
abnormal hindbrain development 13 | 24
decreased circulating calcium ... 13 | 33
decreased circulating free fat... 13 | 39
increased red blood cell distr... 13 | 21
increased rib number 13 | 41
persistence of hyaloid vascula... 13 | 22
abnormal kidney morphology 12 | 30
impaired righting response 12 | 19
increased circulating free fat... 12 | 17
increased erythrocyte cell num... 12 | 26
thrombocytosis 12 | 23

Disease

ovarian cancer 3,802 | 8,484
osteosarcoma 3,039 | 7,933
psoriasis 2,544 | 6,685
medulloblastoma, large-cell 2,406 | 6,234
glioblastoma 2,281 | 5,572
lung cancer 1,995 | 4,466
atypical teratoid / rhabdoid tumor 1,689 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,423 | 3,289
Breast cancer 1,310 | 3,094
malignant mesothelioma 1,282 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 1,280 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,252 | 2,956
invasive ductal carcinoma 1,207 | 2,950
pilocytic astrocytoma 1,198 | 3,086
oligodendroglioma 1,156 | 2,849
primitive neuroectodermal tumor 1,138 | 3,031
non-small cell lung cancer 1,104 | 2,798
lung adenocarcinoma 1,099 | 2,713
pediatric high grade glioma 1,096 | 2,712
ependymoma 1,085 | 2,514
lung carcinoma 1,041 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 1,010 | 1,795
pancreatic cancer 1,000 | 2,300
Cancer 983 | 2,346
astrocytic glioma 912 | 2,241
Multiple myeloma 907 | 1,327
subependymal giant cell astrocytoma 897 | 2,287
Carcinoma 879 | 2,147
ulcerative colitis 856 | 2,087
Pick disease 816 | 1,893
group 3 medulloblastoma 812 | 2,254
adult high grade glioma 763 | 2,148
interstitial cystitis 761 | 2,299
group 4 medulloblastoma 740 | 1,875
diabetes mellitus 717 | 1,663
astrocytoma 715 | 1,493
pituitary cancer 714 | 1,972
ductal carcinoma in situ 702 | 1,745
breast carcinoma 645 | 1,614
cystic fibrosis 631 | 1,665
tuberculosis 631 | 1,557
acute quadriplegic myopathy 630 | 1,157
colon cancer 625 | 1,475
primary pancreatic ductal adenocarcinoma 614 | 1,271
medulloblastoma 599 | 1,524
sonic hedgehog group medulloblastoma 597 | 1,482
juvenile dermatomyositis 576 | 1,189
posterior fossa group A ependymoma 568 | 1,511
dermatomyositis 567 | 933
adrenocortical carcinoma 557 | 1,427
Waldenstrons macroglobulinemia 516 | 765
Rheumatoid Arthritis 476 | 1,160
posterior fossa group B ependymoma 467 | 1,530
atypical teratoid/rhabdoid tumor 422 | 1,095
spina bifida 421 | 1,064
nasopharyngeal carcinoma 408 | 1,056
non primary Sjogren syndrome sicca 382 | 840
active Crohn's disease 361 | 918
Atopic dermatitis 349 | 944
cutaneous lupus erythematosus 349 | 1,056
gastric carcinoma 348 | 832
Duchenne muscular dystrophy 343 | 602
acute myeloid leukemia 342 | 780
esophageal adenocarcinoma 340 | 737
primary Sjogren syndrome 306 | 789
tuberculosis and treatment for 6 months 301 | 686
Alzheimer's disease 286 | 644
progressive supranuclear palsy 285 | 674
aldosterone-producing adenoma 276 | 664
Down syndrome 269 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 266 | 499
Intellectual disability 258 | 573
pancreatic carcinoma 238 | 567
Obesity 231 | 616
Prostatic Neoplasms 228 | 471
IGA Glomerulonephritis 227 | 454
Neurodegenerative disease 221 | 383
hepatocellular carcinoma 221 | 532
mucosa-associated lymphoid tissue lymphoma 208 | 480
fibroadenoma 202 | 557
Amyotrophic Lateral Sclerosis 199 | 431
hereditary spastic paraplegia 198 | 313
Endometriosis 191 | 535
Kidney disease 191 | 396
nephrosclerosis 187 | 329
gastric cancer 185 | 430
Mammary Neoplasms 182 | 410
active ulcerative colitis 176 | 477
Schizophrenia 169 | 501
chronic rhinosinusitis 165 | 512
Parkinson's disease 162 | 364
Polycystic Ovary Syndrome 155 | 332
Multiple Sclerosis 153 | 498
non-small cell lung carcinoma 149 | 413
Stomach Neoplasms 148 | 282
inflammatory breast cancer 146 | 404
Epilepsy 140 | 346
Vascular disease 139 | 281
glioblastoma multiforme 138 | 347
interstitial lung disease 136 | 291

Tissue

Urinary Tract 6,728 | 18,444
Digestive Tract 6,711 | 18,473
Liver and Pancreas 6,711 | 18,136
Female tissues 6,706 | 18,647
Nervous System 6,705 | 18,561
Endocrine System 6,694 | 18,512
Blood and immune system 6,693 | 17,995
Male tissues 6,683 | 17,969
Cardiovascular System 6,674 | 17,958
Respiratory system 6,632 | 17,484
Skin and soft tissues 6,597 | 18,115

Target Family

Non-IDG 3,798 | 11,971
Enzyme 1,954 | 4,146
Transcription Factor 318 | 1,400
Kinase 293 | 634
Transporter 177 | 473
Epigenetic 78 | 242
Ion Channel 57 | 341
GPCR 30 | 406
oGPCR 10 | 421
TF/Epigenetic 9 | 38
Nuclear Receptor 4 | 48

HPM Tissue

Adult Kidney 6,728 | 6,728
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160