Development Level

Tbio 4,606 | 11,445
Tdark 1,193 | 6,588
Tchem 690 | 1,598
Tclin 234 | 613

Collection

RFA-RM-18-021 77 | 328
Kinase: IDG Consortium (Target... 45 | 125
Ion Channel: IDG Consortium (T... 19 | 99
Kinase: IDG Consortium (Comple... 15 | 37
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 493 | 979
preweaning lethality, incomple... 192 | 499
embryonic lethality prior to t... 134 | 278
embryonic lethality prior to o... 129 | 239
abnormal behavior 107 | 298
abnormal embryo size 92 | 220
decreased total body fat amoun... 81 | 207
abnormal bone structure 71 | 187
enlarged heart 71 | 210
decreased body weight 70 | 161
increased circulating alkaline... 59 | 122
hyperactivity 58 | 148
decreased vertical activity 56 | 208
increased lean body mass 55 | 172
abnormal heart morphology 54 | 162
hypoactivity 53 | 132
decreased bone mineral content 51 | 151
decreased bone mineral density 49 | 126
decreased circulating glucose ... 49 | 126
embryonic growth retardation 49 | 106
abnormal seminal vesicle morph... 46 | 114
increased startle reflex 46 | 112
male infertility 44 | 123
decreased lean body mass 43 | 135
increased total body fat amoun... 43 | 134
decreased mean corpuscular vol... 42 | 79
decreased grip strength 41 | 116
cataract 40 | 92
decreased circulating choleste... 40 | 93
increased bone mineral content 40 | 108
increased fasted circulating g... 39 | 76
short tibia 39 | 97
increased mean corpuscular hem... 38 | 96
abnormal lens morphology 37 | 81
decreased prepulse inhibition 36 | 82
increased or absent threshold ... 36 | 101
increased mean corpuscular vol... 34 | 92
prenatal lethality prior to he... 34 | 87
decreased circulating serum al... 33 | 82
decreased body length 32 | 101
decreased circulating HDL chol... 31 | 68
decreased circulating triglyce... 31 | 79
increased circulating HDL chol... 30 | 80
increased circulating choleste... 30 | 66
abnormal behavioral response t... 29 | 66
abnormal retina morphology 29 | 71
decreased lymphocyte cell numb... 29 | 83
decreased startle reflex 29 | 75
impaired glucose tolerance 28 | 75
increased bone mineral density 28 | 72
increased heart weight 28 | 62
thrombocytopenia 28 | 56
decreased fasted circulating g... 27 | 65
decreased leukocyte cell numbe... 27 | 73
decreased mean corpuscular hem... 27 | 50
abnormal sleep behavior 26 | 70
small testis 26 | 58
abnormal gait 25 | 69
decreased circulating total pr... 25 | 49
decreased hemoglobin content 25 | 68
abnormal coat-hair pigmentatio... 24 | 64
abnormal eye morphology 24 | 68
decreased caudal vertebrae num... 24 | 53
abnormal kidney morphology 23 | 65
edema 23 | 59
increased blood urea nitrogen ... 23 | 48
increased mean platelet volume 23 | 45
decreased circulating insulin ... 22 | 76
improved glucose tolerance 22 | 79
increased circulating sodium l... 22 | 71
increased hematocrit 22 | 46
increased monocyte cell number 22 | 63
decreased circulating alkaline... 21 | 46
decreased neutrophil cell numb... 21 | 42
increased erythrocyte cell num... 21 | 39
increased leukocyte cell numbe... 21 | 47
small superior vagus ganglion 21 | 74
abnormal neural tube closure 20 | 46
abnormal skin morphology 20 | 50
decreased circulating alanine ... 20 | 47
decreased erythrocyte cell num... 20 | 62
increased neutrophil cell numb... 20 | 46
limb grasping 20 | 41
pallor 20 | 34
decreased circulating aspartat... 19 | 34
increased circulating creatini... 19 | 38
abnormal testis morphology 18 | 43
decreased mean corpuscular hem... 18 | 31
hydrometra 18 | 53
increased hemoglobin content 18 | 45
abnormal spleen morphology 17 | 55
decreased circulating LDL chol... 17 | 38
decreased hematocrit 17 | 46
abnormal bone mineralization 16 | 38
cardiovascular system phenotyp... 16 | 36
decreased circulating fructosa... 16 | 30
decreased red blood cell distr... 16 | 41
increased circulating chloride... 16 | 41
increased red blood cell distr... 16 | 34
prolonged QT interval 16 | 38

Disease

Carcinoma 4,166 | 11,493
ovarian cancer 3,820 | 8,520
osteosarcoma 3,037 | 7,950
psoriasis 2,542 | 6,694
medulloblastoma, large-cell 2,406 | 6,241
glioblastoma 2,372 | 5,792
lung cancer 2,074 | 4,740
atypical teratoid / rhabdoid tumor 1,976 | 5,112
ependymoma 1,823 | 4,679
group 3 medulloblastoma 1,542 | 4,104
Breast cancer 1,507 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,421 | 3,291
adult high grade glioma 1,407 | 3,801
malignant mesothelioma 1,315 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,277 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,247 | 2,955
invasive ductal carcinoma 1,205 | 2,951
Astrocytoma, Pilocytic 1,187 | 3,081
oligodendroglioma 1,155 | 2,850
primitive neuroectodermal tumor 1,137 | 3,035
non-small cell lung cancer 1,128 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 1,101 | 1,962
lung adenocarcinoma 1,098 | 2,716
Kidney cancer 1,095 | 2,613
astrocytic glioma 1,072 | 2,597
pancreatic cancer 1,050 | 2,398
Cancer 1,041 | 2,499
lung carcinoma 1,041 | 2,843
Multiple myeloma 908 | 1,332
subependymal giant cell astrocytoma 897 | 2,287
Pick disease 817 | 1,894
tuberculosis 792 | 2,010
Autosomal recessive predisposition 772 | 1,442
interstitial cystitis 760 | 2,312
diabetes mellitus 747 | 1,728
group 4 medulloblastoma 729 | 1,855
ulcerative colitis 722 | 1,819
pituitary cancer 711 | 1,972
ductal carcinoma in situ 699 | 1,745
breast carcinoma 657 | 1,638
cystic fibrosis 647 | 1,696
acute quadriplegic myopathy 631 | 1,158
colon cancer 625 | 1,478
juvenile dermatomyositis 577 | 1,187
dermatomyositis 568 | 966
astrocytoma 556 | 1,146
adrenocortical carcinoma 553 | 1,428
primary pancreatic ductal adenocarcinoma 523 | 1,109
Waldenstrons macroglobulinemia 515 | 765
Rheumatoid arthritis 482 | 1,191
Intellectual disability 478 | 1,016
Schizophrenia 464 | 1,160
pediatric high grade glioma 454 | 1,064
spina bifida 426 | 1,074
nasopharyngeal carcinoma 408 | 1,058
Epilepsy 400 | 792
non primary Sjogren syndrome sicca 399 | 891
Liver Cirrhosis, Experimental 390 | 769
active Crohn's disease 362 | 922
Atopic dermatitis 353 | 952
cutaneous lupus erythematosus 349 | 1,057
Duchenne muscular dystrophy 342 | 601
acute myeloid leukemia 342 | 783
Cognitive delay 341 | 608
Global developmental delay 341 | 608
Mental and motor retardation 341 | 608
esophageal adenocarcinoma 339 | 737
gastric carcinoma 336 | 807
Muscle hypotonia 335 | 571
Dull intelligence 330 | 645
Low intelligence 330 | 645
Mental Retardation 330 | 645
Mental deficiency 330 | 645
Poor school performance 330 | 645
Seizures 322 | 596
active ulcerative colitis 308 | 764
primary Sjogren syndrome 290 | 735
Alzheimer's disease 286 | 658
progressive supranuclear palsy 286 | 676
Melanoma 281 | 711
medulloblastoma 278 | 720
Liver cancer 277 | 604
aldosterone-producing adenoma 276 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 272 | 510
Short stature 263 | 531
Obesity 258 | 678
Down syndrome 257 | 499
Bipolar Disorder 253 | 666
pancreatic carcinoma 238 | 562
Neurodegenerative disease 236 | 414
Prostatic Neoplasms 236 | 495
hepatocellular carcinoma 230 | 547
Failure to gain weight 212 | 365
Pediatric failure to thrive 212 | 365
Amyotrophic lateral sclerosis 211 | 451
mucosa-associated lymphoid tissue lymphoma 209 | 484
Skin cancer 204 | 469
Kidney disease 203 | 430
fibroadenoma 202 | 559
hereditary spastic paraplegia 201 | 318

Tissue

Endocrine System 6,596 | 18,159
Digestive Tract 6,506 | 17,369
Female tissues 6,500 | 17,400
Skin and soft tissues 6,481 | 17,230
Male tissues 6,446 | 17,142
Urinary Tract 6,410 | 16,678
Liver and Pancreas 6,407 | 16,750
Blood and immune system 6,404 | 16,909
Nervous System 6,366 | 16,725
Respiratory system 6,308 | 16,393
Cardiovascular System 6,078 | 15,192

Target Family

Non-IDG 3,795 | 12,091
Enzyme 1,952 | 4,145
Transcription Factor 317 | 1,400
Kinase 293 | 634
Transporter 177 | 473
Epigenetic 77 | 242
Ion Channel 59 | 344
GPCR 30 | 408
oGPCR 10 | 421
TF/Epigenetic 9 | 38
Nuclear Receptor 4 | 48

HPM Tissue

Adult Kidney 6,723 | 6,723
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Keratin-associated protein 9-1 KRTAP9-1 Tdark Non-IDG 0.00000 0
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59