Development Level

Tbio 4,176 | 10,625
Tdark 1,265 | 7,003
Tchem 828 | 1,890
Tclin 241 | 602

Collection

Eligible Kinase Proteins 52 | 134
Eligible Ion Channel Proteins 20 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 325 | 633
preweaning lethality, incomple... 97 | 260
embryonic lethality prior to t... 96 | 187
abnormal behavior 94 | 226
embryonic lethality prior to o... 87 | 148
decreased lean body mass 84 | 195
decreased total body fat amoun... 79 | 186
decreased body weight 76 | 174
decreased bone mineral content 65 | 157
abnormal bone structure 57 | 131
abnormal embryo size 56 | 112
increased circulating alkaline... 56 | 119
increased or absent threshold ... 53 | 128
decreased body length 50 | 108
decreased bone mineral density 50 | 126
decreased circulating glucose ... 47 | 121
hyperactivity 43 | 108
decreased grip strength 40 | 123
abnormal lens morphology 39 | 73
increased lean body mass 39 | 107
increased mean corpuscular hem... 39 | 93
abnormal retina morphology 37 | 100
increased mean corpuscular vol... 36 | 91
increased fasted circulating g... 35 | 68
short tibia 35 | 82
decreased circulating triglyce... 34 | 83
increased grip strength 34 | 83
decreased circulating choleste... 31 | 85
decreased mean corpuscular vol... 31 | 50
increased bone mineral content 31 | 92
decreased circulating insulin ... 30 | 75
enlarged heart 30 | 111
increased circulating HDL chol... 30 | 63
decreased circulating HDL chol... 28 | 77
increased circulating sodium l... 28 | 71
decreased circulating serum al... 27 | 79
hypoactivity 27 | 89
increased circulating choleste... 27 | 53
prenatal lethality prior to he... 26 | 64
decreased lumbar vertebrae num... 25 | 62
abnormal sleep behavior 24 | 63
impaired glucose tolerance 24 | 52
male infertility 24 | 62
abnormal retinal pigmentation 23 | 61
decreased leukocyte cell numbe... 23 | 54
increased blood urea nitrogen ... 23 | 44
increased bone mineral density 22 | 52
abnormal bone mineralization 21 | 55
decreased rib number 21 | 59
increased exploration in new e... 21 | 56
increased sacral vertebrae num... 21 | 62
decreased fasted circulating g... 20 | 49
increased circulating chloride... 20 | 43
decreased caudal vertebrae num... 19 | 49
decreased prepulse inhibition 19 | 52
thrombocytopenia 19 | 46
abnormal coat/hair pigmentatio... 18 | 54
decreased circulating alanine ... 18 | 53
decreased eosinophil cell numb... 18 | 41
decreased erythrocyte cell num... 18 | 43
decreased heart weight 18 | 44
decreased startle reflex 18 | 48
improved glucose tolerance 18 | 56
increased leukocyte cell numbe... 18 | 37
increased total body fat amoun... 18 | 57
abnormal gait 17 | 51
cardiovascular system phenotyp... 17 | 35
decreased hemoglobin content 17 | 53
decreased mean corpuscular hem... 17 | 34
decreased neutrophil cell numb... 17 | 37
increased heart weight 17 | 37
increased hemoglobin content 17 | 45
abnormal neural tube closure 16 | 37
decreased circulating LDL chol... 16 | 37
decreased threshold for audito... 16 | 32
enlarged lymph nodes 16 | 27
increased body weight 16 | 42
abnormal behavioral response t... 15 | 52
decreased circulating fructosa... 15 | 31
decreased circulating total pr... 15 | 41
increased NK cell number 15 | 19
increased hematocrit 15 | 36
increased startle reflex 15 | 38
small testis 15 | 37
abnormal eye morphology 14 | 38
abnormal seminal vesicle morph... 14 | 47
decreased circulating free fat... 14 | 39
decreased circulating iron lev... 14 | 25
embryonic growth retardation 14 | 28
increased circulating phosphat... 14 | 24
increased mean corpuscular hem... 14 | 25
abnormal heart morphology 13 | 51
decreased NK T cell number 13 | 28
decreased circulating alkaline... 13 | 41
decreased circulating creatini... 13 | 31
enlarged spleen 13 | 26
decreased circulating aspartat... 12 | 27
decreased circulating calcium ... 12 | 33
increased circulating free fat... 12 | 17
increased circulating potassiu... 12 | 31

Disease

ovarian cancer 3,708 | 8,484
osteosarcoma 2,992 | 7,933
psoriasis 2,480 | 6,685
medulloblastoma, large-cell 2,428 | 6,234
glioblastoma 2,264 | 5,572
lung cancer 1,959 | 4,466
atypical teratoid / rhabdoid tumor 1,682 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,373 | 3,289
Breast cancer 1,298 | 3,094
malignant mesothelioma 1,270 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 1,223 | 2,988
invasive ductal carcinoma 1,219 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,179 | 2,956
pilocytic astrocytoma 1,152 | 3,086
primitive neuroectodermal tumor 1,125 | 3,031
oligodendroglioma 1,122 | 2,849
non-small cell lung cancer 1,096 | 2,798
pediatric high grade glioma 1,082 | 2,712
ependymoma 1,063 | 2,514
lung adenocarcinoma 1,057 | 2,713
lung carcinoma 1,027 | 2,844
Carcinoma 946 | 2,147
pancreatic cancer 936 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 928 | 1,795
Cancer 926 | 2,346
astrocytic glioma 911 | 2,241
subependymal giant cell astrocytoma 909 | 2,287
Multiple myeloma 861 | 1,327
Pick disease 829 | 1,893
group 3 medulloblastoma 820 | 2,254
ulcerative colitis 779 | 2,087
adult high grade glioma 760 | 2,148
group 4 medulloblastoma 739 | 1,875
interstitial cystitis 736 | 2,299
astrocytoma 705 | 1,493
ductal carcinoma in situ 697 | 1,745
diabetes mellitus 694 | 1,663
breast carcinoma 680 | 1,614
pituitary cancer 677 | 1,972
acute quadriplegic myopathy 629 | 1,157
colon cancer 626 | 1,475
cystic fibrosis 609 | 1,665
medulloblastoma 595 | 1,524
tuberculosis 589 | 1,557
sonic hedgehog group medulloblastoma 570 | 1,482
primary pancreatic ductal adenocarcinoma 568 | 1,271
juvenile dermatomyositis 553 | 1,189
posterior fossa group A ependymoma 548 | 1,511
dermatomyositis 545 | 933
adrenocortical carcinoma 529 | 1,427
posterior fossa group B ependymoma 502 | 1,530
Waldenstrons macroglobulinemia 481 | 765
Rheumatoid Arthritis 449 | 1,160
atypical teratoid/rhabdoid tumor 415 | 1,095
spina bifida 396 | 1,064
non primary Sjogren syndrome sicca 382 | 840
nasopharyngeal carcinoma 378 | 1,056
gastric carcinoma 356 | 832
acute myeloid leukemia 353 | 780
Atopic dermatitis 344 | 944
cutaneous lupus erythematosus 343 | 1,056
Duchenne muscular dystrophy 336 | 602
active Crohn's disease 327 | 918
esophageal adenocarcinoma 309 | 737
progressive supranuclear palsy 298 | 674
aldosterone-producing adenoma 289 | 664
primary Sjogren syndrome 285 | 789
Alzheimer's disease 278 | 644
tuberculosis and treatment for 6 months 271 | 686
Intellectual disability 268 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 262 | 499
Down syndrome 255 | 548
Obesity 245 | 616
pancreatic carcinoma 233 | 567
Amyotrophic Lateral Sclerosis 220 | 431
fibroadenoma 218 | 557
Neurodegenerative disease 217 | 383
Prostatic Neoplasms 212 | 471
hereditary spastic paraplegia 211 | 313
hepatocellular carcinoma 209 | 532
IGA Glomerulonephritis 194 | 454
Schizophrenia 191 | 501
Mammary Neoplasms 187 | 410
gastric cancer 181 | 430
mucosa-associated lymphoid tissue lymphoma 180 | 480
Endometriosis 176 | 535
chronic rhinosinusitis 168 | 512
Parkinson's disease 161 | 364
Kidney disease 159 | 396
active ulcerative colitis 159 | 477
Epilepsy 155 | 346
inflammatory breast cancer 151 | 404
Polycystic Ovary Syndrome 149 | 332
non-small cell lung carcinoma 147 | 413
Multiple Sclerosis 146 | 498
Stomach Neoplasms 142 | 282
interstitial lung disease 132 | 291
Heart disease 130 | 279
Becker muscular dystrophy 128 | 187
glioblastoma multiforme 128 | 347

Tissue

Cardiovascular System 6,510 | 17,958
Nervous System 6,497 | 18,561
Female tissues 6,489 | 18,647
Digestive Tract 6,488 | 18,473
Liver and Pancreas 6,483 | 18,136
Urinary Tract 6,483 | 18,444
Endocrine System 6,481 | 18,512
Male tissues 6,474 | 17,969
Blood and immune system 6,471 | 17,995
Respiratory system 6,423 | 17,484
Skin and soft tissues 6,387 | 18,115

Target Family

Non-IDG 3,815 | 11,971
Enzyme 1,834 | 4,146
Kinase 312 | 634
Transcription Factor 203 | 1,400
Transporter 127 | 473
Epigenetic 85 | 242
Ion Channel 73 | 341
GPCR 32 | 406
TF/Epigenetic 12 | 38
oGPCR 11 | 421
Nuclear Receptor 6 | 48

HPM Tissue

Adult Heart 6,510 | 6,510
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193