Development Level

Tbio 4,532 | 11,651
Tdark 1,131 | 6,593
Tchem 599 | 1,388
Tclin 244 | 612

Collection

Kinase: IDG Consortium (Target... 47 | 125
Ion Channel: IDG Consortium (T... 17 | 99
Kinase: IDG Consortium (Comple... 16 | 37
GPCR: IDG Consortium (Targets) 11 | 126

IMPC Phenotype

preweaning lethality, complete... 510 | 979
preweaning lethality, incomple... 198 | 499
embryonic lethality prior to t... 136 | 278
embryonic lethality prior to o... 131 | 239
abnormal behavior 109 | 298
abnormal embryo size 96 | 220
abnormal bone structure 79 | 187
decreased total body fat amoun... 77 | 207
decreased body weight 67 | 161
enlarged heart 66 | 210
increased lean body mass 60 | 172
decreased bone mineral content 57 | 151
increased circulating alkaline... 56 | 122
decreased vertical activity 55 | 208
hyperactivity 54 | 148
abnormal heart morphology 52 | 162
decreased circulating glucose ... 52 | 126
decreased bone mineral density 51 | 126
embryonic growth retardation 49 | 106
increased total body fat amoun... 47 | 134
increased startle reflex 46 | 112
abnormal lens morphology 45 | 81
hypoactivity 44 | 132
short tibia 44 | 97
cataract 43 | 92
male infertility 43 | 123
decreased body length 39 | 101
decreased circulating choleste... 38 | 93
decreased lean body mass 38 | 135
increased mean corpuscular hem... 38 | 96
decreased mean corpuscular vol... 37 | 79
abnormal seminal vesicle morph... 36 | 114
decreased grip strength 36 | 116
increased bone mineral content 36 | 108
increased mean corpuscular vol... 36 | 92
increased circulating choleste... 35 | 66
increased or absent threshold ... 35 | 101
decreased prepulse inhibition 34 | 82
increased fasted circulating g... 34 | 76
prenatal lethality prior to he... 34 | 87
increased circulating HDL chol... 33 | 80
decreased leukocyte cell numbe... 30 | 73
decreased lymphocyte cell numb... 30 | 83
abnormal retina morphology 29 | 71
decreased circulating insulin ... 29 | 76
decreased startle reflex 29 | 75
decreased circulating triglyce... 28 | 79
improved glucose tolerance 28 | 79
increased heart weight 28 | 62
decreased circulating HDL chol... 27 | 68
edema 27 | 59
impaired glucose tolerance 27 | 75
increased circulating sodium l... 27 | 71
abnormal behavioral response t... 26 | 66
decreased mean corpuscular hem... 26 | 50
decreased circulating serum al... 24 | 82
decreased fasted circulating g... 24 | 65
decreased neutrophil cell numb... 24 | 42
thrombocytopenia 24 | 56
abnormal coat-hair pigmentatio... 23 | 64
increased hematocrit 23 | 46
increased leukocyte cell numbe... 23 | 47
increased mean platelet volume 23 | 45
increased monocyte cell number 23 | 63
abnormal eye morphology 22 | 68
abnormal gait 22 | 69
decreased erythrocyte cell num... 22 | 62
decreased hemoglobin content 22 | 68
abnormal kidney morphology 21 | 65
abnormal sleep behavior 21 | 70
enlarged lymph nodes 21 | 37
increased blood urea nitrogen ... 21 | 48
increased bone mineral density 21 | 72
small superior vagus ganglion 21 | 74
pallor 20 | 34
small testis 20 | 58
decreased caudal vertebrae num... 19 | 53
decreased circulating alkaline... 19 | 46
prolonged QT interval 19 | 38
abnormal skin morphology 18 | 50
cardiovascular system phenotyp... 18 | 36
decreased circulating total pr... 18 | 49
decreased hematocrit 18 | 46
decreased red blood cell distr... 18 | 41
enlarged spleen 18 | 41
female infertility 18 | 60
increased erythrocyte cell num... 18 | 39
increased neutrophil cell numb... 18 | 46
abnormal neural tube closure 17 | 46
abnormal spleen morphology 17 | 55
decreased blood urea nitrogen ... 17 | 51
decreased circulating LDL chol... 17 | 38
decreased circulating iron lev... 17 | 32
decreased mean corpuscular hem... 17 | 31
hydrometra 17 | 53
increased circulating chloride... 17 | 41
persistence of hyaloid vascula... 17 | 33
prolonged ST segment 17 | 36
corneal opacity 16 | 32
decreased circulating alanine ... 16 | 47

Disease

Carcinoma 4,127 | 11,493
ovarian cancer 3,725 | 8,520
osteosarcoma 2,993 | 7,950
psoriasis 2,475 | 6,694
medulloblastoma, large-cell 2,431 | 6,241
glioblastoma 2,354 | 5,792
lung cancer 2,044 | 4,740
atypical teratoid / rhabdoid tumor 1,973 | 5,112
ependymoma 1,814 | 4,679
group 3 medulloblastoma 1,556 | 4,104
Breast cancer 1,505 | 3,578
adult high grade glioma 1,400 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,372 | 3,291
malignant mesothelioma 1,303 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,222 | 2,989
invasive ductal carcinoma 1,218 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 1,176 | 2,955
Astrocytoma, Pilocytic 1,149 | 3,081
Kidney cancer 1,141 | 2,613
primitive neuroectodermal tumor 1,126 | 3,035
oligodendroglioma 1,122 | 2,850
non-small cell lung cancer 1,118 | 2,890
astrocytic glioma 1,073 | 2,597
lung adenocarcinoma 1,057 | 2,716
lung carcinoma 1,028 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 1,007 | 1,962
Cancer 982 | 2,499
pancreatic cancer 981 | 2,398
subependymal giant cell astrocytoma 910 | 2,287
Multiple myeloma 863 | 1,332
Pick disease 832 | 1,894
tuberculosis 744 | 2,010
interstitial cystitis 736 | 2,312
Autosomal recessive predisposition 729 | 1,442
diabetes mellitus 727 | 1,728
group 4 medulloblastoma 712 | 1,855
ductal carcinoma in situ 696 | 1,745
breast carcinoma 693 | 1,638
pituitary cancer 675 | 1,972
ulcerative colitis 667 | 1,819
acute quadriplegic myopathy 631 | 1,158
colon cancer 627 | 1,478
cystic fibrosis 620 | 1,696
juvenile dermatomyositis 554 | 1,187
astrocytoma 547 | 1,146
dermatomyositis 547 | 966
adrenocortical carcinoma 529 | 1,428
primary pancreatic ductal adenocarcinoma 492 | 1,109
Waldenstrons macroglobulinemia 480 | 765
Intellectual disability 476 | 1,016
Schizophrenia 468 | 1,160
Rheumatoid arthritis 453 | 1,191
pediatric high grade glioma 446 | 1,064
non primary Sjogren syndrome sicca 399 | 891
Epilepsy 398 | 792
spina bifida 397 | 1,074
nasopharyngeal carcinoma 377 | 1,058
acute myeloid leukemia 354 | 783
Atopic dermatitis 349 | 952
cutaneous lupus erythematosus 343 | 1,057
gastric carcinoma 343 | 807
Liver Cirrhosis, Experimental 340 | 769
Duchenne muscular dystrophy 336 | 601
Muscle hypotonia 329 | 571
active Crohn's disease 329 | 922
Cognitive delay 324 | 608
Global developmental delay 324 | 608
Mental and motor retardation 324 | 608
Dull intelligence 317 | 645
Low intelligence 317 | 645
Mental Retardation 317 | 645
Mental deficiency 317 | 645
Poor school performance 317 | 645
Seizures 310 | 596
esophageal adenocarcinoma 309 | 737
progressive supranuclear palsy 299 | 676
aldosterone-producing adenoma 289 | 665
Melanoma 286 | 711
Liver cancer 281 | 604
Alzheimer's disease 280 | 658
Obesity 277 | 678
Bipolar Disorder 273 | 666
active ulcerative colitis 269 | 764
medulloblastoma 269 | 720
primary Sjogren syndrome 269 | 735
autosomal dominant Emery-Dreifuss muscular dystrophy 268 | 510
Down syndrome 244 | 499
Short stature 242 | 531
Neurodegenerative disease 233 | 414
pancreatic carcinoma 231 | 562
Amyotrophic lateral sclerosis 230 | 451
Skin cancer 220 | 469
Prostatic Neoplasms 219 | 495
fibroadenoma 219 | 559
hepatocellular carcinoma 216 | 547
hereditary spastic paraplegia 215 | 318
Breast Neoplasms 203 | 445
Failure to gain weight 198 | 365
Pediatric failure to thrive 198 | 365
gastric cancer 194 | 459

Tissue

Endocrine System 6,413 | 18,159
Female tissues 6,319 | 17,400
Digestive Tract 6,304 | 17,369
Skin and soft tissues 6,291 | 17,230
Male tissues 6,255 | 17,142
Blood and immune system 6,233 | 16,909
Urinary Tract 6,197 | 16,678
Liver and Pancreas 6,195 | 16,750
Nervous System 6,195 | 16,725
Respiratory system 6,134 | 16,393
Cardiovascular System 5,936 | 15,192

Target Family

Non-IDG 3,812 | 12,091
Enzyme 1,833 | 4,145
Kinase 312 | 634
Transcription Factor 202 | 1,400
Transporter 127 | 473
Epigenetic 85 | 242
Ion Channel 74 | 344
GPCR 32 | 408
TF/Epigenetic 12 | 38
oGPCR 11 | 421
Nuclear Receptor 6 | 48

HPM Tissue

Adult Heart 6,506 | 6,506
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184