Development Level

Tbio 5,163 | 11,178
Tdark 1,218 | 6,569
Tchem 966 | 1,885
Tclin 265 | 612

Collection

Kinase: IDG Consortium (Target... 44 | 125
Kinase: IDG Consortium (Comple... 21 | 37
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 584 | 979
preweaning lethality, incomple... 240 | 499
embryonic lethality prior to t... 153 | 278
embryonic lethality prior to o... 142 | 239
abnormal behavior 134 | 298
abnormal embryo size 115 | 220
decreased total body fat amoun... 105 | 207
decreased body weight 87 | 161
abnormal bone structure 86 | 187
enlarged heart 75 | 210
increased lean body mass 75 | 172
decreased vertical activity 73 | 208
hypoactivity 69 | 132
decreased bone mineral content 68 | 151
increased circulating alkaline... 65 | 122
increased startle reflex 65 | 112
hyperactivity 62 | 148
increased total body fat amoun... 60 | 134
abnormal heart morphology 59 | 162
decreased bone mineral density 59 | 126
decreased circulating glucose ... 59 | 126
embryonic growth retardation 57 | 106
decreased lean body mass 55 | 135
short tibia 54 | 97
decreased grip strength 53 | 116
increased bone mineral content 50 | 108
increased or absent threshold ... 48 | 101
abnormal seminal vesicle morph... 47 | 114
decreased circulating choleste... 47 | 93
increased mean corpuscular hem... 46 | 96
prenatal lethality prior to he... 46 | 87
cataract 45 | 92
abnormal lens morphology 43 | 81
increased fasted circulating g... 43 | 76
decreased prepulse inhibition 42 | 82
increased mean corpuscular vol... 42 | 92
decreased mean corpuscular vol... 41 | 79
male infertility 41 | 123
decreased body length 40 | 101
decreased circulating serum al... 38 | 82
decreased circulating triglyce... 37 | 79
decreased startle reflex 37 | 75
decreased leukocyte cell numbe... 36 | 73
abnormal retina morphology 35 | 71
decreased circulating HDL chol... 35 | 68
decreased circulating insulin ... 35 | 76
increased circulating HDL chol... 35 | 80
edema 34 | 59
increased circulating choleste... 34 | 66
decreased lymphocyte cell numb... 32 | 83
impaired glucose tolerance 32 | 75
improved glucose tolerance 32 | 79
decreased fasted circulating g... 31 | 65
increased bone mineral density 31 | 72
abnormal eye morphology 30 | 68
abnormal sleep behavior 30 | 70
decreased caudal vertebrae num... 30 | 53
increased heart weight 30 | 62
decreased circulating total pr... 29 | 49
thrombocytopenia 29 | 56
abnormal behavioral response t... 28 | 66
abnormal coat-hair pigmentatio... 28 | 64
abnormal gait 28 | 69
abnormal kidney morphology 28 | 65
decreased neutrophil cell numb... 27 | 42
increased circulating sodium l... 26 | 71
decreased circulating alkaline... 25 | 46
decreased erythrocyte cell num... 25 | 62
small superior vagus ganglion 25 | 74
small testis 25 | 58
decreased hemoglobin content 24 | 68
decreased mean corpuscular hem... 24 | 50
increased leukocyte cell numbe... 24 | 47
decreased red blood cell distr... 23 | 41
increased blood urea nitrogen ... 23 | 48
increased grip strength 23 | 41
increased mean platelet volume 23 | 45
increased circulating chloride... 22 | 41
increased hematocrit 22 | 46
increased monocyte cell number 22 | 63
pallor 22 | 34
decreased mean corpuscular hem... 21 | 31
increased hemoglobin content 21 | 45
abnormal bone mineralization 20 | 38
cardiovascular system phenotyp... 20 | 36
decreased circulating alanine ... 20 | 47
decreased circulating chloride... 20 | 30
decreased circulating phosphat... 20 | 27
abnormal neural tube closure 19 | 46
abnormal skin morphology 19 | 50
increased erythrocyte cell num... 19 | 39
abnormal embryo turning 18 | 31
decreased circulating LDL chol... 18 | 38
decreased circulating aspartat... 18 | 34
decreased circulating calcium ... 18 | 36
decreased circulating creatini... 18 | 39
increased circulating triglyce... 18 | 42
increased prepulse inhibition 18 | 32
persistence of hyaloid vascula... 18 | 33
tremors 18 | 39

Disease

Carcinoma 4,848 | 11,192
ovarian cancer 4,350 | 8,297
osteosarcoma 3,547 | 7,766
psoriasis 2,861 | 6,514
medulloblastoma, large-cell 2,768 | 6,086
glioblastoma 2,713 | 5,635
lung cancer 2,368 | 4,607
atypical teratoid / rhabdoid tumor 2,270 | 4,971
ependymoma 2,050 | 4,559
group 3 medulloblastoma 1,797 | 4,002
Breast cancer 1,718 | 3,469
adult high grade glioma 1,629 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 1,613 | 3,204
malignant mesothelioma 1,532 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 1,468 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 1,452 | 2,872
invasive ductal carcinoma 1,449 | 2,867
Astrocytoma, Pilocytic 1,396 | 3,006
Kidney cancer 1,350 | 2,548
non-small cell lung cancer 1,344 | 2,799
primitive neuroectodermal tumor 1,281 | 2,957
oligodendroglioma 1,280 | 2,768
lung adenocarcinoma 1,252 | 2,627
lung carcinoma 1,251 | 2,755
pancreatic cancer 1,216 | 2,322
astrocytic glioma 1,194 | 2,530
Cancer 1,192 | 2,388
pancreatic ductal adenocarcinoma liver metastasis 1,148 | 1,911
subependymal giant cell astrocytoma 1,105 | 2,230
Pick disease 928 | 1,856
Multiple myeloma 916 | 1,296
interstitial cystitis 916 | 2,237
tuberculosis 906 | 1,963
ulcerative colitis 871 | 1,765
group 4 medulloblastoma 856 | 1,806
diabetes mellitus 826 | 1,683
ductal carcinoma in situ 822 | 1,686
breast carcinoma 814 | 1,589
pituitary cancer 812 | 1,915
Autosomal recessive predisposition 795 | 1,407
cystic fibrosis 789 | 1,629
colon cancer 760 | 1,428
acute quadriplegic myopathy 737 | 1,133
juvenile dermatomyositis 696 | 1,147
adrenocortical carcinoma 674 | 1,385
astrocytoma 646 | 1,113
dermatomyositis 630 | 941
primary pancreatic ductal adenocarcinoma 621 | 1,071
Rheumatoid arthritis 567 | 1,156
pediatric high grade glioma 536 | 1,035
Waldenstrons macroglobulinemia 534 | 742
Intellectual disability 526 | 998
Schizophrenia 525 | 1,136
spina bifida 480 | 1,053
cutaneous lupus erythematosus 440 | 1,016
gastric carcinoma 435 | 781
Liver Cirrhosis, Experimental 432 | 733
non primary Sjogren syndrome sicca 429 | 861
nasopharyngeal carcinoma 425 | 1,024
Atopic dermatitis 423 | 915
Epilepsy 416 | 775
Duchenne muscular dystrophy 407 | 587
active Crohn's disease 406 | 882
acute myeloid leukemia 405 | 760
esophageal adenocarcinoma 377 | 696
Dull intelligence 358 | 634
Low intelligence 358 | 634
Mental Retardation 358 | 634
Mental deficiency 358 | 634
Poor school performance 358 | 634
Cognitive delay 357 | 596
Global developmental delay 357 | 596
Mental and motor retardation 357 | 596
primary Sjogren syndrome 355 | 710
autosomal dominant Emery-Dreifuss muscular dystrophy 345 | 492
Muscle hypotonia 343 | 562
progressive supranuclear palsy 338 | 656
Alzheimer's disease 336 | 640
aldosterone-producing adenoma 335 | 646
Seizures 334 | 584
Melanoma 319 | 689
active ulcerative colitis 319 | 736
medulloblastoma 318 | 702
Liver cancer 316 | 589
Obesity 292 | 655
pancreatic carcinoma 283 | 555
Bipolar Disorder 279 | 646
Short stature 279 | 514
Down syndrome 277 | 480
fibroadenoma 273 | 538
Amyotrophic lateral sclerosis 266 | 437
Prostatic Neoplasms 251 | 472
mucosa-associated lymphoid tissue lymphoma 250 | 473
Neurodegenerative disease 243 | 402
hepatocellular carcinoma 242 | 536
sonic hedgehog group medulloblastoma 230 | 459
Breast Neoplasms 229 | 423
Skin cancer 223 | 451
posterior fossa group A ependymoma 216 | 456
gastric cancer 215 | 445

Tissue

Endocrine System 7,514 | 18,159
Female tissues 7,426 | 17,400
Skin and soft tissues 7,411 | 17,230
Digestive Tract 7,410 | 17,369
Male tissues 7,352 | 17,142
Blood and immune system 7,344 | 16,909
Liver and Pancreas 7,328 | 16,750
Urinary Tract 7,299 | 16,678
Nervous System 7,276 | 16,725
Respiratory system 7,243 | 16,393
Cardiovascular System 7,017 | 15,192

Target Family

Non-IDG 4,444 | 12,091
Enzyme 2,074 | 4,145
Transcription Factor 367 | 1,400
Kinase 357 | 634
Transporter 135 | 473
Epigenetic 95 | 242
Ion Channel 66 | 344
GPCR 40 | 408
Nuclear Receptor 12 | 48
oGPCR 12 | 421
TF/Epigenetic 10 | 38

HPM Tissue

Adult Gallbladder 7,612 | 7,612
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162