Development Level

Tbio 5,004 | 10,625
Tdark 1,383 | 7,003
Tchem 971 | 1,890
Tclin 261 | 602

Collection

Eligible Kinase Proteins 50 | 134
Eligible Ion Channel Proteins 18 | 117
Eligible non-olfactory GPCR Proteins 7 | 143

IMPC Term

preweaning lethality, complete... 362 | 633
preweaning lethality, incomple... 127 | 260
abnormal behavior 110 | 226
decreased lean body mass 106 | 195
decreased total body fat amoun... 103 | 186
embryonic lethality prior to t... 103 | 187
decreased body weight 100 | 174
embryonic lethality prior to o... 91 | 148
decreased bone mineral content 75 | 157
abnormal bone structure 71 | 131
increased circulating alkaline... 67 | 119
abnormal embryo size 62 | 112
decreased bone mineral density 62 | 126
decreased grip strength 60 | 123
decreased body length 59 | 108
increased or absent threshold ... 59 | 128
decreased circulating glucose ... 56 | 121
abnormal retina morphology 55 | 100
hyperactivity 50 | 108
increased lean body mass 50 | 107
increased mean corpuscular hem... 50 | 93
increased bone mineral content 46 | 92
hypoactivity 44 | 89
increased fasted circulating g... 44 | 68
decreased circulating choleste... 41 | 85
abnormal lens morphology 40 | 73
decreased circulating HDL chol... 40 | 77
decreased circulating triglyce... 40 | 83
increased grip strength 40 | 83
short tibia 40 | 82
decreased circulating insulin ... 38 | 75
decreased circulating serum al... 38 | 79
decreased mean corpuscular vol... 37 | 50
enlarged heart 37 | 111
increased mean corpuscular vol... 35 | 91
prenatal lethality prior to he... 34 | 64
abnormal retinal pigmentation 32 | 61
abnormal sleep behavior 31 | 63
abnormal bone mineralization 28 | 55
decreased leukocyte cell numbe... 28 | 54
decreased lumbar vertebrae num... 28 | 62
decreased prepulse inhibition 28 | 52
impaired glucose tolerance 28 | 52
increased circulating HDL chol... 27 | 63
increased total body fat amoun... 27 | 57
increased circulating choleste... 26 | 53
increased circulating sodium l... 26 | 71
increased exploration in new e... 26 | 56
decreased rib number 25 | 59
male infertility 25 | 62
thrombocytopenia 25 | 46
decreased circulating total pr... 24 | 41
increased bone mineral density 24 | 52
increased circulating chloride... 24 | 43
increased hemoglobin content 24 | 45
decreased startle reflex 23 | 48
increased blood urea nitrogen ... 23 | 44
increased sacral vertebrae num... 23 | 62
abnormal coat/hair pigmentatio... 22 | 54
decreased fasted circulating g... 22 | 49
decreased heart weight 22 | 44
improved glucose tolerance 22 | 56
abnormal neural tube closure 21 | 37
decreased caudal vertebrae num... 21 | 49
decreased circulating alanine ... 21 | 53
decreased circulating alkaline... 21 | 41
decreased hemoglobin content 21 | 53
increased body weight 21 | 42
increased heart weight 21 | 37
abnormal behavioral response t... 20 | 52
decreased mean corpuscular hem... 20 | 34
decreased neutrophil cell numb... 20 | 37
increased leukocyte cell numbe... 20 | 37
abnormal eye morphology 19 | 38
abnormal gait 19 | 51
decreased circulating free fat... 19 | 39
decreased erythrocyte cell num... 19 | 43
increased circulating potassiu... 19 | 31
abnormal seminal vesicle morph... 18 | 47
cardiovascular system phenotyp... 18 | 35
decreased circulating LDL chol... 18 | 37
decreased circulating chloride... 18 | 32
decreased eosinophil cell numb... 18 | 41
increased hematocrit 18 | 36
increased rib number 18 | 41
decreased circulating calcium ... 17 | 33
decreased circulating creatini... 17 | 31
increased startle reflex 17 | 38
abnormal heart morphology 16 | 51
decreased threshold for audito... 16 | 32
abnormal cranium morphology 15 | 32
decreased circulating fructosa... 15 | 31
enlarged lymph nodes 15 | 27
increased circulating phosphat... 15 | 24
abnormal testis morphology 14 | 30
decreased circulating amylase ... 14 | 24
decreased circulating aspartat... 14 | 27
embryonic growth retardation 14 | 28
small testis 14 | 37
increased circulating free fat... 13 | 17

Disease

ovarian cancer 4,457 | 8,484
osteosarcoma 3,628 | 7,933
psoriasis 2,941 | 6,685
medulloblastoma, large-cell 2,828 | 6,234
glioblastoma 2,675 | 5,572
lung cancer 2,339 | 4,466
atypical teratoid / rhabdoid tumor 1,990 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,661 | 3,289
malignant mesothelioma 1,534 | 3,162
Breast cancer 1,518 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,514 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,500 | 2,956
invasive ductal carcinoma 1,493 | 2,950
pilocytic astrocytoma 1,441 | 3,086
non-small cell lung cancer 1,349 | 2,798
primitive neuroectodermal tumor 1,322 | 3,031
oligodendroglioma 1,318 | 2,849
pediatric high grade glioma 1,297 | 2,712
lung carcinoma 1,296 | 2,844
lung adenocarcinoma 1,294 | 2,713
ependymoma 1,229 | 2,514
pancreatic cancer 1,206 | 2,300
Cancer 1,192 | 2,346
subependymal giant cell astrocytoma 1,135 | 2,287
Carcinoma 1,094 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 1,067 | 1,795
astrocytic glioma 1,034 | 2,241
ulcerative colitis 1,034 | 2,087
group 3 medulloblastoma 965 | 2,254
interstitial cystitis 956 | 2,299
Pick disease 944 | 1,893
Multiple myeloma 943 | 1,327
adult high grade glioma 928 | 2,148
group 4 medulloblastoma 920 | 1,875
astrocytoma 852 | 1,493
ductal carcinoma in situ 852 | 1,745
pituitary cancer 836 | 1,972
breast carcinoma 823 | 1,614
diabetes mellitus 818 | 1,663
cystic fibrosis 809 | 1,665
colon cancer 777 | 1,475
tuberculosis 763 | 1,557
primary pancreatic ductal adenocarcinoma 755 | 1,271
acute quadriplegic myopathy 748 | 1,157
juvenile dermatomyositis 720 | 1,189
sonic hedgehog group medulloblastoma 697 | 1,482
adrenocortical carcinoma 696 | 1,427
medulloblastoma 683 | 1,524
posterior fossa group A ependymoma 681 | 1,511
dermatomyositis 650 | 933
Rheumatoid Arthritis 579 | 1,160
posterior fossa group B ependymoma 563 | 1,530
Waldenstrons macroglobulinemia 553 | 765
atypical teratoid/rhabdoid tumor 494 | 1,095
spina bifida 487 | 1,064
gastric carcinoma 466 | 832
cutaneous lupus erythematosus 461 | 1,056
nasopharyngeal carcinoma 441 | 1,056
Atopic dermatitis 438 | 944
active Crohn's disease 425 | 918
non primary Sjogren syndrome sicca 419 | 840
Duchenne muscular dystrophy 416 | 602
acute myeloid leukemia 414 | 780
esophageal adenocarcinoma 402 | 737
primary Sjogren syndrome 393 | 789
autosomal dominant Emery-Dreifuss muscular dystrophy 348 | 499
progressive supranuclear palsy 346 | 674
aldosterone-producing adenoma 343 | 664
Alzheimer's disease 339 | 644
tuberculosis and treatment for 6 months 329 | 686
Down syndrome 308 | 548
Intellectual disability 286 | 573
pancreatic carcinoma 286 | 567
fibroadenoma 283 | 557
Obesity 264 | 616
Amyotrophic Lateral Sclerosis 262 | 431
mucosa-associated lymphoid tissue lymphoma 255 | 480
IGA Glomerulonephritis 252 | 454
Prostatic Neoplasms 252 | 471
hepatocellular carcinoma 239 | 532
Neurodegenerative disease 231 | 383
Mammary Neoplasms 219 | 410
Endometriosis 215 | 535
hereditary spastic paraplegia 213 | 313
Schizophrenia 208 | 501
gastric cancer 207 | 430
Multiple Sclerosis 203 | 498
Kidney disease 196 | 396
active ulcerative colitis 192 | 477
chronic rhinosinusitis 192 | 512
inflammatory breast cancer 189 | 404
Polycystic Ovary Syndrome 181 | 332
Parkinson's disease 177 | 364
non-small cell lung carcinoma 176 | 413
nephrosclerosis 172 | 329
glioblastoma multiforme 168 | 347
interstitial lung disease 168 | 291
Stomach Neoplasms 164 | 282
sarcoidosis 163 | 358
Vascular disease 156 | 281

Tissue

Liver and Pancreas 7,619 | 18,136
Digestive Tract 7,610 | 18,473
Nervous System 7,607 | 18,561
Female tissues 7,606 | 18,647
Endocrine System 7,593 | 18,512
Male tissues 7,593 | 17,969
Urinary Tract 7,589 | 18,444
Blood and immune system 7,587 | 17,995
Cardiovascular System 7,583 | 17,958
Respiratory system 7,545 | 17,484
Skin and soft tissues 7,487 | 18,115

Target Family

Non-IDG 4,447 | 11,971
Enzyme 2,076 | 4,146
Transcription Factor 368 | 1,400
Kinase 357 | 634
Transporter 136 | 473
Epigenetic 96 | 242
Ion Channel 65 | 341
GPCR 40 | 406
Nuclear Receptor 12 | 48
oGPCR 12 | 421
TF/Epigenetic 10 | 38

HPM Tissue

Adult Gallbladder 7,619 | 7,619
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209