Development Level

Tbio 5,390 | 11,651
Tdark 1,228 | 6,593
Tchem 729 | 1,388
Tclin 265 | 612

Collection

RFA-RM-18-021 68 | 328
Kinase: IDG Consortium (Target... 44 | 125
Kinase: IDG Consortium (Comple... 21 | 37
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 584 | 979
preweaning lethality, incomple... 240 | 499
embryonic lethality prior to t... 153 | 278
embryonic lethality prior to o... 142 | 239
abnormal behavior 134 | 298
abnormal embryo size 115 | 220
decreased total body fat amoun... 105 | 207
decreased body weight 87 | 161
abnormal bone structure 86 | 187
enlarged heart 75 | 210
increased lean body mass 75 | 172
decreased vertical activity 73 | 208
hypoactivity 69 | 132
decreased bone mineral content 68 | 151
increased circulating alkaline... 65 | 122
increased startle reflex 65 | 112
hyperactivity 62 | 148
increased total body fat amoun... 60 | 134
abnormal heart morphology 59 | 162
decreased bone mineral density 59 | 126
decreased circulating glucose ... 59 | 126
embryonic growth retardation 57 | 106
decreased lean body mass 55 | 135
short tibia 54 | 97
decreased grip strength 53 | 116
increased bone mineral content 50 | 108
increased or absent threshold ... 48 | 101
abnormal seminal vesicle morph... 47 | 114
decreased circulating choleste... 47 | 93
increased mean corpuscular hem... 46 | 96
prenatal lethality prior to he... 46 | 87
cataract 45 | 92
abnormal lens morphology 43 | 81
increased fasted circulating g... 43 | 76
decreased prepulse inhibition 42 | 82
increased mean corpuscular vol... 42 | 92
decreased mean corpuscular vol... 41 | 79
male infertility 41 | 123
decreased body length 40 | 101
decreased circulating serum al... 38 | 82
decreased circulating triglyce... 37 | 79
decreased startle reflex 37 | 75
decreased leukocyte cell numbe... 36 | 73
abnormal retina morphology 35 | 71
decreased circulating HDL chol... 35 | 68
decreased circulating insulin ... 35 | 76
increased circulating HDL chol... 35 | 80
edema 34 | 59
increased circulating choleste... 34 | 66
decreased lymphocyte cell numb... 32 | 83
impaired glucose tolerance 32 | 75
improved glucose tolerance 32 | 79
decreased fasted circulating g... 31 | 65
increased bone mineral density 31 | 72
abnormal eye morphology 30 | 68
abnormal sleep behavior 30 | 70
decreased caudal vertebrae num... 30 | 53
increased heart weight 30 | 62
decreased circulating total pr... 29 | 49
thrombocytopenia 29 | 56
abnormal behavioral response t... 28 | 66
abnormal coat-hair pigmentatio... 28 | 64
abnormal gait 28 | 69
abnormal kidney morphology 28 | 65
decreased neutrophil cell numb... 27 | 42
increased circulating sodium l... 26 | 71
decreased circulating alkaline... 25 | 46
decreased erythrocyte cell num... 25 | 62
small superior vagus ganglion 25 | 74
small testis 25 | 58
decreased hemoglobin content 24 | 68
decreased mean corpuscular hem... 24 | 50
increased leukocyte cell numbe... 24 | 47
decreased red blood cell distr... 23 | 41
increased blood urea nitrogen ... 23 | 48
increased grip strength 23 | 41
increased mean platelet volume 23 | 45
increased circulating chloride... 22 | 41
increased hematocrit 22 | 46
increased monocyte cell number 22 | 63
pallor 22 | 34
decreased mean corpuscular hem... 21 | 31
increased hemoglobin content 21 | 45
abnormal bone mineralization 20 | 38
cardiovascular system phenotyp... 20 | 36
decreased circulating alanine ... 20 | 47
decreased circulating chloride... 20 | 30
decreased circulating phosphat... 20 | 27
abnormal neural tube closure 19 | 46
abnormal skin morphology 19 | 50
increased erythrocyte cell num... 19 | 39
abnormal embryo turning 18 | 31
decreased circulating LDL chol... 18 | 38
decreased circulating aspartat... 18 | 34
decreased circulating calcium ... 18 | 36
decreased circulating creatini... 18 | 39
increased circulating triglyce... 18 | 42
increased prepulse inhibition 18 | 32
persistence of hyaloid vascula... 18 | 33
tremors 18 | 39

Disease

Carcinoma 4,964 | 11,493
ovarian cancer 4,469 | 8,520
osteosarcoma 3,628 | 7,950
psoriasis 2,939 | 6,694
medulloblastoma, large-cell 2,828 | 6,241
glioblastoma 2,786 | 5,792
lung cancer 2,437 | 4,740
atypical teratoid / rhabdoid tumor 2,332 | 5,112
ependymoma 2,110 | 4,679
group 3 medulloblastoma 1,837 | 4,104
Breast cancer 1,765 | 3,578
adult high grade glioma 1,675 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,660 | 3,291
malignant mesothelioma 1,576 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,513 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,495 | 2,955
invasive ductal carcinoma 1,492 | 2,951
Astrocytoma, Pilocytic 1,436 | 3,081
non-small cell lung cancer 1,386 | 2,890
Kidney cancer 1,377 | 2,613
primitive neuroectodermal tumor 1,320 | 3,035
oligodendroglioma 1,318 | 2,850
lung carcinoma 1,297 | 2,843
lung adenocarcinoma 1,293 | 2,716
pancreatic cancer 1,255 | 2,398
Cancer 1,251 | 2,499
astrocytic glioma 1,223 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 1,179 | 1,962
subependymal giant cell astrocytoma 1,136 | 2,287
interstitial cystitis 955 | 2,312
Pick disease 946 | 1,894
Multiple myeloma 945 | 1,332
tuberculosis 931 | 2,010
ulcerative colitis 896 | 1,819
group 4 medulloblastoma 870 | 1,855
diabetes mellitus 852 | 1,728
ductal carcinoma in situ 850 | 1,745
breast carcinoma 836 | 1,638
pituitary cancer 834 | 1,972
cystic fibrosis 823 | 1,696
Autosomal recessive predisposition 815 | 1,442
colon cancer 778 | 1,478
acute quadriplegic myopathy 750 | 1,158
juvenile dermatomyositis 721 | 1,187
adrenocortical carcinoma 694 | 1,428
astrocytoma 667 | 1,146
dermatomyositis 651 | 966
primary pancreatic ductal adenocarcinoma 644 | 1,109
Rheumatoid arthritis 586 | 1,191
Waldenstrons macroglobulinemia 552 | 765
pediatric high grade glioma 551 | 1,064
Intellectual disability 535 | 1,016
Schizophrenia 533 | 1,160
spina bifida 490 | 1,074
Liver Cirrhosis, Experimental 461 | 769
cutaneous lupus erythematosus 461 | 1,057
gastric carcinoma 452 | 807
Atopic dermatitis 445 | 952
non primary Sjogren syndrome sicca 443 | 891
nasopharyngeal carcinoma 441 | 1,058
active Crohn's disease 427 | 922
Epilepsy 422 | 792
acute myeloid leukemia 417 | 783
Duchenne muscular dystrophy 416 | 601
esophageal adenocarcinoma 401 | 737
primary Sjogren syndrome 370 | 735
Dull intelligence 363 | 645
Low intelligence 363 | 645
Mental Retardation 363 | 645
Mental deficiency 363 | 645
Poor school performance 363 | 645
Cognitive delay 362 | 608
Global developmental delay 362 | 608
Mental and motor retardation 362 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 356 | 510
Muscle hypotonia 349 | 571
Alzheimer's disease 347 | 658
progressive supranuclear palsy 347 | 676
aldosterone-producing adenoma 343 | 665
Seizures 338 | 596
active ulcerative colitis 330 | 764
medulloblastoma 330 | 720
Liver cancer 327 | 604
Melanoma 327 | 711
Obesity 306 | 678
Bipolar Disorder 289 | 666
Down syndrome 287 | 499
Short stature 287 | 531
pancreatic carcinoma 285 | 562
fibroadenoma 284 | 559
Amyotrophic lateral sclerosis 275 | 451
Prostatic Neoplasms 262 | 495
mucosa-associated lymphoid tissue lymphoma 257 | 484
Neurodegenerative disease 252 | 414
hepatocellular carcinoma 247 | 547
Breast Neoplasms 239 | 445
sonic hedgehog group medulloblastoma 232 | 467
Skin cancer 230 | 469
Mammary Neoplasms 224 | 425
gastric cancer 221 | 459

Tissue

Endocrine System 7,514 | 18,159
Female tissues 7,426 | 17,400
Skin and soft tissues 7,411 | 17,230
Digestive Tract 7,410 | 17,369
Male tissues 7,352 | 17,142
Blood and immune system 7,344 | 16,909
Liver and Pancreas 7,328 | 16,750
Urinary Tract 7,299 | 16,678
Nervous System 7,276 | 16,725
Respiratory system 7,243 | 16,393
Cardiovascular System 7,017 | 15,192

Target Family

Non-IDG 4,444 | 12,091
Enzyme 2,074 | 4,145
Transcription Factor 367 | 1,400
Kinase 357 | 634
Transporter 135 | 473
Epigenetic 95 | 242
Ion Channel 66 | 344
GPCR 40 | 408
Nuclear Receptor 12 | 48
oGPCR 12 | 421
TF/Epigenetic 10 | 38

HPM Tissue

Adult Gallbladder 7,612 | 7,612
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19