Development Level

Tbio 6,135 | 11,651
Tdark 1,789 | 6,593
Tchem 778 | 1,388
Tclin 346 | 612

Collection

RFA-RM-18-021 139 | 328
Kinase: IDG Consortium (Target... 72 | 125
Ion Channel: IDG Consortium (T... 53 | 99
Kinase: IDG Consortium (Comple... 27 | 37
GPCR: IDG Consortium (Targets) 16 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 621 | 979
preweaning lethality, incomple... 281 | 499
abnormal behavior 192 | 298
embryonic lethality prior to t... 167 | 278
embryonic lethality prior to o... 151 | 239
decreased total body fat amoun... 130 | 207
abnormal embryo size 116 | 220
abnormal bone structure 113 | 187
increased lean body mass 105 | 172
decreased body weight 104 | 161
hyperactivity 97 | 148
decreased vertical activity 93 | 208
decreased bone mineral content 90 | 151
hypoactivity 80 | 132
enlarged heart 78 | 210
increased circulating alkaline... 77 | 122
increased total body fat amoun... 74 | 134
decreased bone mineral density 72 | 126
decreased lean body mass 71 | 135
decreased circulating glucose ... 70 | 126
decreased grip strength 69 | 116
increased startle reflex 67 | 112
increased bone mineral content 66 | 108
abnormal heart morphology 62 | 162
abnormal seminal vesicle morph... 62 | 114
short tibia 62 | 97
cataract 60 | 92
embryonic growth retardation 58 | 106
male infertility 58 | 123
decreased body length 57 | 101
decreased circulating choleste... 57 | 93
abnormal lens morphology 56 | 81
increased mean corpuscular hem... 56 | 96
increased or absent threshold ... 56 | 101
decreased prepulse inhibition 53 | 82
prenatal lethality prior to he... 52 | 87
increased mean corpuscular vol... 50 | 92
decreased startle reflex 49 | 75
decreased circulating serum al... 47 | 82
decreased circulating triglyce... 47 | 79
increased fasted circulating g... 47 | 76
decreased mean corpuscular vol... 46 | 79
decreased circulating HDL chol... 43 | 68
impaired glucose tolerance 43 | 75
improved glucose tolerance 43 | 79
abnormal gait 42 | 69
abnormal retina morphology 41 | 71
decreased circulating insulin ... 41 | 76
decreased lymphocyte cell numb... 41 | 83
abnormal behavioral response t... 40 | 66
decreased leukocyte cell numbe... 40 | 73
abnormal sleep behavior 39 | 70
increased circulating HDL chol... 39 | 80
increased heart weight 39 | 62
increased bone mineral density 38 | 72
increased circulating choleste... 37 | 66
increased circulating sodium l... 37 | 71
decreased fasted circulating g... 36 | 65
small superior vagus ganglion 36 | 74
abnormal eye morphology 34 | 68
thrombocytopenia 34 | 56
decreased erythrocyte cell num... 33 | 62
decreased hemoglobin content 33 | 68
decreased mean corpuscular hem... 33 | 50
increased mean platelet volume 32 | 45
abnormal kidney morphology 31 | 65
decreased caudal vertebrae num... 31 | 53
edema 31 | 59
increased hematocrit 31 | 46
increased leukocyte cell numbe... 31 | 47
small testis 31 | 58
decreased neutrophil cell numb... 30 | 42
abnormal coat-hair pigmentatio... 29 | 64
decreased circulating alkaline... 29 | 46
decreased circulating total pr... 29 | 49
increased circulating chloride... 29 | 41
increased monocyte cell number 28 | 63
limb grasping 28 | 41
decreased circulating LDL chol... 27 | 38
increased blood urea nitrogen ... 26 | 48
increased circulating triglyce... 26 | 42
increased erythrocyte cell num... 26 | 39
increased red blood cell distr... 26 | 34
abnormal skin morphology 25 | 50
decreased circulating alanine ... 25 | 47
hydrometra 25 | 53
increased hemoglobin content 25 | 45
increased neutrophil cell numb... 25 | 46
abnormal spleen morphology 24 | 55
decreased blood urea nitrogen ... 24 | 51
decreased circulating calcium ... 24 | 36
decreased mean corpuscular hem... 24 | 31
cardiovascular system phenotyp... 23 | 36
decreased hematocrit 23 | 46
decreased red blood cell distr... 23 | 41
female infertility 23 | 60
increased prepulse inhibition 23 | 32
tremors 23 | 39
decreased circulating aspartat... 22 | 34
prolonged QT interval 22 | 38

Disease

Carcinoma 5,971 | 11,493
ovarian cancer 4,981 | 8,520
osteosarcoma 4,215 | 7,950
medulloblastoma, large-cell 3,663 | 6,241
glioblastoma 3,456 | 5,792
psoriasis 3,336 | 6,694
atypical teratoid / rhabdoid tumor 3,108 | 5,112
ependymoma 2,779 | 4,679
lung cancer 2,680 | 4,740
group 3 medulloblastoma 2,385 | 4,104
adult high grade glioma 2,231 | 3,801
Breast cancer 2,004 | 3,578
oligodendroglioma 1,833 | 2,850
primitive neuroectodermal tumor 1,831 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 1,824 | 3,291
Astrocytoma, Pilocytic 1,801 | 3,081
malignant mesothelioma 1,776 | 3,232
astrocytic glioma 1,698 | 2,597
Kidney cancer 1,668 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 1,635 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,631 | 2,955
invasive ductal carcinoma 1,573 | 2,951
non-small cell lung cancer 1,479 | 2,890
lung carcinoma 1,445 | 2,843
subependymal giant cell astrocytoma 1,427 | 2,287
lung adenocarcinoma 1,386 | 2,716
Pick disease 1,310 | 1,894
pancreatic cancer 1,290 | 2,398
Cancer 1,239 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 1,211 | 1,962
group 4 medulloblastoma 1,099 | 1,855
tuberculosis 1,043 | 2,010
interstitial cystitis 1,025 | 2,312
pituitary cancer 1,008 | 1,972
Multiple myeloma 1,001 | 1,332
ductal carcinoma in situ 897 | 1,745
ulcerative colitis 893 | 1,819
cystic fibrosis 877 | 1,696
breast carcinoma 866 | 1,638
diabetes mellitus 866 | 1,728
Autosomal recessive predisposition 850 | 1,442
colon cancer 825 | 1,478
acute quadriplegic myopathy 765 | 1,158
adrenocortical carcinoma 746 | 1,428
astrocytoma 740 | 1,146
juvenile dermatomyositis 720 | 1,187
Schizophrenia 704 | 1,160
dermatomyositis 668 | 966
Rheumatoid arthritis 650 | 1,191
Intellectual disability 638 | 1,016
primary pancreatic ductal adenocarcinoma 638 | 1,109
pediatric high grade glioma 616 | 1,064
spina bifida 586 | 1,074
Waldenstrons macroglobulinemia 569 | 765
Epilepsy 558 | 792
nasopharyngeal carcinoma 498 | 1,058
non primary Sjogren syndrome sicca 491 | 891
cutaneous lupus erythematosus 489 | 1,057
active Crohn's disease 462 | 922
progressive supranuclear palsy 460 | 676
acute myeloid leukemia 445 | 783
Atopic dermatitis 434 | 952
gastric carcinoma 427 | 807
Alzheimer's disease 424 | 658
Liver cancer 417 | 604
medulloblastoma 415 | 720
Cognitive delay 412 | 608
Global developmental delay 412 | 608
Mental and motor retardation 412 | 608
Dull intelligence 410 | 645
Low intelligence 410 | 645
Mental Retardation 410 | 645
Mental deficiency 410 | 645
Poor school performance 410 | 645
Liver Cirrhosis, Experimental 408 | 769
Seizures 406 | 596
esophageal adenocarcinoma 406 | 737
Muscle hypotonia 400 | 571
Melanoma 398 | 711
Bipolar Disorder 387 | 666
Duchenne muscular dystrophy 384 | 601
primary Sjogren syndrome 382 | 735
active ulcerative colitis 379 | 764
aldosterone-producing adenoma 377 | 665
Down syndrome 350 | 499
Obesity 333 | 678
autosomal dominant Emery-Dreifuss muscular dystrophy 317 | 510
Amyotrophic lateral sclerosis 313 | 451
Neurodegenerative disease 312 | 414
Short stature 306 | 531
pancreatic carcinoma 304 | 562
Skin cancer 283 | 469
hepatocellular carcinoma 277 | 547
fibroadenoma 266 | 559
Prostatic Neoplasms 263 | 495
Multiple Sclerosis 255 | 540
gastric cancer 252 | 459
hereditary spastic paraplegia 250 | 318
sonic hedgehog group medulloblastoma 245 | 467
tuberculosis and treatment for 6 months 244 | 409

Tissue

Endocrine System 8,920 | 18,159
Female tissues 8,775 | 17,400
Digestive Tract 8,762 | 17,369
Skin and soft tissues 8,752 | 17,230
Male tissues 8,700 | 17,142
Nervous System 8,661 | 16,725
Blood and immune system 8,628 | 16,909
Liver and Pancreas 8,609 | 16,750
Urinary Tract 8,580 | 16,678
Respiratory system 8,506 | 16,393
Cardiovascular System 8,160 | 15,192

Target Family

Non-IDG 5,213 | 12,091
Enzyme 2,300 | 4,145
Transcription Factor 464 | 1,400
Kinase 444 | 634
Transporter 225 | 473
Ion Channel 184 | 344
Epigenetic 106 | 242
GPCR 77 | 408
oGPCR 16 | 421
TF/Epigenetic 12 | 38
Nuclear Receptor 7 | 48

HPM Tissue

Adult Frontal Cortex 9,048 | 9,048
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66