Development Level

Tbio 5,656 | 10,625
Tdark 2,004 | 7,003
Tchem 1,053 | 1,890
Tclin 341 | 602

Collection

Eligible Kinase Proteins 82 | 134
Eligible Ion Channel Proteins 54 | 117
Eligible non-olfactory GPCR Proteins 17 | 143

IMPC Term

preweaning lethality, complete... 388 | 633
abnormal behavior 149 | 226
preweaning lethality, incomple... 146 | 260
decreased lean body mass 131 | 195
decreased total body fat amoun... 124 | 186
embryonic lethality prior to t... 117 | 187
decreased body weight 112 | 174
decreased bone mineral content 100 | 157
embryonic lethality prior to o... 98 | 148
abnormal bone structure 83 | 131
increased circulating alkaline... 80 | 119
decreased bone mineral density 78 | 126
decreased grip strength 74 | 123
hyperactivity 73 | 108
increased or absent threshold ... 72 | 128
decreased body length 68 | 108
decreased circulating glucose ... 68 | 121
abnormal embryo size 66 | 112
increased lean body mass 66 | 107
increased mean corpuscular hem... 61 | 93
decreased circulating choleste... 58 | 85
increased bone mineral content 57 | 92
decreased circulating HDL chol... 55 | 77
abnormal retina morphology 54 | 100
short tibia 54 | 82
hypoactivity 53 | 89
abnormal lens morphology 52 | 73
decreased circulating triglyce... 51 | 83
increased mean corpuscular vol... 49 | 91
decreased circulating serum al... 48 | 79
increased fasted circulating g... 46 | 68
increased grip strength 43 | 83
decreased circulating insulin ... 41 | 75
increased circulating sodium l... 40 | 71
prenatal lethality prior to he... 40 | 64
abnormal sleep behavior 39 | 63
enlarged heart 38 | 111
decreased mean corpuscular vol... 36 | 50
male infertility 35 | 62
decreased lumbar vertebrae num... 34 | 62
abnormal retinal pigmentation 33 | 61
decreased rib number 33 | 59
impaired glucose tolerance 33 | 52
abnormal gait 32 | 51
decreased prepulse inhibition 32 | 52
increased circulating HDL chol... 32 | 63
decreased fasted circulating g... 31 | 49
decreased leukocyte cell numbe... 31 | 54
decreased startle reflex 31 | 48
increased circulating choleste... 31 | 53
increased sacral vertebrae num... 31 | 62
abnormal bone mineralization 30 | 55
increased bone mineral density 30 | 52
increased circulating chloride... 30 | 43
abnormal behavioral response t... 29 | 52
improved glucose tolerance 29 | 56
increased blood urea nitrogen ... 29 | 44
increased total body fat amoun... 29 | 57
thrombocytopenia 29 | 46
decreased hemoglobin content 28 | 53
decreased caudal vertebrae num... 27 | 49
decreased circulating alanine ... 27 | 53
increased exploration in new e... 27 | 56
increased hemoglobin content 27 | 45
decreased circulating LDL chol... 26 | 37
decreased eosinophil cell numb... 25 | 41
increased body weight 25 | 42
increased leukocyte cell numbe... 25 | 37
increased startle reflex 25 | 38
abnormal coat/hair pigmentatio... 24 | 54
decreased mean corpuscular hem... 24 | 34
increased heart weight 24 | 37
abnormal neural tube closure 23 | 37
abnormal seminal vesicle morph... 23 | 47
decreased circulating alkaline... 23 | 41
decreased circulating free fat... 23 | 39
decreased circulating total pr... 23 | 41
decreased erythrocyte cell num... 23 | 43
decreased heart weight 23 | 44
increased hematocrit 23 | 36
increased rib number 23 | 41
cardiovascular system phenotyp... 22 | 35
decreased circulating fructosa... 22 | 31
limb grasping 22 | 35
abnormal cranium morphology 21 | 32
decreased neutrophil cell numb... 21 | 37
decreased circulating aspartat... 20 | 27
decreased circulating calcium ... 20 | 33
increased circulating calcium ... 20 | 32
tremors 20 | 34
abnormal eye morphology 19 | 38
decreased circulating creatini... 19 | 31
straub tail 19 | 26
abnormal spleen morphology 18 | 36
increased erythrocyte cell num... 18 | 26
small testis 18 | 37
abnormal locomotor activation 17 | 26
decreased blood urea nitrogen ... 17 | 31
female infertility 17 | 34
abnormal epididymis morphology 16 | 31

Disease

ovarian cancer 4,964 | 8,484
osteosarcoma 4,220 | 7,933
medulloblastoma, large-cell 3,664 | 6,234
psoriasis 3,340 | 6,685
glioblastoma 3,327 | 5,572
atypical teratoid / rhabdoid tumor 2,643 | 4,369
lung cancer 2,535 | 4,466
oligodendroglioma 1,834 | 2,849
primitive neuroectodermal tumor 1,832 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 1,826 | 3,289
pilocytic astrocytoma 1,811 | 3,086
malignant mesothelioma 1,742 | 3,162
Breast cancer 1,739 | 3,094
ependymoma 1,650 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 1,637 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,635 | 2,956
pediatric high grade glioma 1,628 | 2,712
invasive ductal carcinoma 1,575 | 2,950
lung carcinoma 1,446 | 2,844
astrocytic glioma 1,438 | 2,241
non-small cell lung cancer 1,438 | 2,798
subependymal giant cell astrocytoma 1,426 | 2,287
lung adenocarcinoma 1,388 | 2,713
Carcinoma 1,374 | 2,147
Pick disease 1,309 | 1,893
pancreatic cancer 1,227 | 2,300
adult high grade glioma 1,218 | 2,148
group 3 medulloblastoma 1,205 | 2,254
Cancer 1,178 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 1,110 | 1,795
group 4 medulloblastoma 1,106 | 1,875
ulcerative colitis 1,046 | 2,087
interstitial cystitis 1,025 | 2,299
pituitary cancer 1,011 | 1,972
astrocytoma 998 | 1,493
Multiple myeloma 997 | 1,327
medulloblastoma 973 | 1,524
ductal carcinoma in situ 900 | 1,745
cystic fibrosis 864 | 1,665
sonic hedgehog group medulloblastoma 856 | 1,482
breast carcinoma 852 | 1,614
diabetes mellitus 838 | 1,663
colon cancer 825 | 1,475
tuberculosis 822 | 1,557
posterior fossa group A ependymoma 802 | 1,511
acute quadriplegic myopathy 764 | 1,157
adrenocortical carcinoma 749 | 1,427
primary pancreatic ductal adenocarcinoma 738 | 1,271
posterior fossa group B ependymoma 730 | 1,530
juvenile dermatomyositis 719 | 1,189
dermatomyositis 668 | 933
atypical teratoid/rhabdoid tumor 646 | 1,095
Rheumatoid Arthritis 634 | 1,160
spina bifida 581 | 1,064
Waldenstrons macroglobulinemia 570 | 765
nasopharyngeal carcinoma 497 | 1,056
cutaneous lupus erythematosus 489 | 1,056
non primary Sjogren syndrome sicca 470 | 840
active Crohn's disease 461 | 918
progressive supranuclear palsy 460 | 674
gastric carcinoma 442 | 832
acute myeloid leukemia 441 | 780
Atopic dermatitis 430 | 944
Alzheimer's disease 415 | 644
esophageal adenocarcinoma 406 | 737
primary Sjogren syndrome 402 | 789
tuberculosis and treatment for 6 months 392 | 686
Duchenne muscular dystrophy 384 | 602
aldosterone-producing adenoma 377 | 664
Down syndrome 374 | 548
Intellectual disability 369 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 313 | 499
pancreatic carcinoma 307 | 567
Obesity 302 | 616
Schizophrenia 301 | 501
Amyotrophic Lateral Sclerosis 294 | 431
Neurodegenerative disease 294 | 383
hepatocellular carcinoma 268 | 532
fibroadenoma 266 | 557
IGA Glomerulonephritis 263 | 454
Epilepsy 258 | 346
Prostatic Neoplasms 254 | 471
hereditary spastic paraplegia 245 | 313
gastric cancer 239 | 430
Endometriosis 238 | 535
Multiple Sclerosis 236 | 498
chronic rhinosinusitis 236 | 512
Parkinson's disease 227 | 364
active ulcerative colitis 224 | 477
mucosa-associated lymphoid tissue lymphoma 222 | 480
non-small cell lung carcinoma 208 | 413
Mammary Neoplasms 207 | 410
glioblastoma multiforme 192 | 347
inflammatory breast cancer 191 | 404
Autistic Disorder 187 | 320
Polycystic Ovary Syndrome 185 | 332
sarcoidosis 181 | 358
Kidney disease 177 | 396
tuberculosis and treatment for 3 months 176 | 327
Stomach Neoplasms 167 | 282

Tissue

Nervous System 9,054 | 18,561
Female tissues 9,031 | 18,647
Digestive Tract 9,023 | 18,473
Liver and Pancreas 9,008 | 18,136
Endocrine System 9,006 | 18,512
Urinary Tract 9,006 | 18,444
Male tissues 8,995 | 17,969
Blood and immune system 8,991 | 17,995
Cardiovascular System 8,990 | 17,958
Respiratory system 8,912 | 17,484
Skin and soft tissues 8,882 | 18,115

Target Family

Non-IDG 5,219 | 11,971
Enzyme 2,302 | 4,146
Transcription Factor 465 | 1,400
Kinase 444 | 634
Transporter 225 | 473
Ion Channel 180 | 341
Epigenetic 107 | 242
GPCR 77 | 406
oGPCR 16 | 421
TF/Epigenetic 12 | 38
Nuclear Receptor 7 | 48

HPM Tissue

Adult Frontal Cortex 9,054 | 9,054
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27