Development Level

Tbio 5,879 | 11,178
Tdark 1,775 | 6,569
Tchem 1,048 | 1,885
Tclin 346 | 612

Collection

Kinase: IDG Consortium (Target... 72 | 125
Ion Channel: IDG Consortium (T... 53 | 99
Kinase: IDG Consortium (Comple... 27 | 37
GPCR: IDG Consortium (Targets) 16 | 126
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 621 | 979
preweaning lethality, incomple... 281 | 499
abnormal behavior 192 | 298
embryonic lethality prior to t... 167 | 278
embryonic lethality prior to o... 151 | 239
decreased total body fat amoun... 130 | 207
abnormal embryo size 116 | 220
abnormal bone structure 113 | 187
increased lean body mass 105 | 172
decreased body weight 104 | 161
hyperactivity 97 | 148
decreased vertical activity 93 | 208
decreased bone mineral content 90 | 151
hypoactivity 80 | 132
enlarged heart 78 | 210
increased circulating alkaline... 77 | 122
increased total body fat amoun... 74 | 134
decreased bone mineral density 72 | 126
decreased lean body mass 71 | 135
decreased circulating glucose ... 70 | 126
decreased grip strength 69 | 116
increased startle reflex 67 | 112
increased bone mineral content 66 | 108
abnormal heart morphology 62 | 162
abnormal seminal vesicle morph... 62 | 114
short tibia 62 | 97
cataract 60 | 92
embryonic growth retardation 58 | 106
male infertility 58 | 123
decreased body length 57 | 101
decreased circulating choleste... 57 | 93
abnormal lens morphology 56 | 81
increased mean corpuscular hem... 56 | 96
increased or absent threshold ... 56 | 101
decreased prepulse inhibition 53 | 82
prenatal lethality prior to he... 52 | 87
increased mean corpuscular vol... 50 | 92
decreased startle reflex 49 | 75
decreased circulating serum al... 47 | 82
decreased circulating triglyce... 47 | 79
increased fasted circulating g... 47 | 76
decreased mean corpuscular vol... 46 | 79
decreased circulating HDL chol... 43 | 68
impaired glucose tolerance 43 | 75
improved glucose tolerance 43 | 79
abnormal gait 42 | 69
abnormal retina morphology 41 | 71
decreased circulating insulin ... 41 | 76
decreased lymphocyte cell numb... 41 | 83
abnormal behavioral response t... 40 | 66
decreased leukocyte cell numbe... 40 | 73
abnormal sleep behavior 39 | 70
increased circulating HDL chol... 39 | 80
increased heart weight 39 | 62
increased bone mineral density 38 | 72
increased circulating choleste... 37 | 66
increased circulating sodium l... 37 | 71
decreased fasted circulating g... 36 | 65
small superior vagus ganglion 36 | 74
abnormal eye morphology 34 | 68
thrombocytopenia 34 | 56
decreased erythrocyte cell num... 33 | 62
decreased hemoglobin content 33 | 68
decreased mean corpuscular hem... 33 | 50
increased mean platelet volume 32 | 45
abnormal kidney morphology 31 | 65
decreased caudal vertebrae num... 31 | 53
edema 31 | 59
increased hematocrit 31 | 46
increased leukocyte cell numbe... 31 | 47
small testis 31 | 58
decreased neutrophil cell numb... 30 | 42
abnormal coat-hair pigmentatio... 29 | 64
decreased circulating alkaline... 29 | 46
decreased circulating total pr... 29 | 49
increased circulating chloride... 29 | 41
increased monocyte cell number 28 | 63
limb grasping 28 | 41
decreased circulating LDL chol... 27 | 38
increased blood urea nitrogen ... 26 | 48
increased circulating triglyce... 26 | 42
increased erythrocyte cell num... 26 | 39
increased red blood cell distr... 26 | 34
abnormal skin morphology 25 | 50
decreased circulating alanine ... 25 | 47
hydrometra 25 | 53
increased hemoglobin content 25 | 45
increased neutrophil cell numb... 25 | 46
abnormal spleen morphology 24 | 55
decreased blood urea nitrogen ... 24 | 51
decreased circulating calcium ... 24 | 36
decreased mean corpuscular hem... 24 | 31
cardiovascular system phenotyp... 23 | 36
decreased hematocrit 23 | 46
decreased red blood cell distr... 23 | 41
female infertility 23 | 60
increased prepulse inhibition 23 | 32
tremors 23 | 39
decreased circulating aspartat... 22 | 34
prolonged QT interval 22 | 38

Disease

Carcinoma 5,838 | 11,192
ovarian cancer 4,862 | 8,297
osteosarcoma 4,134 | 7,766
medulloblastoma, large-cell 3,586 | 6,086
glioblastoma 3,382 | 5,635
psoriasis 3,266 | 6,514
atypical teratoid / rhabdoid tumor 3,037 | 4,971
ependymoma 2,715 | 4,559
lung cancer 2,619 | 4,607
group 3 medulloblastoma 2,341 | 4,002
adult high grade glioma 2,179 | 3,701
Breast cancer 1,955 | 3,469
oligodendroglioma 1,793 | 2,768
primitive neuroectodermal tumor 1,793 | 2,957
intraductal papillary-mucinous neoplasm (IPMN) 1,782 | 3,204
Astrocytoma, Pilocytic 1,761 | 3,006
malignant mesothelioma 1,737 | 3,135
astrocytic glioma 1,662 | 2,530
Kidney cancer 1,637 | 2,548
intraductal papillary-mucinous adenoma (IPMA) 1,598 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 1,597 | 2,902
invasive ductal carcinoma 1,537 | 2,867
non-small cell lung cancer 1,443 | 2,799
lung carcinoma 1,399 | 2,755
subependymal giant cell astrocytoma 1,396 | 2,230
lung adenocarcinoma 1,350 | 2,627
Pick disease 1,280 | 1,856
pancreatic cancer 1,256 | 2,322
Cancer 1,194 | 2,388
pancreatic ductal adenocarcinoma liver metastasis 1,180 | 1,911
group 4 medulloblastoma 1,075 | 1,806
tuberculosis 1,026 | 1,963
interstitial cystitis 991 | 2,237
pituitary cancer 982 | 1,915
Multiple myeloma 971 | 1,296
ductal carcinoma in situ 874 | 1,686
ulcerative colitis 870 | 1,765
cystic fibrosis 850 | 1,629
breast carcinoma 848 | 1,589
diabetes mellitus 843 | 1,683
Autosomal recessive predisposition 835 | 1,407
colon cancer 805 | 1,428
acute quadriplegic myopathy 755 | 1,133
adrenocortical carcinoma 726 | 1,385
astrocytoma 719 | 1,113
juvenile dermatomyositis 696 | 1,147
Schizophrenia 694 | 1,136
dermatomyositis 648 | 941
Rheumatoid arthritis 635 | 1,156
Intellectual disability 632 | 998
primary pancreatic ductal adenocarcinoma 622 | 1,071
pediatric high grade glioma 606 | 1,035
spina bifida 576 | 1,053
Waldenstrons macroglobulinemia 553 | 742
Epilepsy 551 | 775
nasopharyngeal carcinoma 486 | 1,024
non primary Sjogren syndrome sicca 480 | 861
cutaneous lupus erythematosus 474 | 1,016
progressive supranuclear palsy 444 | 656
active Crohn's disease 442 | 882
acute myeloid leukemia 432 | 760
Atopic dermatitis 418 | 915
gastric carcinoma 418 | 781
Alzheimer's disease 410 | 640
Liver cancer 409 | 589
Cognitive delay 407 | 596
Global developmental delay 407 | 596
Mental and motor retardation 407 | 596
medulloblastoma 407 | 702
Dull intelligence 405 | 634
Low intelligence 405 | 634
Mental Retardation 405 | 634
Mental deficiency 405 | 634
Poor school performance 405 | 634
Seizures 403 | 584
Muscle hypotonia 396 | 562
Liver Cirrhosis, Experimental 393 | 733
Melanoma 391 | 689
esophageal adenocarcinoma 389 | 696
Bipolar Disorder 379 | 646
Duchenne muscular dystrophy 378 | 587
aldosterone-producing adenoma 367 | 646
active ulcerative colitis 365 | 736
primary Sjogren syndrome 365 | 710
Down syndrome 335 | 480
Obesity 320 | 655
autosomal dominant Emery-Dreifuss muscular dystrophy 311 | 492
Amyotrophic lateral sclerosis 304 | 437
Neurodegenerative disease 301 | 402
pancreatic carcinoma 301 | 555
Short stature 300 | 514
Skin cancer 277 | 451
hepatocellular carcinoma 272 | 536
fibroadenoma 258 | 538
Prostatic Neoplasms 254 | 472
Multiple Sclerosis 252 | 527
hereditary spastic paraplegia 247 | 313
gastric cancer 246 | 445
sonic hedgehog group medulloblastoma 241 | 459
Endometriosis 239 | 521

Tissue

Endocrine System 8,920 | 18,159
Female tissues 8,775 | 17,400
Digestive Tract 8,762 | 17,369
Skin and soft tissues 8,752 | 17,230
Male tissues 8,700 | 17,142
Nervous System 8,661 | 16,725
Blood and immune system 8,628 | 16,909
Liver and Pancreas 8,609 | 16,750
Urinary Tract 8,580 | 16,678
Respiratory system 8,506 | 16,393
Cardiovascular System 8,160 | 15,192

Target Family

Non-IDG 5,213 | 12,091
Enzyme 2,300 | 4,145
Transcription Factor 464 | 1,400
Kinase 444 | 634
Transporter 225 | 473
Ion Channel 184 | 344
Epigenetic 106 | 242
GPCR 77 | 408
oGPCR 16 | 421
TF/Epigenetic 12 | 38
Nuclear Receptor 7 | 48

HPM Tissue

Adult Frontal Cortex 9,048 | 9,048
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254