Development Level

Tbio 3,354 | 10,625
Tdark 725 | 7,003
Tchem 676 | 1,890
Tclin 184 | 602

Collection

Eligible Kinase Proteins 25 | 134
Eligible Ion Channel Proteins 14 | 117
Eligible non-olfactory GPCR Proteins 3 | 143

IMPC Term

preweaning lethality, complete... 260 | 633
preweaning lethality, incomple... 80 | 260
embryonic lethality prior to t... 70 | 187
decreased lean body mass 65 | 195
abnormal behavior 64 | 226
embryonic lethality prior to o... 64 | 148
decreased total body fat amoun... 61 | 186
decreased body weight 60 | 174
decreased bone mineral content 48 | 157
abnormal embryo size 44 | 112
increased circulating alkaline... 43 | 119
abnormal bone structure 38 | 131
hyperactivity 38 | 108
increased or absent threshold ... 38 | 128
decreased bone mineral density 36 | 126
decreased body length 35 | 108
decreased circulating glucose ... 33 | 121
increased mean corpuscular hem... 32 | 93
abnormal retina morphology 31 | 100
decreased circulating choleste... 31 | 85
decreased circulating HDL chol... 30 | 77
decreased grip strength 30 | 123
decreased mean corpuscular vol... 30 | 50
increased lean body mass 30 | 107
enlarged heart 29 | 111
increased grip strength 27 | 83
decreased circulating triglyce... 26 | 83
hypoactivity 26 | 89
increased fasted circulating g... 26 | 68
increased mean corpuscular vol... 26 | 91
abnormal lens morphology 25 | 73
prenatal lethality prior to he... 25 | 64
increased circulating sodium l... 24 | 71
decreased circulating insulin ... 23 | 75
decreased circulating serum al... 23 | 79
short tibia 23 | 82
abnormal sleep behavior 21 | 63
increased bone mineral content 21 | 92
decreased lumbar vertebrae num... 19 | 62
increased exploration in new e... 19 | 56
abnormal retinal pigmentation 18 | 61
decreased rib number 18 | 59
increased body weight 18 | 42
male infertility 18 | 62
abnormal coat/hair pigmentatio... 17 | 54
decreased circulating alanine ... 17 | 53
decreased circulating total pr... 17 | 41
increased circulating HDL chol... 17 | 63
increased hemoglobin content 17 | 45
decreased caudal vertebrae num... 16 | 49
decreased circulating LDL chol... 16 | 37
decreased fasted circulating g... 16 | 49
impaired glucose tolerance 16 | 52
increased blood urea nitrogen ... 16 | 44
increased bone mineral density 16 | 52
increased circulating choleste... 16 | 53
decreased hemoglobin content 15 | 53
decreased mean corpuscular hem... 15 | 34
increased circulating chloride... 15 | 43
increased hematocrit 15 | 36
increased leukocyte cell numbe... 15 | 37
thrombocytopenia 15 | 46
abnormal behavioral response t... 14 | 52
abnormal bone mineralization 14 | 55
abnormal gait 14 | 51
decreased eosinophil cell numb... 14 | 41
increased startle reflex 14 | 38
abnormal neural tube closure 13 | 37
abnormal seminal vesicle morph... 13 | 47
cardiovascular system phenotyp... 13 | 35
decreased circulating alkaline... 13 | 41
decreased circulating calcium ... 13 | 33
decreased leukocyte cell numbe... 13 | 54
decreased prepulse inhibition 13 | 52
decreased startle reflex 13 | 48
improved glucose tolerance 13 | 56
increased heart weight 13 | 37
increased sacral vertebrae num... 13 | 62
increased total body fat amoun... 13 | 57
decreased circulating fructosa... 12 | 31
decreased neutrophil cell numb... 12 | 37
decreased threshold for audito... 12 | 32
abnormal heart morphology 11 | 51
abnormal skin morphology 11 | 23
decreased circulating aspartat... 11 | 27
decreased heart weight 11 | 44
decreased mean corpuscular hem... 11 | 19
increased circulating phosphat... 11 | 24
thrombocytosis 11 | 23
abnormal kidney morphology 10 | 30
abnormal rib morphology 10 | 28
decreased T cell number 10 | 31
decreased circulating free fat... 10 | 39
decreased circulating iron lev... 10 | 25
decreased circulating sodium l... 10 | 18
increased NK cell number 10 | 19
increased circulating free fat... 10 | 17
increased rib number 10 | 41
straub tail 10 | 26
tremors 10 | 34

Disease

ovarian cancer 2,892 | 8,484
osteosarcoma 2,221 | 7,933
psoriasis 2,014 | 6,685
medulloblastoma, large-cell 1,843 | 6,234
glioblastoma 1,741 | 5,572
lung cancer 1,591 | 4,466
atypical teratoid / rhabdoid tumor 1,262 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,116 | 3,289
Breast cancer 1,029 | 3,094
malignant mesothelioma 982 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 970 | 2,988
invasive ductal carcinoma 964 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 955 | 2,956
pilocytic astrocytoma 932 | 3,086
non-small cell lung cancer 927 | 2,798
lung adenocarcinoma 881 | 2,713
oligodendroglioma 879 | 2,849
pediatric high grade glioma 873 | 2,712
primitive neuroectodermal tumor 858 | 3,031
Cancer 836 | 2,346
pancreatic cancer 832 | 2,300
ependymoma 829 | 2,514
lung carcinoma 792 | 2,844
Multiple myeloma 756 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 738 | 1,795
subependymal giant cell astrocytoma 718 | 2,287
astrocytic glioma 658 | 2,241
ulcerative colitis 643 | 2,087
Carcinoma 629 | 2,147
group 3 medulloblastoma 616 | 2,254
Pick disease 610 | 1,893
diabetes mellitus 591 | 1,663
astrocytoma 590 | 1,493
interstitial cystitis 590 | 2,299
ductal carcinoma in situ 571 | 1,745
adult high grade glioma 570 | 2,148
breast carcinoma 556 | 1,614
colon cancer 547 | 1,475
acute quadriplegic myopathy 541 | 1,157
group 4 medulloblastoma 541 | 1,875
pituitary cancer 525 | 1,972
cystic fibrosis 517 | 1,665
primary pancreatic ductal adenocarcinoma 512 | 1,271
juvenile dermatomyositis 472 | 1,189
tuberculosis 470 | 1,557
sonic hedgehog group medulloblastoma 459 | 1,482
dermatomyositis 458 | 933
posterior fossa group A ependymoma 458 | 1,511
Waldenstrons macroglobulinemia 441 | 765
medulloblastoma 441 | 1,524
adrenocortical carcinoma 423 | 1,427
Rheumatoid Arthritis 393 | 1,160
nasopharyngeal carcinoma 350 | 1,056
spina bifida 340 | 1,064
atypical teratoid/rhabdoid tumor 334 | 1,095
posterior fossa group B ependymoma 325 | 1,530
esophageal adenocarcinoma 324 | 737
Duchenne muscular dystrophy 313 | 602
Atopic dermatitis 304 | 944
gastric carcinoma 293 | 832
cutaneous lupus erythematosus 286 | 1,056
non primary Sjogren syndrome sicca 285 | 840
active Crohn's disease 274 | 918
acute myeloid leukemia 256 | 780
primary Sjogren syndrome 231 | 789
autosomal dominant Emery-Dreifuss muscular dystrophy 227 | 499
progressive supranuclear palsy 225 | 674
aldosterone-producing adenoma 224 | 664
Alzheimer's disease 223 | 644
Down syndrome 221 | 548
tuberculosis and treatment for 6 months 207 | 686
Intellectual disability 199 | 573
fibroadenoma 186 | 557
Obesity 181 | 616
pancreatic carcinoma 179 | 567
IGA Glomerulonephritis 178 | 454
Amyotrophic Lateral Sclerosis 174 | 431
Prostatic Neoplasms 172 | 471
Neurodegenerative disease 168 | 383
mucosa-associated lymphoid tissue lymphoma 166 | 480
hereditary spastic paraplegia 163 | 313
Mammary Neoplasms 152 | 410
hepatocellular carcinoma 151 | 532
Endometriosis 144 | 535
Polycystic Ovary Syndrome 137 | 332
Schizophrenia 135 | 501
active ulcerative colitis 134 | 477
Kidney disease 133 | 396
gastric cancer 131 | 430
Parkinson's disease 128 | 364
Stomach Neoplasms 126 | 282
inflammatory breast cancer 122 | 404
Becker muscular dystrophy 120 | 187
Vascular disease 114 | 281
non-small cell lung carcinoma 113 | 413
interstitial lung disease 111 | 291
Multiple Sclerosis 110 | 498
chronic rhinosinusitis 109 | 512
nephrosclerosis 109 | 329
glioblastoma multiforme 107 | 347

Tissue

Digestive Tract 4,939 | 18,473
Liver and Pancreas 4,935 | 18,136
Nervous System 4,933 | 18,561
Urinary Tract 4,933 | 18,444
Female tissues 4,932 | 18,647
Blood and immune system 4,929 | 17,995
Endocrine System 4,926 | 18,512
Cardiovascular System 4,923 | 17,958
Male tissues 4,921 | 17,969
Respiratory system 4,902 | 17,484
Skin and soft tissues 4,851 | 18,115

Target Family

Non-IDG 3,008 | 11,971
Enzyme 1,417 | 4,146
Kinase 210 | 634
Transcription Factor 101 | 1,400
Transporter 91 | 473
Epigenetic 46 | 242
Ion Channel 41 | 341
GPCR 13 | 406
TF/Epigenetic 5 | 38
oGPCR 4 | 421
Nuclear Receptor 3 | 48

HPM Tissue

Adult Esophagus 4,939 | 4,939
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290