Development Level

Tbio 3,630 | 11,651
Tdark 639 | 6,593
Tchem 480 | 1,388
Tclin 187 | 612

Collection

RFA-RM-18-021 38 | 328
Kinase: IDG Consortium (Target... 22 | 125
Kinase: IDG Consortium (Comple... 12 | 37
Ion Channel: IDG Consortium (T... 11 | 99
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 402 | 979
preweaning lethality, incomple... 145 | 499
embryonic lethality prior to t... 105 | 278
embryonic lethality prior to o... 98 | 239
abnormal behavior 84 | 298
abnormal embryo size 70 | 220
decreased total body fat amoun... 59 | 207
abnormal bone structure 57 | 187
decreased body weight 55 | 161
enlarged heart 53 | 210
hyperactivity 50 | 148
decreased vertical activity 46 | 208
decreased bone mineral content 45 | 151
decreased bone mineral density 41 | 126
hypoactivity 40 | 132
increased circulating alkaline... 40 | 122
increased lean body mass 40 | 172
increased startle reflex 39 | 112
abnormal heart morphology 37 | 162
decreased circulating glucose ... 37 | 126
decreased circulating choleste... 36 | 93
embryonic growth retardation 35 | 106
decreased lean body mass 34 | 135
decreased mean corpuscular vol... 33 | 79
increased mean corpuscular hem... 33 | 96
prenatal lethality prior to he... 33 | 87
abnormal seminal vesicle morph... 32 | 114
decreased grip strength 31 | 116
abnormal lens morphology 30 | 81
cataract 30 | 92
increased bone mineral content 30 | 108
increased total body fat amoun... 30 | 134
increased or absent threshold ... 27 | 101
abnormal sleep behavior 26 | 70
decreased circulating HDL chol... 26 | 68
male infertility 26 | 123
short tibia 26 | 97
decreased body length 25 | 101
decreased circulating triglyce... 25 | 79
increased fasted circulating g... 25 | 76
abnormal behavioral response t... 24 | 66
decreased prepulse inhibition 24 | 82
decreased circulating serum al... 23 | 82
decreased lymphocyte cell numb... 23 | 83
edema 23 | 59
increased circulating sodium l... 23 | 71
increased mean corpuscular vol... 23 | 92
decreased fasted circulating g... 22 | 65
increased heart weight 22 | 62
abnormal coat-hair pigmentatio... 21 | 64
abnormal eye morphology 20 | 68
abnormal kidney morphology 20 | 65
abnormal retina morphology 20 | 71
abnormal skin morphology 20 | 50
decreased hemoglobin content 20 | 68
increased circulating choleste... 20 | 66
abnormal gait 19 | 69
decreased circulating alkaline... 19 | 46
decreased circulating insulin ... 19 | 76
decreased mean corpuscular hem... 19 | 50
decreased startle reflex 19 | 75
impaired glucose tolerance 19 | 75
increased circulating HDL chol... 19 | 80
increased leukocyte cell numbe... 19 | 47
thrombocytopenia 19 | 56
decreased circulating total pr... 18 | 49
decreased leukocyte cell numbe... 18 | 73
decreased neutrophil cell numb... 18 | 42
improved glucose tolerance 18 | 79
cardiovascular system phenotyp... 17 | 36
decreased caudal vertebrae num... 17 | 53
decreased circulating alanine ... 17 | 47
decreased erythrocyte cell num... 17 | 62
increased bone mineral density 17 | 72
increased hematocrit 17 | 46
increased monocyte cell number 17 | 63
decreased circulating LDL chol... 16 | 38
increased blood urea nitrogen ... 16 | 48
increased erythrocyte cell num... 16 | 39
increased hemoglobin content 16 | 45
increased neutrophil cell numb... 16 | 46
decreased blood urea nitrogen ... 15 | 51
increased grip strength 15 | 41
small testis 15 | 58
abnormal neural tube closure 14 | 46
decreased mean corpuscular hem... 14 | 31
increased circulating chloride... 14 | 41
increased mean platelet volume 14 | 45
pallor 14 | 34
tremors 14 | 39
decreased circulating aspartat... 13 | 34
decreased circulating iron lev... 13 | 32
decreased hematocrit 13 | 46
increased circulating creatini... 13 | 38
abnormal epididymis morphology 12 | 42
decreased circulating calcium ... 12 | 36
decreased red blood cell distr... 12 | 41
increased circulating total pr... 12 | 28
prolonged QT interval 12 | 38
thrombocytosis 12 | 27

Disease

Carcinoma 3,058 | 11,493
ovarian cancer 2,900 | 8,520
osteosarcoma 2,222 | 7,950
psoriasis 2,011 | 6,694
medulloblastoma, large-cell 1,844 | 6,241
glioblastoma 1,819 | 5,792
lung cancer 1,634 | 4,740
atypical teratoid / rhabdoid tumor 1,504 | 5,112
ependymoma 1,408 | 4,679
Breast cancer 1,180 | 3,578
group 3 medulloblastoma 1,177 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 1,115 | 3,291
adult high grade glioma 1,068 | 3,801
malignant mesothelioma 1,013 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 969 | 2,989
invasive ductal carcinoma 963 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 951 | 2,955
non-small cell lung cancer 943 | 2,890
Astrocytoma, Pilocytic 924 | 3,081
lung adenocarcinoma 881 | 2,716
Cancer 879 | 2,499
oligodendroglioma 878 | 2,850
primitive neuroectodermal tumor 858 | 3,035
pancreatic cancer 856 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 821 | 1,962
lung carcinoma 794 | 2,843
Kidney cancer 787 | 2,613
astrocytic glioma 783 | 2,597
Multiple myeloma 758 | 1,332
subependymal giant cell astrocytoma 719 | 2,287
Pick disease 612 | 1,894
diabetes mellitus 610 | 1,728
Autosomal recessive predisposition 590 | 1,442
interstitial cystitis 588 | 2,312
tuberculosis 578 | 2,010
ductal carcinoma in situ 570 | 1,745
breast carcinoma 565 | 1,638
colon cancer 548 | 1,478
acute quadriplegic myopathy 543 | 1,158
ulcerative colitis 537 | 1,819
cystic fibrosis 529 | 1,696
pituitary cancer 524 | 1,972
group 4 medulloblastoma 521 | 1,855
juvenile dermatomyositis 473 | 1,187
astrocytoma 466 | 1,146
dermatomyositis 459 | 966
Waldenstrons macroglobulinemia 440 | 765
primary pancreatic ductal adenocarcinoma 431 | 1,109
adrenocortical carcinoma 423 | 1,428
Rheumatoid arthritis 394 | 1,191
pediatric high grade glioma 378 | 1,064
Intellectual disability 364 | 1,016
Schizophrenia 357 | 1,160
nasopharyngeal carcinoma 350 | 1,058
spina bifida 338 | 1,074
esophageal adenocarcinoma 323 | 737
Duchenne muscular dystrophy 312 | 601
Atopic dermatitis 308 | 952
Liver Cirrhosis, Experimental 304 | 769
non primary Sjogren syndrome sicca 302 | 891
Epilepsy 297 | 792
cutaneous lupus erythematosus 286 | 1,057
gastric carcinoma 284 | 807
active Crohn's disease 276 | 922
acute myeloid leukemia 258 | 783
Muscle hypotonia 253 | 571
Dull intelligence 248 | 645
Low intelligence 248 | 645
Mental Retardation 248 | 645
Mental deficiency 248 | 645
Poor school performance 248 | 645
Cognitive delay 247 | 608
Global developmental delay 247 | 608
Mental and motor retardation 247 | 608
Seizures 246 | 596
active ulcerative colitis 239 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 233 | 510
Alzheimer's disease 226 | 658
progressive supranuclear palsy 225 | 676
aldosterone-producing adenoma 224 | 665
medulloblastoma 214 | 720
primary Sjogren syndrome 214 | 735
Down syndrome 211 | 499
Bipolar Disorder 199 | 666
Melanoma 199 | 711
Obesity 199 | 678
Short stature 193 | 531
Liver cancer 190 | 604
fibroadenoma 187 | 559
Neurodegenerative disease 184 | 414
Amyotrophic lateral sclerosis 179 | 451
pancreatic carcinoma 179 | 562
Prostatic Neoplasms 177 | 495
hereditary spastic paraplegia 166 | 318
mucosa-associated lymphoid tissue lymphoma 166 | 484
Breast Neoplasms 165 | 445
Failure to gain weight 165 | 365
Pediatric failure to thrive 165 | 365
hepatocellular carcinoma 157 | 547
Mammary Neoplasms 155 | 425

Tissue

Endocrine System 4,859 | 18,159
Female tissues 4,814 | 17,400
Skin and soft tissues 4,813 | 17,230
Digestive Tract 4,812 | 17,369
Blood and immune system 4,774 | 16,909
Male tissues 4,756 | 17,142
Liver and Pancreas 4,739 | 16,750
Urinary Tract 4,724 | 16,678
Nervous System 4,691 | 16,725
Respiratory system 4,658 | 16,393
Cardiovascular System 4,502 | 15,192

Target Family

Non-IDG 3,007 | 12,091
Enzyme 1,415 | 4,145
Kinase 210 | 634
Transcription Factor 101 | 1,400
Transporter 91 | 473
Epigenetic 46 | 242
Ion Channel 41 | 344
GPCR 13 | 408
TF/Epigenetic 5 | 38
oGPCR 4 | 421
Nuclear Receptor 3 | 48

HPM Tissue

Adult Esophagus 4,936 | 4,936
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184