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Target Filters...

Development Level

Tbio 5,226 | 10,625
Tdark 1,431 | 7,003
Tchem 1,004 | 1,890
Tclin 260 | 602

Collection

Eligible Kinase Proteins 66 | 134
Eligible Ion Channel Proteins 28 | 117
Eligible non-olfactory GPCR Proteins 13 | 145

IMPC Term

preweaning lethality, complete... 375 | 633
preweaning lethality, incomple... 130 | 260
embryonic lethality prior to t... 113 | 187
abnormal behavior 109 | 226
decreased lean body mass 106 | 195
decreased total body fat amoun... 102 | 186
embryonic lethality prior to o... 102 | 148
decreased body weight 97 | 174
decreased bone mineral content 77 | 157
abnormal bone structure 70 | 131
increased circulating alkaline... 70 | 119
increased or absent threshold ... 68 | 128
abnormal embryo size 66 | 112
decreased grip strength 64 | 123
decreased bone mineral density 62 | 126
decreased circulating glucose ... 61 | 121
decreased body length 59 | 108
abnormal retina morphology 56 | 100
increased mean corpuscular hem... 53 | 93
hyperactivity 52 | 108
increased lean body mass 50 | 107
hypoactivity 47 | 89
increased bone mineral content 47 | 92
abnormal lens morphology 45 | 73
decreased circulating choleste... 45 | 85
decreased circulating triglyce... 45 | 83
short tibia 45 | 82
enlarged heart 43 | 111
decreased circulating HDL chol... 41 | 77
decreased circulating insulin ... 41 | 75
decreased circulating serum al... 39 | 79
decreased mean corpuscular vol... 39 | 50
increased mean corpuscular vol... 39 | 91
increased grip strength 38 | 83
prenatal lethality prior to he... 35 | 64
increased fasted circulating g... 34 | 68
abnormal sleep behavior 33 | 63
increased circulating HDL chol... 32 | 63
decreased lumbar vertebrae num... 31 | 62
increased circulating choleste... 30 | 53
increased circulating sodium l... 30 | 71
abnormal bone mineralization 29 | 55
male infertility 29 | 62
decreased leukocyte cell numbe... 28 | 54
impaired glucose tolerance 28 | 52
abnormal retinal pigmentation 27 | 61
increased body weight 27 | 42
increased exploration in new e... 27 | 56
decreased fasted circulating g... 26 | 49
increased bone mineral density 26 | 52
abnormal coat/hair pigmentatio... 25 | 54
decreased circulating alanine ... 25 | 53
increased hemoglobin content 25 | 45
increased sacral vertebrae num... 25 | 62
increased total body fat amoun... 25 | 57
thrombocytopenia 25 | 46
decreased hemoglobin content 24 | 53
decreased rib number 24 | 59
increased blood urea nitrogen ... 24 | 44
abnormal gait 23 | 51
decreased heart weight 23 | 44
abnormal seminal vesicle morph... 22 | 47
cardiovascular system phenotyp... 22 | 35
decreased caudal vertebrae num... 22 | 49
decreased circulating alkaline... 22 | 41
decreased prepulse inhibition 22 | 52
improved glucose tolerance 22 | 56
abnormal neural tube closure 21 | 37
decreased eosinophil cell numb... 21 | 41
decreased mean corpuscular hem... 21 | 34
decreased startle reflex 21 | 48
abnormal behavioral response t... 20 | 52
decreased circulating calcium ... 20 | 33
decreased circulating free fat... 20 | 39
decreased circulating total pr... 20 | 41
decreased erythrocyte cell num... 20 | 43
increased circulating chloride... 20 | 43
increased hematocrit 20 | 36
small testis 20 | 37
abnormal heart morphology 19 | 51
decreased circulating LDL chol... 19 | 37
increased leukocyte cell numbe... 19 | 37
increased startle reflex 19 | 38
abnormal cranium morphology 18 | 32
abnormal eye morphology 18 | 38
increased circulating phosphat... 18 | 24
increased circulating potassiu... 18 | 31
increased heart weight 18 | 37
abnormal testis morphology 17 | 30
decreased circulating creatini... 17 | 31
decreased circulating fructosa... 17 | 31
decreased threshold for audito... 17 | 32
increased circulating calcium ... 17 | 32
decreased circulating aspartat... 16 | 27
decreased circulating chloride... 16 | 32
decreased neutrophil cell numb... 16 | 37
increased rib number 16 | 41
tremors 16 | 34
abnormal spleen morphology 15 | 36
decreased circulating iron lev... 15 | 25

Disease

ovarian cancer 4,615 | 8,492
osteosarcoma 3,743 | 7,933
psoriasis 3,044 | 6,685
medulloblastoma, large-cell 2,974 | 6,234
glioblastoma 2,767 | 5,572
lung cancer 2,390 | 4,473
atypical teratoid / rhabdoid tumor 2,071 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,732 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 1,574 | 2,988
malignant mesothelioma 1,567 | 3,163
Breast cancer 1,557 | 3,099
intraductal papillary-mucinous adenoma (IPMA) 1,549 | 2,956
invasive ductal carcinoma 1,517 | 2,950
pilocytic astrocytoma 1,494 | 3,086
oligodendroglioma 1,386 | 2,849
non-small cell lung cancer 1,381 | 2,798
primitive neuroectodermal tumor 1,355 | 3,031
pediatric high grade glioma 1,339 | 2,712
lung adenocarcinoma 1,330 | 2,714
ependymoma 1,292 | 2,514
lung carcinoma 1,289 | 2,844
pancreatic cancer 1,229 | 2,300
subependymal giant cell astrocytoma 1,183 | 2,287
Cancer 1,180 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 1,119 | 1,795
astrocytic glioma 1,099 | 2,241
Carcinoma 1,064 | 2,147
ulcerative colitis 1,022 | 2,087
Pick disease 996 | 1,893
group 3 medulloblastoma 991 | 2,254
Multiple myeloma 989 | 1,328
interstitial cystitis 981 | 2,299
adult high grade glioma 971 | 2,148
group 4 medulloblastoma 926 | 1,875
astrocytoma 881 | 1,493
pituitary cancer 859 | 1,972
ductal carcinoma in situ 846 | 1,745
colon cancer 838 | 1,475
breast carcinoma 821 | 1,614
diabetes mellitus 814 | 1,663
cystic fibrosis 787 | 1,670
tuberculosis 783 | 1,563
primary pancreatic ductal adenocarcinoma 755 | 1,271
acute quadriplegic myopathy 730 | 1,157
sonic hedgehog group medulloblastoma 713 | 1,482
medulloblastoma 712 | 1,524
juvenile dermatomyositis 699 | 1,189
adrenocortical carcinoma 682 | 1,427
posterior fossa group A ependymoma 679 | 1,511
dermatomyositis 664 | 967
Waldenstrons macroglobulinemia 591 | 765
Rheumatoid Arthritis 585 | 1,171
posterior fossa group B ependymoma 579 | 1,530
spina bifida 511 | 1,064
atypical teratoid/rhabdoid tumor 509 | 1,095
cutaneous lupus erythematosus 471 | 1,056
nasopharyngeal carcinoma 465 | 1,056
active Crohn's disease 446 | 918
non primary Sjogren syndrome sicca 431 | 840
gastric carcinoma 430 | 832
acute myeloid leukemia 427 | 785
esophageal adenocarcinoma 425 | 737
Atopic dermatitis 420 | 944
Duchenne muscular dystrophy 404 | 602
primary Sjogren syndrome 390 | 789
progressive supranuclear palsy 366 | 674
aldosterone-producing adenoma 347 | 664
tuberculosis and treatment for 6 months 344 | 686
Alzheimer's disease 334 | 644
Intellectual disability 322 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 322 | 499
Down syndrome 312 | 548
pancreatic carcinoma 290 | 567
fibroadenoma 271 | 557
Obesity 269 | 616
IGA Glomerulonephritis 260 | 454
Prostatic Neoplasms 259 | 471
Amyotrophic Lateral Sclerosis 255 | 432
hepatocellular carcinoma 255 | 550
Neurodegenerative disease 248 | 383
mucosa-associated lymphoid tissue lymphoma 240 | 480
hereditary spastic paraplegia 223 | 313
Mammary Neoplasms 216 | 410
Schizophrenia 211 | 503
Endometriosis 209 | 535
gastric cancer 205 | 436
Multiple Sclerosis 202 | 498
active ulcerative colitis 201 | 477
inflammatory breast cancer 182 | 404
non-small cell lung carcinoma 182 | 413
Parkinson's disease 180 | 364
Kidney disease 179 | 397
chronic rhinosinusitis 179 | 512
Polycystic Ovary Syndrome 177 | 335
glioblastoma multiforme 171 | 347
interstitial lung disease 171 | 292
nephrosclerosis 170 | 329
Stomach Neoplasms 162 | 282
sarcoidosis 160 | 368
Vascular disease 155 | 281

Tissue

Digestive Tract 7,921 | 18,473
Female tissues 7,899 | 18,647
Nervous System 7,899 | 18,561
Urinary Tract 7,895 | 18,444
Blood and immune system 7,894 | 17,995
Liver and Pancreas 7,894 | 18,136
Endocrine System 7,886 | 18,512
Male tissues 7,886 | 17,969
Cardiovascular System 7,871 | 17,958
Respiratory system 7,825 | 17,484
Skin and soft tissues 7,781 | 18,115

Target Family

Non-IDG 4,704 | 11,969
Enzyme 2,200 | 4,146
Kinase 390 | 634
Transcription Factor 228 | 1,400
Transporter 159 | 473
Epigenetic 91 | 242
Ion Channel 84 | 341
GPCR 36 | 408
TF/Epigenetic 13 | 38
Nuclear Receptor 8 | 48
oGPCR 8 | 421

HPM Tissue

Adult Colon 7,921 | 7,921
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Adult Adrenal 8,479 | 8,479
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82