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Target Filters...

Development Level

Tbio 5,413 | 11,178
Tdark 1,239 | 6,569
Tchem 999 | 1,885
Tclin 264 | 612

Collection

Kinase: IDG Consortium (Target... 59 | 125
Ion Channel: IDG Consortium (T... 28 | 99
Kinase: IDG Consortium (Comple... 20 | 37
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 608 | 979
preweaning lethality, incomple... 245 | 499
embryonic lethality prior to t... 165 | 278
embryonic lethality prior to o... 161 | 239
abnormal behavior 134 | 298
abnormal embryo size 126 | 220
decreased total body fat amoun... 98 | 207
abnormal bone structure 95 | 187
decreased body weight 89 | 161
enlarged heart 83 | 210
decreased vertical activity 75 | 208
increased lean body mass 75 | 172
decreased bone mineral content 74 | 151
hypoactivity 71 | 132
decreased circulating glucose ... 69 | 126
increased circulating alkaline... 69 | 122
hyperactivity 68 | 148
embryonic growth retardation 64 | 106
abnormal heart morphology 62 | 162
decreased bone mineral density 61 | 126
increased total body fat amoun... 61 | 134
decreased grip strength 59 | 116
increased startle reflex 58 | 112
increased or absent threshold ... 57 | 101
short tibia 57 | 97
abnormal seminal vesicle morph... 54 | 114
decreased lean body mass 52 | 135
increased bone mineral content 52 | 108
increased mean corpuscular hem... 51 | 96
male infertility 51 | 123
decreased mean corpuscular vol... 50 | 79
decreased circulating choleste... 47 | 93
prenatal lethality prior to he... 47 | 87
abnormal lens morphology 46 | 81
cataract 46 | 92
decreased body length 44 | 101
decreased prepulse inhibition 44 | 82
increased mean corpuscular vol... 42 | 92
increased circulating HDL chol... 41 | 80
abnormal retina morphology 39 | 71
increased circulating choleste... 39 | 66
decreased circulating insulin ... 38 | 76
decreased lymphocyte cell numb... 38 | 83
decreased startle reflex 38 | 75
decreased circulating serum al... 37 | 82
decreased leukocyte cell numbe... 37 | 73
decreased circulating HDL chol... 35 | 68
increased fasted circulating g... 35 | 76
increased heart weight 35 | 62
decreased circulating triglyce... 34 | 79
impaired glucose tolerance 34 | 75
abnormal eye morphology 33 | 68
abnormal sleep behavior 33 | 70
improved glucose tolerance 33 | 79
edema 32 | 59
increased bone mineral density 32 | 72
abnormal gait 31 | 69
decreased fasted circulating g... 31 | 65
thrombocytopenia 31 | 56
abnormal coat-hair pigmentatio... 30 | 64
abnormal kidney morphology 30 | 65
small superior vagus ganglion 30 | 74
small testis 30 | 58
abnormal behavioral response t... 29 | 66
increased circulating sodium l... 29 | 71
decreased mean corpuscular hem... 28 | 50
decreased erythrocyte cell num... 27 | 62
decreased hemoglobin content 27 | 68
increased mean platelet volume 26 | 45
increased neutrophil cell numb... 26 | 46
abnormal skin morphology 25 | 50
decreased blood urea nitrogen ... 25 | 51
decreased circulating alkaline... 25 | 46
decreased circulating total pr... 25 | 49
decreased neutrophil cell numb... 25 | 42
increased hemoglobin content 25 | 45
increased leukocyte cell numbe... 25 | 47
increased monocyte cell number 25 | 63
decreased caudal vertebrae num... 24 | 53
increased blood urea nitrogen ... 24 | 48
increased hematocrit 24 | 46
abnormal spleen morphology 23 | 55
cardiovascular system phenotyp... 23 | 36
decreased circulating aspartat... 23 | 34
female infertility 23 | 60
increased erythrocyte cell num... 23 | 39
abnormal bone mineralization 22 | 38
decreased circulating alanine ... 22 | 47
hydrometra 22 | 53
pallor 22 | 34
tremors 22 | 39
decreased circulating calcium ... 21 | 36
decreased hematocrit 21 | 46
decreased mean corpuscular hem... 21 | 31
enlarged spleen 21 | 41
increased circulating triglyce... 21 | 42
decreased circulating LDL chol... 20 | 38
decreased red blood cell distr... 20 | 41
increased circulating phosphat... 20 | 26
increased prepulse inhibition 20 | 32

Disease

Carcinoma 4,915 | 11,192
ovarian cancer 4,508 | 8,297
osteosarcoma 3,665 | 7,766
psoriasis 2,967 | 6,514
medulloblastoma, large-cell 2,913 | 6,086
glioblastoma 2,809 | 5,635
lung cancer 2,413 | 4,607
atypical teratoid / rhabdoid tumor 2,355 | 4,971
ependymoma 2,137 | 4,559
group 3 medulloblastoma 1,831 | 4,002
Breast cancer 1,742 | 3,469
adult high grade glioma 1,702 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 1,687 | 3,204
malignant mesothelioma 1,567 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 1,530 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 1,502 | 2,872
invasive ductal carcinoma 1,479 | 2,867
Astrocytoma, Pilocytic 1,447 | 3,006
non-small cell lung cancer 1,372 | 2,799
oligodendroglioma 1,349 | 2,768
primitive neuroectodermal tumor 1,315 | 2,957
Kidney cancer 1,302 | 2,548
lung adenocarcinoma 1,288 | 2,627
astrocytic glioma 1,260 | 2,530
lung carcinoma 1,246 | 2,755
pancreatic cancer 1,244 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 1,201 | 1,911
Cancer 1,191 | 2,388
subependymal giant cell astrocytoma 1,152 | 2,230
Pick disease 979 | 1,856
Multiple myeloma 964 | 1,296
interstitial cystitis 945 | 2,237
tuberculosis 936 | 1,963
group 4 medulloblastoma 891 | 1,806
ulcerative colitis 847 | 1,765
pituitary cancer 839 | 1,915
diabetes mellitus 822 | 1,683
ductal carcinoma in situ 818 | 1,686
breast carcinoma 817 | 1,589
Autosomal recessive predisposition 816 | 1,407
colon cancer 816 | 1,428
cystic fibrosis 774 | 1,629
acute quadriplegic myopathy 720 | 1,133
juvenile dermatomyositis 676 | 1,147
astrocytoma 672 | 1,113
adrenocortical carcinoma 661 | 1,385
dermatomyositis 646 | 941
primary pancreatic ductal adenocarcinoma 623 | 1,071
Rheumatoid arthritis 577 | 1,156
Waldenstrons macroglobulinemia 571 | 742
Intellectual disability 553 | 998
pediatric high grade glioma 550 | 1,035
Schizophrenia 525 | 1,136
spina bifida 507 | 1,053
nasopharyngeal carcinoma 452 | 1,024
cutaneous lupus erythematosus 450 | 1,016
non primary Sjogren syndrome sicca 436 | 861
Epilepsy 434 | 775
active Crohn's disease 431 | 882
Liver Cirrhosis, Experimental 427 | 733
acute myeloid leukemia 416 | 760
Atopic dermatitis 412 | 915
gastric carcinoma 406 | 781
esophageal adenocarcinoma 402 | 696
Duchenne muscular dystrophy 392 | 587
Cognitive delay 375 | 596
Global developmental delay 375 | 596
Mental and motor retardation 375 | 596
Dull intelligence 368 | 634
Low intelligence 368 | 634
Mental Retardation 368 | 634
Mental deficiency 368 | 634
Poor school performance 368 | 634
Muscle hypotonia 357 | 562
progressive supranuclear palsy 357 | 656
primary Sjogren syndrome 353 | 710
Seizures 348 | 584
active ulcerative colitis 341 | 736
aldosterone-producing adenoma 339 | 646
Alzheimer's disease 323 | 640
medulloblastoma 323 | 702
autosomal dominant Emery-Dreifuss muscular dystrophy 317 | 492
Melanoma 309 | 689
Liver cancer 305 | 589
Short stature 291 | 514
Obesity 288 | 655
Down syndrome 284 | 480
pancreatic carcinoma 284 | 555
Bipolar Disorder 280 | 646
Amyotrophic lateral sclerosis 263 | 437
fibroadenoma 263 | 538
Prostatic Neoplasms 258 | 472
Neurodegenerative disease 257 | 402
hepatocellular carcinoma 247 | 536
mucosa-associated lymphoid tissue lymphoma 236 | 473
sonic hedgehog group medulloblastoma 230 | 459
Breast Neoplasms 226 | 423
hereditary spastic paraplegia 224 | 313
Failure to gain weight 218 | 359
Small head 218 | 366

Tissue

Endocrine System 7,798 | 18,159
Female tissues 7,702 | 17,400
Digestive Tract 7,701 | 17,369
Skin and soft tissues 7,692 | 17,230
Male tissues 7,642 | 17,142
Blood and immune system 7,618 | 16,909
Liver and Pancreas 7,600 | 16,750
Urinary Tract 7,593 | 16,678
Nervous System 7,540 | 16,725
Respiratory system 7,506 | 16,393
Cardiovascular System 7,258 | 15,192

Target Family

Non-IDG 4,698 | 12,091
Enzyme 2,199 | 4,145
Kinase 390 | 634
Transcription Factor 228 | 1,400
Transporter 158 | 473
Epigenetic 90 | 242
Ion Channel 87 | 344
GPCR 36 | 408
TF/Epigenetic 13 | 38
Nuclear Receptor 8 | 48
oGPCR 8 | 421

HPM Tissue

Adult Colon 7,915 | 7,915
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Zinc finger protein 526 ZNF526 Tdark Transcription Factor 0.70 0.20 51
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148