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Target Filters...

Development Level

Tbio 5,647 | 11,651
Tdark 1,251 | 6,593
Tchem 753 | 1,388
Tclin 264 | 612

Collection

RFA-RM-18-021 101 | 328
Kinase: IDG Consortium (Target... 59 | 125
Ion Channel: IDG Consortium (T... 28 | 99
Kinase: IDG Consortium (Comple... 20 | 37
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 608 | 979
preweaning lethality, incomple... 245 | 499
embryonic lethality prior to t... 165 | 278
embryonic lethality prior to o... 161 | 239
abnormal behavior 134 | 298
abnormal embryo size 126 | 220
decreased total body fat amoun... 98 | 207
abnormal bone structure 95 | 187
decreased body weight 89 | 161
enlarged heart 83 | 210
decreased vertical activity 75 | 208
increased lean body mass 75 | 172
decreased bone mineral content 74 | 151
hypoactivity 71 | 132
decreased circulating glucose ... 69 | 126
increased circulating alkaline... 69 | 122
hyperactivity 68 | 148
embryonic growth retardation 64 | 106
abnormal heart morphology 62 | 162
decreased bone mineral density 61 | 126
increased total body fat amoun... 61 | 134
decreased grip strength 59 | 116
increased startle reflex 58 | 112
increased or absent threshold ... 57 | 101
short tibia 57 | 97
abnormal seminal vesicle morph... 54 | 114
decreased lean body mass 52 | 135
increased bone mineral content 52 | 108
increased mean corpuscular hem... 51 | 96
male infertility 51 | 123
decreased mean corpuscular vol... 50 | 79
decreased circulating choleste... 47 | 93
prenatal lethality prior to he... 47 | 87
abnormal lens morphology 46 | 81
cataract 46 | 92
decreased body length 44 | 101
decreased prepulse inhibition 44 | 82
increased mean corpuscular vol... 42 | 92
increased circulating HDL chol... 41 | 80
abnormal retina morphology 39 | 71
increased circulating choleste... 39 | 66
decreased circulating insulin ... 38 | 76
decreased lymphocyte cell numb... 38 | 83
decreased startle reflex 38 | 75
decreased circulating serum al... 37 | 82
decreased leukocyte cell numbe... 37 | 73
decreased circulating HDL chol... 35 | 68
increased fasted circulating g... 35 | 76
increased heart weight 35 | 62
decreased circulating triglyce... 34 | 79
impaired glucose tolerance 34 | 75
abnormal eye morphology 33 | 68
abnormal sleep behavior 33 | 70
improved glucose tolerance 33 | 79
edema 32 | 59
increased bone mineral density 32 | 72
abnormal gait 31 | 69
decreased fasted circulating g... 31 | 65
thrombocytopenia 31 | 56
abnormal coat-hair pigmentatio... 30 | 64
abnormal kidney morphology 30 | 65
small superior vagus ganglion 30 | 74
small testis 30 | 58
abnormal behavioral response t... 29 | 66
increased circulating sodium l... 29 | 71
decreased mean corpuscular hem... 28 | 50
decreased erythrocyte cell num... 27 | 62
decreased hemoglobin content 27 | 68
increased mean platelet volume 26 | 45
increased neutrophil cell numb... 26 | 46
abnormal skin morphology 25 | 50
decreased blood urea nitrogen ... 25 | 51
decreased circulating alkaline... 25 | 46
decreased circulating total pr... 25 | 49
decreased neutrophil cell numb... 25 | 42
increased hemoglobin content 25 | 45
increased leukocyte cell numbe... 25 | 47
increased monocyte cell number 25 | 63
decreased caudal vertebrae num... 24 | 53
increased blood urea nitrogen ... 24 | 48
increased hematocrit 24 | 46
abnormal spleen morphology 23 | 55
cardiovascular system phenotyp... 23 | 36
decreased circulating aspartat... 23 | 34
female infertility 23 | 60
increased erythrocyte cell num... 23 | 39
abnormal bone mineralization 22 | 38
decreased circulating alanine ... 22 | 47
hydrometra 22 | 53
pallor 22 | 34
tremors 22 | 39
decreased circulating calcium ... 21 | 36
decreased hematocrit 21 | 46
decreased mean corpuscular hem... 21 | 31
enlarged spleen 21 | 41
increased circulating triglyce... 21 | 42
decreased circulating LDL chol... 20 | 38
decreased red blood cell distr... 20 | 41
increased circulating phosphat... 20 | 26
increased prepulse inhibition 20 | 32

Disease

Carcinoma 5,035 | 11,493
ovarian cancer 4,624 | 8,520
osteosarcoma 3,742 | 7,950
psoriasis 3,041 | 6,694
medulloblastoma, large-cell 2,976 | 6,241
glioblastoma 2,883 | 5,792
lung cancer 2,482 | 4,740
atypical teratoid / rhabdoid tumor 2,420 | 5,112
ependymoma 2,193 | 4,679
group 3 medulloblastoma 1,871 | 4,104
Breast cancer 1,787 | 3,578
adult high grade glioma 1,748 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,731 | 3,291
malignant mesothelioma 1,606 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,573 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,544 | 2,955
invasive ductal carcinoma 1,516 | 2,951
Astrocytoma, Pilocytic 1,488 | 3,081
non-small cell lung cancer 1,413 | 2,890
oligodendroglioma 1,386 | 2,850
primitive neuroectodermal tumor 1,354 | 3,035
Kidney cancer 1,329 | 2,613
lung adenocarcinoma 1,329 | 2,716
lung carcinoma 1,291 | 2,843
astrocytic glioma 1,289 | 2,597
pancreatic cancer 1,279 | 2,398
Cancer 1,246 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 1,230 | 1,962
subependymal giant cell astrocytoma 1,184 | 2,287
Pick disease 999 | 1,894
Multiple myeloma 992 | 1,332
interstitial cystitis 980 | 2,312
tuberculosis 961 | 2,010
group 4 medulloblastoma 911 | 1,855
ulcerative colitis 872 | 1,819
pituitary cancer 858 | 1,972
diabetes mellitus 848 | 1,728
ductal carcinoma in situ 844 | 1,745
breast carcinoma 839 | 1,638
colon cancer 839 | 1,478
Autosomal recessive predisposition 838 | 1,442
cystic fibrosis 800 | 1,696
acute quadriplegic myopathy 732 | 1,158
juvenile dermatomyositis 700 | 1,187
astrocytoma 693 | 1,146
adrenocortical carcinoma 679 | 1,428
dermatomyositis 665 | 966
primary pancreatic ductal adenocarcinoma 646 | 1,109
Rheumatoid arthritis 593 | 1,191
Waldenstrons macroglobulinemia 590 | 765
pediatric high grade glioma 564 | 1,064
Intellectual disability 562 | 1,016
Schizophrenia 534 | 1,160
spina bifida 515 | 1,074
cutaneous lupus erythematosus 471 | 1,057
nasopharyngeal carcinoma 466 | 1,058
Liver Cirrhosis, Experimental 453 | 769
non primary Sjogren syndrome sicca 451 | 891
active Crohn's disease 449 | 922
Epilepsy 440 | 792
Atopic dermatitis 427 | 952
acute myeloid leukemia 427 | 783
esophageal adenocarcinoma 425 | 737
gastric carcinoma 416 | 807
Duchenne muscular dystrophy 403 | 601
Cognitive delay 381 | 608
Global developmental delay 381 | 608
Mental and motor retardation 381 | 608
Dull intelligence 373 | 645
Low intelligence 373 | 645
Mental Retardation 373 | 645
Mental deficiency 373 | 645
Poor school performance 373 | 645
primary Sjogren syndrome 371 | 735
progressive supranuclear palsy 367 | 676
Muscle hypotonia 362 | 571
Seizures 352 | 596
active ulcerative colitis 352 | 764
aldosterone-producing adenoma 347 | 665
Alzheimer's disease 335 | 658
medulloblastoma 331 | 720
autosomal dominant Emery-Dreifuss muscular dystrophy 329 | 510
Melanoma 317 | 711
Liver cancer 315 | 604
Obesity 302 | 678
Short stature 301 | 531
Down syndrome 292 | 499
Bipolar Disorder 288 | 666
pancreatic carcinoma 287 | 562
fibroadenoma 272 | 559
Amyotrophic lateral sclerosis 270 | 451
Prostatic Neoplasms 270 | 495
Neurodegenerative disease 266 | 414
hepatocellular carcinoma 252 | 547
mucosa-associated lymphoid tissue lymphoma 242 | 484
Breast Neoplasms 237 | 445
sonic hedgehog group medulloblastoma 234 | 467
hereditary spastic paraplegia 226 | 318
Mammary Neoplasms 223 | 425
Failure to gain weight 222 | 365

Tissue

Endocrine System 7,798 | 18,159
Female tissues 7,702 | 17,400
Digestive Tract 7,701 | 17,369
Skin and soft tissues 7,692 | 17,230
Male tissues 7,642 | 17,142
Blood and immune system 7,618 | 16,909
Liver and Pancreas 7,600 | 16,750
Urinary Tract 7,593 | 16,678
Nervous System 7,540 | 16,725
Respiratory system 7,506 | 16,393
Cardiovascular System 7,258 | 15,192

Target Family

Non-IDG 4,698 | 12,091
Enzyme 2,199 | 4,145
Kinase 390 | 634
Transcription Factor 228 | 1,400
Transporter 158 | 473
Epigenetic 90 | 242
Ion Channel 87 | 344
GPCR 36 | 408
TF/Epigenetic 13 | 38
Nuclear Receptor 8 | 48
oGPCR 8 | 421

HPM Tissue

Adult Colon 7,915 | 7,915
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Fetal Liver 8,402 | 8,402
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18