Development Level

Tbio 5,405 | 10,625
Tdark 1,764 | 7,003
Tchem 1,026 | 1,890
Tclin 283 | 602

Collection

Kinase: IDG Consortium (Targets) 52 | 125
Ion Channel: IDG Consortium (Targets) 25 | 102
Kinase: IDG Consortium (Complete/Control) 22 | 37
GPCR: IDG Consortium (Targets) 9 | 128
GPCR: IDG Consortium (Complete/Control) 1 | 24

IMPC Phenotype

preweaning lethality, complete... 393 | 633
preweaning lethality, incomple... 147 | 260
abnormal behavior 123 | 226
embryonic lethality prior to t... 122 | 187
decreased lean body mass 118 | 195
decreased total body fat amoun... 115 | 186
embryonic lethality prior to o... 108 | 148
decreased body weight 99 | 174
decreased bone mineral content 87 | 157
abnormal bone structure 71 | 131
abnormal embryo size 69 | 112
increased circulating alkaline... 69 | 119
decreased grip strength 66 | 123
increased or absent threshold ... 66 | 128
decreased body length 65 | 108
decreased circulating glucose ... 64 | 121
decreased bone mineral density 61 | 126
hyperactivity 57 | 108
increased bone mineral content 57 | 92
increased lean body mass 56 | 107
abnormal retina morphology 55 | 100
increased mean corpuscular hem... 55 | 93
decreased circulating serum al... 49 | 79
enlarged heart 48 | 111
short tibia 48 | 82
hypoactivity 47 | 89
decreased circulating choleste... 45 | 85
abnormal lens morphology 44 | 73
increased mean corpuscular vol... 44 | 91
decreased circulating HDL chol... 43 | 77
decreased circulating triglyce... 43 | 83
increased fasted circulating g... 41 | 68
increased grip strength 39 | 83
decreased mean corpuscular vol... 38 | 50
prenatal lethality prior to he... 38 | 64
decreased circulating insulin ... 36 | 75
decreased rib number 36 | 59
abnormal retinal pigmentation 34 | 61
decreased lumbar vertebrae num... 33 | 62
male infertility 33 | 62
increased circulating choleste... 32 | 53
abnormal sleep behavior 31 | 63
impaired glucose tolerance 31 | 52
increased bone mineral density 31 | 52
increased circulating HDL chol... 31 | 63
decreased caudal vertebrae num... 30 | 49
decreased leukocyte cell numbe... 30 | 54
increased sacral vertebrae num... 30 | 62
abnormal bone mineralization 29 | 55
decreased circulating total pr... 29 | 41
improved glucose tolerance 29 | 56
increased circulating sodium l... 29 | 71
increased blood urea nitrogen ... 28 | 44
decreased hemoglobin content 27 | 53
decreased prepulse inhibition 27 | 52
decreased fasted circulating g... 26 | 49
decreased startle reflex 26 | 48
increased exploration in new e... 26 | 56
abnormal coat-hair pigmentatio... 25 | 54
abnormal gait 25 | 51
decreased circulating alanine ... 25 | 53
decreased circulating alkaline... 25 | 41
increased total body fat amoun... 25 | 57
decreased erythrocyte cell num... 24 | 43
increased body weight 24 | 42
increased heart weight 24 | 37
abnormal behavioral response t... 23 | 52
decreased circulating fructosa... 23 | 31
decreased heart weight 23 | 44
increased circulating chloride... 23 | 43
increased hemoglobin content 23 | 45
thrombocytopenia 23 | 46
abnormal seminal vesicle morph... 22 | 47
decreased mean corpuscular hem... 22 | 34
increased hematocrit 22 | 36
increased leukocyte cell numbe... 22 | 37
decreased circulating LDL chol... 21 | 37
abnormal cranium morphology 20 | 32
abnormal heart morphology 20 | 51
abnormal neural tube closure 20 | 37
cardiovascular system phenotyp... 20 | 35
decreased circulating calcium ... 20 | 33
increased circulating potassiu... 20 | 31
abnormal eye morphology 19 | 38
decreased eosinophil cell numb... 19 | 41
decreased neutrophil cell numb... 19 | 37
limb grasping 19 | 35
decreased circulating free fat... 18 | 39
small testis 18 | 37
tremors 18 | 34
decreased circulating amylase ... 17 | 24
decreased circulating aspartat... 17 | 27
decreased threshold for audito... 17 | 32
embryonic growth retardation 17 | 28
increased rib number 17 | 41
abnormal testis morphology 16 | 30
decreased circulating iron lev... 16 | 25
increased erythrocyte cell num... 16 | 26
increased mean corpuscular hem... 16 | 25
increased startle reflex 16 | 38

Disease

ovarian cancer 4,836 | 8,491
osteosarcoma 3,987 | 7,933
medulloblastoma, large-cell 3,138 | 6,234
psoriasis 3,117 | 6,685
glioblastoma 2,923 | 5,572
lung cancer 2,498 | 4,473
atypical teratoid / rhabdoid tumor 2,219 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,737 | 3,289
malignant mesothelioma 1,643 | 3,163
Breast cancer 1,624 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 1,565 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,550 | 2,956
invasive ductal carcinoma 1,527 | 2,950
pilocytic astrocytoma 1,526 | 3,086
primitive neuroectodermal tumor 1,475 | 3,031
oligodendroglioma 1,468 | 2,849
pediatric high grade glioma 1,399 | 2,712
non-small cell lung cancer 1,384 | 2,798
ependymoma 1,374 | 2,514
lung carcinoma 1,355 | 2,844
lung adenocarcinoma 1,309 | 2,714
subependymal giant cell astrocytoma 1,224 | 2,287
pancreatic cancer 1,212 | 2,300
Carcinoma 1,206 | 2,147
Cancer 1,180 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 1,178 | 1,795
astrocytic glioma 1,155 | 2,241
Pick disease 1,105 | 1,893
group 3 medulloblastoma 1,094 | 2,254
Multiple myeloma 1,024 | 1,327
adult high grade glioma 1,019 | 2,148
ulcerative colitis 1,019 | 2,087
group 4 medulloblastoma 990 | 1,875
interstitial cystitis 945 | 2,299
astrocytoma 905 | 1,493
pituitary cancer 904 | 1,972
diabetes mellitus 853 | 1,663
ductal carcinoma in situ 853 | 1,745
breast carcinoma 822 | 1,614
cystic fibrosis 793 | 1,670
tuberculosis 788 | 1,563
acute quadriplegic myopathy 778 | 1,157
colon cancer 773 | 1,475
medulloblastoma 761 | 1,524
adrenocortical carcinoma 755 | 1,427
primary pancreatic ductal adenocarcinoma 749 | 1,271
juvenile dermatomyositis 748 | 1,189
sonic hedgehog group medulloblastoma 731 | 1,482
posterior fossa group A ependymoma 703 | 1,511
dermatomyositis 688 | 966
posterior fossa group B ependymoma 636 | 1,530
Rheumatoid Arthritis 634 | 1,170
Waldenstrons macroglobulinemia 588 | 764
atypical teratoid/rhabdoid tumor 535 | 1,095
spina bifida 513 | 1,064
nasopharyngeal carcinoma 468 | 1,056
non primary Sjogren syndrome sicca 460 | 840
active Crohn's disease 458 | 918
cutaneous lupus erythematosus 456 | 1,056
acute myeloid leukemia 434 | 785
gastric carcinoma 430 | 832
Atopic dermatitis 417 | 944
primary Sjogren syndrome 401 | 788
esophageal adenocarcinoma 396 | 737
Duchenne muscular dystrophy 392 | 602
progressive supranuclear palsy 391 | 674
tuberculosis and treatment for 6 months 386 | 686
Alzheimer's disease 378 | 644
aldosterone-producing adenoma 376 | 664
Intellectual disability 335 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 323 | 499
Down syndrome 320 | 548
pancreatic carcinoma 313 | 567
hepatocellular carcinoma 300 | 550
Obesity 296 | 616
IGA Glomerulonephritis 275 | 454
Prostatic Neoplasms 275 | 471
Neurodegenerative disease 274 | 383
Amyotrophic Lateral Sclerosis 267 | 432
fibroadenoma 257 | 557
mucosa-associated lymphoid tissue lymphoma 238 | 480
hereditary spastic paraplegia 234 | 313
gastric cancer 233 | 436
Mammary Neoplasms 224 | 410
Schizophrenia 221 | 503
Multiple Sclerosis 214 | 498
active ulcerative colitis 214 | 477
Endometriosis 209 | 535
Parkinson's disease 204 | 364
chronic rhinosinusitis 197 | 512
non-small cell lung carcinoma 192 | 413
inflammatory breast cancer 190 | 404
Polycystic Ovary Syndrome 185 | 334
Kidney disease 180 | 397
sarcoidosis 177 | 368
Epilepsy 173 | 346
Stomach Neoplasms 170 | 282
glioblastoma multiforme 168 | 347
interstitial lung disease 168 | 292
Vascular disease 160 | 281

Tissue

Endocrine System 8,478 | 18,511
Female tissues 8,468 | 18,646
Nervous System 8,467 | 18,560
Digestive Tract 8,465 | 18,472
Liver and Pancreas 8,458 | 18,135
Blood and immune system 8,456 | 17,994
Male tissues 8,453 | 17,968
Urinary Tract 8,449 | 18,443
Cardiovascular System 8,434 | 17,957
Respiratory system 8,399 | 17,483
Skin and soft tissues 8,336 | 18,114

Target Family

Non-IDG 4,938 | 11,969
Enzyme 2,297 | 4,146
Transcription Factor 410 | 1,400
Kinase 385 | 634
Transporter 182 | 473
Epigenetic 116 | 242
Ion Channel 91 | 341
GPCR 31 | 408
TF/Epigenetic 13 | 38
oGPCR 9 | 421
Nuclear Receptor 6 | 48

HPM Tissue

Adult Adrenal 8,478 | 8,478
Adult Testis 10,842 | 10,842
Adult Ovary 10,200 | 10,200
Adult Retina 10,123 | 10,123
CD8 Cells 9,848 | 9,848
Fetal Heart 9,238 | 9,238
Adult Pancreas 9,174 | 9,174
Fetal Ovary 9,126 | 9,126
Adult Liver 9,121 | 9,121
B Cells 9,090 | 9,090
Adult Frontal Cortex 9,053 | 9,053
Adult Prostate 8,962 | 8,962
Fetal Gut 8,647 | 8,647
NK Cells 8,480 | 8,480
Fetal Liver 8,409 | 8,409
Adult Rectum 8,031 | 8,031
Fetal Testis 7,960 | 7,960
Adult Colon 7,920 | 7,920
Fetal Brain 7,870 | 7,870
CD4 Cells 7,778 | 7,778
Adult Gallbladder 7,618 | 7,618
Adult Urinary Bladder 7,600 | 7,600
Adult Spinal Cord 7,598 | 7,598
Monocytes 7,426 | 7,426
Adult Kidney 6,727 | 6,727
Adult Lung 6,668 | 6,668
Adult Heart 6,509 | 6,509
Platelets 6,132 | 6,132
Placenta 6,086 | 6,086
Adult Esophagus 4,938 | 4,938

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521