Development Level

Tbio 5,405 | 10,625
Tdark 1,764 | 7,003
Tchem 1,027 | 1,890
Tclin 283 | 602

Collection

Eligible Kinase Proteins 56 | 134
Eligible Ion Channel Proteins 29 | 117
Eligible non-olfactory GPCR Proteins 8 | 143

IMPC Term

preweaning lethality, complete... 393 | 633
preweaning lethality, incomple... 147 | 260
abnormal behavior 123 | 226
embryonic lethality prior to t... 122 | 187
decreased lean body mass 118 | 195
decreased total body fat amoun... 115 | 186
embryonic lethality prior to o... 108 | 148
decreased body weight 99 | 174
decreased bone mineral content 87 | 157
abnormal bone structure 71 | 131
abnormal embryo size 69 | 112
increased circulating alkaline... 69 | 119
decreased grip strength 66 | 123
increased or absent threshold ... 66 | 128
decreased body length 65 | 108
decreased circulating glucose ... 64 | 121
decreased bone mineral density 61 | 126
hyperactivity 57 | 108
increased bone mineral content 57 | 92
increased lean body mass 56 | 107
abnormal retina morphology 55 | 100
increased mean corpuscular hem... 55 | 93
decreased circulating serum al... 49 | 79
enlarged heart 48 | 111
short tibia 48 | 82
hypoactivity 47 | 89
decreased circulating choleste... 45 | 85
abnormal lens morphology 44 | 73
increased mean corpuscular vol... 44 | 91
decreased circulating HDL chol... 43 | 77
decreased circulating triglyce... 43 | 83
increased fasted circulating g... 41 | 68
increased grip strength 39 | 83
decreased mean corpuscular vol... 38 | 50
prenatal lethality prior to he... 38 | 64
decreased circulating insulin ... 36 | 75
decreased rib number 36 | 59
abnormal retinal pigmentation 34 | 61
decreased lumbar vertebrae num... 33 | 62
male infertility 33 | 62
increased circulating choleste... 32 | 53
abnormal sleep behavior 31 | 63
impaired glucose tolerance 31 | 52
increased bone mineral density 31 | 52
increased circulating HDL chol... 31 | 63
decreased caudal vertebrae num... 30 | 49
decreased leukocyte cell numbe... 30 | 54
increased sacral vertebrae num... 30 | 62
abnormal bone mineralization 29 | 55
decreased circulating total pr... 29 | 41
improved glucose tolerance 29 | 56
increased circulating sodium l... 29 | 71
increased blood urea nitrogen ... 28 | 44
decreased hemoglobin content 27 | 53
decreased prepulse inhibition 27 | 52
decreased fasted circulating g... 26 | 49
decreased startle reflex 26 | 48
increased exploration in new e... 26 | 56
abnormal coat/hair pigmentatio... 25 | 54
abnormal gait 25 | 51
decreased circulating alanine ... 25 | 53
decreased circulating alkaline... 25 | 41
increased total body fat amoun... 25 | 57
decreased erythrocyte cell num... 24 | 43
increased body weight 24 | 42
increased heart weight 24 | 37
abnormal behavioral response t... 23 | 52
decreased circulating fructosa... 23 | 31
decreased heart weight 23 | 44
increased circulating chloride... 23 | 43
increased hemoglobin content 23 | 45
thrombocytopenia 23 | 46
abnormal seminal vesicle morph... 22 | 47
decreased mean corpuscular hem... 22 | 34
increased hematocrit 22 | 36
increased leukocyte cell numbe... 22 | 37
decreased circulating LDL chol... 21 | 37
abnormal cranium morphology 20 | 32
abnormal heart morphology 20 | 51
abnormal neural tube closure 20 | 37
cardiovascular system phenotyp... 20 | 35
decreased circulating calcium ... 20 | 33
increased circulating potassiu... 20 | 31
abnormal eye morphology 19 | 38
decreased eosinophil cell numb... 19 | 41
decreased neutrophil cell numb... 19 | 37
limb grasping 19 | 35
decreased circulating free fat... 18 | 39
small testis 18 | 37
tremors 18 | 34
decreased circulating amylase ... 17 | 24
decreased circulating aspartat... 17 | 27
decreased threshold for audito... 17 | 32
embryonic growth retardation 17 | 28
increased rib number 17 | 41
abnormal testis morphology 16 | 30
decreased circulating iron lev... 16 | 25
increased erythrocyte cell num... 16 | 26
increased mean corpuscular hem... 16 | 25
increased startle reflex 16 | 38

Disease

ovarian cancer 4,831 | 8,484
osteosarcoma 3,987 | 7,933
medulloblastoma, large-cell 3,138 | 6,234
psoriasis 3,117 | 6,685
glioblastoma 2,923 | 5,572
lung cancer 2,495 | 4,466
atypical teratoid / rhabdoid tumor 2,219 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,737 | 3,289
malignant mesothelioma 1,643 | 3,162
Breast cancer 1,623 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,565 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,550 | 2,956
invasive ductal carcinoma 1,527 | 2,950
pilocytic astrocytoma 1,526 | 3,086
primitive neuroectodermal tumor 1,475 | 3,031
oligodendroglioma 1,468 | 2,849
pediatric high grade glioma 1,399 | 2,712
non-small cell lung cancer 1,384 | 2,798
ependymoma 1,374 | 2,514
lung carcinoma 1,355 | 2,844
lung adenocarcinoma 1,309 | 2,713
subependymal giant cell astrocytoma 1,224 | 2,287
pancreatic cancer 1,212 | 2,300
Carcinoma 1,206 | 2,147
Cancer 1,180 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 1,178 | 1,795
astrocytic glioma 1,155 | 2,241
Pick disease 1,105 | 1,893
group 3 medulloblastoma 1,094 | 2,254
Multiple myeloma 1,025 | 1,327
adult high grade glioma 1,019 | 2,148
ulcerative colitis 1,019 | 2,087
group 4 medulloblastoma 990 | 1,875
interstitial cystitis 945 | 2,299
astrocytoma 905 | 1,493
pituitary cancer 904 | 1,972
diabetes mellitus 853 | 1,663
ductal carcinoma in situ 853 | 1,745
breast carcinoma 822 | 1,614
cystic fibrosis 791 | 1,665
tuberculosis 786 | 1,557
acute quadriplegic myopathy 778 | 1,157
colon cancer 773 | 1,475
medulloblastoma 761 | 1,524
adrenocortical carcinoma 755 | 1,427
primary pancreatic ductal adenocarcinoma 749 | 1,271
juvenile dermatomyositis 748 | 1,189
sonic hedgehog group medulloblastoma 731 | 1,482
posterior fossa group A ependymoma 703 | 1,511
dermatomyositis 688 | 933
posterior fossa group B ependymoma 636 | 1,530
Rheumatoid Arthritis 634 | 1,160
Waldenstrons macroglobulinemia 589 | 765
atypical teratoid/rhabdoid tumor 535 | 1,095
spina bifida 513 | 1,064
nasopharyngeal carcinoma 468 | 1,056
non primary Sjogren syndrome sicca 460 | 840
active Crohn's disease 458 | 918
cutaneous lupus erythematosus 456 | 1,056
acute myeloid leukemia 432 | 780
gastric carcinoma 430 | 832
Atopic dermatitis 417 | 944
primary Sjogren syndrome 402 | 789
esophageal adenocarcinoma 396 | 737
Duchenne muscular dystrophy 392 | 602
progressive supranuclear palsy 391 | 674
tuberculosis and treatment for 6 months 386 | 686
Alzheimer's disease 378 | 644
aldosterone-producing adenoma 376 | 664
Intellectual disability 335 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 323 | 499
Down syndrome 320 | 548
pancreatic carcinoma 313 | 567
Obesity 296 | 616
hepatocellular carcinoma 288 | 532
IGA Glomerulonephritis 275 | 454
Prostatic Neoplasms 275 | 471
Neurodegenerative disease 274 | 383
Amyotrophic Lateral Sclerosis 267 | 431
fibroadenoma 257 | 557
mucosa-associated lymphoid tissue lymphoma 238 | 480
hereditary spastic paraplegia 234 | 313
gastric cancer 229 | 430
Mammary Neoplasms 224 | 410
Schizophrenia 219 | 501
Multiple Sclerosis 214 | 498
active ulcerative colitis 214 | 477
Endometriosis 209 | 535
Parkinson's disease 204 | 364
chronic rhinosinusitis 197 | 512
non-small cell lung carcinoma 192 | 413
inflammatory breast cancer 190 | 404
Polycystic Ovary Syndrome 184 | 332
Kidney disease 180 | 396
sarcoidosis 176 | 358
Epilepsy 173 | 346
Stomach Neoplasms 170 | 282
glioblastoma multiforme 168 | 347
interstitial lung disease 167 | 291
Vascular disease 160 | 281

Tissue

Endocrine System 8,479 | 18,512
Female tissues 8,469 | 18,647
Nervous System 8,468 | 18,561
Digestive Tract 8,466 | 18,473
Liver and Pancreas 8,459 | 18,136
Blood and immune system 8,457 | 17,995
Male tissues 8,454 | 17,969
Urinary Tract 8,450 | 18,444
Cardiovascular System 8,435 | 17,958
Respiratory system 8,400 | 17,484
Skin and soft tissues 8,337 | 18,115

Target Family

Non-IDG 4,938 | 11,971
Enzyme 2,298 | 4,146
Transcription Factor 410 | 1,400
Kinase 385 | 634
Transporter 182 | 473
Epigenetic 116 | 242
Ion Channel 91 | 341
GPCR 31 | 406
TF/Epigenetic 13 | 38
oGPCR 9 | 421
Nuclear Receptor 6 | 48

HPM Tissue

Adult Adrenal 8,479 | 8,479
Adult Testis 10,843 | 10,843
Adult Ovary 10,201 | 10,201
Adult Retina 10,124 | 10,124
CD8 Cells 9,849 | 9,849
Fetal Heart 9,239 | 9,239
Adult Pancreas 9,175 | 9,175
Fetal Ovary 9,127 | 9,127
Adult Liver 9,122 | 9,122
B Cells 9,091 | 9,091
Adult Frontal Cortex 9,054 | 9,054
Adult Prostate 8,963 | 8,963
Fetal Gut 8,648 | 8,648
NK Cells 8,481 | 8,481
Fetal Liver 8,410 | 8,410
Adult Rectum 8,032 | 8,032
Fetal Testis 7,961 | 7,961
Adult Colon 7,921 | 7,921
Fetal Brain 7,871 | 7,871
CD4 Cells 7,779 | 7,779
Adult Gallbladder 7,619 | 7,619
Adult Urinary Bladder 7,601 | 7,601
Adult Spinal Cord 7,599 | 7,599
Monocytes 7,427 | 7,427
Adult Kidney 6,728 | 6,728
Adult Lung 6,669 | 6,669
Adult Heart 6,510 | 6,510
Platelets 6,133 | 6,133
Placenta 6,087 | 6,087
Adult Esophagus 4,939 | 4,939

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209