Development Level

Tbio 10,226 | 11,651
Tdark 3,829 | 6,593
Tchem 1,241 | 1,388
Tclin 518 | 612

Collection

RFA-RM-18-021 246 | 328
Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 62 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 947 | 979
preweaning lethality, incomple... 464 | 499
embryonic lethality prior to t... 274 | 278
abnormal behavior 272 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
enlarged heart 192 | 210
decreased total body fat amoun... 191 | 207
decreased vertical activity 178 | 208
abnormal bone structure 166 | 187
increased lean body mass 159 | 172
abnormal heart morphology 152 | 162
decreased body weight 149 | 161
decreased bone mineral content 136 | 151
hyperactivity 129 | 148
decreased lean body mass 122 | 135
increased total body fat amoun... 119 | 134
hypoactivity 113 | 132
decreased bone mineral density 111 | 126
decreased circulating glucose ... 111 | 126
increased circulating alkaline... 110 | 122
increased startle reflex 102 | 112
male infertility 102 | 123
abnormal seminal vesicle morph... 101 | 114
decreased grip strength 101 | 116
embryonic growth retardation 101 | 106
increased bone mineral content 97 | 108
decreased body length 92 | 101
short tibia 92 | 97
increased or absent threshold ... 90 | 101
decreased circulating choleste... 88 | 93
increased mean corpuscular hem... 87 | 96
increased mean corpuscular vol... 87 | 92
cataract 85 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 76 | 83
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 73 | 79
decreased prepulse inhibition 72 | 82
increased bone mineral density 69 | 72
increased fasted circulating g... 68 | 76
small superior vagus ganglion 68 | 74
decreased leukocyte cell numbe... 67 | 73
impaired glucose tolerance 67 | 75
increased circulating HDL chol... 67 | 80
decreased startle reflex 66 | 75
improved glucose tolerance 66 | 79
abnormal eye morphology 65 | 68
decreased circulating HDL chol... 65 | 68
decreased circulating insulin ... 65 | 76
abnormal retina morphology 64 | 71
abnormal sleep behavior 62 | 70
abnormal gait 61 | 69
abnormal coat-hair pigmentatio... 60 | 64
decreased erythrocyte cell num... 59 | 62
decreased fasted circulating g... 59 | 65
abnormal kidney morphology 58 | 65
decreased hemoglobin content 58 | 68
increased circulating choleste... 58 | 66
increased monocyte cell number 58 | 63
abnormal behavioral response t... 57 | 66
increased circulating sodium l... 57 | 71
edema 55 | 59
increased heart weight 55 | 62
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
small testis 53 | 58
thrombocytopenia 51 | 56
hydrometra 49 | 53
abnormal skin morphology 48 | 50
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
abnormal neural tube closure 46 | 46
female infertility 46 | 60
decreased mean corpuscular hem... 45 | 50
decreased circulating alkaline... 44 | 46
increased neutrophil cell numb... 43 | 46
decreased circulating alanine ... 42 | 47
decreased hematocrit 42 | 46
enlarged spleen 41 | 41
increased blood urea nitrogen ... 41 | 48
increased hematocrit 41 | 46
increased leukocyte cell numbe... 41 | 47
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
increased circulating triglyce... 38 | 42
decreased red blood cell distr... 37 | 41
increased hemoglobin content 37 | 45
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
increased erythrocyte cell num... 35 | 39
limb grasping 35 | 41
tremors 35 | 39
abnormal epididymis morphology 34 | 42
increased grip strength 34 | 41
increased mean corpuscular hem... 33 | 36

Disease

Carcinoma 9,692 | 11,493
ovarian cancer 8,088 | 8,520
osteosarcoma 7,435 | 7,950
medulloblastoma, large-cell 5,721 | 6,241
psoriasis 5,692 | 6,694
glioblastoma 5,399 | 5,792
atypical teratoid / rhabdoid tumor 4,729 | 5,112
lung cancer 4,466 | 4,740
ependymoma 4,291 | 4,679
group 3 medulloblastoma 3,807 | 4,104
adult high grade glioma 3,444 | 3,801
Breast cancer 3,374 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,184 | 3,291
malignant mesothelioma 3,106 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,897 | 2,989
invasive ductal carcinoma 2,886 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,860 | 2,955
primitive neuroectodermal tumor 2,800 | 3,035
non-small cell lung cancer 2,794 | 2,890
Astrocytoma, Pilocytic 2,793 | 3,081
lung carcinoma 2,632 | 2,843
oligodendroglioma 2,610 | 2,850
lung adenocarcinoma 2,582 | 2,716
astrocytic glioma 2,385 | 2,597
pancreatic cancer 2,286 | 2,398
Kidney cancer 2,259 | 2,613
interstitial cystitis 2,246 | 2,312
Cancer 2,215 | 2,499
subependymal giant cell astrocytoma 2,141 | 2,287
tuberculosis 1,931 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,872 | 1,962
pituitary cancer 1,821 | 1,972
Pick disease 1,786 | 1,894
group 4 medulloblastoma 1,742 | 1,855
ulcerative colitis 1,731 | 1,819
ductal carcinoma in situ 1,701 | 1,745
cystic fibrosis 1,617 | 1,696
breast carcinoma 1,581 | 1,638
colon cancer 1,421 | 1,478
adrenocortical carcinoma 1,391 | 1,428
diabetes mellitus 1,313 | 1,728
Multiple myeloma 1,305 | 1,332
Autosomal recessive predisposition 1,276 | 1,442
juvenile dermatomyositis 1,159 | 1,187
acute quadriplegic myopathy 1,127 | 1,158
astrocytoma 1,098 | 1,146
Rheumatoid arthritis 1,093 | 1,191
primary pancreatic ductal adenocarcinoma 1,080 | 1,109
spina bifida 1,033 | 1,074
pediatric high grade glioma 1,010 | 1,064
cutaneous lupus erythematosus 1,008 | 1,057
nasopharyngeal carcinoma 994 | 1,058
Schizophrenia 993 | 1,160
Intellectual disability 925 | 1,016
dermatomyositis 916 | 966
active Crohn's disease 875 | 922
Atopic dermatitis 868 | 952
non primary Sjogren syndrome sicca 817 | 891
acute myeloid leukemia 771 | 783
gastric carcinoma 767 | 807
Waldenstrons macroglobulinemia 759 | 765
Liver Cirrhosis, Experimental 724 | 769
primary Sjogren syndrome 720 | 735
active ulcerative colitis 714 | 764
esophageal adenocarcinoma 713 | 737
Epilepsy 704 | 792
medulloblastoma 670 | 720
aldosterone-producing adenoma 646 | 665
progressive supranuclear palsy 646 | 676
Alzheimer's disease 591 | 658
Dull intelligence 587 | 645
Low intelligence 587 | 645
Mental Retardation 587 | 645
Mental deficiency 587 | 645
Poor school performance 587 | 645
Duchenne muscular dystrophy 576 | 601
Obesity 570 | 678
Cognitive delay 566 | 608
Global developmental delay 566 | 608
Mental and motor retardation 566 | 608
Bipolar Disorder 562 | 666
Melanoma 555 | 711
pancreatic carcinoma 547 | 562
fibroadenoma 538 | 559
Muscle hypotonia 536 | 571
Seizures 536 | 596
hepatocellular carcinoma 534 | 547
Endometriosis 503 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 510
Liver cancer 491 | 604
Short stature 487 | 531
Down syndrome 471 | 499
chronic rhinosinusitis 467 | 512
Prostatic Neoplasms 463 | 495
Multiple Sclerosis 454 | 540
mucosa-associated lymphoid tissue lymphoma 453 | 484
gastric cancer 449 | 459
posterior fossa group A ependymoma 444 | 468
sonic hedgehog group medulloblastoma 436 | 467
Amyotrophic lateral sclerosis 425 | 451

Tissue

Urinary Tract 15,814 | 16,678
Endocrine System 15,773 | 18,159
Digestive Tract 15,767 | 17,369
Female tissues 15,739 | 17,400
Skin and soft tissues 15,706 | 17,230
Male tissues 15,673 | 17,142
Blood and immune system 15,635 | 16,909
Liver and Pancreas 15,633 | 16,750
Respiratory system 15,484 | 16,393
Nervous System 15,409 | 16,725
Cardiovascular System 14,716 | 15,192

Target Family

Non-IDG 9,187 | 12,091
Enzyme 3,675 | 4,145
Transcription Factor 1,160 | 1,400
Kinase 586 | 634
Transporter 375 | 473
GPCR 263 | 408
Ion Channel 247 | 344
Epigenetic 225 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 20 | 421

HPA RNA Tissue

urinary bladder 15,814 | 15,814
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50