Development Level

Tbio 9,809 | 11,178
Tdark 3,817 | 6,569
Tchem 1,670 | 1,885
Tclin 518 | 612

Collection

Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 62 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 947 | 979
preweaning lethality, incomple... 464 | 499
embryonic lethality prior to t... 274 | 278
abnormal behavior 272 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
enlarged heart 192 | 210
decreased total body fat amoun... 191 | 207
decreased vertical activity 178 | 208
abnormal bone structure 166 | 187
increased lean body mass 159 | 172
abnormal heart morphology 152 | 162
decreased body weight 149 | 161
decreased bone mineral content 136 | 151
hyperactivity 129 | 148
decreased lean body mass 122 | 135
increased total body fat amoun... 119 | 134
hypoactivity 113 | 132
decreased bone mineral density 111 | 126
decreased circulating glucose ... 111 | 126
increased circulating alkaline... 110 | 122
increased startle reflex 102 | 112
male infertility 102 | 123
abnormal seminal vesicle morph... 101 | 114
decreased grip strength 101 | 116
embryonic growth retardation 101 | 106
increased bone mineral content 97 | 108
decreased body length 92 | 101
short tibia 92 | 97
increased or absent threshold ... 90 | 101
decreased circulating choleste... 88 | 93
increased mean corpuscular hem... 87 | 96
increased mean corpuscular vol... 87 | 92
cataract 85 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 76 | 83
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 73 | 79
decreased prepulse inhibition 72 | 82
increased bone mineral density 69 | 72
increased fasted circulating g... 68 | 76
small superior vagus ganglion 68 | 74
decreased leukocyte cell numbe... 67 | 73
impaired glucose tolerance 67 | 75
increased circulating HDL chol... 67 | 80
decreased startle reflex 66 | 75
improved glucose tolerance 66 | 79
abnormal eye morphology 65 | 68
decreased circulating HDL chol... 65 | 68
decreased circulating insulin ... 65 | 76
abnormal retina morphology 64 | 71
abnormal sleep behavior 62 | 70
abnormal gait 61 | 69
abnormal coat-hair pigmentatio... 60 | 64
decreased erythrocyte cell num... 59 | 62
decreased fasted circulating g... 59 | 65
abnormal kidney morphology 58 | 65
decreased hemoglobin content 58 | 68
increased circulating choleste... 58 | 66
increased monocyte cell number 58 | 63
abnormal behavioral response t... 57 | 66
increased circulating sodium l... 57 | 71
edema 55 | 59
increased heart weight 55 | 62
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
small testis 53 | 58
thrombocytopenia 51 | 56
hydrometra 49 | 53
abnormal skin morphology 48 | 50
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
abnormal neural tube closure 46 | 46
female infertility 46 | 60
decreased mean corpuscular hem... 45 | 50
decreased circulating alkaline... 44 | 46
increased neutrophil cell numb... 43 | 46
decreased circulating alanine ... 42 | 47
decreased hematocrit 42 | 46
enlarged spleen 41 | 41
increased blood urea nitrogen ... 41 | 48
increased hematocrit 41 | 46
increased leukocyte cell numbe... 41 | 47
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
increased circulating triglyce... 38 | 42
decreased red blood cell distr... 37 | 41
increased hemoglobin content 37 | 45
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
increased erythrocyte cell num... 35 | 39
limb grasping 35 | 41
tremors 35 | 39
abnormal epididymis morphology 34 | 42
increased grip strength 34 | 41
increased mean corpuscular hem... 33 | 36

Disease

Carcinoma 9,450 | 11,192
ovarian cancer 7,879 | 8,297
osteosarcoma 7,260 | 7,766
medulloblastoma, large-cell 5,583 | 6,086
psoriasis 5,543 | 6,514
glioblastoma 5,257 | 5,635
atypical teratoid / rhabdoid tumor 4,597 | 4,971
lung cancer 4,345 | 4,607
ependymoma 4,184 | 4,559
group 3 medulloblastoma 3,717 | 4,002
adult high grade glioma 3,354 | 3,701
Breast cancer 3,277 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,104 | 3,204
malignant mesothelioma 3,014 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 2,817 | 2,902
invasive ductal carcinoma 2,804 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,785 | 2,872
primitive neuroectodermal tumor 2,728 | 2,957
Astrocytoma, Pilocytic 2,724 | 3,006
non-small cell lung cancer 2,708 | 2,799
lung carcinoma 2,548 | 2,755
oligodendroglioma 2,536 | 2,768
lung adenocarcinoma 2,498 | 2,627
astrocytic glioma 2,325 | 2,530
pancreatic cancer 2,219 | 2,322
Kidney cancer 2,205 | 2,548
interstitial cystitis 2,172 | 2,237
Cancer 2,122 | 2,388
subependymal giant cell astrocytoma 2,091 | 2,230
tuberculosis 1,884 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,826 | 1,911
pituitary cancer 1,766 | 1,915
Pick disease 1,752 | 1,856
group 4 medulloblastoma 1,699 | 1,806
ulcerative colitis 1,680 | 1,765
ductal carcinoma in situ 1,644 | 1,686
cystic fibrosis 1,560 | 1,629
breast carcinoma 1,534 | 1,589
colon cancer 1,376 | 1,428
adrenocortical carcinoma 1,350 | 1,385
diabetes mellitus 1,276 | 1,683
Multiple myeloma 1,269 | 1,296
Autosomal recessive predisposition 1,249 | 1,407
juvenile dermatomyositis 1,120 | 1,147
acute quadriplegic myopathy 1,102 | 1,133
astrocytoma 1,067 | 1,113
Rheumatoid arthritis 1,059 | 1,156
primary pancreatic ductal adenocarcinoma 1,044 | 1,071
spina bifida 1,015 | 1,053
pediatric high grade glioma 984 | 1,035
Schizophrenia 974 | 1,136
cutaneous lupus erythematosus 972 | 1,016
nasopharyngeal carcinoma 962 | 1,024
Intellectual disability 911 | 998
dermatomyositis 891 | 941
active Crohn's disease 840 | 882
Atopic dermatitis 834 | 915
non primary Sjogren syndrome sicca 791 | 861
acute myeloid leukemia 748 | 760
gastric carcinoma 742 | 781
Waldenstrons macroglobulinemia 737 | 742
primary Sjogren syndrome 695 | 710
Epilepsy 691 | 775
Liver Cirrhosis, Experimental 690 | 733
active ulcerative colitis 690 | 736
esophageal adenocarcinoma 675 | 696
medulloblastoma 653 | 702
aldosterone-producing adenoma 629 | 646
progressive supranuclear palsy 629 | 656
Dull intelligence 579 | 634
Low intelligence 579 | 634
Mental Retardation 579 | 634
Mental deficiency 579 | 634
Poor school performance 579 | 634
Alzheimer's disease 574 | 640
Duchenne muscular dystrophy 562 | 587
Cognitive delay 558 | 596
Global developmental delay 558 | 596
Mental and motor retardation 558 | 596
Obesity 554 | 655
Bipolar Disorder 545 | 646
pancreatic carcinoma 540 | 555
Melanoma 539 | 689
Muscle hypotonia 530 | 562
Seizures 528 | 584
hepatocellular carcinoma 523 | 536
fibroadenoma 518 | 538
Endometriosis 486 | 521
Liver cancer 479 | 589
autosomal dominant Emery-Dreifuss muscular dystrophy 475 | 492
Short stature 474 | 514
chronic rhinosinusitis 461 | 505
Down syndrome 453 | 480
Multiple Sclerosis 443 | 527
mucosa-associated lymphoid tissue lymphoma 443 | 473
Prostatic Neoplasms 442 | 472
gastric cancer 435 | 445
posterior fossa group A ependymoma 432 | 456
sonic hedgehog group medulloblastoma 428 | 459
Amyotrophic lateral sclerosis 411 | 437

Tissue

Urinary Tract 15,814 | 16,678
Endocrine System 15,773 | 18,159
Digestive Tract 15,767 | 17,369
Female tissues 15,739 | 17,400
Skin and soft tissues 15,706 | 17,230
Male tissues 15,673 | 17,142
Blood and immune system 15,635 | 16,909
Liver and Pancreas 15,633 | 16,750
Respiratory system 15,484 | 16,393
Nervous System 15,409 | 16,725
Cardiovascular System 14,716 | 15,192

Target Family

Non-IDG 9,187 | 12,091
Enzyme 3,675 | 4,145
Transcription Factor 1,160 | 1,400
Kinase 586 | 634
Transporter 375 | 473
GPCR 263 | 408
Ion Channel 247 | 344
Epigenetic 225 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 20 | 421

HPA RNA Tissue

urinary bladder 15,814 | 15,814
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101