Development Level

Tbio 8,269 | 10,625
Tdark 3,378 | 7,003
Tchem 1,484 | 1,890
Tclin 386 | 602

Collection

Eligible Kinase Proteins 105 | 134
Eligible non-olfactory GPCR Proteins 46 | 143
Eligible Ion Channel Proteins 43 | 117

IMPC Term

preweaning lethality, complete... 587 | 633
preweaning lethality, incomple... 217 | 260
abnormal behavior 189 | 226
embryonic lethality prior to t... 182 | 187
decreased lean body mass 166 | 195
decreased total body fat amoun... 159 | 186
decreased body weight 149 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 129 | 157
increased circulating alkaline... 105 | 119
abnormal bone structure 104 | 131
abnormal embryo size 104 | 112
increased or absent threshold ... 104 | 128
decreased bone mineral density 99 | 126
decreased grip strength 96 | 123
decreased circulating glucose ... 95 | 121
decreased body length 92 | 108
increased lean body mass 90 | 107
enlarged heart 89 | 111
abnormal retina morphology 87 | 100
hyperactivity 87 | 108
increased mean corpuscular hem... 83 | 93
increased bone mineral content 81 | 92
increased mean corpuscular vol... 81 | 91
short tibia 74 | 82
decreased circulating choleste... 73 | 85
decreased circulating serum al... 71 | 79
increased grip strength 71 | 83
hypoactivity 70 | 89
decreased circulating triglyce... 69 | 83
decreased circulating HDL chol... 67 | 77
abnormal lens morphology 63 | 73
prenatal lethality prior to he... 60 | 64
increased fasted circulating g... 57 | 68
decreased lumbar vertebrae num... 56 | 62
decreased circulating insulin ... 55 | 75
increased sacral vertebrae num... 54 | 62
abnormal retinal pigmentation 53 | 61
increased circulating sodium l... 51 | 71
decreased rib number 50 | 59
abnormal sleep behavior 48 | 63
increased circulating HDL chol... 48 | 63
decreased mean corpuscular vol... 46 | 50
increased total body fat amoun... 46 | 57
male infertility 46 | 62
abnormal bone mineralization 45 | 55
abnormal coat/hair pigmentatio... 45 | 54
decreased hemoglobin content 45 | 53
decreased leukocyte cell numbe... 45 | 54
increased bone mineral density 45 | 52
decreased prepulse inhibition 43 | 52
improved glucose tolerance 43 | 56
increased circulating choleste... 43 | 53
decreased caudal vertebrae num... 42 | 49
decreased circulating alanine ... 42 | 53
impaired glucose tolerance 42 | 52
decreased fasted circulating g... 41 | 49
abnormal gait 40 | 51
decreased erythrocyte cell num... 40 | 43
increased exploration in new e... 40 | 56
decreased startle reflex 39 | 48
decreased circulating total pr... 38 | 41
thrombocytopenia 38 | 46
abnormal behavioral response t... 37 | 52
abnormal heart morphology 37 | 51
decreased eosinophil cell numb... 37 | 41
increased blood urea nitrogen ... 37 | 44
increased body weight 37 | 42
increased hemoglobin content 36 | 45
decreased heart weight 35 | 44
increased rib number 35 | 41
abnormal neural tube closure 34 | 37
abnormal seminal vesicle morph... 34 | 47
decreased circulating alkaline... 34 | 41
decreased circulating free fat... 34 | 39
decreased circulating LDL chol... 33 | 37
abnormal eye morphology 32 | 38
decreased neutrophil cell numb... 32 | 37
increased hematocrit 31 | 36
increased leukocyte cell numbe... 31 | 37
increased startle reflex 31 | 38
small testis 31 | 37
decreased circulating fructosa... 30 | 31
decreased mean corpuscular hem... 30 | 34
abnormal cranium morphology 29 | 32
abnormal spleen morphology 29 | 36
cardiovascular system phenotyp... 29 | 35
decreased circulating calcium ... 29 | 33
increased circulating chloride... 29 | 43
decreased T cell number 28 | 31
tremors 28 | 34
decreased circulating creatini... 27 | 31
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
increased circulating calcium ... 26 | 32
abnormal testis morphology 25 | 30
decreased blood urea nitrogen ... 25 | 31
limb grasping 25 | 35
decreased circulating aspartat... 24 | 27
increased circulating potassiu... 24 | 31

Disease

ovarian cancer 7,624 | 8,484
osteosarcoma 6,870 | 7,933
medulloblastoma, large-cell 5,090 | 6,234
psoriasis 4,914 | 6,685
glioblastoma 4,690 | 5,572
lung cancer 4,073 | 4,466
atypical teratoid / rhabdoid tumor 3,590 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,987 | 3,289
malignant mesothelioma 2,844 | 3,162
Breast cancer 2,767 | 3,094
invasive ductal carcinoma 2,742 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,706 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,668 | 2,956
non-small cell lung cancer 2,533 | 2,798
primitive neuroectodermal tumor 2,457 | 3,031
pilocytic astrocytoma 2,420 | 3,086
lung adenocarcinoma 2,323 | 2,713
oligodendroglioma 2,310 | 2,849
lung carcinoma 2,299 | 2,844
pediatric high grade glioma 2,229 | 2,712
interstitial cystitis 2,136 | 2,299
ependymoma 2,111 | 2,514
pancreatic cancer 2,066 | 2,300
subependymal giant cell astrocytoma 1,942 | 2,287
group 3 medulloblastoma 1,904 | 2,254
Cancer 1,897 | 2,346
ulcerative colitis 1,876 | 2,087
astrocytic glioma 1,857 | 2,241
adult high grade glioma 1,697 | 2,148
Pick disease 1,642 | 1,893
group 4 medulloblastoma 1,621 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,616 | 1,795
ductal carcinoma in situ 1,600 | 1,745
pituitary cancer 1,581 | 1,972
Carcinoma 1,506 | 2,147
breast carcinoma 1,453 | 1,614
cystic fibrosis 1,453 | 1,665
tuberculosis 1,425 | 1,557
adrenocortical carcinoma 1,316 | 1,427
colon cancer 1,309 | 1,475
Multiple myeloma 1,297 | 1,327
astrocytoma 1,297 | 1,493
medulloblastoma 1,219 | 1,524
sonic hedgehog group medulloblastoma 1,213 | 1,482
primary pancreatic ductal adenocarcinoma 1,195 | 1,271
posterior fossa group A ependymoma 1,194 | 1,511
posterior fossa group B ependymoma 1,152 | 1,530
juvenile dermatomyositis 1,128 | 1,189
diabetes mellitus 1,120 | 1,663
acute quadriplegic myopathy 1,084 | 1,157
Rheumatoid Arthritis 1,028 | 1,160
spina bifida 970 | 1,064
cutaneous lupus erythematosus 937 | 1,056
dermatomyositis 901 | 933
atypical teratoid/rhabdoid tumor 894 | 1,095
nasopharyngeal carcinoma 894 | 1,056
active Crohn's disease 790 | 918
Atopic dermatitis 777 | 944
primary Sjogren syndrome 755 | 789
gastric carcinoma 751 | 832
Waldenstrons macroglobulinemia 747 | 765
acute myeloid leukemia 739 | 780
non primary Sjogren syndrome sicca 689 | 840
esophageal adenocarcinoma 676 | 737
tuberculosis and treatment for 6 months 665 | 686
aldosterone-producing adenoma 615 | 664
progressive supranuclear palsy 606 | 674
Duchenne muscular dystrophy 553 | 602
pancreatic carcinoma 524 | 567
Alzheimer's disease 512 | 644
hepatocellular carcinoma 500 | 532
fibroadenoma 485 | 557
Down syndrome 477 | 548
Intellectual disability 469 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 469 | 499
Obesity 446 | 616
Endometriosis 441 | 535
IGA Glomerulonephritis 433 | 454
mucosa-associated lymphoid tissue lymphoma 415 | 480
Prostatic Neoplasms 400 | 471
chronic rhinosinusitis 399 | 512
gastric cancer 396 | 430
active ulcerative colitis 392 | 477
Amyotrophic Lateral Sclerosis 376 | 431
Multiple Sclerosis 365 | 498
Mammary Neoplasms 362 | 410
inflammatory breast cancer 345 | 404
Schizophrenia 336 | 501
Neurodegenerative disease 330 | 383
sarcoidosis 322 | 358
tuberculosis and treatment for 3 months 314 | 327
non-small cell lung carcinoma 311 | 413
hereditary spastic paraplegia 303 | 313
urothelial carcinoma 288 | 318
glioblastoma multiforme 287 | 347
interstitial lung disease 273 | 291
Polycystic Ovary Syndrome 269 | 332
Kidney disease 266 | 396
Parkinson's disease 265 | 364
Asthma 258 | 349

Tissue

Digestive Tract 13,517 | 18,473
Urinary Tract 13,517 | 18,444
Female tissues 13,515 | 18,647
Skin and soft tissues 13,513 | 18,115
Endocrine System 13,510 | 18,512
Liver and Pancreas 13,510 | 18,136
Nervous System 13,509 | 18,561
Male tissues 13,504 | 17,969
Blood and immune system 13,501 | 17,995
Cardiovascular System 13,500 | 17,958
Respiratory system 13,498 | 17,484

Target Family

Non-IDG 7,790 | 11,971
Enzyme 3,284 | 4,146
Transcription Factor 1,016 | 1,400
Kinase 541 | 634
Transporter 295 | 473
Epigenetic 211 | 242
GPCR 173 | 406
Ion Channel 136 | 341
Nuclear Receptor 37 | 48
TF/Epigenetic 32 | 38
oGPCR 2 | 421

HPA RNA Tissue

urinary bladder 13,517 | 13,517
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248