1. Home
  2. Targets
Target Filters...

Development Level

Tbio 8,045 | 10,625
Tdark 3,248 | 7,003
Tchem 1,413 | 1,890
Tclin 361 | 602

Collection

Eligible Kinase Proteins 95 | 134
Eligible Ion Channel Proteins 39 | 117
Eligible non-olfactory GPCR Proteins 34 | 143

IMPC Term

preweaning lethality, complete... 577 | 633
preweaning lethality, incomple... 216 | 260
abnormal behavior 179 | 226
embryonic lethality prior to t... 177 | 187
decreased lean body mass 164 | 195
decreased total body fat amoun... 158 | 186
decreased body weight 147 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 125 | 157
increased circulating alkaline... 105 | 119
decreased bone mineral density 100 | 126
abnormal bone structure 98 | 131
abnormal embryo size 98 | 112
increased or absent threshold ... 98 | 128
decreased circulating glucose ... 95 | 121
decreased body length 93 | 108
decreased grip strength 91 | 123
enlarged heart 86 | 111
abnormal retina morphology 84 | 100
hyperactivity 82 | 108
increased lean body mass 82 | 107
increased mean corpuscular hem... 82 | 93
increased bone mineral content 79 | 92
increased mean corpuscular vol... 76 | 91
decreased circulating choleste... 72 | 85
short tibia 72 | 82
decreased circulating triglyce... 69 | 83
hypoactivity 69 | 89
decreased circulating serum al... 67 | 79
decreased circulating HDL chol... 66 | 77
increased grip strength 65 | 83
abnormal lens morphology 62 | 73
prenatal lethality prior to he... 60 | 64
increased fasted circulating g... 55 | 68
decreased lumbar vertebrae num... 54 | 62
decreased circulating insulin ... 53 | 75
increased sacral vertebrae num... 53 | 62
increased circulating sodium l... 51 | 71
abnormal retinal pigmentation 50 | 61
decreased rib number 49 | 59
decreased leukocyte cell numbe... 46 | 54
increased circulating HDL chol... 46 | 63
abnormal bone mineralization 45 | 55
abnormal coat/hair pigmentatio... 45 | 54
abnormal sleep behavior 45 | 63
increased bone mineral density 45 | 52
male infertility 45 | 62
decreased mean corpuscular vol... 44 | 50
decreased hemoglobin content 43 | 53
increased circulating choleste... 42 | 53
increased exploration in new e... 42 | 56
increased total body fat amoun... 42 | 57
decreased prepulse inhibition 41 | 52
improved glucose tolerance 41 | 56
decreased caudal vertebrae num... 40 | 49
decreased circulating alanine ... 40 | 53
impaired glucose tolerance 40 | 52
decreased circulating total pr... 39 | 41
abnormal gait 37 | 51
decreased erythrocyte cell num... 37 | 43
decreased fasted circulating g... 37 | 49
increased blood urea nitrogen ... 37 | 44
decreased startle reflex 36 | 48
thrombocytopenia 36 | 46
abnormal behavioral response t... 35 | 52
abnormal heart morphology 35 | 51
increased body weight 35 | 42
increased hemoglobin content 35 | 45
decreased eosinophil cell numb... 34 | 41
decreased heart weight 34 | 44
decreased circulating free fat... 33 | 39
increased rib number 33 | 41
abnormal eye morphology 32 | 38
abnormal seminal vesicle morph... 32 | 47
decreased circulating LDL chol... 32 | 37
abnormal neural tube closure 31 | 37
increased hematocrit 31 | 36
decreased circulating alkaline... 30 | 41
increased leukocyte cell numbe... 30 | 37
small testis 30 | 37
decreased circulating fructosa... 29 | 31
decreased neutrophil cell numb... 29 | 37
increased circulating chloride... 29 | 43
decreased circulating calcium ... 28 | 33
decreased mean corpuscular hem... 28 | 34
increased startle reflex 28 | 38
abnormal cranium morphology 27 | 32
cardiovascular system phenotyp... 27 | 35
decreased T cell number 27 | 31
embryonic growth retardation 27 | 28
increased circulating potassiu... 27 | 31
tremors 27 | 34
abnormal spleen morphology 26 | 36
decreased blood urea nitrogen ... 26 | 31
abnormal testis morphology 25 | 30
decreased circulating creatini... 25 | 31
increased circulating calcium ... 25 | 32
increased heart weight 25 | 37
abnormal rib morphology 24 | 28
decreased circulating chloride... 24 | 32

Disease

ovarian cancer 7,404 | 8,484
osteosarcoma 6,667 | 7,933
medulloblastoma, large-cell 4,891 | 6,234
psoriasis 4,771 | 6,685
glioblastoma 4,483 | 5,572
lung cancer 3,924 | 4,466
atypical teratoid / rhabdoid tumor 3,427 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,862 | 3,289
malignant mesothelioma 2,732 | 3,162
Breast cancer 2,630 | 3,094
invasive ductal carcinoma 2,566 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,562 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,506 | 2,956
non-small cell lung cancer 2,442 | 2,798
primitive neuroectodermal tumor 2,331 | 3,031
pilocytic astrocytoma 2,268 | 3,086
lung adenocarcinoma 2,185 | 2,713
oligodendroglioma 2,169 | 2,849
lung carcinoma 2,152 | 2,844
pediatric high grade glioma 2,127 | 2,712
ependymoma 2,013 | 2,514
pancreatic cancer 1,993 | 2,300
interstitial cystitis 1,935 | 2,299
Cancer 1,852 | 2,346
subependymal giant cell astrocytoma 1,850 | 2,287
group 3 medulloblastoma 1,847 | 2,254
ulcerative colitis 1,808 | 2,087
astrocytic glioma 1,744 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,593 | 1,795
adult high grade glioma 1,585 | 2,148
Pick disease 1,579 | 1,893
group 4 medulloblastoma 1,534 | 1,875
pituitary cancer 1,483 | 1,972
ductal carcinoma in situ 1,473 | 1,745
Carcinoma 1,399 | 2,147
tuberculosis 1,388 | 1,557
breast carcinoma 1,364 | 1,614
cystic fibrosis 1,354 | 1,665
Multiple myeloma 1,293 | 1,327
astrocytoma 1,250 | 1,493
adrenocortical carcinoma 1,233 | 1,427
colon cancer 1,202 | 1,475
primary pancreatic ductal adenocarcinoma 1,160 | 1,271
medulloblastoma 1,159 | 1,524
sonic hedgehog group medulloblastoma 1,135 | 1,482
juvenile dermatomyositis 1,117 | 1,189
diabetes mellitus 1,115 | 1,663
posterior fossa group A ependymoma 1,114 | 1,511
posterior fossa group B ependymoma 1,069 | 1,530
acute quadriplegic myopathy 1,059 | 1,157
Rheumatoid Arthritis 1,004 | 1,160
spina bifida 972 | 1,064
cutaneous lupus erythematosus 913 | 1,056
dermatomyositis 897 | 933
nasopharyngeal carcinoma 873 | 1,056
atypical teratoid/rhabdoid tumor 843 | 1,095
active Crohn's disease 757 | 918
primary Sjogren syndrome 756 | 789
Atopic dermatitis 745 | 944
Waldenstrons macroglobulinemia 745 | 765
acute myeloid leukemia 732 | 780
gastric carcinoma 720 | 832
esophageal adenocarcinoma 678 | 737
non primary Sjogren syndrome sicca 672 | 840
tuberculosis and treatment for 6 months 664 | 686
progressive supranuclear palsy 587 | 674
aldosterone-producing adenoma 580 | 664
Duchenne muscular dystrophy 538 | 602
pancreatic carcinoma 518 | 567
hepatocellular carcinoma 489 | 532
Alzheimer's disease 483 | 644
Down syndrome 458 | 548
Intellectual disability 458 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 457 | 499
IGA Glomerulonephritis 429 | 454
fibroadenoma 424 | 557
Endometriosis 420 | 535
Obesity 412 | 616
mucosa-associated lymphoid tissue lymphoma 399 | 480
gastric cancer 392 | 430
Prostatic Neoplasms 386 | 471
active ulcerative colitis 374 | 477
Amyotrophic Lateral Sclerosis 360 | 431
chronic rhinosinusitis 360 | 512
Multiple Sclerosis 352 | 498
Mammary Neoplasms 349 | 410
inflammatory breast cancer 333 | 404
sarcoidosis 319 | 358
Neurodegenerative disease 318 | 383
Schizophrenia 314 | 501
tuberculosis and treatment for 3 months 305 | 327
hereditary spastic paraplegia 299 | 313
non-small cell lung carcinoma 277 | 413
Polycystic Ovary Syndrome 272 | 332
glioblastoma multiforme 267 | 347
Kidney disease 262 | 396
urothelial carcinoma 258 | 318
interstitial lung disease 256 | 291
Parkinson's disease 249 | 364
Stomach Neoplasms 247 | 282

Tissue

Blood and immune system 13,067 | 17,995
Digestive Tract 13,066 | 18,473
Female tissues 13,061 | 18,647
Skin and soft tissues 13,059 | 18,115
Endocrine System 13,058 | 18,512
Nervous System 13,054 | 18,561
Urinary Tract 13,050 | 18,444
Liver and Pancreas 13,046 | 18,136
Respiratory system 13,033 | 17,484
Cardiovascular System 13,028 | 17,958
Male tissues 13,024 | 17,969

Target Family

Non-IDG 7,559 | 11,971
Enzyme 3,202 | 4,146
Transcription Factor 965 | 1,400
Kinase 520 | 634
Transporter 290 | 473
Epigenetic 209 | 242
GPCR 140 | 406
Ion Channel 120 | 341
TF/Epigenetic 31 | 38
Nuclear Receptor 30 | 48
oGPCR 1 | 421

HPA RNA Tissue

tonsil 13,067 | 13,067
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108