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Development Level

Tbio 9,995 | 11,651
Tdark 3,719 | 6,593
Tchem 1,213 | 1,388
Tclin 473 | 612

Collection

RFA-RM-18-021 233 | 328
Kinase: IDG Consortium (Target... 106 | 125
Ion Channel: IDG Consortium (T... 69 | 99
GPCR: IDG Consortium (Targets) 61 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 936 | 979
preweaning lethality, incomple... 456 | 499
embryonic lethality prior to t... 268 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 185 | 210
decreased vertical activity 164 | 208
abnormal bone structure 160 | 187
increased lean body mass 154 | 172
abnormal heart morphology 147 | 162
decreased body weight 144 | 161
decreased bone mineral content 129 | 151
hyperactivity 124 | 148
decreased lean body mass 119 | 135
decreased circulating glucose ... 114 | 126
increased total body fat amoun... 113 | 134
decreased bone mineral density 110 | 126
hypoactivity 110 | 132
increased circulating alkaline... 110 | 122
embryonic growth retardation 101 | 106
decreased grip strength 97 | 116
male infertility 97 | 123
abnormal seminal vesicle morph... 96 | 114
increased startle reflex 96 | 112
increased bone mineral content 94 | 108
decreased body length 93 | 101
short tibia 91 | 97
increased or absent threshold ... 90 | 101
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 86 | 96
increased mean corpuscular vol... 86 | 92
prenatal lethality prior to he... 84 | 87
cataract 83 | 92
decreased lymphocyte cell numb... 77 | 83
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased prepulse inhibition 70 | 82
decreased mean corpuscular vol... 69 | 79
increased bone mineral density 68 | 72
increased fasted circulating g... 68 | 76
small superior vagus ganglion 68 | 74
decreased circulating triglyce... 67 | 79
decreased leukocyte cell numbe... 67 | 73
increased circulating HDL chol... 67 | 80
impaired glucose tolerance 65 | 75
abnormal eye morphology 64 | 68
abnormal retina morphology 64 | 71
decreased circulating HDL chol... 64 | 68
decreased circulating insulin ... 64 | 76
decreased startle reflex 64 | 75
improved glucose tolerance 64 | 79
abnormal sleep behavior 61 | 70
increased circulating sodium l... 61 | 71
abnormal coat-hair pigmentatio... 59 | 64
decreased fasted circulating g... 59 | 65
abnormal behavioral response t... 58 | 66
decreased erythrocyte cell num... 58 | 62
increased monocyte cell number 58 | 63
abnormal kidney morphology 57 | 65
decreased hemoglobin content 57 | 68
abnormal gait 56 | 69
edema 56 | 59
increased circulating choleste... 55 | 66
increased heart weight 54 | 62
small testis 52 | 58
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 50 | 53
thrombocytopenia 49 | 56
decreased circulating total pr... 48 | 49
hydrometra 48 | 53
female infertility 47 | 60
abnormal skin morphology 46 | 50
decreased mean corpuscular hem... 46 | 50
decreased blood urea nitrogen ... 45 | 51
abnormal neural tube closure 44 | 46
decreased circulating alanine ... 43 | 47
increased neutrophil cell numb... 43 | 46
decreased circulating alkaline... 42 | 46
increased hematocrit 42 | 46
decreased hematocrit 41 | 46
increased blood urea nitrogen ... 41 | 48
increased leukocyte cell numbe... 41 | 47
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
enlarged spleen 38 | 41
increased hemoglobin content 38 | 45
decreased circulating LDL chol... 37 | 38
decreased neutrophil cell numb... 37 | 42
decreased red blood cell distr... 36 | 41
increased erythrocyte cell num... 36 | 39
abnormal cranium morphology 35 | 36
increased circulating chloride... 35 | 41
increased circulating triglyce... 35 | 42
tremors 35 | 39
abnormal bone mineralization 34 | 38
increased grip strength 34 | 41
decreased circulating creatini... 33 | 39
pallor 33 | 34

Disease

Carcinoma 9,409 | 11,493
ovarian cancer 8,009 | 8,520
osteosarcoma 7,326 | 7,950
medulloblastoma, large-cell 5,612 | 6,241
psoriasis 5,559 | 6,694
glioblastoma 5,285 | 5,792
atypical teratoid / rhabdoid tumor 4,633 | 5,112
lung cancer 4,418 | 4,740
ependymoma 4,176 | 4,679
group 3 medulloblastoma 3,719 | 4,104
adult high grade glioma 3,352 | 3,801
Breast cancer 3,330 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,122 | 3,291
malignant mesothelioma 3,066 | 3,232
invasive ductal carcinoma 2,847 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,837 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,797 | 2,955
non-small cell lung cancer 2,775 | 2,890
primitive neuroectodermal tumor 2,735 | 3,035
Astrocytoma, Pilocytic 2,732 | 3,081
lung carcinoma 2,556 | 2,843
oligodendroglioma 2,549 | 2,850
lung adenocarcinoma 2,529 | 2,716
astrocytic glioma 2,333 | 2,597
pancreatic cancer 2,233 | 2,398
Kidney cancer 2,191 | 2,613
interstitial cystitis 2,189 | 2,312
Cancer 2,161 | 2,499
subependymal giant cell astrocytoma 2,105 | 2,287
tuberculosis 1,913 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,835 | 1,962
pituitary cancer 1,769 | 1,972
Pick disease 1,762 | 1,894
group 4 medulloblastoma 1,717 | 1,855
ulcerative colitis 1,709 | 1,819
ductal carcinoma in situ 1,680 | 1,745
cystic fibrosis 1,602 | 1,696
breast carcinoma 1,556 | 1,638
colon cancer 1,372 | 1,478
adrenocortical carcinoma 1,366 | 1,428
Multiple myeloma 1,304 | 1,332
diabetes mellitus 1,298 | 1,728
Autosomal recessive predisposition 1,237 | 1,442
juvenile dermatomyositis 1,156 | 1,187
acute quadriplegic myopathy 1,120 | 1,158
astrocytoma 1,086 | 1,146
Rheumatoid arthritis 1,074 | 1,191
primary pancreatic ductal adenocarcinoma 1,065 | 1,109
spina bifida 1,034 | 1,074
cutaneous lupus erythematosus 1,001 | 1,057
pediatric high grade glioma 991 | 1,064
nasopharyngeal carcinoma 989 | 1,058
Schizophrenia 942 | 1,160
dermatomyositis 914 | 966
Intellectual disability 905 | 1,016
Atopic dermatitis 873 | 952
active Crohn's disease 857 | 922
non primary Sjogren syndrome sicca 801 | 891
acute myeloid leukemia 771 | 783
gastric carcinoma 761 | 807
Waldenstrons macroglobulinemia 757 | 765
primary Sjogren syndrome 718 | 735
esophageal adenocarcinoma 716 | 737
Liver Cirrhosis, Experimental 706 | 769
active ulcerative colitis 697 | 764
Epilepsy 679 | 792
medulloblastoma 657 | 720
progressive supranuclear palsy 636 | 676
aldosterone-producing adenoma 626 | 665
Dull intelligence 575 | 645
Low intelligence 575 | 645
Mental Retardation 575 | 645
Mental deficiency 575 | 645
Poor school performance 575 | 645
Duchenne muscular dystrophy 574 | 601
Alzheimer's disease 572 | 658
Cognitive delay 555 | 608
Global developmental delay 555 | 608
Mental and motor retardation 555 | 608
Obesity 548 | 678
Bipolar Disorder 543 | 666
pancreatic carcinoma 540 | 562
hepatocellular carcinoma 527 | 547
Muscle hypotonia 524 | 571
Melanoma 521 | 711
Seizures 521 | 596
fibroadenoma 521 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Endometriosis 490 | 540
Short stature 469 | 531
Liver cancer 468 | 604
chronic rhinosinusitis 461 | 512
Down syndrome 457 | 499
Prostatic Neoplasms 450 | 495
gastric cancer 443 | 459
Multiple Sclerosis 442 | 540
mucosa-associated lymphoid tissue lymphoma 439 | 484
posterior fossa group A ependymoma 432 | 468
sonic hedgehog group medulloblastoma 418 | 467
Amyotrophic lateral sclerosis 417 | 451

Tissue

Blood and immune system 15,400 | 16,909
Digestive Tract 15,352 | 17,369
Endocrine System 15,330 | 18,159
Female tissues 15,314 | 17,400
Skin and soft tissues 15,296 | 17,230
Male tissues 15,207 | 17,142
Urinary Tract 15,156 | 16,678
Liver and Pancreas 15,147 | 16,750
Respiratory system 15,068 | 16,393
Nervous System 14,970 | 16,725
Cardiovascular System 14,361 | 15,192

Target Family

Non-IDG 8,970 | 12,091
Enzyme 3,590 | 4,145
Transcription Factor 1,130 | 1,400
Kinase 574 | 634
Transporter 360 | 473
GPCR 244 | 408
Epigenetic 230 | 242
Ion Channel 220 | 344
Nuclear Receptor 37 | 48
TF/Epigenetic 33 | 38
oGPCR 12 | 421

HPA RNA Tissue

tonsil 15,400 | 15,400
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50