Development Level

Tbio 7,793 | 10,625
Tdark 3,364 | 7,003
Tchem 1,346 | 1,890
Tclin 334 | 602

Collection

Eligible Kinase Proteins 98 | 134
Eligible Ion Channel Proteins 40 | 117
Eligible non-olfactory GPCR Proteins 31 | 143

IMPC Term

preweaning lethality, complete... 571 | 633
preweaning lethality, incomple... 212 | 260
abnormal behavior 185 | 226
embryonic lethality prior to t... 173 | 187
decreased total body fat amoun... 157 | 186
decreased lean body mass 156 | 195
decreased body weight 147 | 174
embryonic lethality prior to o... 143 | 148
decreased bone mineral content 123 | 157
decreased bone mineral density 101 | 126
abnormal embryo size 100 | 112
abnormal bone structure 99 | 131
increased circulating alkaline... 99 | 119
increased or absent threshold ... 96 | 128
decreased circulating glucose ... 92 | 121
decreased body length 91 | 108
decreased grip strength 88 | 123
hyperactivity 85 | 108
abnormal retina morphology 82 | 100
increased mean corpuscular hem... 82 | 93
increased lean body mass 81 | 107
enlarged heart 78 | 111
increased bone mineral content 78 | 92
increased mean corpuscular vol... 77 | 91
hypoactivity 72 | 89
decreased circulating choleste... 70 | 85
short tibia 69 | 82
decreased circulating serum al... 67 | 79
decreased circulating HDL chol... 65 | 77
decreased circulating triglyce... 63 | 83
increased grip strength 63 | 83
prenatal lethality prior to he... 58 | 64
abnormal lens morphology 57 | 73
increased fasted circulating g... 55 | 68
decreased lumbar vertebrae num... 52 | 62
increased sacral vertebrae num... 52 | 62
abnormal retinal pigmentation 50 | 61
decreased circulating insulin ... 50 | 75
decreased rib number 49 | 59
increased circulating sodium l... 49 | 71
male infertility 49 | 62
abnormal sleep behavior 46 | 63
abnormal coat/hair pigmentatio... 45 | 54
decreased leukocyte cell numbe... 45 | 54
decreased mean corpuscular vol... 45 | 50
abnormal bone mineralization 44 | 55
decreased hemoglobin content 44 | 53
decreased prepulse inhibition 42 | 52
increased bone mineral density 42 | 52
increased circulating HDL chol... 42 | 63
increased total body fat amoun... 42 | 57
impaired glucose tolerance 41 | 52
decreased caudal vertebrae num... 40 | 49
increased circulating choleste... 40 | 53
decreased circulating alanine ... 39 | 53
decreased erythrocyte cell num... 39 | 43
decreased fasted circulating g... 38 | 49
improved glucose tolerance 38 | 56
abnormal gait 37 | 51
abnormal behavioral response t... 36 | 52
decreased circulating total pr... 36 | 41
decreased startle reflex 36 | 48
increased exploration in new e... 36 | 56
thrombocytopenia 36 | 46
abnormal neural tube closure 35 | 37
decreased eosinophil cell numb... 34 | 41
decreased heart weight 33 | 44
increased blood urea nitrogen ... 33 | 44
increased body weight 33 | 42
abnormal heart morphology 32 | 51
decreased circulating LDL chol... 32 | 37
increased hemoglobin content 32 | 45
increased rib number 32 | 41
abnormal seminal vesicle morph... 31 | 47
decreased circulating free fat... 31 | 39
abnormal cranium morphology 30 | 32
abnormal eye morphology 30 | 38
decreased circulating alkaline... 30 | 41
decreased neutrophil cell numb... 30 | 37
increased hematocrit 30 | 36
decreased circulating fructosa... 29 | 31
decreased mean corpuscular hem... 29 | 34
increased startle reflex 29 | 38
decreased circulating calcium ... 28 | 33
tremors 28 | 34
decreased T cell number 27 | 31
decreased circulating creatini... 27 | 31
increased circulating chloride... 27 | 43
increased heart weight 27 | 37
increased leukocyte cell numbe... 27 | 37
small testis 27 | 37
cardiovascular system phenotyp... 26 | 35
abnormal spleen morphology 25 | 36
increased circulating iron lev... 25 | 25
increased circulating potassiu... 25 | 31
decreased B cell number 24 | 30
embryonic growth retardation 24 | 28
limb grasping 24 | 35
decreased circulating aspartat... 23 | 27
decreased circulating chloride... 23 | 32

Disease

ovarian cancer 7,358 | 8,484
osteosarcoma 6,499 | 7,933
medulloblastoma, large-cell 4,883 | 6,234
psoriasis 4,499 | 6,685
glioblastoma 4,484 | 5,572
lung cancer 3,829 | 4,466
atypical teratoid / rhabdoid tumor 3,464 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,780 | 3,289
malignant mesothelioma 2,645 | 3,162
Breast cancer 2,589 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 2,527 | 2,956
invasive ductal carcinoma 2,525 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,512 | 2,988
primitive neuroectodermal tumor 2,327 | 3,031
pilocytic astrocytoma 2,313 | 3,086
non-small cell lung cancer 2,259 | 2,798
oligodendroglioma 2,214 | 2,849
lung carcinoma 2,173 | 2,844
pediatric high grade glioma 2,114 | 2,712
lung adenocarcinoma 2,101 | 2,713
ependymoma 2,062 | 2,514
subependymal giant cell astrocytoma 1,904 | 2,287
pancreatic cancer 1,870 | 2,300
group 3 medulloblastoma 1,809 | 2,254
astrocytic glioma 1,786 | 2,241
interstitial cystitis 1,752 | 2,299
Cancer 1,699 | 2,346
ulcerative colitis 1,674 | 2,087
Pick disease 1,628 | 1,893
adult high grade glioma 1,595 | 2,148
group 4 medulloblastoma 1,589 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,582 | 1,795
pituitary cancer 1,535 | 1,972
Carcinoma 1,473 | 2,147
ductal carcinoma in situ 1,433 | 1,745
breast carcinoma 1,321 | 1,614
cystic fibrosis 1,303 | 1,665
tuberculosis 1,300 | 1,557
Multiple myeloma 1,288 | 1,327
astrocytoma 1,274 | 1,493
adrenocortical carcinoma 1,197 | 1,427
medulloblastoma 1,174 | 1,524
posterior fossa group B ependymoma 1,174 | 1,530
colon cancer 1,169 | 1,475
sonic hedgehog group medulloblastoma 1,164 | 1,482
primary pancreatic ductal adenocarcinoma 1,151 | 1,271
juvenile dermatomyositis 1,113 | 1,189
posterior fossa group A ependymoma 1,091 | 1,511
diabetes mellitus 1,082 | 1,663
acute quadriplegic myopathy 1,068 | 1,157
Rheumatoid Arthritis 954 | 1,160
spina bifida 898 | 1,064
dermatomyositis 892 | 933
atypical teratoid/rhabdoid tumor 840 | 1,095
cutaneous lupus erythematosus 796 | 1,056
nasopharyngeal carcinoma 766 | 1,056
gastric carcinoma 731 | 832
Waldenstrons macroglobulinemia 729 | 765
acute myeloid leukemia 720 | 780
active Crohn's disease 714 | 918
primary Sjogren syndrome 659 | 789
non primary Sjogren syndrome sicca 652 | 840
tuberculosis and treatment for 6 months 642 | 686
Atopic dermatitis 639 | 944
progressive supranuclear palsy 595 | 674
esophageal adenocarcinoma 587 | 737
aldosterone-producing adenoma 583 | 664
Duchenne muscular dystrophy 544 | 602
Alzheimer's disease 492 | 644
pancreatic carcinoma 492 | 567
hepatocellular carcinoma 475 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 466 | 499
Down syndrome 462 | 548
Intellectual disability 460 | 573
fibroadenoma 434 | 557
Obesity 407 | 616
IGA Glomerulonephritis 386 | 454
chronic rhinosinusitis 386 | 512
Prostatic Neoplasms 381 | 471
Endometriosis 374 | 535
gastric cancer 373 | 430
Amyotrophic Lateral Sclerosis 369 | 431
active ulcerative colitis 359 | 477
mucosa-associated lymphoid tissue lymphoma 356 | 480
Neurodegenerative disease 324 | 383
Mammary Neoplasms 323 | 410
Schizophrenia 316 | 501
inflammatory breast cancer 307 | 404
Multiple Sclerosis 306 | 498
hereditary spastic paraplegia 300 | 313
tuberculosis and treatment for 3 months 283 | 327
sarcoidosis 282 | 358
glioblastoma multiforme 270 | 347
non-small cell lung carcinoma 270 | 413
urothelial carcinoma 261 | 318
Polycystic Ovary Syndrome 253 | 332
interstitial lung disease 249 | 291
Parkinson's disease 246 | 364
Kidney disease 245 | 396
nephrosclerosis 241 | 329

Tissue

Endocrine System 12,837 | 18,512
Female tissues 12,834 | 18,647
Nervous System 12,834 | 18,561
Urinary Tract 12,833 | 18,444
Digestive Tract 12,832 | 18,473
Liver and Pancreas 12,831 | 18,136
Male tissues 12,830 | 17,969
Skin and soft tissues 12,827 | 18,115
Cardiovascular System 12,823 | 17,958
Blood and immune system 12,820 | 17,995
Respiratory system 12,820 | 17,484

Target Family

Non-IDG 7,408 | 11,971
Enzyme 3,156 | 4,146
Transcription Factor 947 | 1,400
Kinase 514 | 634
Transporter 288 | 473
Epigenetic 216 | 242
Ion Channel 127 | 341
GPCR 113 | 406
Nuclear Receptor 34 | 48
TF/Epigenetic 31 | 38
oGPCR 3 | 421

HPA RNA Tissue

thyroid gland 12,837 | 12,837
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108