Development Level

Tbio 11,116 | 11,651
Tdark 4,885 | 6,593
Tchem 1,348 | 1,388
Tclin 587 | 612

Collection

RFA-RM-18-021 297 | 328
Kinase: IDG Consortium (Target... 123 | 125
Ion Channel: IDG Consortium (T... 94 | 99
GPCR: IDG Consortium (Targets) 87 | 126
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 969 | 979
preweaning lethality, incomple... 492 | 499
abnormal behavior 294 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 218 | 220
enlarged heart 203 | 210
decreased total body fat amoun... 201 | 207
decreased vertical activity 190 | 208
abnormal bone structure 180 | 187
increased lean body mass 165 | 172
decreased body weight 158 | 161
abnormal heart morphology 156 | 162
decreased bone mineral content 148 | 151
hyperactivity 145 | 148
decreased lean body mass 130 | 135
hypoactivity 129 | 132
increased total body fat amoun... 127 | 134
decreased circulating glucose ... 123 | 126
decreased bone mineral density 122 | 126
increased circulating alkaline... 119 | 122
male infertility 119 | 123
decreased grip strength 112 | 116
abnormal seminal vesicle morph... 110 | 114
increased bone mineral content 106 | 108
increased startle reflex 106 | 112
embryonic growth retardation 105 | 106
decreased body length 99 | 101
increased or absent threshold ... 99 | 101
short tibia 96 | 97
increased mean corpuscular hem... 93 | 96
increased mean corpuscular vol... 92 | 92
cataract 89 | 92
decreased circulating choleste... 89 | 93
prenatal lethality prior to he... 86 | 87
decreased circulating serum al... 82 | 82
decreased lymphocyte cell numb... 81 | 83
decreased prepulse inhibition 81 | 82
abnormal lens morphology 78 | 81
decreased circulating triglyce... 77 | 79
improved glucose tolerance 76 | 79
increased circulating HDL chol... 76 | 80
decreased mean corpuscular vol... 75 | 79
decreased leukocyte cell numbe... 73 | 73
decreased startle reflex 73 | 75
increased fasted circulating g... 73 | 76
impaired glucose tolerance 71 | 75
increased bone mineral density 71 | 72
increased circulating sodium l... 70 | 71
small superior vagus ganglion 69 | 74
abnormal retina morphology 68 | 71
decreased circulating insulin ... 68 | 76
abnormal gait 67 | 69
abnormal sleep behavior 67 | 70
abnormal eye morphology 66 | 68
decreased hemoglobin content 66 | 68
increased circulating choleste... 66 | 66
decreased circulating HDL chol... 65 | 68
abnormal behavioral response t... 64 | 66
abnormal coat-hair pigmentatio... 64 | 64
decreased fasted circulating g... 63 | 65
increased monocyte cell number 62 | 63
decreased erythrocyte cell num... 61 | 62
abnormal kidney morphology 59 | 65
increased heart weight 59 | 62
edema 58 | 59
small testis 56 | 58
abnormal spleen morphology 55 | 55
female infertility 55 | 60
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
abnormal skin morphology 50 | 50
decreased blood urea nitrogen ... 50 | 51
hydrometra 50 | 53
decreased circulating total pr... 49 | 49
decreased mean corpuscular hem... 48 | 50
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
decreased circulating alanine ... 45 | 47
decreased circulating alkaline... 45 | 46
decreased hematocrit 45 | 46
increased neutrophil cell numb... 45 | 46
increased mean platelet volume 44 | 45
increased hemoglobin content 43 | 45
increased circulating triglyce... 42 | 42
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
abnormal testis morphology 40 | 43
decreased red blood cell distr... 40 | 41
abnormal epididymis morphology 39 | 42
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
limb grasping 39 | 41
decreased circulating creatini... 38 | 39
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
tremors 37 | 39

Disease

Carcinoma 10,812 | 11,493
ovarian cancer 8,343 | 8,520
osteosarcoma 7,701 | 7,950
psoriasis 6,246 | 6,694
medulloblastoma, large-cell 6,090 | 6,241
glioblastoma 5,693 | 5,792
atypical teratoid / rhabdoid tumor 5,023 | 5,112
lung cancer 4,621 | 4,740
ependymoma 4,607 | 4,679
group 3 medulloblastoma 4,038 | 4,104
adult high grade glioma 3,713 | 3,801
Breast cancer 3,510 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,229 | 3,291
malignant mesothelioma 3,173 | 3,232
Astrocytoma, Pilocytic 3,031 | 3,081
primitive neuroectodermal tumor 2,990 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,935 | 2,989
invasive ductal carcinoma 2,919 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,899 | 2,955
non-small cell lung cancer 2,835 | 2,890
oligodendroglioma 2,802 | 2,850
lung carcinoma 2,781 | 2,843
lung adenocarcinoma 2,653 | 2,716
astrocytic glioma 2,557 | 2,597
Kidney cancer 2,541 | 2,613
pancreatic cancer 2,343 | 2,398
Cancer 2,320 | 2,499
subependymal giant cell astrocytoma 2,252 | 2,287
interstitial cystitis 2,247 | 2,312
tuberculosis 1,941 | 2,010
pituitary cancer 1,930 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,927 | 1,962
Pick disease 1,871 | 1,894
group 4 medulloblastoma 1,823 | 1,855
ulcerative colitis 1,764 | 1,819
ductal carcinoma in situ 1,726 | 1,745
cystic fibrosis 1,652 | 1,696
breast carcinoma 1,608 | 1,638
diabetes mellitus 1,473 | 1,728
colon cancer 1,434 | 1,478
adrenocortical carcinoma 1,417 | 1,428
Autosomal recessive predisposition 1,403 | 1,442
Multiple myeloma 1,311 | 1,332
juvenile dermatomyositis 1,173 | 1,187
acute quadriplegic myopathy 1,147 | 1,158
astrocytoma 1,127 | 1,146
Rheumatoid arthritis 1,115 | 1,191
Schizophrenia 1,102 | 1,160
primary pancreatic ductal adenocarcinoma 1,097 | 1,109
spina bifida 1,052 | 1,074
pediatric high grade glioma 1,049 | 1,064
nasopharyngeal carcinoma 1,035 | 1,058
cutaneous lupus erythematosus 1,031 | 1,057
Intellectual disability 998 | 1,016
dermatomyositis 923 | 966
Atopic dermatitis 897 | 952
active Crohn's disease 897 | 922
non primary Sjogren syndrome sicca 866 | 891
gastric carcinoma 790 | 807
acute myeloid leukemia 780 | 783
Epilepsy 777 | 792
Waldenstrons macroglobulinemia 762 | 765
Liver Cirrhosis, Experimental 751 | 769
active ulcerative colitis 740 | 764
primary Sjogren syndrome 720 | 735
esophageal adenocarcinoma 714 | 737
medulloblastoma 705 | 720
Melanoma 669 | 711
progressive supranuclear palsy 664 | 676
aldosterone-producing adenoma 661 | 665
Obesity 647 | 678
Bipolar Disorder 638 | 666
Alzheimer's disease 636 | 658
Dull intelligence 635 | 645
Low intelligence 635 | 645
Mental Retardation 635 | 645
Mental deficiency 635 | 645
Poor school performance 635 | 645
Cognitive delay 599 | 608
Global developmental delay 599 | 608
Mental and motor retardation 599 | 608
Duchenne muscular dystrophy 591 | 601
Seizures 587 | 596
Liver cancer 582 | 604
Muscle hypotonia 563 | 571
fibroadenoma 552 | 559
pancreatic carcinoma 552 | 562
hepatocellular carcinoma 539 | 547
Endometriosis 530 | 540
Short stature 515 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 503 | 510
chronic rhinosinusitis 503 | 512
Multiple Sclerosis 489 | 540
Down syndrome 485 | 499
Prostatic Neoplasms 481 | 495
mucosa-associated lymphoid tissue lymphoma 464 | 484
posterior fossa group A ependymoma 462 | 468
sonic hedgehog group medulloblastoma 457 | 467
gastric cancer 450 | 459
Skin cancer 445 | 469

Tissue

Endocrine System 17,936 | 18,159
Female tissues 17,082 | 17,400
Digestive Tract 17,027 | 17,369
Skin and soft tissues 16,909 | 17,230
Male tissues 16,872 | 17,142
Blood and immune system 16,649 | 16,909
Nervous System 16,526 | 16,725
Liver and Pancreas 16,520 | 16,750
Urinary Tract 16,451 | 16,678
Respiratory system 16,239 | 16,393
Cardiovascular System 15,114 | 15,192

Target Family

Non-IDG 10,492 | 12,091
Enzyme 3,940 | 4,145
Transcription Factor 1,347 | 1,400
Kinase 626 | 634
Transporter 448 | 473
GPCR 330 | 408
Ion Channel 328 | 344
Epigenetic 241 | 242
oGPCR 100 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 36 | 38

HPA RNA Tissue

testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50