Development Level

Tbio 8,675 | 10,625
Tdark 4,303 | 7,003
Tchem 1,500 | 1,890
Tclin 404 | 602

Collection

Kinase: IDG Consortium (Targets) 109 | 125
Ion Channel: IDG Consortium (Targets) 49 | 102
GPCR: IDG Consortium (Targets) 38 | 128
Kinase: IDG Consortium (Complete/Control) 36 | 37
GPCR: IDG Consortium (Complete/Control) 14 | 24

IMPC Phenotype

preweaning lethality, complete... 595 | 633
preweaning lethality, incomple... 226 | 260
abnormal behavior 202 | 226
embryonic lethality prior to t... 179 | 187
decreased lean body mass 177 | 195
decreased total body fat amoun... 163 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 143 | 157
abnormal bone structure 112 | 131
increased circulating alkaline... 109 | 119
increased or absent threshold ... 109 | 128
decreased bone mineral density 108 | 126
decreased grip strength 107 | 123
abnormal embryo size 105 | 112
decreased circulating glucose ... 101 | 121
decreased body length 98 | 108
abnormal retina morphology 93 | 100
hyperactivity 91 | 108
increased lean body mass 91 | 107
enlarged heart 88 | 111
increased mean corpuscular hem... 87 | 93
increased mean corpuscular vol... 85 | 91
increased bone mineral content 83 | 92
decreased circulating choleste... 77 | 85
short tibia 77 | 82
hypoactivity 73 | 89
increased grip strength 72 | 83
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 69 | 79
decreased circulating triglyce... 69 | 83
abnormal lens morphology 65 | 73
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 59 | 64
decreased circulating insulin ... 57 | 75
decreased lumbar vertebrae num... 57 | 62
increased sacral vertebrae num... 56 | 62
abnormal retinal pigmentation 55 | 61
abnormal sleep behavior 55 | 63
increased circulating HDL chol... 55 | 63
increased circulating sodium l... 55 | 71
male infertility 55 | 62
decreased rib number 51 | 59
abnormal coat-hair pigmentatio... 50 | 54
decreased leukocyte cell numbe... 50 | 54
increased total body fat amoun... 49 | 57
abnormal bone mineralization 48 | 55
decreased mean corpuscular vol... 48 | 50
decreased hemoglobin content 47 | 53
increased circulating choleste... 47 | 53
decreased prepulse inhibition 46 | 52
abnormal behavioral response t... 45 | 52
abnormal gait 45 | 51
decreased caudal vertebrae num... 45 | 49
increased bone mineral density 45 | 52
impaired glucose tolerance 44 | 52
improved glucose tolerance 44 | 56
increased exploration in new e... 44 | 56
decreased circulating alanine ... 43 | 53
decreased startle reflex 42 | 48
increased hemoglobin content 41 | 45
abnormal heart morphology 40 | 51
decreased erythrocyte cell num... 40 | 43
decreased fasted circulating g... 40 | 49
thrombocytopenia 40 | 46
decreased circulating total pr... 39 | 41
increased blood urea nitrogen ... 38 | 44
decreased heart weight 37 | 44
decreased eosinophil cell numb... 36 | 41
increased body weight 36 | 42
increased rib number 36 | 41
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
increased startle reflex 35 | 38
abnormal seminal vesicle morph... 34 | 47
decreased circulating alkaline... 34 | 41
abnormal eye morphology 33 | 38
decreased circulating free fat... 33 | 39
increased circulating chloride... 33 | 43
decreased mean corpuscular hem... 32 | 34
decreased neutrophil cell numb... 32 | 37
increased hematocrit 32 | 36
increased leukocyte cell numbe... 32 | 37
cardiovascular system phenotyp... 31 | 35
abnormal spleen morphology 30 | 36
small testis 30 | 37
decreased circulating fructosa... 29 | 31
tremors 29 | 34
abnormal cranium morphology 28 | 32
decreased circulating calcium ... 28 | 33
decreased circulating creatini... 28 | 31
increased circulating potassiu... 28 | 31
limb grasping 28 | 35
decreased B cell number 27 | 30
decreased threshold for audito... 27 | 32
embryonic growth retardation 27 | 28
increased circulating calcium ... 27 | 32
increased heart weight 27 | 37
decreased T cell number 26 | 31
female infertility 26 | 34

Disease

ovarian cancer 7,743 | 8,491
osteosarcoma 6,933 | 7,933
medulloblastoma, large-cell 5,443 | 6,234
psoriasis 5,123 | 6,685
glioblastoma 4,960 | 5,572
lung cancer 4,040 | 4,473
atypical teratoid / rhabdoid tumor 3,851 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,948 | 3,289
malignant mesothelioma 2,847 | 3,163
Breast cancer 2,766 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,672 | 2,988
invasive ductal carcinoma 2,666 | 2,950
primitive neuroectodermal tumor 2,650 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,627 | 2,956
pilocytic astrocytoma 2,615 | 3,086
oligodendroglioma 2,459 | 2,849
non-small cell lung cancer 2,424 | 2,798
pediatric high grade glioma 2,375 | 2,712
lung carcinoma 2,370 | 2,844
lung adenocarcinoma 2,287 | 2,714
ependymoma 2,237 | 2,514
subependymal giant cell astrocytoma 2,052 | 2,287
group 3 medulloblastoma 2,017 | 2,254
pancreatic cancer 1,975 | 2,300
astrocytic glioma 1,951 | 2,241
interstitial cystitis 1,873 | 2,299
Cancer 1,859 | 2,346
adult high grade glioma 1,822 | 2,148
ulcerative colitis 1,770 | 2,087
Carcinoma 1,767 | 2,147
Pick disease 1,742 | 1,893
pituitary cancer 1,684 | 1,972
group 4 medulloblastoma 1,683 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,616 | 1,795
ductal carcinoma in situ 1,536 | 1,745
breast carcinoma 1,434 | 1,614
cystic fibrosis 1,404 | 1,670
tuberculosis 1,367 | 1,563
astrocytoma 1,361 | 1,493
posterior fossa group B ependymoma 1,338 | 1,530
medulloblastoma 1,328 | 1,524
adrenocortical carcinoma 1,325 | 1,427
Multiple myeloma 1,298 | 1,327
sonic hedgehog group medulloblastoma 1,294 | 1,482
posterior fossa group A ependymoma 1,279 | 1,511
colon cancer 1,262 | 1,475
primary pancreatic ductal adenocarcinoma 1,171 | 1,271
diabetes mellitus 1,153 | 1,663
juvenile dermatomyositis 1,139 | 1,189
acute quadriplegic myopathy 1,095 | 1,157
Rheumatoid Arthritis 987 | 1,170
atypical teratoid/rhabdoid tumor 962 | 1,095
spina bifida 919 | 1,064
dermatomyositis 902 | 966
nasopharyngeal carcinoma 888 | 1,056
cutaneous lupus erythematosus 867 | 1,056
active Crohn's disease 763 | 918
Atopic dermatitis 747 | 944
gastric carcinoma 744 | 832
acute myeloid leukemia 743 | 785
Waldenstrons macroglobulinemia 735 | 764
non primary Sjogren syndrome sicca 724 | 840
primary Sjogren syndrome 697 | 788
tuberculosis and treatment for 6 months 645 | 686
progressive supranuclear palsy 626 | 674
aldosterone-producing adenoma 623 | 664
esophageal adenocarcinoma 609 | 737
Duchenne muscular dystrophy 553 | 602
Alzheimer's disease 546 | 644
Intellectual disability 506 | 573
pancreatic carcinoma 504 | 567
hepatocellular carcinoma 496 | 550
Down syndrome 483 | 548
fibroadenoma 476 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 470 | 499
Obesity 459 | 616
Endometriosis 442 | 535
chronic rhinosinusitis 442 | 512
IGA Glomerulonephritis 419 | 454
Amyotrophic Lateral Sclerosis 395 | 432
Prostatic Neoplasms 394 | 471
active ulcerative colitis 394 | 477
mucosa-associated lymphoid tissue lymphoma 386 | 480
gastric cancer 384 | 436
Schizophrenia 380 | 503
Neurodegenerative disease 349 | 383
Multiple Sclerosis 348 | 498
Mammary Neoplasms 343 | 410
inflammatory breast cancer 342 | 404
hereditary spastic paraplegia 307 | 313
non-small cell lung carcinoma 307 | 413
glioblastoma multiforme 303 | 347
tuberculosis and treatment for 3 months 297 | 327
sarcoidosis 292 | 368
Polycystic Ovary Syndrome 287 | 334
Parkinson's disease 283 | 364
urothelial carcinoma 267 | 318
interstitial lung disease 258 | 292
Epilepsy 256 | 346
Kidney disease 256 | 397

Tissue

Endocrine System 14,882 | 18,511
Female tissues 14,846 | 18,646
Nervous System 14,828 | 18,560
Digestive Tract 14,805 | 18,472
Urinary Tract 14,792 | 18,443
Skin and soft tissues 14,759 | 18,114
Male tissues 14,743 | 17,968
Liver and Pancreas 14,725 | 18,135
Cardiovascular System 14,678 | 17,957
Blood and immune system 14,676 | 17,994
Respiratory system 14,555 | 17,483

Target Family

Non-IDG 8,751 | 11,969
Enzyme 3,467 | 4,146
Transcription Factor 1,093 | 1,400
Kinase 573 | 634
Transporter 342 | 473
Epigenetic 235 | 242
Ion Channel 188 | 341
GPCR 150 | 408
Nuclear Receptor 38 | 48
TF/Epigenetic 32 | 38
oGPCR 13 | 421

HPA RNA Tissue

testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
lung 13,653 | 13,653
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
small intestine 13,471 | 13,471
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
kidney 13,341 | 13,341
adrenal gland 13,296 | 13,296
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
adipose tissue 12,955 | 12,955
skin 12,911 | 12,911
salivary gland 12,839 | 12,839
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
heart muscle 12,601 | 12,601
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131