Development Level

Tbio 8,675 | 10,625
Tdark 4,303 | 7,003
Tchem 1,501 | 1,890
Tclin 404 | 602

Collection

Eligible Kinase Proteins 117 | 134
Eligible Ion Channel Proteins 51 | 117
Eligible non-olfactory GPCR Proteins 40 | 143

IMPC Term

preweaning lethality, complete... 595 | 633
preweaning lethality, incomple... 226 | 260
abnormal behavior 202 | 226
embryonic lethality prior to t... 179 | 187
decreased lean body mass 177 | 195
decreased total body fat amoun... 163 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 143 | 157
abnormal bone structure 112 | 131
increased circulating alkaline... 109 | 119
increased or absent threshold ... 109 | 128
decreased bone mineral density 108 | 126
decreased grip strength 107 | 123
abnormal embryo size 105 | 112
decreased circulating glucose ... 101 | 121
decreased body length 98 | 108
abnormal retina morphology 93 | 100
hyperactivity 91 | 108
increased lean body mass 91 | 107
enlarged heart 88 | 111
increased mean corpuscular hem... 87 | 93
increased mean corpuscular vol... 85 | 91
increased bone mineral content 83 | 92
decreased circulating choleste... 77 | 85
short tibia 77 | 82
hypoactivity 73 | 89
increased grip strength 72 | 83
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 69 | 79
decreased circulating triglyce... 69 | 83
abnormal lens morphology 65 | 73
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 59 | 64
decreased circulating insulin ... 57 | 75
decreased lumbar vertebrae num... 57 | 62
increased sacral vertebrae num... 56 | 62
abnormal retinal pigmentation 55 | 61
abnormal sleep behavior 55 | 63
increased circulating HDL chol... 55 | 63
increased circulating sodium l... 55 | 71
male infertility 55 | 62
decreased rib number 51 | 59
abnormal coat/hair pigmentatio... 50 | 54
decreased leukocyte cell numbe... 50 | 54
increased total body fat amoun... 49 | 57
abnormal bone mineralization 48 | 55
decreased mean corpuscular vol... 48 | 50
decreased hemoglobin content 47 | 53
increased circulating choleste... 47 | 53
decreased prepulse inhibition 46 | 52
abnormal behavioral response t... 45 | 52
abnormal gait 45 | 51
decreased caudal vertebrae num... 45 | 49
increased bone mineral density 45 | 52
impaired glucose tolerance 44 | 52
improved glucose tolerance 44 | 56
increased exploration in new e... 44 | 56
decreased circulating alanine ... 43 | 53
decreased startle reflex 42 | 48
increased hemoglobin content 41 | 45
abnormal heart morphology 40 | 51
decreased erythrocyte cell num... 40 | 43
decreased fasted circulating g... 40 | 49
thrombocytopenia 40 | 46
decreased circulating total pr... 39 | 41
increased blood urea nitrogen ... 38 | 44
decreased heart weight 37 | 44
decreased eosinophil cell numb... 36 | 41
increased body weight 36 | 42
increased rib number 36 | 41
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
increased startle reflex 35 | 38
abnormal seminal vesicle morph... 34 | 47
decreased circulating alkaline... 34 | 41
abnormal eye morphology 33 | 38
decreased circulating free fat... 33 | 39
increased circulating chloride... 33 | 43
decreased mean corpuscular hem... 32 | 34
decreased neutrophil cell numb... 32 | 37
increased hematocrit 32 | 36
increased leukocyte cell numbe... 32 | 37
cardiovascular system phenotyp... 31 | 35
abnormal spleen morphology 30 | 36
small testis 30 | 37
decreased circulating fructosa... 29 | 31
tremors 29 | 34
abnormal cranium morphology 28 | 32
decreased circulating calcium ... 28 | 33
decreased circulating creatini... 28 | 31
increased circulating potassiu... 28 | 31
limb grasping 28 | 35
decreased B cell number 27 | 30
decreased threshold for audito... 27 | 32
embryonic growth retardation 27 | 28
increased circulating calcium ... 27 | 32
increased heart weight 27 | 37
decreased T cell number 26 | 31
female infertility 26 | 34

Disease

ovarian cancer 7,736 | 8,484
osteosarcoma 6,933 | 7,933
medulloblastoma, large-cell 5,443 | 6,234
psoriasis 5,123 | 6,685
glioblastoma 4,960 | 5,572
lung cancer 4,035 | 4,466
atypical teratoid / rhabdoid tumor 3,851 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,948 | 3,289
malignant mesothelioma 2,846 | 3,162
Breast cancer 2,763 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,672 | 2,988
invasive ductal carcinoma 2,666 | 2,950
primitive neuroectodermal tumor 2,650 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,627 | 2,956
pilocytic astrocytoma 2,615 | 3,086
oligodendroglioma 2,459 | 2,849
non-small cell lung cancer 2,424 | 2,798
pediatric high grade glioma 2,375 | 2,712
lung carcinoma 2,370 | 2,844
lung adenocarcinoma 2,286 | 2,713
ependymoma 2,237 | 2,514
subependymal giant cell astrocytoma 2,052 | 2,287
group 3 medulloblastoma 2,017 | 2,254
pancreatic cancer 1,975 | 2,300
astrocytic glioma 1,951 | 2,241
interstitial cystitis 1,873 | 2,299
Cancer 1,859 | 2,346
adult high grade glioma 1,822 | 2,148
ulcerative colitis 1,770 | 2,087
Carcinoma 1,767 | 2,147
Pick disease 1,742 | 1,893
pituitary cancer 1,684 | 1,972
group 4 medulloblastoma 1,683 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,616 | 1,795
ductal carcinoma in situ 1,536 | 1,745
breast carcinoma 1,434 | 1,614
cystic fibrosis 1,401 | 1,665
tuberculosis 1,362 | 1,557
astrocytoma 1,361 | 1,493
posterior fossa group B ependymoma 1,338 | 1,530
medulloblastoma 1,328 | 1,524
adrenocortical carcinoma 1,325 | 1,427
Multiple myeloma 1,299 | 1,327
sonic hedgehog group medulloblastoma 1,294 | 1,482
posterior fossa group A ependymoma 1,279 | 1,511
colon cancer 1,262 | 1,475
primary pancreatic ductal adenocarcinoma 1,171 | 1,271
diabetes mellitus 1,153 | 1,663
juvenile dermatomyositis 1,139 | 1,189
acute quadriplegic myopathy 1,095 | 1,157
Rheumatoid Arthritis 987 | 1,160
atypical teratoid/rhabdoid tumor 962 | 1,095
spina bifida 919 | 1,064
dermatomyositis 902 | 933
nasopharyngeal carcinoma 888 | 1,056
cutaneous lupus erythematosus 867 | 1,056
active Crohn's disease 763 | 918
Atopic dermatitis 747 | 944
gastric carcinoma 744 | 832
acute myeloid leukemia 738 | 780
Waldenstrons macroglobulinemia 736 | 765
non primary Sjogren syndrome sicca 724 | 840
primary Sjogren syndrome 698 | 789
tuberculosis and treatment for 6 months 645 | 686
progressive supranuclear palsy 626 | 674
aldosterone-producing adenoma 623 | 664
esophageal adenocarcinoma 609 | 737
Duchenne muscular dystrophy 553 | 602
Alzheimer's disease 546 | 644
Intellectual disability 506 | 573
pancreatic carcinoma 504 | 567
Down syndrome 483 | 548
hepatocellular carcinoma 480 | 532
fibroadenoma 476 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 470 | 499
Obesity 459 | 616
Endometriosis 442 | 535
chronic rhinosinusitis 442 | 512
IGA Glomerulonephritis 419 | 454
Amyotrophic Lateral Sclerosis 394 | 431
Prostatic Neoplasms 394 | 471
active ulcerative colitis 394 | 477
mucosa-associated lymphoid tissue lymphoma 386 | 480
Schizophrenia 378 | 501
gastric cancer 378 | 430
Neurodegenerative disease 349 | 383
Multiple Sclerosis 348 | 498
Mammary Neoplasms 343 | 410
inflammatory breast cancer 342 | 404
hereditary spastic paraplegia 307 | 313
non-small cell lung carcinoma 307 | 413
glioblastoma multiforme 303 | 347
tuberculosis and treatment for 3 months 297 | 327
sarcoidosis 292 | 358
Polycystic Ovary Syndrome 288 | 332
Parkinson's disease 283 | 364
urothelial carcinoma 267 | 318
interstitial lung disease 257 | 291
Epilepsy 256 | 346
Kidney disease 255 | 396

Tissue

Endocrine System 14,883 | 18,512
Female tissues 14,847 | 18,647
Nervous System 14,829 | 18,561
Digestive Tract 14,806 | 18,473
Urinary Tract 14,793 | 18,444
Skin and soft tissues 14,760 | 18,115
Male tissues 14,744 | 17,969
Liver and Pancreas 14,726 | 18,136
Cardiovascular System 14,679 | 17,958
Blood and immune system 14,677 | 17,995
Respiratory system 14,556 | 17,484

Target Family

Non-IDG 8,751 | 11,971
Enzyme 3,468 | 4,146
Transcription Factor 1,093 | 1,400
Kinase 573 | 634
Transporter 342 | 473
Epigenetic 235 | 242
Ion Channel 188 | 341
GPCR 150 | 406
Nuclear Receptor 38 | 48
TF/Epigenetic 32 | 38
oGPCR 13 | 421

HPA RNA Tissue

testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102