Development Level

Tbio 10,168 | 11,445
Tdark 3,939 | 6,588
Tchem 1,456 | 1,598
Tclin 536 | 613

Collection

RFA-RM-18-021 251 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 72 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 949 | 979
preweaning lethality, incomple... 472 | 499
abnormal behavior 283 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 193 | 210
decreased vertical activity 176 | 208
abnormal bone structure 169 | 187
increased lean body mass 161 | 172
decreased body weight 152 | 161
abnormal heart morphology 149 | 162
decreased bone mineral content 138 | 151
hyperactivity 138 | 148
decreased lean body mass 126 | 135
increased total body fat amoun... 121 | 134
hypoactivity 118 | 132
decreased bone mineral density 115 | 126
decreased circulating glucose ... 115 | 126
increased circulating alkaline... 110 | 122
decreased grip strength 103 | 116
increased startle reflex 103 | 112
abnormal seminal vesicle morph... 101 | 114
embryonic growth retardation 101 | 106
male infertility 99 | 123
increased bone mineral content 98 | 108
decreased body length 94 | 101
increased or absent threshold ... 93 | 101
short tibia 93 | 97
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 89 | 96
increased mean corpuscular vol... 88 | 92
cataract 85 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 80 | 83
decreased circulating serum al... 78 | 82
abnormal lens morphology 76 | 81
decreased circulating triglyce... 75 | 79
decreased prepulse inhibition 75 | 82
decreased mean corpuscular vol... 73 | 79
increased circulating HDL chol... 72 | 80
small superior vagus ganglion 71 | 74
increased bone mineral density 70 | 72
decreased leukocyte cell numbe... 69 | 73
impaired glucose tolerance 69 | 75
improved glucose tolerance 69 | 79
increased fasted circulating g... 69 | 76
decreased startle reflex 67 | 75
abnormal eye morphology 66 | 68
decreased circulating HDL chol... 66 | 68
decreased circulating insulin ... 66 | 76
abnormal retina morphology 65 | 71
increased circulating sodium l... 65 | 71
abnormal gait 64 | 69
abnormal sleep behavior 64 | 70
decreased hemoglobin content 61 | 68
increased circulating choleste... 61 | 66
abnormal behavioral response t... 60 | 66
decreased erythrocyte cell num... 60 | 62
increased monocyte cell number 60 | 63
abnormal kidney morphology 59 | 65
decreased fasted circulating g... 59 | 65
abnormal coat-hair pigmentatio... 58 | 64
edema 56 | 59
increased heart weight 54 | 62
thrombocytopenia 54 | 56
small testis 53 | 58
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 52 | 53
hydrometra 50 | 53
abnormal skin morphology 48 | 50
decreased circulating total pr... 47 | 49
increased blood urea nitrogen ... 47 | 48
decreased blood urea nitrogen ... 46 | 51
female infertility 46 | 60
abnormal neural tube closure 45 | 46
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
decreased mean corpuscular hem... 44 | 50
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased leukocyte cell numbe... 42 | 47
enlarged spleen 41 | 41
abnormal testis morphology 40 | 43
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 40 | 42
increased hematocrit 40 | 46
increased mean platelet volume 39 | 45
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
increased hemoglobin content 38 | 45
decreased circulating LDL chol... 37 | 38
increased circulating creatini... 37 | 38
limb grasping 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41

Disease

Carcinoma 9,797 | 11,493
ovarian cancer 8,150 | 8,520
osteosarcoma 7,460 | 7,950
medulloblastoma, large-cell 5,809 | 6,241
psoriasis 5,786 | 6,694
glioblastoma 5,502 | 5,792
atypical teratoid / rhabdoid tumor 4,832 | 5,112
lung cancer 4,484 | 4,740
ependymoma 4,398 | 4,679
group 3 medulloblastoma 3,866 | 4,104
adult high grade glioma 3,541 | 3,801
Breast cancer 3,405 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,231 | 3,291
malignant mesothelioma 3,102 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,939 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,909 | 2,955
Astrocytoma, Pilocytic 2,896 | 3,081
invasive ductal carcinoma 2,881 | 2,951
primitive neuroectodermal tumor 2,863 | 3,035
non-small cell lung cancer 2,785 | 2,890
lung carcinoma 2,706 | 2,843
oligodendroglioma 2,684 | 2,850
lung adenocarcinoma 2,599 | 2,716
astrocytic glioma 2,457 | 2,597
pancreatic cancer 2,319 | 2,398
Kidney cancer 2,302 | 2,613
Cancer 2,237 | 2,499
interstitial cystitis 2,223 | 2,312
subependymal giant cell astrocytoma 2,191 | 2,287
tuberculosis 1,919 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,903 | 1,962
pituitary cancer 1,862 | 1,972
Pick disease 1,833 | 1,894
group 4 medulloblastoma 1,765 | 1,855
ulcerative colitis 1,751 | 1,819
ductal carcinoma in situ 1,692 | 1,745
cystic fibrosis 1,617 | 1,696
breast carcinoma 1,583 | 1,638
colon cancer 1,429 | 1,478
adrenocortical carcinoma 1,391 | 1,428
diabetes mellitus 1,372 | 1,728
Multiple myeloma 1,308 | 1,332
Autosomal recessive predisposition 1,300 | 1,442
juvenile dermatomyositis 1,155 | 1,187
acute quadriplegic myopathy 1,123 | 1,158
astrocytoma 1,112 | 1,146
primary pancreatic ductal adenocarcinoma 1,097 | 1,109
Rheumatoid arthritis 1,084 | 1,191
spina bifida 1,023 | 1,074
pediatric high grade glioma 1,020 | 1,064
cutaneous lupus erythematosus 1,007 | 1,057
Schizophrenia 1,000 | 1,160
nasopharyngeal carcinoma 991 | 1,058
Intellectual disability 938 | 1,016
dermatomyositis 918 | 966
active Crohn's disease 899 | 922
Atopic dermatitis 855 | 952
non primary Sjogren syndrome sicca 818 | 891
gastric carcinoma 793 | 807
acute myeloid leukemia 777 | 783
Waldenstrons macroglobulinemia 759 | 765
active ulcerative colitis 739 | 764
Liver Cirrhosis, Experimental 735 | 769
Epilepsy 729 | 792
primary Sjogren syndrome 720 | 735
esophageal adenocarcinoma 701 | 737
medulloblastoma 680 | 720
aldosterone-producing adenoma 647 | 665
progressive supranuclear palsy 647 | 676
Obesity 602 | 678
Alzheimer's disease 601 | 658
Dull intelligence 592 | 645
Low intelligence 592 | 645
Mental Retardation 592 | 645
Mental deficiency 592 | 645
Poor school performance 592 | 645
Bipolar Disorder 577 | 666
Cognitive delay 577 | 608
Global developmental delay 577 | 608
Mental and motor retardation 577 | 608
Duchenne muscular dystrophy 575 | 601
Melanoma 572 | 711
Seizures 552 | 596
pancreatic carcinoma 548 | 562
fibroadenoma 542 | 559
Muscle hypotonia 539 | 571
hepatocellular carcinoma 537 | 547
Liver cancer 516 | 604
Endometriosis 508 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Short stature 489 | 531
Down syndrome 477 | 499
chronic rhinosinusitis 473 | 512
Prostatic Neoplasms 463 | 495
Multiple Sclerosis 462 | 540
mucosa-associated lymphoid tissue lymphoma 456 | 484
posterior fossa group A ependymoma 453 | 468
gastric cancer 450 | 459
sonic hedgehog group medulloblastoma 439 | 467
Amyotrophic lateral sclerosis 428 | 451

Tissue

Digestive Tract 16,099 | 17,369
Endocrine System 16,038 | 18,159
Female tissues 15,962 | 17,400
Skin and soft tissues 15,929 | 17,230
Male tissues 15,881 | 17,142
Liver and Pancreas 15,851 | 16,750
Blood and immune system 15,803 | 16,909
Urinary Tract 15,774 | 16,678
Respiratory system 15,655 | 16,393
Nervous System 15,648 | 16,725
Cardiovascular System 14,776 | 15,192

Target Family

Non-IDG 9,372 | 12,091
Enzyme 3,727 | 4,145
Transcription Factor 1,166 | 1,400
Kinase 595 | 634
Transporter 391 | 473
GPCR 274 | 408
Ion Channel 254 | 344
Epigenetic 231 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 34 | 38
oGPCR 8 | 421

HPA RNA Tissue

stomach 16,099 | 16,099
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39