Development Level

Tbio 8,265 | 10,625
Tdark 3,389 | 7,003
Tchem 1,475 | 1,890
Tclin 379 | 602

Collection

Eligible Kinase Proteins 101 | 134
Eligible Ion Channel Proteins 42 | 117
Eligible non-olfactory GPCR Proteins 42 | 143

IMPC Term

preweaning lethality, complete... 579 | 633
preweaning lethality, incomple... 216 | 260
abnormal behavior 187 | 226
embryonic lethality prior to t... 180 | 187
decreased lean body mass 166 | 195
decreased total body fat amoun... 162 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 131 | 157
decreased bone mineral density 104 | 126
increased or absent threshold ... 103 | 128
increased circulating alkaline... 102 | 119
abnormal bone structure 100 | 131
abnormal embryo size 100 | 112
decreased circulating glucose ... 96 | 121
decreased body length 95 | 108
decreased grip strength 94 | 123
enlarged heart 90 | 111
increased lean body mass 90 | 107
abnormal retina morphology 87 | 100
hyperactivity 86 | 108
increased mean corpuscular hem... 82 | 93
increased bone mineral content 81 | 92
increased mean corpuscular vol... 78 | 91
decreased circulating choleste... 74 | 85
decreased circulating serum al... 72 | 79
hypoactivity 72 | 89
short tibia 72 | 82
decreased circulating triglyce... 70 | 83
decreased circulating HDL chol... 69 | 77
increased grip strength 67 | 83
abnormal lens morphology 65 | 73
prenatal lethality prior to he... 59 | 64
increased fasted circulating g... 57 | 68
decreased circulating insulin ... 56 | 75
increased circulating sodium l... 55 | 71
decreased lumbar vertebrae num... 54 | 62
increased sacral vertebrae num... 54 | 62
abnormal retinal pigmentation 53 | 61
decreased rib number 50 | 59
abnormal coat/hair pigmentatio... 49 | 54
abnormal sleep behavior 47 | 63
decreased mean corpuscular vol... 47 | 50
decreased leukocyte cell numbe... 46 | 54
increased bone mineral density 46 | 52
male infertility 46 | 62
abnormal bone mineralization 45 | 55
decreased hemoglobin content 45 | 53
impaired glucose tolerance 45 | 52
increased circulating HDL chol... 45 | 63
increased total body fat amoun... 44 | 57
decreased circulating alanine ... 43 | 53
decreased fasted circulating g... 43 | 49
improved glucose tolerance 43 | 56
decreased prepulse inhibition 42 | 52
increased circulating choleste... 42 | 53
increased exploration in new e... 42 | 56
decreased caudal vertebrae num... 41 | 49
decreased erythrocyte cell num... 40 | 43
abnormal gait 39 | 51
decreased circulating total pr... 39 | 41
decreased startle reflex 38 | 48
increased blood urea nitrogen ... 38 | 44
abnormal behavioral response t... 37 | 52
abnormal heart morphology 37 | 51
increased body weight 37 | 42
increased hemoglobin content 37 | 45
thrombocytopenia 37 | 46
decreased circulating LDL chol... 35 | 37
decreased eosinophil cell numb... 35 | 41
abnormal seminal vesicle morph... 34 | 47
increased rib number 34 | 41
abnormal eye morphology 32 | 38
abnormal neural tube closure 32 | 37
decreased heart weight 32 | 44
decreased neutrophil cell numb... 32 | 37
increased startle reflex 32 | 38
decreased circulating free fat... 31 | 39
increased hematocrit 31 | 36
decreased circulating alkaline... 30 | 41
decreased circulating fructosa... 30 | 31
increased circulating chloride... 30 | 43
increased leukocyte cell numbe... 30 | 37
abnormal cranium morphology 29 | 32
cardiovascular system phenotyp... 29 | 35
decreased circulating calcium ... 29 | 33
decreased mean corpuscular hem... 29 | 34
small testis 29 | 37
decreased T cell number 28 | 31
tremors 28 | 34
decreased circulating chloride... 27 | 32
decreased circulating creatini... 27 | 31
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased blood urea nitrogen ... 26 | 31
embryonic growth retardation 26 | 28
decreased threshold for audito... 25 | 32
increased circulating calcium ... 25 | 32
limb grasping 25 | 35
decreased circulating aspartat... 24 | 27

Disease

ovarian cancer 7,559 | 8,484
osteosarcoma 6,799 | 7,933
medulloblastoma, large-cell 5,077 | 6,234
psoriasis 4,875 | 6,685
glioblastoma 4,665 | 5,572
lung cancer 4,028 | 4,466
atypical teratoid / rhabdoid tumor 3,586 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,060 | 3,289
malignant mesothelioma 2,810 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 2,755 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,724 | 2,956
Breast cancer 2,711 | 3,094
invasive ductal carcinoma 2,650 | 2,950
non-small cell lung cancer 2,454 | 2,798
primitive neuroectodermal tumor 2,447 | 3,031
pilocytic astrocytoma 2,390 | 3,086
lung carcinoma 2,329 | 2,844
lung adenocarcinoma 2,306 | 2,713
oligodendroglioma 2,285 | 2,849
pediatric high grade glioma 2,235 | 2,712
ependymoma 2,092 | 2,514
pancreatic cancer 2,086 | 2,300
interstitial cystitis 1,988 | 2,299
subependymal giant cell astrocytoma 1,955 | 2,287
ulcerative colitis 1,893 | 2,087
group 3 medulloblastoma 1,882 | 2,254
Cancer 1,881 | 2,346
astrocytic glioma 1,827 | 2,241
adult high grade glioma 1,670 | 2,148
Pick disease 1,659 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,641 | 1,795
group 4 medulloblastoma 1,600 | 1,875
pituitary cancer 1,575 | 1,972
ductal carcinoma in situ 1,536 | 1,745
Carcinoma 1,444 | 2,147
breast carcinoma 1,418 | 1,614
cystic fibrosis 1,407 | 1,665
tuberculosis 1,392 | 1,557
astrocytoma 1,304 | 1,493
Multiple myeloma 1,300 | 1,327
colon cancer 1,293 | 1,475
adrenocortical carcinoma 1,277 | 1,427
medulloblastoma 1,219 | 1,524
primary pancreatic ductal adenocarcinoma 1,215 | 1,271
sonic hedgehog group medulloblastoma 1,198 | 1,482
posterior fossa group A ependymoma 1,171 | 1,511
posterior fossa group B ependymoma 1,155 | 1,530
diabetes mellitus 1,138 | 1,663
juvenile dermatomyositis 1,124 | 1,189
acute quadriplegic myopathy 1,069 | 1,157
Rheumatoid Arthritis 1,010 | 1,160
spina bifida 945 | 1,064
cutaneous lupus erythematosus 908 | 1,056
dermatomyositis 893 | 933
atypical teratoid/rhabdoid tumor 890 | 1,095
nasopharyngeal carcinoma 861 | 1,056
active Crohn's disease 819 | 918
gastric carcinoma 798 | 832
primary Sjogren syndrome 750 | 789
Waldenstrons macroglobulinemia 744 | 765
acute myeloid leukemia 733 | 780
Atopic dermatitis 730 | 944
non primary Sjogren syndrome sicca 688 | 840
tuberculosis and treatment for 6 months 658 | 686
esophageal adenocarcinoma 654 | 737
progressive supranuclear palsy 609 | 674
aldosterone-producing adenoma 599 | 664
Duchenne muscular dystrophy 544 | 602
pancreatic carcinoma 507 | 567
Alzheimer's disease 503 | 644
hepatocellular carcinoma 490 | 532
Down syndrome 481 | 548
Intellectual disability 477 | 573
fibroadenoma 472 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 462 | 499
Obesity 444 | 616
Endometriosis 440 | 535
IGA Glomerulonephritis 425 | 454
active ulcerative colitis 409 | 477
Prostatic Neoplasms 405 | 471
mucosa-associated lymphoid tissue lymphoma 395 | 480
chronic rhinosinusitis 393 | 512
gastric cancer 387 | 430
Amyotrophic Lateral Sclerosis 372 | 431
Mammary Neoplasms 352 | 410
Multiple Sclerosis 346 | 498
inflammatory breast cancer 344 | 404
Schizophrenia 334 | 501
Neurodegenerative disease 330 | 383
sarcoidosis 321 | 358
tuberculosis and treatment for 3 months 309 | 327
hereditary spastic paraplegia 303 | 313
non-small cell lung carcinoma 302 | 413
urothelial carcinoma 278 | 318
Polycystic Ovary Syndrome 277 | 332
glioblastoma multiforme 276 | 347
Kidney disease 268 | 396
Parkinson's disease 267 | 364
nephrosclerosis 263 | 329
interstitial lung disease 256 | 291

Tissue

Digestive Tract 13,508 | 18,473
Endocrine System 13,501 | 18,512
Female tissues 13,499 | 18,647
Liver and Pancreas 13,496 | 18,136
Nervous System 13,495 | 18,561
Skin and soft tissues 13,493 | 18,115
Urinary Tract 13,493 | 18,444
Male tissues 13,482 | 17,969
Blood and immune system 13,475 | 17,995
Cardiovascular System 13,472 | 17,958
Respiratory system 13,469 | 17,484

Target Family

Non-IDG 7,771 | 11,971
Enzyme 3,323 | 4,146
Transcription Factor 989 | 1,400
Kinase 542 | 634
Transporter 309 | 473
Epigenetic 208 | 242
GPCR 154 | 406
Ion Channel 142 | 341
Nuclear Receptor 36 | 48
TF/Epigenetic 32 | 38
oGPCR 2 | 421

HPA RNA Tissue

stomach 13,508 | 13,508
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248