Development Level

Tbio 9,922 | 11,178
Tdark 3,931 | 6,569
Tchem 1,711 | 1,885
Tclin 535 | 612

Collection

Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 72 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 949 | 979
preweaning lethality, incomple... 472 | 499
abnormal behavior 283 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 193 | 210
decreased vertical activity 176 | 208
abnormal bone structure 169 | 187
increased lean body mass 161 | 172
decreased body weight 152 | 161
abnormal heart morphology 149 | 162
decreased bone mineral content 138 | 151
hyperactivity 138 | 148
decreased lean body mass 126 | 135
increased total body fat amoun... 121 | 134
hypoactivity 118 | 132
decreased bone mineral density 115 | 126
decreased circulating glucose ... 115 | 126
increased circulating alkaline... 110 | 122
decreased grip strength 103 | 116
increased startle reflex 103 | 112
abnormal seminal vesicle morph... 101 | 114
embryonic growth retardation 101 | 106
male infertility 99 | 123
increased bone mineral content 98 | 108
decreased body length 94 | 101
increased or absent threshold ... 93 | 101
short tibia 93 | 97
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 89 | 96
increased mean corpuscular vol... 88 | 92
cataract 85 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 80 | 83
decreased circulating serum al... 78 | 82
abnormal lens morphology 76 | 81
decreased circulating triglyce... 75 | 79
decreased prepulse inhibition 75 | 82
decreased mean corpuscular vol... 73 | 79
increased circulating HDL chol... 72 | 80
small superior vagus ganglion 71 | 74
increased bone mineral density 70 | 72
decreased leukocyte cell numbe... 69 | 73
impaired glucose tolerance 69 | 75
improved glucose tolerance 69 | 79
increased fasted circulating g... 69 | 76
decreased startle reflex 67 | 75
abnormal eye morphology 66 | 68
decreased circulating HDL chol... 66 | 68
decreased circulating insulin ... 66 | 76
abnormal retina morphology 65 | 71
increased circulating sodium l... 65 | 71
abnormal gait 64 | 69
abnormal sleep behavior 64 | 70
decreased hemoglobin content 61 | 68
increased circulating choleste... 61 | 66
abnormal behavioral response t... 60 | 66
decreased erythrocyte cell num... 60 | 62
increased monocyte cell number 60 | 63
abnormal kidney morphology 59 | 65
decreased fasted circulating g... 59 | 65
abnormal coat-hair pigmentatio... 58 | 64
edema 56 | 59
increased heart weight 54 | 62
thrombocytopenia 54 | 56
small testis 53 | 58
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 52 | 53
hydrometra 50 | 53
abnormal skin morphology 48 | 50
decreased circulating total pr... 47 | 49
increased blood urea nitrogen ... 47 | 48
decreased blood urea nitrogen ... 46 | 51
female infertility 46 | 60
abnormal neural tube closure 45 | 46
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
decreased mean corpuscular hem... 44 | 50
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased leukocyte cell numbe... 42 | 47
enlarged spleen 41 | 41
abnormal testis morphology 40 | 43
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 40 | 42
increased hematocrit 40 | 46
increased mean platelet volume 39 | 45
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
increased hemoglobin content 38 | 45
decreased circulating LDL chol... 37 | 38
increased circulating creatini... 37 | 38
limb grasping 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41

Disease

Carcinoma 9,556 | 11,192
ovarian cancer 7,936 | 8,297
osteosarcoma 7,286 | 7,766
medulloblastoma, large-cell 5,667 | 6,086
psoriasis 5,633 | 6,514
glioblastoma 5,359 | 5,635
atypical teratoid / rhabdoid tumor 4,700 | 4,971
lung cancer 4,361 | 4,607
ependymoma 4,291 | 4,559
group 3 medulloblastoma 3,773 | 4,002
adult high grade glioma 3,452 | 3,701
Breast cancer 3,307 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,145 | 3,204
malignant mesothelioma 3,010 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 2,855 | 2,902
Astrocytoma, Pilocytic 2,828 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 2,828 | 2,872
invasive ductal carcinoma 2,800 | 2,867
primitive neuroectodermal tumor 2,792 | 2,957
non-small cell lung cancer 2,701 | 2,799
lung carcinoma 2,623 | 2,755
oligodendroglioma 2,610 | 2,768
lung adenocarcinoma 2,514 | 2,627
astrocytic glioma 2,398 | 2,530
Kidney cancer 2,251 | 2,548
pancreatic cancer 2,247 | 2,322
interstitial cystitis 2,152 | 2,237
subependymal giant cell astrocytoma 2,141 | 2,230
Cancer 2,135 | 2,388
tuberculosis 1,873 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,854 | 1,911
pituitary cancer 1,805 | 1,915
Pick disease 1,799 | 1,856
group 4 medulloblastoma 1,723 | 1,806
ulcerative colitis 1,698 | 1,765
ductal carcinoma in situ 1,634 | 1,686
cystic fibrosis 1,555 | 1,629
breast carcinoma 1,535 | 1,589
colon cancer 1,383 | 1,428
adrenocortical carcinoma 1,350 | 1,385
diabetes mellitus 1,330 | 1,683
Multiple myeloma 1,272 | 1,296
Autosomal recessive predisposition 1,270 | 1,407
juvenile dermatomyositis 1,116 | 1,147
acute quadriplegic myopathy 1,098 | 1,133
astrocytoma 1,081 | 1,113
primary pancreatic ductal adenocarcinoma 1,059 | 1,071
Rheumatoid arthritis 1,051 | 1,156
spina bifida 1,006 | 1,053
pediatric high grade glioma 992 | 1,035
Schizophrenia 981 | 1,136
cutaneous lupus erythematosus 970 | 1,016
nasopharyngeal carcinoma 960 | 1,024
Intellectual disability 924 | 998
dermatomyositis 893 | 941
active Crohn's disease 862 | 882
Atopic dermatitis 821 | 915
non primary Sjogren syndrome sicca 790 | 861
gastric carcinoma 767 | 781
acute myeloid leukemia 754 | 760
Waldenstrons macroglobulinemia 737 | 742
Epilepsy 716 | 775
active ulcerative colitis 713 | 736
Liver Cirrhosis, Experimental 701 | 733
primary Sjogren syndrome 695 | 710
esophageal adenocarcinoma 664 | 696
medulloblastoma 663 | 702
aldosterone-producing adenoma 629 | 646
progressive supranuclear palsy 629 | 656
Alzheimer's disease 584 | 640
Dull intelligence 584 | 634
Low intelligence 584 | 634
Mental Retardation 584 | 634
Mental deficiency 584 | 634
Poor school performance 584 | 634
Obesity 583 | 655
Cognitive delay 569 | 596
Global developmental delay 569 | 596
Mental and motor retardation 569 | 596
Duchenne muscular dystrophy 561 | 587
Bipolar Disorder 560 | 646
Melanoma 557 | 689
Seizures 544 | 584
pancreatic carcinoma 541 | 555
Muscle hypotonia 533 | 562
hepatocellular carcinoma 526 | 536
fibroadenoma 521 | 538
Liver cancer 506 | 589
Endometriosis 489 | 521
Short stature 478 | 514
autosomal dominant Emery-Dreifuss muscular dystrophy 476 | 492
chronic rhinosinusitis 467 | 505
Down syndrome 459 | 480
Multiple Sclerosis 450 | 527
mucosa-associated lymphoid tissue lymphoma 447 | 473
Prostatic Neoplasms 443 | 472
posterior fossa group A ependymoma 441 | 456
gastric cancer 436 | 445
sonic hedgehog group medulloblastoma 431 | 459
Amyotrophic lateral sclerosis 415 | 437

Tissue

Digestive Tract 16,099 | 17,369
Endocrine System 16,038 | 18,159
Female tissues 15,962 | 17,400
Skin and soft tissues 15,929 | 17,230
Male tissues 15,881 | 17,142
Liver and Pancreas 15,851 | 16,750
Blood and immune system 15,803 | 16,909
Urinary Tract 15,774 | 16,678
Respiratory system 15,655 | 16,393
Nervous System 15,648 | 16,725
Cardiovascular System 14,776 | 15,192

Target Family

Non-IDG 9,372 | 12,091
Enzyme 3,727 | 4,145
Transcription Factor 1,166 | 1,400
Kinase 595 | 634
Transporter 391 | 473
GPCR 274 | 408
Ion Channel 254 | 344
Epigenetic 231 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 34 | 38
oGPCR 8 | 421

HPA RNA Tissue

stomach 16,099 | 16,099
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101