Development Level

Tbio 10,227 | 11,651
Tdark 3,978 | 6,593
Tchem 1,253 | 1,388
Tclin 514 | 612

Collection

RFA-RM-18-021 247 | 328
Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 942 | 979
preweaning lethality, incomple... 464 | 499
abnormal behavior 278 | 298
embryonic lethality prior to t... 273 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
enlarged heart 191 | 210
decreased total body fat amoun... 189 | 207
decreased vertical activity 171 | 208
abnormal bone structure 169 | 187
increased lean body mass 156 | 172
abnormal heart morphology 151 | 162
decreased body weight 148 | 161
hyperactivity 137 | 148
decreased bone mineral content 136 | 151
decreased lean body mass 122 | 135
increased total body fat amoun... 118 | 134
decreased circulating glucose ... 117 | 126
hypoactivity 117 | 132
decreased bone mineral density 116 | 126
increased circulating alkaline... 112 | 122
increased startle reflex 104 | 112
embryonic growth retardation 102 | 106
abnormal seminal vesicle morph... 101 | 114
decreased grip strength 101 | 116
male infertility 101 | 123
increased bone mineral content 98 | 108
decreased body length 93 | 101
short tibia 93 | 97
increased or absent threshold ... 92 | 101
increased mean corpuscular vol... 88 | 92
decreased circulating choleste... 87 | 93
increased mean corpuscular hem... 87 | 96
cataract 86 | 92
prenatal lethality prior to he... 83 | 87
decreased lymphocyte cell numb... 77 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 72 | 79
increased bone mineral density 70 | 72
increased circulating HDL chol... 70 | 80
decreased leukocyte cell numbe... 69 | 73
decreased startle reflex 69 | 75
increased fasted circulating g... 69 | 76
improved glucose tolerance 68 | 79
decreased circulating insulin ... 67 | 76
small superior vagus ganglion 67 | 74
abnormal retina morphology 66 | 71
abnormal eye morphology 65 | 68
impaired glucose tolerance 65 | 75
abnormal sleep behavior 64 | 70
decreased circulating HDL chol... 64 | 68
abnormal gait 63 | 69
increased circulating sodium l... 62 | 71
abnormal behavioral response t... 60 | 66
increased circulating choleste... 60 | 66
abnormal coat-hair pigmentatio... 59 | 64
decreased erythrocyte cell num... 59 | 62
decreased hemoglobin content 59 | 68
abnormal kidney morphology 58 | 65
decreased fasted circulating g... 58 | 65
edema 57 | 59
increased monocyte cell number 56 | 63
increased heart weight 55 | 62
small testis 54 | 58
decreased caudal vertebrae num... 52 | 53
thrombocytopenia 52 | 56
female infertility 51 | 60
abnormal spleen morphology 49 | 55
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 46 | 50
hydrometra 46 | 53
abnormal skin morphology 45 | 50
decreased blood urea nitrogen ... 45 | 51
increased leukocyte cell numbe... 45 | 47
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 43 | 46
increased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
decreased circulating alanine ... 42 | 47
decreased hematocrit 42 | 46
increased blood urea nitrogen ... 42 | 48
abnormal testis morphology 41 | 43
increased mean platelet volume 41 | 45
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 39 | 42
increased hemoglobin content 38 | 45
abnormal bone mineralization 37 | 38
decreased red blood cell distr... 37 | 41
enlarged spleen 37 | 41
decreased circulating LDL chol... 36 | 38
increased circulating chloride... 36 | 41
increased erythrocyte cell num... 36 | 39
tremors 36 | 39
abnormal cranium morphology 34 | 36
decreased circulating creatini... 34 | 39
increased grip strength 34 | 41
limb grasping 34 | 41

Disease

Carcinoma 9,678 | 11,493
ovarian cancer 8,085 | 8,520
osteosarcoma 7,456 | 7,950
medulloblastoma, large-cell 5,733 | 6,241
psoriasis 5,645 | 6,694
glioblastoma 5,414 | 5,792
atypical teratoid / rhabdoid tumor 4,746 | 5,112
lung cancer 4,443 | 4,740
ependymoma 4,311 | 4,679
group 3 medulloblastoma 3,831 | 4,104
adult high grade glioma 3,469 | 3,801
Breast cancer 3,350 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,149 | 3,291
malignant mesothelioma 3,084 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,871 | 2,989
invasive ductal carcinoma 2,853 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,839 | 2,955
Astrocytoma, Pilocytic 2,820 | 3,081
primitive neuroectodermal tumor 2,805 | 3,035
non-small cell lung cancer 2,722 | 2,890
oligodendroglioma 2,629 | 2,850
lung carcinoma 2,623 | 2,843
lung adenocarcinoma 2,546 | 2,716
astrocytic glioma 2,396 | 2,597
pancreatic cancer 2,250 | 2,398
Kidney cancer 2,247 | 2,613
Cancer 2,214 | 2,499
interstitial cystitis 2,154 | 2,312
subependymal giant cell astrocytoma 2,148 | 2,287
tuberculosis 1,938 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,865 | 1,962
pituitary cancer 1,816 | 1,972
Pick disease 1,786 | 1,894
group 4 medulloblastoma 1,754 | 1,855
ulcerative colitis 1,716 | 1,819
ductal carcinoma in situ 1,663 | 1,745
cystic fibrosis 1,565 | 1,696
breast carcinoma 1,554 | 1,638
colon cancer 1,389 | 1,478
adrenocortical carcinoma 1,378 | 1,428
diabetes mellitus 1,333 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,281 | 1,442
juvenile dermatomyositis 1,155 | 1,187
acute quadriplegic myopathy 1,126 | 1,158
astrocytoma 1,105 | 1,146
Rheumatoid arthritis 1,087 | 1,191
primary pancreatic ductal adenocarcinoma 1,077 | 1,109
pediatric high grade glioma 1,009 | 1,064
spina bifida 1,005 | 1,074
cutaneous lupus erythematosus 990 | 1,057
Schizophrenia 982 | 1,160
nasopharyngeal carcinoma 967 | 1,058
Intellectual disability 931 | 1,016
dermatomyositis 918 | 966
active Crohn's disease 857 | 922
Atopic dermatitis 839 | 952
non primary Sjogren syndrome sicca 812 | 891
acute myeloid leukemia 778 | 783
gastric carcinoma 765 | 807
Waldenstrons macroglobulinemia 761 | 765
Liver Cirrhosis, Experimental 727 | 769
primary Sjogren syndrome 717 | 735
Epilepsy 711 | 792
active ulcerative colitis 692 | 764
esophageal adenocarcinoma 670 | 737
medulloblastoma 659 | 720
progressive supranuclear palsy 647 | 676
aldosterone-producing adenoma 635 | 665
Alzheimer's disease 591 | 658
Dull intelligence 586 | 645
Low intelligence 586 | 645
Mental Retardation 586 | 645
Mental deficiency 586 | 645
Poor school performance 586 | 645
Duchenne muscular dystrophy 575 | 601
Obesity 574 | 678
Cognitive delay 569 | 608
Global developmental delay 569 | 608
Mental and motor retardation 569 | 608
pancreatic carcinoma 555 | 562
Bipolar Disorder 554 | 666
Seizures 539 | 596
Muscle hypotonia 538 | 571
Melanoma 536 | 711
hepatocellular carcinoma 536 | 547
fibroadenoma 526 | 559
Endometriosis 495 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 493 | 510
Liver cancer 491 | 604
Short stature 485 | 531
Down syndrome 467 | 499
chronic rhinosinusitis 465 | 512
mucosa-associated lymphoid tissue lymphoma 465 | 484
Multiple Sclerosis 454 | 540
Prostatic Neoplasms 454 | 495
gastric cancer 453 | 459
posterior fossa group A ependymoma 440 | 468
sonic hedgehog group medulloblastoma 431 | 467
Amyotrophic lateral sclerosis 426 | 451

Tissue

Blood and immune system 15,972 | 16,909
Endocrine System 15,920 | 18,159
Digestive Tract 15,870 | 17,369
Female tissues 15,841 | 17,400
Skin and soft tissues 15,792 | 17,230
Male tissues 15,700 | 17,142
Liver and Pancreas 15,644 | 16,750
Urinary Tract 15,564 | 16,678
Respiratory system 15,552 | 16,393
Nervous System 15,527 | 16,725
Cardiovascular System 14,669 | 15,192

Target Family

Non-IDG 9,335 | 12,091
Enzyme 3,682 | 4,145
Transcription Factor 1,138 | 1,400
Kinase 589 | 634
Transporter 373 | 473
GPCR 267 | 408
Ion Channel 255 | 344
Epigenetic 229 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 34 | 38
oGPCR 24 | 421

HPA RNA Tissue

spleen 15,972 | 15,972
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50