Development Level

Tbio 7,926 | 10,625
Tdark 3,282 | 7,003
Tchem 1,411 | 1,890
Tclin 381 | 602

Collection

Eligible Kinase Proteins 94 | 134
Eligible Ion Channel Proteins 40 | 117
Eligible non-olfactory GPCR Proteins 40 | 143

IMPC Term

preweaning lethality, complete... 577 | 633
preweaning lethality, incomple... 209 | 260
abnormal behavior 184 | 226
embryonic lethality prior to t... 176 | 187
decreased lean body mass 162 | 195
decreased total body fat amoun... 151 | 186
decreased body weight 146 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 127 | 157
increased circulating alkaline... 101 | 119
abnormal bone structure 98 | 131
decreased bone mineral density 98 | 126
abnormal embryo size 97 | 112
decreased circulating glucose ... 97 | 121
increased or absent threshold ... 95 | 128
decreased grip strength 91 | 123
decreased body length 90 | 108
hyperactivity 84 | 108
increased lean body mass 83 | 107
increased mean corpuscular hem... 83 | 93
abnormal retina morphology 82 | 100
increased mean corpuscular vol... 80 | 91
increased bone mineral content 79 | 92
enlarged heart 77 | 111
short tibia 70 | 82
decreased circulating choleste... 69 | 85
hypoactivity 68 | 89
decreased circulating serum al... 66 | 79
increased grip strength 66 | 83
decreased circulating HDL chol... 64 | 77
decreased circulating triglyce... 64 | 83
abnormal lens morphology 60 | 73
prenatal lethality prior to he... 58 | 64
increased fasted circulating g... 55 | 68
decreased lumbar vertebrae num... 54 | 62
increased sacral vertebrae num... 52 | 62
abnormal retinal pigmentation 51 | 61
decreased circulating insulin ... 51 | 75
increased circulating sodium l... 51 | 71
abnormal sleep behavior 48 | 63
decreased rib number 48 | 59
abnormal coat/hair pigmentatio... 45 | 54
decreased leukocyte cell numbe... 45 | 54
abnormal bone mineralization 44 | 55
decreased hemoglobin content 44 | 53
increased bone mineral density 44 | 52
increased circulating HDL chol... 44 | 63
male infertility 44 | 62
decreased mean corpuscular vol... 43 | 50
increased circulating choleste... 43 | 53
decreased prepulse inhibition 42 | 52
decreased circulating alanine ... 41 | 53
impaired glucose tolerance 41 | 52
increased total body fat amoun... 41 | 57
decreased erythrocyte cell num... 40 | 43
increased exploration in new e... 40 | 56
decreased fasted circulating g... 39 | 49
improved glucose tolerance 39 | 56
thrombocytopenia 39 | 46
abnormal gait 38 | 51
abnormal behavioral response t... 37 | 52
decreased caudal vertebrae num... 37 | 49
decreased circulating total pr... 37 | 41
increased blood urea nitrogen ... 37 | 44
decreased startle reflex 36 | 48
increased hemoglobin content 36 | 45
increased body weight 34 | 42
increased rib number 34 | 41
decreased circulating free fat... 33 | 39
decreased eosinophil cell numb... 33 | 41
decreased circulating LDL chol... 32 | 37
abnormal heart morphology 31 | 51
abnormal neural tube closure 31 | 37
decreased heart weight 31 | 44
increased leukocyte cell numbe... 31 | 37
abnormal seminal vesicle morph... 30 | 47
increased circulating chloride... 30 | 43
increased hematocrit 30 | 36
abnormal eye morphology 29 | 38
decreased circulating alkaline... 29 | 41
decreased mean corpuscular hem... 29 | 34
decreased neutrophil cell numb... 29 | 37
increased startle reflex 29 | 38
abnormal cranium morphology 28 | 32
decreased circulating fructosa... 28 | 31
tremors 28 | 34
decreased circulating calcium ... 27 | 33
decreased circulating creatini... 27 | 31
small testis 27 | 37
cardiovascular system phenotyp... 26 | 35
decreased T cell number 26 | 31
embryonic growth retardation 26 | 28
increased circulating potassiu... 26 | 31
abnormal spleen morphology 25 | 36
decreased circulating chloride... 25 | 32
increased circulating calcium ... 25 | 32
decreased B cell number 24 | 30
decreased CD8-positive, alpha-... 24 | 26
increased heart weight 24 | 37
decreased NK T cell number 23 | 28

Disease

ovarian cancer 7,319 | 8,484
osteosarcoma 6,677 | 7,933
medulloblastoma, large-cell 4,881 | 6,234
psoriasis 4,582 | 6,685
glioblastoma 4,493 | 5,572
lung cancer 3,862 | 4,466
atypical teratoid / rhabdoid tumor 3,443 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,748 | 3,289
malignant mesothelioma 2,682 | 3,162
Breast cancer 2,573 | 3,094
invasive ductal carcinoma 2,514 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,493 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,457 | 2,956
primitive neuroectodermal tumor 2,328 | 3,031
non-small cell lung cancer 2,285 | 2,798
pilocytic astrocytoma 2,271 | 3,086
oligodendroglioma 2,161 | 2,849
pediatric high grade glioma 2,122 | 2,712
lung carcinoma 2,113 | 2,844
lung adenocarcinoma 2,106 | 2,713
ependymoma 2,011 | 2,514
subependymal giant cell astrocytoma 1,878 | 2,287
pancreatic cancer 1,866 | 2,300
group 3 medulloblastoma 1,822 | 2,254
Cancer 1,805 | 2,346
interstitial cystitis 1,790 | 2,299
ulcerative colitis 1,760 | 2,087
astrocytic glioma 1,720 | 2,241
Pick disease 1,593 | 1,893
adult high grade glioma 1,591 | 2,148
group 4 medulloblastoma 1,581 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,560 | 1,795
pituitary cancer 1,467 | 1,972
Carcinoma 1,418 | 2,147
tuberculosis 1,406 | 1,557
ductal carcinoma in situ 1,400 | 1,745
breast carcinoma 1,342 | 1,614
Multiple myeloma 1,296 | 1,327
astrocytoma 1,276 | 1,493
cystic fibrosis 1,270 | 1,665
adrenocortical carcinoma 1,237 | 1,427
colon cancer 1,190 | 1,475
medulloblastoma 1,164 | 1,524
sonic hedgehog group medulloblastoma 1,149 | 1,482
primary pancreatic ductal adenocarcinoma 1,122 | 1,271
posterior fossa group A ependymoma 1,116 | 1,511
juvenile dermatomyositis 1,110 | 1,189
diabetes mellitus 1,097 | 1,663
posterior fossa group B ependymoma 1,066 | 1,530
acute quadriplegic myopathy 1,052 | 1,157
Rheumatoid Arthritis 1,006 | 1,160
dermatomyositis 895 | 933
cutaneous lupus erythematosus 870 | 1,056
atypical teratoid/rhabdoid tumor 849 | 1,095
spina bifida 838 | 1,064
Waldenstrons macroglobulinemia 754 | 765
primary Sjogren syndrome 741 | 789
nasopharyngeal carcinoma 740 | 1,056
acute myeloid leukemia 734 | 780
active Crohn's disease 716 | 918
gastric carcinoma 699 | 832
tuberculosis and treatment for 6 months 665 | 686
Atopic dermatitis 663 | 944
non primary Sjogren syndrome sicca 655 | 840
progressive supranuclear palsy 587 | 674
aldosterone-producing adenoma 577 | 664
esophageal adenocarcinoma 574 | 737
Duchenne muscular dystrophy 524 | 602
pancreatic carcinoma 522 | 567
hepatocellular carcinoma 499 | 532
Alzheimer's disease 491 | 644
Intellectual disability 465 | 573
Down syndrome 458 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 448 | 499
IGA Glomerulonephritis 423 | 454
fibroadenoma 421 | 557
Obesity 416 | 616
mucosa-associated lymphoid tissue lymphoma 416 | 480
gastric cancer 399 | 430
Endometriosis 398 | 535
Prostatic Neoplasms 371 | 471
Amyotrophic Lateral Sclerosis 364 | 431
Multiple Sclerosis 356 | 498
chronic rhinosinusitis 354 | 512
Mammary Neoplasms 342 | 410
active ulcerative colitis 341 | 477
Schizophrenia 324 | 501
Neurodegenerative disease 323 | 383
inflammatory breast cancer 320 | 404
sarcoidosis 320 | 358
tuberculosis and treatment for 3 months 307 | 327
hereditary spastic paraplegia 298 | 313
non-small cell lung carcinoma 273 | 413
Polycystic Ovary Syndrome 268 | 332
glioblastoma multiforme 268 | 347
Parkinson's disease 260 | 364
Kidney disease 255 | 396
Crohn's disease 245 | 304
interstitial lung disease 241 | 291
urothelial carcinoma 240 | 318

Tissue

Blood and immune system 13,000 | 17,995
Digestive Tract 12,998 | 18,473
Female tissues 12,994 | 18,647
Endocrine System 12,993 | 18,512
Skin and soft tissues 12,992 | 18,115
Urinary Tract 12,992 | 18,444
Nervous System 12,991 | 18,561
Liver and Pancreas 12,990 | 18,136
Respiratory system 12,985 | 17,484
Cardiovascular System 12,975 | 17,958
Male tissues 12,975 | 17,969

Target Family

Non-IDG 7,477 | 11,971
Enzyme 3,178 | 4,146
Transcription Factor 969 | 1,400
Kinase 519 | 634
Transporter 279 | 473
Epigenetic 211 | 242
GPCR 161 | 406
Ion Channel 136 | 341
Nuclear Receptor 35 | 48
TF/Epigenetic 32 | 38
oGPCR 3 | 421

HPA RNA Tissue

spleen 13,000 | 13,000
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108