Development Level

Tbio 10,056 | 11,445
Tdark 3,847 | 6,588
Tchem 1,439 | 1,598
Tclin 515 | 613

Collection

RFA-RM-18-021 245 | 328
Kinase: IDG Consortium (Target... 110 | 125
Ion Channel: IDG Consortium (T... 71 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 462 | 499
abnormal behavior 277 | 298
embryonic lethality prior to t... 273 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 192 | 207
enlarged heart 180 | 210
decreased vertical activity 169 | 208
abnormal bone structure 167 | 187
increased lean body mass 160 | 172
decreased body weight 148 | 161
abnormal heart morphology 142 | 162
hyperactivity 138 | 148
decreased bone mineral content 136 | 151
decreased lean body mass 125 | 135
increased total body fat amoun... 122 | 134
hypoactivity 119 | 132
decreased circulating glucose ... 116 | 126
decreased bone mineral density 112 | 126
increased circulating alkaline... 111 | 122
decreased grip strength 105 | 116
male infertility 105 | 123
increased startle reflex 104 | 112
embryonic growth retardation 101 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 96 | 114
increased or absent threshold ... 94 | 101
decreased body length 93 | 101
increased mean corpuscular vol... 91 | 92
short tibia 91 | 97
increased mean corpuscular hem... 89 | 96
decreased circulating choleste... 87 | 93
cataract 85 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 78 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 75 | 82
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 70 | 79
decreased leukocyte cell numbe... 69 | 73
decreased startle reflex 69 | 75
improved glucose tolerance 69 | 79
increased bone mineral density 69 | 72
increased circulating HDL chol... 69 | 80
abnormal retina morphology 67 | 71
impaired glucose tolerance 67 | 75
increased fasted circulating g... 67 | 76
increased circulating sodium l... 65 | 71
abnormal eye morphology 64 | 68
decreased circulating HDL chol... 64 | 68
decreased circulating insulin ... 64 | 76
small superior vagus ganglion 64 | 74
abnormal gait 63 | 69
abnormal sleep behavior 63 | 70
abnormal behavioral response t... 60 | 66
decreased hemoglobin content 59 | 68
abnormal coat-hair pigmentatio... 58 | 64
abnormal kidney morphology 58 | 65
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 58 | 65
increased circulating choleste... 58 | 66
increased monocyte cell number 58 | 63
increased heart weight 56 | 62
edema 55 | 59
small testis 54 | 58
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
abnormal spleen morphology 50 | 55
female infertility 50 | 60
abnormal skin morphology 48 | 50
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 44 | 46
decreased blood urea nitrogen ... 44 | 51
decreased circulating alkaline... 44 | 46
hydrometra 44 | 53
decreased circulating alanine ... 43 | 47
increased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
decreased hematocrit 42 | 46
increased blood urea nitrogen ... 42 | 48
increased hemoglobin content 42 | 45
increased leukocyte cell numbe... 41 | 47
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 39 | 41
enlarged spleen 39 | 41
increased circulating triglyce... 38 | 42
increased erythrocyte cell num... 38 | 39
limb grasping 38 | 41
decreased circulating LDL chol... 37 | 38
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
increased circulating chloride... 36 | 41
tremors 35 | 39
increased grip strength 34 | 41
prolonged QT interval 34 | 38

Disease

Carcinoma 9,729 | 11,493
ovarian cancer 8,104 | 8,520
osteosarcoma 7,442 | 7,950
medulloblastoma, large-cell 5,795 | 6,241
psoriasis 5,706 | 6,694
glioblastoma 5,485 | 5,792
atypical teratoid / rhabdoid tumor 4,822 | 5,112
lung cancer 4,474 | 4,740
ependymoma 4,387 | 4,679
group 3 medulloblastoma 3,864 | 4,104
adult high grade glioma 3,511 | 3,801
Breast cancer 3,379 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,169 | 3,291
malignant mesothelioma 3,098 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,893 | 2,989
invasive ductal carcinoma 2,885 | 2,951
Astrocytoma, Pilocytic 2,873 | 3,081
primitive neuroectodermal tumor 2,873 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,854 | 2,955
non-small cell lung cancer 2,769 | 2,890
oligodendroglioma 2,680 | 2,850
lung carcinoma 2,655 | 2,843
lung adenocarcinoma 2,558 | 2,716
astrocytic glioma 2,460 | 2,597
Kidney cancer 2,299 | 2,613
pancreatic cancer 2,281 | 2,398
Cancer 2,214 | 2,499
interstitial cystitis 2,203 | 2,312
subependymal giant cell astrocytoma 2,168 | 2,287
tuberculosis 1,915 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,867 | 1,962
pituitary cancer 1,841 | 1,972
Pick disease 1,830 | 1,894
group 4 medulloblastoma 1,767 | 1,855
ulcerative colitis 1,750 | 1,819
ductal carcinoma in situ 1,705 | 1,745
cystic fibrosis 1,604 | 1,696
breast carcinoma 1,577 | 1,638
colon cancer 1,435 | 1,478
adrenocortical carcinoma 1,390 | 1,428
diabetes mellitus 1,325 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,268 | 1,442
juvenile dermatomyositis 1,158 | 1,187
acute quadriplegic myopathy 1,126 | 1,158
astrocytoma 1,102 | 1,146
Rheumatoid arthritis 1,083 | 1,191
primary pancreatic ductal adenocarcinoma 1,081 | 1,109
pediatric high grade glioma 1,012 | 1,064
spina bifida 1,012 | 1,074
cutaneous lupus erythematosus 999 | 1,057
Schizophrenia 996 | 1,160
nasopharyngeal carcinoma 978 | 1,058
Intellectual disability 939 | 1,016
dermatomyositis 916 | 966
active Crohn's disease 881 | 922
Atopic dermatitis 858 | 952
non primary Sjogren syndrome sicca 805 | 891
acute myeloid leukemia 767 | 783
gastric carcinoma 765 | 807
Waldenstrons macroglobulinemia 754 | 765
Epilepsy 728 | 792
active ulcerative colitis 727 | 764
Liver Cirrhosis, Experimental 719 | 769
primary Sjogren syndrome 713 | 735
esophageal adenocarcinoma 698 | 737
medulloblastoma 679 | 720
progressive supranuclear palsy 651 | 676
aldosterone-producing adenoma 649 | 665
Alzheimer's disease 600 | 658
Dull intelligence 595 | 645
Low intelligence 595 | 645
Mental Retardation 595 | 645
Mental deficiency 595 | 645
Poor school performance 595 | 645
Obesity 583 | 678
Duchenne muscular dystrophy 574 | 601
Cognitive delay 568 | 608
Global developmental delay 568 | 608
Mental and motor retardation 568 | 608
Bipolar Disorder 564 | 666
Melanoma 561 | 711
Seizures 549 | 596
pancreatic carcinoma 547 | 562
fibroadenoma 544 | 559
Muscle hypotonia 540 | 571
hepatocellular carcinoma 531 | 547
Liver cancer 506 | 604
Endometriosis 501 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 496 | 510
Short stature 484 | 531
Down syndrome 471 | 499
chronic rhinosinusitis 461 | 512
Prostatic Neoplasms 459 | 495
gastric cancer 450 | 459
Multiple Sclerosis 449 | 540
mucosa-associated lymphoid tissue lymphoma 449 | 484
posterior fossa group A ependymoma 449 | 468
sonic hedgehog group medulloblastoma 445 | 467
Amyotrophic lateral sclerosis 431 | 451

Tissue

Skin and soft tissues 15,857 | 17,230
Endocrine System 15,813 | 18,159
Female tissues 15,802 | 17,400
Digestive Tract 15,797 | 17,369
Male tissues 15,712 | 17,142
Liver and Pancreas 15,641 | 16,750
Urinary Tract 15,597 | 16,678
Blood and immune system 15,587 | 16,909
Nervous System 15,472 | 16,725
Respiratory system 15,456 | 16,393
Cardiovascular System 14,713 | 15,192

Target Family

Non-IDG 9,220 | 12,091
Enzyme 3,663 | 4,145
Transcription Factor 1,162 | 1,400
Kinase 590 | 634
Transporter 387 | 473
GPCR 271 | 408
Ion Channel 249 | 344
Epigenetic 229 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 33 | 38
oGPCR 11 | 421

HPA RNA Tissue

smooth muscle 15,857 | 15,857
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39