Development Level

Tbio 8,095 | 10,625
Tdark 3,294 | 7,003
Tchem 1,431 | 1,890
Tclin 373 | 602

Collection

Eligible Kinase Proteins 100 | 134
Eligible Ion Channel Proteins 45 | 117
Eligible non-olfactory GPCR Proteins 31 | 143

IMPC Term

preweaning lethality, complete... 575 | 633
preweaning lethality, incomple... 212 | 260
abnormal behavior 194 | 226
embryonic lethality prior to t... 176 | 187
decreased lean body mass 170 | 195
decreased total body fat amoun... 163 | 186
decreased body weight 153 | 174
embryonic lethality prior to o... 144 | 148
decreased bone mineral content 132 | 157
increased circulating alkaline... 106 | 119
abnormal bone structure 105 | 131
decreased bone mineral density 105 | 126
increased or absent threshold ... 101 | 128
abnormal embryo size 99 | 112
decreased body length 98 | 108
decreased circulating glucose ... 97 | 121
decreased grip strength 96 | 123
increased lean body mass 92 | 107
hyperactivity 90 | 108
abnormal retina morphology 87 | 100
increased bone mineral content 83 | 92
increased mean corpuscular hem... 82 | 93
increased mean corpuscular vol... 79 | 91
enlarged heart 78 | 111
decreased circulating choleste... 74 | 85
hypoactivity 72 | 89
short tibia 72 | 82
decreased circulating triglyce... 69 | 83
decreased circulating HDL chol... 68 | 77
decreased circulating serum al... 67 | 79
increased grip strength 67 | 83
abnormal lens morphology 60 | 73
prenatal lethality prior to he... 57 | 64
decreased lumbar vertebrae num... 56 | 62
decreased circulating insulin ... 55 | 75
increased fasted circulating g... 55 | 68
increased sacral vertebrae num... 55 | 62
abnormal retinal pigmentation 52 | 61
increased circulating sodium l... 50 | 71
decreased rib number 49 | 59
abnormal sleep behavior 47 | 63
decreased mean corpuscular vol... 47 | 50
increased circulating HDL chol... 47 | 63
abnormal bone mineralization 46 | 55
increased bone mineral density 46 | 52
increased total body fat amoun... 45 | 57
abnormal coat/hair pigmentatio... 44 | 54
decreased leukocyte cell numbe... 44 | 54
improved glucose tolerance 44 | 56
increased circulating choleste... 44 | 53
decreased hemoglobin content 43 | 53
male infertility 43 | 62
abnormal gait 42 | 51
decreased prepulse inhibition 41 | 52
decreased circulating alanine ... 40 | 53
increased exploration in new e... 40 | 56
decreased caudal vertebrae num... 39 | 49
decreased erythrocyte cell num... 39 | 43
decreased fasted circulating g... 39 | 49
impaired glucose tolerance 39 | 52
decreased circulating total pr... 38 | 41
thrombocytopenia 38 | 46
abnormal behavioral response t... 37 | 52
decreased startle reflex 37 | 48
decreased circulating LDL chol... 36 | 37
decreased heart weight 36 | 44
increased blood urea nitrogen ... 36 | 44
increased body weight 36 | 42
increased rib number 36 | 41
increased hemoglobin content 34 | 45
abnormal heart morphology 33 | 51
abnormal neural tube closure 33 | 37
decreased eosinophil cell numb... 33 | 41
decreased neutrophil cell numb... 33 | 37
decreased circulating free fat... 32 | 39
abnormal eye morphology 31 | 38
abnormal seminal vesicle morph... 31 | 47
decreased circulating alkaline... 31 | 41
decreased circulating fructosa... 30 | 31
decreased mean corpuscular hem... 30 | 34
increased circulating chloride... 30 | 43
increased leukocyte cell numbe... 30 | 37
increased startle reflex 30 | 38
abnormal cranium morphology 29 | 32
decreased T cell number 28 | 31
increased hematocrit 28 | 36
small testis 28 | 37
tremors 28 | 34
abnormal spleen morphology 27 | 36
cardiovascular system phenotyp... 27 | 35
decreased circulating calcium ... 27 | 33
decreased circulating creatini... 27 | 31
embryonic growth retardation 26 | 28
increased circulating calcium ... 26 | 32
increased circulating potassiu... 26 | 31
increased heart weight 26 | 37
limb grasping 26 | 35
decreased circulating chloride... 25 | 32
decreased NK T cell number 24 | 28
increased circulating iron lev... 24 | 25

Disease

ovarian cancer 7,502 | 8,484
osteosarcoma 6,690 | 7,933
medulloblastoma, large-cell 5,057 | 6,234
psoriasis 4,749 | 6,685
glioblastoma 4,675 | 5,572
lung cancer 3,987 | 4,466
atypical teratoid / rhabdoid tumor 3,596 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,913 | 3,289
malignant mesothelioma 2,785 | 3,162
Breast cancer 2,704 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,662 | 2,988
invasive ductal carcinoma 2,653 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,617 | 2,956
primitive neuroectodermal tumor 2,450 | 3,031
pilocytic astrocytoma 2,410 | 3,086
non-small cell lung cancer 2,387 | 2,798
oligodendroglioma 2,313 | 2,849
lung carcinoma 2,256 | 2,844
pediatric high grade glioma 2,227 | 2,712
lung adenocarcinoma 2,224 | 2,713
ependymoma 2,103 | 2,514
pancreatic cancer 1,971 | 2,300
subependymal giant cell astrocytoma 1,938 | 2,287
group 3 medulloblastoma 1,885 | 2,254
interstitial cystitis 1,855 | 2,299
astrocytic glioma 1,851 | 2,241
ulcerative colitis 1,836 | 2,087
Cancer 1,835 | 2,346
adult high grade glioma 1,666 | 2,148
Pick disease 1,649 | 1,893
group 4 medulloblastoma 1,615 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,607 | 1,795
pituitary cancer 1,567 | 1,972
ductal carcinoma in situ 1,516 | 1,745
Carcinoma 1,502 | 2,147
breast carcinoma 1,416 | 1,614
cystic fibrosis 1,384 | 1,665
tuberculosis 1,371 | 1,557
colon cancer 1,304 | 1,475
astrocytoma 1,301 | 1,493
Multiple myeloma 1,292 | 1,327
adrenocortical carcinoma 1,285 | 1,427
medulloblastoma 1,220 | 1,524
sonic hedgehog group medulloblastoma 1,208 | 1,482
posterior fossa group A ependymoma 1,194 | 1,511
primary pancreatic ductal adenocarcinoma 1,175 | 1,271
posterior fossa group B ependymoma 1,130 | 1,530
juvenile dermatomyositis 1,123 | 1,189
diabetes mellitus 1,103 | 1,663
acute quadriplegic myopathy 1,077 | 1,157
Rheumatoid Arthritis 993 | 1,160
dermatomyositis 894 | 933
spina bifida 888 | 1,064
atypical teratoid/rhabdoid tumor 879 | 1,095
cutaneous lupus erythematosus 874 | 1,056
nasopharyngeal carcinoma 802 | 1,056
active Crohn's disease 780 | 918
gastric carcinoma 741 | 832
Waldenstrons macroglobulinemia 738 | 765
Atopic dermatitis 735 | 944
acute myeloid leukemia 730 | 780
primary Sjogren syndrome 706 | 789
non primary Sjogren syndrome sicca 668 | 840
tuberculosis and treatment for 6 months 653 | 686
esophageal adenocarcinoma 617 | 737
aldosterone-producing adenoma 609 | 664
progressive supranuclear palsy 604 | 674
Duchenne muscular dystrophy 554 | 602
Alzheimer's disease 512 | 644
pancreatic carcinoma 505 | 567
hepatocellular carcinoma 486 | 532
Down syndrome 480 | 548
Intellectual disability 474 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 470 | 499
fibroadenoma 457 | 557
Obesity 443 | 616
IGA Glomerulonephritis 428 | 454
Endometriosis 426 | 535
mucosa-associated lymphoid tissue lymphoma 393 | 480
Prostatic Neoplasms 387 | 471
chronic rhinosinusitis 384 | 512
Amyotrophic Lateral Sclerosis 383 | 431
gastric cancer 379 | 430
active ulcerative colitis 377 | 477
Mammary Neoplasms 348 | 410
Multiple Sclerosis 340 | 498
Schizophrenia 336 | 501
Neurodegenerative disease 333 | 383
inflammatory breast cancer 331 | 404
hereditary spastic paraplegia 302 | 313
tuberculosis and treatment for 3 months 299 | 327
sarcoidosis 297 | 358
glioblastoma multiforme 292 | 347
non-small cell lung carcinoma 292 | 413
Parkinson's disease 270 | 364
urothelial carcinoma 269 | 318
Polycystic Ovary Syndrome 266 | 332
Kidney disease 263 | 396
interstitial lung disease 259 | 291
nephrosclerosis 249 | 329

Tissue

Digestive Tract 13,193 | 18,473
Skin and soft tissues 13,193 | 18,115
Endocrine System 13,192 | 18,512
Female tissues 13,192 | 18,647
Urinary Tract 13,190 | 18,444
Liver and Pancreas 13,188 | 18,136
Nervous System 13,188 | 18,561
Cardiovascular System 13,180 | 17,958
Male tissues 13,180 | 17,969
Blood and immune system 13,179 | 17,995
Respiratory system 13,177 | 17,484

Target Family

Non-IDG 7,579 | 11,971
Enzyme 3,241 | 4,146
Transcription Factor 982 | 1,400
Kinase 528 | 634
Transporter 293 | 473
Epigenetic 210 | 242
GPCR 153 | 406
Ion Channel 139 | 341
Nuclear Receptor 34 | 48
TF/Epigenetic 31 | 38
oGPCR 3 | 421

HPA RNA Tissue

smooth muscle 13,193 | 13,193
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27