Development Level

Tbio 8,231 | 10,625
Tdark 3,349 | 7,003
Tchem 1,498 | 1,890
Tclin 393 | 602

Collection

Kinase: IDG Consortium (Targets) 92 | 125
Ion Channel: IDG Consortium (Targets) 43 | 102
GPCR: IDG Consortium (Targets) 39 | 127
Kinase: IDG Consortium (Complete/Control) 31 | 37
GPCR: IDG Consortium (Complete/Control) 13 | 26

IMPC Phenotype

preweaning lethality, complete... 581 | 633
preweaning lethality, incomple... 219 | 260
abnormal behavior 188 | 226
embryonic lethality prior to t... 178 | 187
decreased lean body mass 166 | 195
decreased total body fat amoun... 161 | 186
decreased body weight 157 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 128 | 157
increased or absent threshold ... 104 | 128
increased circulating alkaline... 103 | 119
abnormal embryo size 100 | 112
decreased bone mineral density 100 | 126
abnormal bone structure 99 | 131
decreased body length 99 | 108
decreased circulating glucose ... 98 | 121
decreased grip strength 95 | 123
increased lean body mass 91 | 107
abnormal retina morphology 88 | 100
hyperactivity 87 | 108
enlarged heart 84 | 111
increased mean corpuscular hem... 84 | 93
increased bone mineral content 83 | 92
increased mean corpuscular vol... 76 | 91
decreased circulating choleste... 75 | 85
short tibia 73 | 82
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 70 | 79
decreased circulating triglyce... 70 | 83
hypoactivity 70 | 89
increased grip strength 69 | 83
abnormal lens morphology 63 | 73
prenatal lethality prior to he... 58 | 64
decreased lumbar vertebrae num... 55 | 62
increased circulating sodium l... 55 | 71
increased fasted circulating g... 54 | 68
increased sacral vertebrae num... 54 | 62
abnormal retinal pigmentation 52 | 61
decreased circulating insulin ... 52 | 75
decreased rib number 49 | 59
increased circulating HDL chol... 49 | 63
abnormal bone mineralization 47 | 55
abnormal coat-hair pigmentatio... 47 | 54
abnormal sleep behavior 47 | 63
decreased mean corpuscular vol... 47 | 50
decreased leukocyte cell numbe... 46 | 54
increased bone mineral density 45 | 52
increased circulating choleste... 45 | 53
decreased hemoglobin content 44 | 53
increased total body fat amoun... 44 | 57
male infertility 44 | 62
decreased circulating alanine ... 43 | 53
improved glucose tolerance 43 | 56
decreased prepulse inhibition 42 | 52
impaired glucose tolerance 42 | 52
decreased caudal vertebrae num... 40 | 49
increased exploration in new e... 40 | 56
abnormal gait 39 | 51
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
decreased startle reflex 39 | 48
decreased fasted circulating g... 38 | 49
increased blood urea nitrogen ... 38 | 44
increased body weight 38 | 42
thrombocytopenia 38 | 46
abnormal behavioral response t... 36 | 52
abnormal heart morphology 35 | 51
decreased circulating LDL chol... 35 | 37
increased hemoglobin content 35 | 45
increased rib number 35 | 41
decreased heart weight 34 | 44
abnormal neural tube closure 33 | 37
abnormal eye morphology 32 | 38
abnormal seminal vesicle morph... 32 | 47
decreased eosinophil cell numb... 32 | 41
decreased neutrophil cell numb... 32 | 37
increased startle reflex 32 | 38
decreased circulating free fat... 31 | 39
decreased mean corpuscular hem... 31 | 34
increased circulating chloride... 31 | 43
cardiovascular system phenotyp... 30 | 35
decreased circulating alkaline... 30 | 41
decreased circulating fructosa... 30 | 31
increased hematocrit 30 | 36
increased leukocyte cell numbe... 30 | 37
abnormal cranium morphology 29 | 32
decreased circulating calcium ... 29 | 33
small testis 29 | 37
tremors 29 | 34
decreased T cell number 27 | 31
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased blood urea nitrogen ... 26 | 31
decreased circulating creatini... 26 | 31
increased circulating calcium ... 26 | 32
increased circulating potassiu... 26 | 31
limb grasping 26 | 35
decreased circulating aspartat... 25 | 27

Disease

ovarian cancer 7,529 | 8,491
osteosarcoma 6,772 | 7,933
medulloblastoma, large-cell 5,064 | 6,234
psoriasis 4,860 | 6,685
glioblastoma 4,646 | 5,572
lung cancer 4,005 | 4,473
atypical teratoid / rhabdoid tumor 3,542 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,001 | 3,289
malignant mesothelioma 2,783 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 2,716 | 2,988
Breast cancer 2,690 | 3,098
intraductal papillary-mucinous adenoma (IPMA) 2,672 | 2,956
invasive ductal carcinoma 2,651 | 2,950
primitive neuroectodermal tumor 2,428 | 3,031
non-small cell lung cancer 2,426 | 2,798
pilocytic astrocytoma 2,393 | 3,086
lung carcinoma 2,283 | 2,844
lung adenocarcinoma 2,279 | 2,714
oligodendroglioma 2,278 | 2,849
pediatric high grade glioma 2,214 | 2,712
ependymoma 2,076 | 2,514
pancreatic cancer 2,040 | 2,300
interstitial cystitis 1,948 | 2,299
subependymal giant cell astrocytoma 1,948 | 2,287
ulcerative colitis 1,912 | 2,087
Cancer 1,893 | 2,346
group 3 medulloblastoma 1,878 | 2,254
astrocytic glioma 1,816 | 2,241
adult high grade glioma 1,666 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 1,648 | 1,795
Pick disease 1,646 | 1,893
group 4 medulloblastoma 1,608 | 1,875
pituitary cancer 1,548 | 1,972
ductal carcinoma in situ 1,529 | 1,745
Carcinoma 1,446 | 2,147
breast carcinoma 1,424 | 1,614
tuberculosis 1,382 | 1,563
cystic fibrosis 1,375 | 1,670
colon cancer 1,327 | 1,475
Multiple myeloma 1,298 | 1,327
astrocytoma 1,294 | 1,493
adrenocortical carcinoma 1,276 | 1,427
sonic hedgehog group medulloblastoma 1,195 | 1,482
medulloblastoma 1,192 | 1,524
primary pancreatic ductal adenocarcinoma 1,192 | 1,271
posterior fossa group A ependymoma 1,172 | 1,511
diabetes mellitus 1,155 | 1,663
posterior fossa group B ependymoma 1,125 | 1,530
juvenile dermatomyositis 1,122 | 1,189
acute quadriplegic myopathy 1,067 | 1,157
Rheumatoid Arthritis 1,005 | 1,170
spina bifida 926 | 1,064
cutaneous lupus erythematosus 910 | 1,056
dermatomyositis 896 | 966
atypical teratoid/rhabdoid tumor 891 | 1,095
active Crohn's disease 832 | 918
nasopharyngeal carcinoma 830 | 1,056
gastric carcinoma 749 | 832
primary Sjogren syndrome 744 | 788
Waldenstrons macroglobulinemia 742 | 764
Atopic dermatitis 738 | 944
acute myeloid leukemia 735 | 785
non primary Sjogren syndrome sicca 681 | 840
tuberculosis and treatment for 6 months 656 | 686
esophageal adenocarcinoma 643 | 737
progressive supranuclear palsy 609 | 674
aldosterone-producing adenoma 607 | 664
Duchenne muscular dystrophy 547 | 602
pancreatic carcinoma 513 | 567
Alzheimer's disease 511 | 644
hepatocellular carcinoma 510 | 550
Down syndrome 477 | 548
Intellectual disability 468 | 573
fibroadenoma 464 | 557
Obesity 460 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 459 | 499
Endometriosis 432 | 535
IGA Glomerulonephritis 427 | 454
active ulcerative colitis 409 | 477
Prostatic Neoplasms 406 | 471
gastric cancer 395 | 436
mucosa-associated lymphoid tissue lymphoma 386 | 480
chronic rhinosinusitis 379 | 512
Amyotrophic Lateral Sclerosis 368 | 432
Mammary Neoplasms 349 | 410
inflammatory breast cancer 338 | 404
Multiple Sclerosis 336 | 498
Schizophrenia 336 | 503
Neurodegenerative disease 326 | 383
sarcoidosis 312 | 368
non-small cell lung carcinoma 308 | 413
hereditary spastic paraplegia 306 | 313
tuberculosis and treatment for 3 months 304 | 327
glioblastoma multiforme 278 | 347
Parkinson's disease 275 | 364
nephrosclerosis 274 | 329
Polycystic Ovary Syndrome 273 | 334
urothelial carcinoma 272 | 318
Kidney disease 270 | 397
interstitial lung disease 255 | 292

Tissue

Digestive Tract 13,471 | 18,472
Nervous System 13,466 | 18,560
Endocrine System 13,465 | 18,511
Female tissues 13,462 | 18,646
Liver and Pancreas 13,462 | 18,135
Urinary Tract 13,461 | 18,443
Skin and soft tissues 13,459 | 18,114
Blood and immune system 13,445 | 17,994
Male tissues 13,434 | 17,968
Cardiovascular System 13,431 | 17,957
Respiratory system 13,422 | 17,483

Target Family

Non-IDG 7,717 | 11,969
Enzyme 3,339 | 4,146
Transcription Factor 970 | 1,400
Kinase 540 | 634
Transporter 323 | 473
Epigenetic 209 | 242
GPCR 157 | 408
Ion Channel 144 | 341
Nuclear Receptor 37 | 48
TF/Epigenetic 32 | 38
oGPCR 3 | 421

HPA RNA Tissue

small intestine 13,471 | 13,471
testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
lung 13,653 | 13,653
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
kidney 13,341 | 13,341
adrenal gland 13,296 | 13,296
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
adipose tissue 12,955 | 12,955
skin 12,911 | 12,911
salivary gland 12,839 | 12,839
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
heart muscle 12,601 | 12,601
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66