Development Level

Tbio 8,231 | 10,625
Tdark 3,349 | 7,003
Tchem 1,499 | 1,890
Tclin 393 | 602

Collection

Eligible Kinase Proteins 98 | 134
Eligible Ion Channel Proteins 42 | 117
Eligible non-olfactory GPCR Proteins 40 | 143

IMPC Term

preweaning lethality, complete... 581 | 633
preweaning lethality, incomple... 219 | 260
abnormal behavior 188 | 226
embryonic lethality prior to t... 178 | 187
decreased lean body mass 166 | 195
decreased total body fat amoun... 161 | 186
decreased body weight 157 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 128 | 157
increased or absent threshold ... 104 | 128
increased circulating alkaline... 103 | 119
abnormal embryo size 100 | 112
decreased bone mineral density 100 | 126
abnormal bone structure 99 | 131
decreased body length 99 | 108
decreased circulating glucose ... 98 | 121
decreased grip strength 95 | 123
increased lean body mass 91 | 107
abnormal retina morphology 88 | 100
hyperactivity 87 | 108
enlarged heart 84 | 111
increased mean corpuscular hem... 84 | 93
increased bone mineral content 83 | 92
increased mean corpuscular vol... 76 | 91
decreased circulating choleste... 75 | 85
short tibia 73 | 82
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 70 | 79
decreased circulating triglyce... 70 | 83
hypoactivity 70 | 89
increased grip strength 69 | 83
abnormal lens morphology 63 | 73
prenatal lethality prior to he... 58 | 64
decreased lumbar vertebrae num... 55 | 62
increased circulating sodium l... 55 | 71
increased fasted circulating g... 54 | 68
increased sacral vertebrae num... 54 | 62
abnormal retinal pigmentation 52 | 61
decreased circulating insulin ... 52 | 75
decreased rib number 49 | 59
increased circulating HDL chol... 49 | 63
abnormal bone mineralization 47 | 55
abnormal coat/hair pigmentatio... 47 | 54
abnormal sleep behavior 47 | 63
decreased mean corpuscular vol... 47 | 50
decreased leukocyte cell numbe... 46 | 54
increased bone mineral density 45 | 52
increased circulating choleste... 45 | 53
decreased hemoglobin content 44 | 53
increased total body fat amoun... 44 | 57
male infertility 44 | 62
decreased circulating alanine ... 43 | 53
improved glucose tolerance 43 | 56
decreased prepulse inhibition 42 | 52
impaired glucose tolerance 42 | 52
decreased caudal vertebrae num... 40 | 49
increased exploration in new e... 40 | 56
abnormal gait 39 | 51
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
decreased startle reflex 39 | 48
decreased fasted circulating g... 38 | 49
increased blood urea nitrogen ... 38 | 44
increased body weight 38 | 42
thrombocytopenia 38 | 46
abnormal behavioral response t... 36 | 52
abnormal heart morphology 35 | 51
decreased circulating LDL chol... 35 | 37
increased hemoglobin content 35 | 45
increased rib number 35 | 41
decreased heart weight 34 | 44
abnormal neural tube closure 33 | 37
abnormal eye morphology 32 | 38
abnormal seminal vesicle morph... 32 | 47
decreased eosinophil cell numb... 32 | 41
decreased neutrophil cell numb... 32 | 37
increased startle reflex 32 | 38
decreased circulating free fat... 31 | 39
decreased mean corpuscular hem... 31 | 34
increased circulating chloride... 31 | 43
cardiovascular system phenotyp... 30 | 35
decreased circulating alkaline... 30 | 41
decreased circulating fructosa... 30 | 31
increased hematocrit 30 | 36
increased leukocyte cell numbe... 30 | 37
abnormal cranium morphology 29 | 32
decreased circulating calcium ... 29 | 33
small testis 29 | 37
tremors 29 | 34
decreased T cell number 27 | 31
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased blood urea nitrogen ... 26 | 31
decreased circulating creatini... 26 | 31
increased circulating calcium ... 26 | 32
increased circulating potassiu... 26 | 31
limb grasping 26 | 35
decreased circulating aspartat... 25 | 27

Disease

ovarian cancer 7,525 | 8,484
osteosarcoma 6,772 | 7,933
medulloblastoma, large-cell 5,064 | 6,234
psoriasis 4,860 | 6,685
glioblastoma 4,646 | 5,572
lung cancer 3,999 | 4,466
atypical teratoid / rhabdoid tumor 3,542 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,001 | 3,289
malignant mesothelioma 2,782 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 2,716 | 2,988
Breast cancer 2,688 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 2,672 | 2,956
invasive ductal carcinoma 2,651 | 2,950
primitive neuroectodermal tumor 2,428 | 3,031
non-small cell lung cancer 2,426 | 2,798
pilocytic astrocytoma 2,393 | 3,086
lung carcinoma 2,283 | 2,844
lung adenocarcinoma 2,278 | 2,713
oligodendroglioma 2,278 | 2,849
pediatric high grade glioma 2,214 | 2,712
ependymoma 2,076 | 2,514
pancreatic cancer 2,040 | 2,300
interstitial cystitis 1,948 | 2,299
subependymal giant cell astrocytoma 1,948 | 2,287
ulcerative colitis 1,912 | 2,087
Cancer 1,893 | 2,346
group 3 medulloblastoma 1,878 | 2,254
astrocytic glioma 1,816 | 2,241
adult high grade glioma 1,666 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 1,648 | 1,795
Pick disease 1,646 | 1,893
group 4 medulloblastoma 1,608 | 1,875
pituitary cancer 1,548 | 1,972
ductal carcinoma in situ 1,529 | 1,745
Carcinoma 1,446 | 2,147
breast carcinoma 1,424 | 1,614
tuberculosis 1,377 | 1,557
cystic fibrosis 1,372 | 1,665
colon cancer 1,327 | 1,475
Multiple myeloma 1,299 | 1,327
astrocytoma 1,294 | 1,493
adrenocortical carcinoma 1,276 | 1,427
sonic hedgehog group medulloblastoma 1,195 | 1,482
medulloblastoma 1,192 | 1,524
primary pancreatic ductal adenocarcinoma 1,192 | 1,271
posterior fossa group A ependymoma 1,172 | 1,511
diabetes mellitus 1,155 | 1,663
posterior fossa group B ependymoma 1,125 | 1,530
juvenile dermatomyositis 1,122 | 1,189
acute quadriplegic myopathy 1,067 | 1,157
Rheumatoid Arthritis 1,005 | 1,160
spina bifida 926 | 1,064
cutaneous lupus erythematosus 910 | 1,056
dermatomyositis 896 | 933
atypical teratoid/rhabdoid tumor 891 | 1,095
active Crohn's disease 832 | 918
nasopharyngeal carcinoma 830 | 1,056
gastric carcinoma 749 | 832
primary Sjogren syndrome 745 | 789
Waldenstrons macroglobulinemia 743 | 765
Atopic dermatitis 738 | 944
acute myeloid leukemia 730 | 780
non primary Sjogren syndrome sicca 681 | 840
tuberculosis and treatment for 6 months 656 | 686
esophageal adenocarcinoma 643 | 737
progressive supranuclear palsy 609 | 674
aldosterone-producing adenoma 607 | 664
Duchenne muscular dystrophy 547 | 602
pancreatic carcinoma 513 | 567
Alzheimer's disease 511 | 644
hepatocellular carcinoma 493 | 532
Down syndrome 477 | 548
Intellectual disability 468 | 573
fibroadenoma 464 | 557
Obesity 460 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 459 | 499
Endometriosis 432 | 535
IGA Glomerulonephritis 427 | 454
active ulcerative colitis 409 | 477
Prostatic Neoplasms 406 | 471
gastric cancer 389 | 430
mucosa-associated lymphoid tissue lymphoma 386 | 480
chronic rhinosinusitis 379 | 512
Amyotrophic Lateral Sclerosis 368 | 431
Mammary Neoplasms 349 | 410
inflammatory breast cancer 338 | 404
Multiple Sclerosis 336 | 498
Schizophrenia 334 | 501
Neurodegenerative disease 326 | 383
sarcoidosis 312 | 358
non-small cell lung carcinoma 308 | 413
hereditary spastic paraplegia 306 | 313
tuberculosis and treatment for 3 months 304 | 327
glioblastoma multiforme 278 | 347
Parkinson's disease 275 | 364
Polycystic Ovary Syndrome 274 | 332
nephrosclerosis 274 | 329
urothelial carcinoma 272 | 318
Kidney disease 270 | 396
interstitial lung disease 254 | 291

Tissue

Digestive Tract 13,472 | 18,473
Nervous System 13,467 | 18,561
Endocrine System 13,466 | 18,512
Female tissues 13,463 | 18,647
Liver and Pancreas 13,463 | 18,136
Urinary Tract 13,462 | 18,444
Skin and soft tissues 13,460 | 18,115
Blood and immune system 13,446 | 17,995
Male tissues 13,435 | 17,969
Cardiovascular System 13,432 | 17,958
Respiratory system 13,423 | 17,484

Target Family

Non-IDG 7,717 | 11,971
Enzyme 3,340 | 4,146
Transcription Factor 970 | 1,400
Kinase 540 | 634
Transporter 323 | 473
Epigenetic 209 | 242
GPCR 157 | 406
Ion Channel 144 | 341
Nuclear Receptor 37 | 48
TF/Epigenetic 32 | 38
oGPCR 3 | 421

HPA RNA Tissue

small intestine 13,472 | 13,472
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108